id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-158628-71n1tgrw	Russo, Giulia	In Silico Trial to test COVID-19 candidate vaccines: a case study with UISS platform	2020-05-05		.txt	text/plain	5596	296	50	Recently, specific findings about the genome sequencing of SARS-CoV-2 in different countries where cases of infection were registered, revealed its relative intrinsic genomic variability, its virus dynamics and the related host response mechanisms, unveiling interesting knowledge useful for the formulation of innovative strategies for preventive vaccination. Specifically, SARS-CoV-2 sequencing along with its relative intrinsic genomic variability [10] , the presence of minority variants generated during SARS-CoV-2 replication [11] , the involved cellular factors that favors SARS-CoV-2 cell entry [12] , the timing in which viral load peaks (during the first week of illness), its gradual decline (over the second week) and the increasing of both IgG and IgM antibodies (around day 10 after symptom onset) represent some of the relevant insights so far delineated and considered by research community about SARS-CoV-2 virus [13] . UISS is an immune system simulation platform that was designed to be applied to several and different scenarios, especially to carry on in silico trials to predict the efficacy of a specific prophylactic or therapeutic vaccine against a particular disease.	./cache/cord-158628-71n1tgrw.txt	./txt/cord-158628-71n1tgrw.txt