id	sid	tid	token	lemma	pos
cord-263532-q044i7ym	1	1	key	key	NN
cord-263532-q044i7ym	1	2	:	:	:
cord-263532-q044i7ym	1	3	cord-263532-q044i7ym	cord-263532-q044i7ym	NNP
cord-263532-q044i7ym	1	4	authors	author	NNS
cord-263532-q044i7ym	1	5	:	:	:
cord-263532-q044i7ym	1	6	Goyal	Goyal	NNP
cord-263532-q044i7ym	1	7	,	,	,
cord-263532-q044i7ym	1	8	Bhupesh	Bhupesh	NNP
cord-263532-q044i7ym	1	9	;	;	:
cord-263532-q044i7ym	1	10	Goyal	Goyal	NNP
cord-263532-q044i7ym	1	11	,	,	,
cord-263532-q044i7ym	2	1	Deepti	Deepti	NNP
cord-263532-q044i7ym	2	2	title	title	NN
cord-263532-q044i7ym	2	3	:	:	:
cord-263532-q044i7ym	3	1	Targeting	target	VBG
cord-263532-q044i7ym	3	2	the	the	DT
cord-263532-q044i7ym	3	3	Dimerization	Dimerization	NNP
cord-263532-q044i7ym	3	4	of	of	IN
cord-263532-q044i7ym	3	5	the	the	DT
cord-263532-q044i7ym	3	6	Main	Main	NNP
cord-263532-q044i7ym	3	7	Protease	Protease	NNP
cord-263532-q044i7ym	3	8	of	of	IN
cord-263532-q044i7ym	3	9	Coronaviruses	Coronaviruses	NNPS
cord-263532-q044i7ym	3	10	:	:	:
cord-263532-q044i7ym	4	1	A	a	DT
cord-263532-q044i7ym	4	2	Potential	potential	JJ
cord-263532-q044i7ym	4	3	Broad	Broad	NNP
cord-263532-q044i7ym	4	4	-	-	HYPH
cord-263532-q044i7ym	4	5	Spectrum	Spectrum	NNP
cord-263532-q044i7ym	4	6	Therapeutic	Therapeutic	NNP
cord-263532-q044i7ym	4	7	Strategy	Strategy	NNP
cord-263532-q044i7ym	4	8	date	date	NN
cord-263532-q044i7ym	4	9	:	:	:
cord-263532-q044i7ym	4	10	2020	2020	CD
cord-263532-q044i7ym	4	11	-	-	HYPH
cord-263532-q044i7ym	4	12	05	05	CD
cord-263532-q044i7ym	4	13	-	-	SYM
cord-263532-q044i7ym	4	14	13	13	CD
cord-263532-q044i7ym	4	15	journal	journal	NN
cord-263532-q044i7ym	4	16	:	:	:
cord-263532-q044i7ym	5	1	ACS	ACS	NNP
cord-263532-q044i7ym	5	2	Comb	Comb	NNP
cord-263532-q044i7ym	5	3	Sci	Sci	NNP
cord-263532-q044i7ym	5	4	DOI	DOI	NNP
cord-263532-q044i7ym	5	5	:	:	:
cord-263532-q044i7ym	6	1	10.1021/	10.1021/	NNP
cord-263532-q044i7ym	7	1	acscombsci.0c00058	acscombsci.0c00058	NNP
cord-263532-q044i7ym	7	2	sha	sha	NN
cord-263532-q044i7ym	7	3	:	:	:
cord-263532-q044i7ym	8	1	3a7dfaff7af07135c55d7b151bbcc2d2ee3e62a3	3a7dfaff7af07135c55d7b151bbcc2d2ee3e62a3	CD
cord-263532-q044i7ym	8	2	doc_id	doc_id	CD
cord-263532-q044i7ym	8	3	:	:	:
cord-263532-q044i7ym	8	4	263532	263532	CD
cord-263532-q044i7ym	8	5	cord_uid	cord_uid	FW
cord-263532-q044i7ym	8	6	:	:	:
cord-263532-q044i7ym	9	1	q044i7ym	q044i7ym	JJ
cord-263532-q044i7ym	9	2	[	[	-LRB-
cord-263532-q044i7ym	9	3	Image	image	NN
cord-263532-q044i7ym	9	4	:	:	:
cord-263532-q044i7ym	9	5	see	see	VB
cord-263532-q044i7ym	9	6	text	text	NN
cord-263532-q044i7ym	9	7	]	]	-RRB-
cord-263532-q044i7ym	10	1	A	a	DT
cord-263532-q044i7ym	10	2	new	new	JJ
cord-263532-q044i7ym	10	3	coronavirus	coronavirus	NN
cord-263532-q044i7ym	10	4	(	(	-LRB-
cord-263532-q044i7ym	10	5	CoV	CoV	NNP
cord-263532-q044i7ym	10	6	)	)	-RRB-
cord-263532-q044i7ym	10	7	caused	cause	VBD
cord-263532-q044i7ym	10	8	a	a	DT
cord-263532-q044i7ym	10	9	pandemic	pandemic	NN
cord-263532-q044i7ym	10	10	named	name	VBN
cord-263532-q044i7ym	10	11	COVID-19	COVID-19	NNP
cord-263532-q044i7ym	10	12	,	,	,
cord-263532-q044i7ym	10	13	which	which	WDT
cord-263532-q044i7ym	10	14	has	have	VBZ
cord-263532-q044i7ym	10	15	become	become	VBN
cord-263532-q044i7ym	10	16	a	a	DT
cord-263532-q044i7ym	10	17	global	global	JJ
cord-263532-q044i7ym	10	18	health	health	NN
cord-263532-q044i7ym	10	19	care	care	NN
cord-263532-q044i7ym	10	20	emergency	emergency	NN
cord-263532-q044i7ym	10	21	in	in	IN
cord-263532-q044i7ym	10	22	the	the	DT
cord-263532-q044i7ym	10	23	present	present	JJ
cord-263532-q044i7ym	10	24	time	time	NN
cord-263532-q044i7ym	10	25	.	.	.
cord-263532-q044i7ym	11	1	The	the	DT
cord-263532-q044i7ym	11	2	virus	virus	NN
cord-263532-q044i7ym	11	3	is	be	VBZ
cord-263532-q044i7ym	11	4	referred	refer	VBN
cord-263532-q044i7ym	11	5	to	to	IN
cord-263532-q044i7ym	11	6	as	as	IN
cord-263532-q044i7ym	11	7	SARS	SARS	NNP
cord-263532-q044i7ym	11	8	-	-	HYPH
cord-263532-q044i7ym	11	9	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	11	10	(	(	-LRB-
cord-263532-q044i7ym	11	11	severe	severe	JJ
cord-263532-q044i7ym	11	12	acute	acute	JJ
cord-263532-q044i7ym	11	13	respiratory	respiratory	JJ
cord-263532-q044i7ym	11	14	syndrome	syndrome	NN
cord-263532-q044i7ym	11	15	-	-	HYPH
cord-263532-q044i7ym	11	16	coronavirus-2	coronavirus-2	NN
cord-263532-q044i7ym	11	17	)	)	-RRB-
cord-263532-q044i7ym	11	18	and	and	CC
cord-263532-q044i7ym	11	19	has	have	VBZ
cord-263532-q044i7ym	11	20	a	a	DT
cord-263532-q044i7ym	11	21	genome	genome	NN
cord-263532-q044i7ym	11	22	similar	similar	JJ
cord-263532-q044i7ym	11	23	(	(	-LRB-
cord-263532-q044i7ym	11	24	∼82	∼82	NNP
cord-263532-q044i7ym	11	25	%	%	NN
cord-263532-q044i7ym	11	26	)	)	-RRB-
cord-263532-q044i7ym	11	27	to	to	IN
cord-263532-q044i7ym	11	28	that	that	DT
cord-263532-q044i7ym	11	29	of	of	IN
cord-263532-q044i7ym	11	30	the	the	DT
cord-263532-q044i7ym	11	31	previously	previously	RB
cord-263532-q044i7ym	11	32	known	know	VBN
cord-263532-q044i7ym	11	33	SARS	SARS	NNP
cord-263532-q044i7ym	11	34	-	-	HYPH
cord-263532-q044i7ym	11	35	CoV	CoV	NNP
cord-263532-q044i7ym	11	36	(	(	-LRB-
cord-263532-q044i7ym	11	37	SARS	SARS	NNP
cord-263532-q044i7ym	11	38	coronavirus	coronavirus	NN
cord-263532-q044i7ym	11	39	)	)	-RRB-
cord-263532-q044i7ym	11	40	.	.	.
cord-263532-q044i7ym	12	1	An	an	DT
cord-263532-q044i7ym	12	2	attractive	attractive	JJ
cord-263532-q044i7ym	12	3	therapeutic	therapeutic	JJ
cord-263532-q044i7ym	12	4	target	target	NN
cord-263532-q044i7ym	12	5	for	for	IN
cord-263532-q044i7ym	12	6	CoVs	CoVs	NNP
cord-263532-q044i7ym	12	7	is	be	VBZ
cord-263532-q044i7ym	12	8	the	the	DT
cord-263532-q044i7ym	12	9	main	main	JJ
cord-263532-q044i7ym	12	10	protease	protease	NN
cord-263532-q044i7ym	12	11	(	(	-LRB-
cord-263532-q044i7ym	12	12	M(pro	M(pro	NNP
cord-263532-q044i7ym	12	13	)	)	-RRB-
cord-263532-q044i7ym	12	14	)	)	-RRB-
cord-263532-q044i7ym	12	15	or	or	CC
cord-263532-q044i7ym	12	16	3-chymotrypsin	3-chymotrypsin	CD
cord-263532-q044i7ym	12	17	-	-	HYPH
cord-263532-q044i7ym	12	18	like	like	JJ
cord-263532-q044i7ym	12	19	cysteine	cysteine	NN
cord-263532-q044i7ym	12	20	protease	protease	NN
cord-263532-q044i7ym	12	21	(	(	-LRB-
cord-263532-q044i7ym	12	22	3CL(pro	3cl(pro	CD
cord-263532-q044i7ym	12	23	)	)	-RRB-
cord-263532-q044i7ym	12	24	)	)	-RRB-
cord-263532-q044i7ym	12	25	,	,	,
cord-263532-q044i7ym	12	26	as	as	IN
cord-263532-q044i7ym	12	27	this	this	DT
cord-263532-q044i7ym	12	28	enzyme	enzyme	NN
cord-263532-q044i7ym	12	29	plays	play	VBZ
cord-263532-q044i7ym	12	30	a	a	DT
cord-263532-q044i7ym	12	31	key	key	JJ
cord-263532-q044i7ym	12	32	role	role	NN
cord-263532-q044i7ym	12	33	in	in	IN
cord-263532-q044i7ym	12	34	polyprotein	polyprotein	JJ
cord-263532-q044i7ym	12	35	processing	processing	NN
cord-263532-q044i7ym	12	36	and	and	CC
cord-263532-q044i7ym	12	37	is	be	VBZ
cord-263532-q044i7ym	12	38	active	active	JJ
cord-263532-q044i7ym	12	39	in	in	IN
cord-263532-q044i7ym	12	40	a	a	DT
cord-263532-q044i7ym	12	41	dimeric	dimeric	JJ
cord-263532-q044i7ym	12	42	form	form	NN
cord-263532-q044i7ym	12	43	.	.	.
cord-263532-q044i7ym	13	1	Further	further	RB
cord-263532-q044i7ym	13	2	,	,	,
cord-263532-q044i7ym	13	3	M(pro	M(pro	NNP
cord-263532-q044i7ym	13	4	)	)	-RRB-
cord-263532-q044i7ym	13	5	is	be	VBZ
cord-263532-q044i7ym	13	6	highly	highly	RB
cord-263532-q044i7ym	13	7	conserved	conserve	VBN
cord-263532-q044i7ym	13	8	among	among	IN
cord-263532-q044i7ym	13	9	various	various	JJ
cord-263532-q044i7ym	13	10	CoVs	CoVs	NNP
cord-263532-q044i7ym	13	11	,	,	,
cord-263532-q044i7ym	13	12	and	and	CC
cord-263532-q044i7ym	13	13	a	a	DT
cord-263532-q044i7ym	13	14	mutation	mutation	NN
cord-263532-q044i7ym	13	15	in	in	IN
cord-263532-q044i7ym	13	16	M(pro	M(pro	NNP
cord-263532-q044i7ym	13	17	)	)	-RRB-
cord-263532-q044i7ym	13	18	is	be	VBZ
cord-263532-q044i7ym	13	19	often	often	RB
cord-263532-q044i7ym	13	20	lethal	lethal	JJ
cord-263532-q044i7ym	13	21	to	to	IN
cord-263532-q044i7ym	13	22	the	the	DT
cord-263532-q044i7ym	13	23	virus	virus	NN
cord-263532-q044i7ym	13	24	.	.	.
cord-263532-q044i7ym	14	1	Thus	thus	RB
cord-263532-q044i7ym	14	2	,	,	,
cord-263532-q044i7ym	14	3	drugs	drug	NNS
cord-263532-q044i7ym	14	4	targeting	target	VBG
cord-263532-q044i7ym	14	5	the	the	DT
cord-263532-q044i7ym	14	6	M(pro	M(pro	NNP
cord-263532-q044i7ym	14	7	)	)	-RRB-
cord-263532-q044i7ym	14	8	enzyme	enzyme	NN
cord-263532-q044i7ym	14	9	significantly	significantly	RB
cord-263532-q044i7ym	14	10	reduce	reduce	VB
cord-263532-q044i7ym	14	11	the	the	DT
cord-263532-q044i7ym	14	12	risk	risk	NN
cord-263532-q044i7ym	14	13	of	of	IN
cord-263532-q044i7ym	14	14	mutation	mutation	NN
cord-263532-q044i7ym	14	15	-	-	HYPH
cord-263532-q044i7ym	14	16	mediated	mediate	VBN
cord-263532-q044i7ym	14	17	drug	drug	NN
cord-263532-q044i7ym	14	18	resistance	resistance	NN
cord-263532-q044i7ym	14	19	and	and	CC
cord-263532-q044i7ym	14	20	display	display	VB
cord-263532-q044i7ym	14	21	broad	broad	JJ
cord-263532-q044i7ym	14	22	-	-	HYPH
cord-263532-q044i7ym	14	23	spectrum	spectrum	NN
cord-263532-q044i7ym	14	24	antiviral	antiviral	JJ
cord-263532-q044i7ym	14	25	activity	activity	NN
cord-263532-q044i7ym	14	26	.	.	.
cord-263532-q044i7ym	15	1	The	the	DT
cord-263532-q044i7ym	15	2	combinatorial	combinatorial	JJ
cord-263532-q044i7ym	15	3	design	design	NN
cord-263532-q044i7ym	15	4	of	of	IN
cord-263532-q044i7ym	15	5	peptide	peptide	NN
cord-263532-q044i7ym	15	6	-	-	HYPH
cord-263532-q044i7ym	15	7	based	base	VBN
cord-263532-q044i7ym	15	8	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	15	9	targeting	target	VBG
cord-263532-q044i7ym	15	10	the	the	DT
cord-263532-q044i7ym	15	11	dimerization	dimerization	NN
cord-263532-q044i7ym	15	12	of	of	IN
cord-263532-q044i7ym	15	13	SARS	SARS	NNP
cord-263532-q044i7ym	15	14	-	-	HYPH
cord-263532-q044i7ym	15	15	CoV	CoV	NNP
cord-263532-q044i7ym	15	16	M(pro	M(pro	NNP
cord-263532-q044i7ym	15	17	)	)	-RRB-
cord-263532-q044i7ym	15	18	represents	represent	VBZ
cord-263532-q044i7ym	15	19	a	a	DT
cord-263532-q044i7ym	15	20	potential	potential	JJ
cord-263532-q044i7ym	15	21	therapeutic	therapeutic	JJ
cord-263532-q044i7ym	15	22	strategy	strategy	NN
cord-263532-q044i7ym	15	23	.	.	.
cord-263532-q044i7ym	16	1	In	in	IN
cord-263532-q044i7ym	16	2	this	this	DT
cord-263532-q044i7ym	16	3	regard	regard	NN
cord-263532-q044i7ym	16	4	,	,	,
cord-263532-q044i7ym	16	5	we	-PRON-	PRP
cord-263532-q044i7ym	16	6	have	have	VBP
cord-263532-q044i7ym	16	7	compiled	compile	VBN
cord-263532-q044i7ym	16	8	the	the	DT
cord-263532-q044i7ym	16	9	literature	literature	NN
cord-263532-q044i7ym	16	10	reports	report	NNS
cord-263532-q044i7ym	16	11	highlighting	highlight	VBG
cord-263532-q044i7ym	16	12	the	the	DT
cord-263532-q044i7ym	16	13	effect	effect	NN
cord-263532-q044i7ym	16	14	of	of	IN
cord-263532-q044i7ym	16	15	mutations	mutation	NNS
cord-263532-q044i7ym	16	16	and	and	CC
cord-263532-q044i7ym	16	17	N	n	CD
cord-263532-q044i7ym	16	18	-	-	HYPH
cord-263532-q044i7ym	16	19	terminal	terminal	JJ
cord-263532-q044i7ym	16	20	deletion	deletion	NN
cord-263532-q044i7ym	16	21	of	of	IN
cord-263532-q044i7ym	16	22	residues	residue	NNS
cord-263532-q044i7ym	16	23	of	of	IN
cord-263532-q044i7ym	16	24	SARS	SARS	NNP
cord-263532-q044i7ym	16	25	-	-	HYPH
cord-263532-q044i7ym	16	26	CoV	CoV	NNP
cord-263532-q044i7ym	16	27	M(pro	M(pro	NNP
cord-263532-q044i7ym	16	28	)	)	-RRB-
cord-263532-q044i7ym	16	29	on	on	IN
cord-263532-q044i7ym	16	30	its	-PRON-	PRP$
cord-263532-q044i7ym	16	31	dimerization	dimerization	NN
cord-263532-q044i7ym	16	32	and	and	CC
cord-263532-q044i7ym	16	33	,	,	,
cord-263532-q044i7ym	16	34	thus	thus	RB
cord-263532-q044i7ym	16	35	,	,	,
cord-263532-q044i7ym	16	36	catalytic	catalytic	JJ
cord-263532-q044i7ym	16	37	activity	activity	NN
cord-263532-q044i7ym	16	38	.	.	.
cord-263532-q044i7ym	17	1	We	-PRON-	PRP
cord-263532-q044i7ym	17	2	believe	believe	VBP
cord-263532-q044i7ym	17	3	that	that	IN
cord-263532-q044i7ym	17	4	the	the	DT
cord-263532-q044i7ym	17	5	present	present	JJ
cord-263532-q044i7ym	17	6	review	review	NN
cord-263532-q044i7ym	17	7	will	will	MD
cord-263532-q044i7ym	17	8	stimulate	stimulate	VB
cord-263532-q044i7ym	17	9	research	research	NN
cord-263532-q044i7ym	17	10	in	in	IN
cord-263532-q044i7ym	17	11	this	this	DT
cord-263532-q044i7ym	17	12	less	less	RBR
cord-263532-q044i7ym	17	13	explored	explore	VBN
cord-263532-q044i7ym	17	14	yet	yet	CC
cord-263532-q044i7ym	17	15	quite	quite	RB
cord-263532-q044i7ym	17	16	significant	significant	JJ
cord-263532-q044i7ym	17	17	area	area	NN
cord-263532-q044i7ym	17	18	.	.	.
cord-263532-q044i7ym	18	1	The	the	DT
cord-263532-q044i7ym	18	2	effect	effect	NN
cord-263532-q044i7ym	18	3	of	of	IN
cord-263532-q044i7ym	18	4	the	the	DT
cord-263532-q044i7ym	18	5	COVID-19	covid-19	JJ
cord-263532-q044i7ym	18	6	epidemic	epidemic	NN
cord-263532-q044i7ym	18	7	and	and	CC
cord-263532-q044i7ym	18	8	the	the	DT
cord-263532-q044i7ym	18	9	possibility	possibility	NN
cord-263532-q044i7ym	18	10	of	of	IN
cord-263532-q044i7ym	18	11	future	future	JJ
cord-263532-q044i7ym	18	12	CoV	cov	NN
cord-263532-q044i7ym	18	13	outbreaks	outbreak	NNS
cord-263532-q044i7ym	18	14	strongly	strongly	RB
cord-263532-q044i7ym	18	15	emphasize	emphasize	VBP
cord-263532-q044i7ym	18	16	the	the	DT
cord-263532-q044i7ym	18	17	urgent	urgent	JJ
cord-263532-q044i7ym	18	18	need	need	NN
cord-263532-q044i7ym	18	19	for	for	IN
cord-263532-q044i7ym	18	20	the	the	DT
cord-263532-q044i7ym	18	21	design	design	NN
cord-263532-q044i7ym	18	22	and	and	CC
cord-263532-q044i7ym	18	23	development	development	NN
cord-263532-q044i7ym	18	24	of	of	IN
cord-263532-q044i7ym	18	25	potent	potent	JJ
cord-263532-q044i7ym	18	26	antiviral	antiviral	JJ
cord-263532-q044i7ym	18	27	agents	agent	NNS
cord-263532-q044i7ym	18	28	against	against	IN
cord-263532-q044i7ym	18	29	CoV	CoV	NNP
cord-263532-q044i7ym	18	30	infections	infection	NNS
cord-263532-q044i7ym	18	31	.	.	.
cord-263532-q044i7ym	19	1	Coronaviruses	Coronaviruses	NNP
cord-263532-q044i7ym	19	2	(	(	-LRB-
cord-263532-q044i7ym	19	3	CoVs	CoVs	NNP
cord-263532-q044i7ym	19	4	)	)	-RRB-
cord-263532-q044i7ym	19	5	have	have	VBP
cord-263532-q044i7ym	19	6	been	be	VBN
cord-263532-q044i7ym	19	7	known	know	VBN
cord-263532-q044i7ym	19	8	since	since	IN
cord-263532-q044i7ym	19	9	1947	1947	CD
cord-263532-q044i7ym	19	10	,	,	,
cord-263532-q044i7ym	19	11	when	when	WRB
cord-263532-q044i7ym	19	12	the	the	DT
cord-263532-q044i7ym	19	13	first	first	JJ
cord-263532-q044i7ym	19	14	prototype	prototype	NN
cord-263532-q044i7ym	19	15	murine	murine	JJ
cord-263532-q044i7ym	19	16	strain	strain	NN
cord-263532-q044i7ym	19	17	JHM	JHM	NNP
cord-263532-q044i7ym	19	18	was	be	VBD
cord-263532-q044i7ym	19	19	reported	report	VBN
cord-263532-q044i7ym	19	20	.	.	.
cord-263532-q044i7ym	20	1	1	1	CD
cord-263532-q044i7ym	20	2	,	,	,
cord-263532-q044i7ym	20	3	2	2	CD
cord-263532-q044i7ym	20	4	CoVs	CoVs	NNP
cord-263532-q044i7ym	20	5	are	be	VBP
cord-263532-q044i7ym	20	6	enveloped	envelop	VBN
cord-263532-q044i7ym	20	7	viruses	virus	NNS
cord-263532-q044i7ym	20	8	consisting	consist	VBG
cord-263532-q044i7ym	20	9	of	of	IN
cord-263532-q044i7ym	20	10	single	single	JJ
cord-263532-q044i7ym	20	11	positive	positive	JJ
cord-263532-q044i7ym	20	12	-	-	HYPH
cord-263532-q044i7ym	20	13	strand	strand	NN
cord-263532-q044i7ym	20	14	RNA	RNA	NNP
cord-263532-q044i7ym	20	15	,	,	,
cord-263532-q044i7ym	20	16	and	and	CC
cord-263532-q044i7ym	20	17	they	-PRON-	PRP
cord-263532-q044i7ym	20	18	infect	infect	VBP
cord-263532-q044i7ym	20	19	various	various	JJ
cord-263532-q044i7ym	20	20	vertebrates	vertebrate	NNS
cord-263532-q044i7ym	20	21	(	(	-LRB-
cord-263532-q044i7ym	20	22	bats	bat	NNS
cord-263532-q044i7ym	20	23	,	,	,
cord-263532-q044i7ym	20	24	pets	pet	NNS
cord-263532-q044i7ym	20	25	,	,	,
cord-263532-q044i7ym	20	26	livestock	livestock	NN
cord-263532-q044i7ym	20	27	,	,	,
cord-263532-q044i7ym	20	28	poultry	poultry	NN
cord-263532-q044i7ym	20	29	,	,	,
cord-263532-q044i7ym	20	30	and	and	CC
cord-263532-q044i7ym	20	31	humans	human	NNS
cord-263532-q044i7ym	20	32	)	)	-RRB-
cord-263532-q044i7ym	20	33	.	.	.
cord-263532-q044i7ym	21	1	Among	among	IN
cord-263532-q044i7ym	21	2	humans	human	NNS
cord-263532-q044i7ym	21	3	,	,	,
cord-263532-q044i7ym	21	4	CoVs	CoVs	NNP
cord-263532-q044i7ym	21	5	are	be	VBP
cord-263532-q044i7ym	21	6	responsible	responsible	JJ
cord-263532-q044i7ym	21	7	for	for	IN
cord-263532-q044i7ym	21	8	respiratory	respiratory	JJ
cord-263532-q044i7ym	21	9	,	,	,
cord-263532-q044i7ym	21	10	gastrointestinal	gastrointestinal	JJ
cord-263532-q044i7ym	21	11	,	,	,
cord-263532-q044i7ym	21	12	and	and	CC
cord-263532-q044i7ym	21	13	neurological	neurological	JJ
cord-263532-q044i7ym	21	14	problems	problem	NNS
cord-263532-q044i7ym	21	15	.	.	.
cord-263532-q044i7ym	22	1	3	3	CD
cord-263532-q044i7ym	22	2	,	,	,
cord-263532-q044i7ym	22	3	4	4	CD
cord-263532-q044i7ym	22	4	CoVs	cov	NNS
cord-263532-q044i7ym	22	5	belong	belong	VBP
cord-263532-q044i7ym	22	6	to	to	IN
cord-263532-q044i7ym	22	7	subfamily	subfamily	NN
cord-263532-q044i7ym	22	8	Coronavirinae	Coronavirinae	NNP
cord-263532-q044i7ym	22	9	of	of	IN
cord-263532-q044i7ym	22	10	the	the	DT
cord-263532-q044i7ym	22	11	family	family	NN
cord-263532-q044i7ym	22	12	Coronaviridae	Coronaviridae	NNP
cord-263532-q044i7ym	22	13	.	.	.
cord-263532-q044i7ym	23	1	The	the	DT
cord-263532-q044i7ym	23	2	Coronavirinae	Coronavirinae	NNP
cord-263532-q044i7ym	23	3	is	be	VBZ
cord-263532-q044i7ym	23	4	further	far	RBR
cord-263532-q044i7ym	23	5	subdivided	subdivide	VBN
cord-263532-q044i7ym	23	6	into	into	IN
cord-263532-q044i7ym	23	7	four	four	CD
cord-263532-q044i7ym	23	8	genera	genus	NNS
cord-263532-q044i7ym	23	9	(	(	-LRB-
cord-263532-q044i7ym	23	10	α	α	NN
cord-263532-q044i7ym	23	11	,	,	,
cord-263532-q044i7ym	23	12	β	β	NN
cord-263532-q044i7ym	23	13	,	,	,
cord-263532-q044i7ym	23	14	γ	γ	NNP
cord-263532-q044i7ym	23	15	,	,	,
cord-263532-q044i7ym	23	16	and	and	CC
cord-263532-q044i7ym	23	17	δ	δ	NN
cord-263532-q044i7ym	23	18	)	)	-RRB-
cord-263532-q044i7ym	23	19	.	.	.
cord-263532-q044i7ym	24	1	Each	each	DT
cord-263532-q044i7ym	24	2	genus	genus	NN
cord-263532-q044i7ym	24	3	is	be	VBZ
cord-263532-q044i7ym	24	4	further	further	RB
cord-263532-q044i7ym	24	5	divided	divide	VBN
cord-263532-q044i7ym	24	6	into	into	IN
cord-263532-q044i7ym	24	7	four	four	CD
cord-263532-q044i7ym	24	8	lineage	lineage	NN
cord-263532-q044i7ym	24	9	subgroups	subgroup	NNS
cord-263532-q044i7ym	24	10	.	.	.
cord-263532-q044i7ym	25	1	A	a	DT
cord-263532-q044i7ym	25	2	new	new	JJ
cord-263532-q044i7ym	25	3	coronavirus	coronavirus	NN
cord-263532-q044i7ym	25	4	resulted	result	VBD
cord-263532-q044i7ym	25	5	in	in	IN
cord-263532-q044i7ym	25	6	the	the	DT
cord-263532-q044i7ym	25	7	outbreak	outbreak	NN
cord-263532-q044i7ym	25	8	of	of	IN
cord-263532-q044i7ym	25	9	a	a	DT
cord-263532-q044i7ym	25	10	pneumonialike	pneumonialike	JJ
cord-263532-q044i7ym	25	11	illness	illness	NN
cord-263532-q044i7ym	25	12	in	in	IN
cord-263532-q044i7ym	25	13	Wuhan	Wuhan	NNP
cord-263532-q044i7ym	25	14	,	,	,
cord-263532-q044i7ym	25	15	China	China	NNP
cord-263532-q044i7ym	25	16	,	,	,
cord-263532-q044i7ym	25	17	in	in	IN
cord-263532-q044i7ym	25	18	late	late	JJ
cord-263532-q044i7ym	25	19	December	December	NNP
cord-263532-q044i7ym	25	20	2019	2019	CD
cord-263532-q044i7ym	25	21	,	,	,
cord-263532-q044i7ym	25	22	and	and	CC
cord-263532-q044i7ym	25	23	has	have	VBZ
cord-263532-q044i7ym	25	24	become	become	VBN
cord-263532-q044i7ym	25	25	a	a	DT
cord-263532-q044i7ym	25	26	life	life	NN
cord-263532-q044i7ym	25	27	-	-	HYPH
cord-263532-q044i7ym	25	28	threatening	threaten	VBG
cord-263532-q044i7ym	25	29	concern	concern	NN
cord-263532-q044i7ym	25	30	worldwide	worldwide	RB
cord-263532-q044i7ym	25	31	in	in	IN
cord-263532-q044i7ym	25	32	the	the	DT
cord-263532-q044i7ym	25	33	present	present	JJ
cord-263532-q044i7ym	25	34	time	time	NN
cord-263532-q044i7ym	25	35	.	.	.
cord-263532-q044i7ym	26	1	5	5	CD
cord-263532-q044i7ym	26	2	,	,	,
cord-263532-q044i7ym	26	3	6	6	CD
cord-263532-q044i7ym	27	1	The	the	DT
cord-263532-q044i7ym	27	2	virus	virus	NN
cord-263532-q044i7ym	27	3	has	have	VBZ
cord-263532-q044i7ym	27	4	been	be	VBN
cord-263532-q044i7ym	27	5	termed	term	VBN
cord-263532-q044i7ym	27	6	SARS	SARS	NNP
cord-263532-q044i7ym	27	7	-	-	HYPH
cord-263532-q044i7ym	27	8	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	27	9	(	(	-LRB-
cord-263532-q044i7ym	27	10	severe	severe	JJ
cord-263532-q044i7ym	27	11	acute	acute	JJ
cord-263532-q044i7ym	27	12	respiratory	respiratory	JJ
cord-263532-q044i7ym	27	13	syndrome	syndrome	NN
cord-263532-q044i7ym	27	14	-	-	HYPH
cord-263532-q044i7ym	27	15	cororavirus-2	cororavirus-2	NNP
cord-263532-q044i7ym	27	16	)	)	-RRB-
cord-263532-q044i7ym	27	17	,	,	,
cord-263532-q044i7ym	27	18	7	7	CD
cord-263532-q044i7ym	27	19	as	as	IN
cord-263532-q044i7ym	27	20	the	the	DT
cord-263532-q044i7ym	27	21	RNA	RNA	NNP
cord-263532-q044i7ym	27	22	genome	genome	NN
cord-263532-q044i7ym	27	23	is	be	VBZ
cord-263532-q044i7ym	27	24	∼82	∼82	NN
cord-263532-q044i7ym	27	25	%	%	NN
cord-263532-q044i7ym	27	26	similar	similar	JJ
cord-263532-q044i7ym	27	27	to	to	IN
cord-263532-q044i7ym	27	28	that	that	DT
cord-263532-q044i7ym	27	29	of	of	IN
cord-263532-q044i7ym	27	30	the	the	DT
cord-263532-q044i7ym	27	31	SARS	SARS	NNP
cord-263532-q044i7ym	27	32	coronavirus	coronavirus	NN
cord-263532-q044i7ym	27	33	(	(	-LRB-
cord-263532-q044i7ym	27	34	SARS	SARS	NNP
cord-263532-q044i7ym	27	35	-	-	HYPH
cord-263532-q044i7ym	27	36	CoV	CoV	NNP
cord-263532-q044i7ym	27	37	)	)	-RRB-
cord-263532-q044i7ym	27	38	.	.	.
cord-263532-q044i7ym	28	1	5	5	CD
cord-263532-q044i7ym	28	2	,	,	,
cord-263532-q044i7ym	28	3	6	6	CD
cord-263532-q044i7ym	28	4	SARS	SARS	NNP
cord-263532-q044i7ym	28	5	-	-	HYPH
cord-263532-q044i7ym	28	6	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	28	7	belongs	belong	VBZ
cord-263532-q044i7ym	28	8	to	to	IN
cord-263532-q044i7ym	28	9	the	the	DT
cord-263532-q044i7ym	28	10	β	β	NN
cord-263532-q044i7ym	28	11	-	-	HYPH
cord-263532-q044i7ym	28	12	coronavirus	coronavirus	NN
cord-263532-q044i7ym	28	13	group	group	NN
cord-263532-q044i7ym	28	14	.	.	.
cord-263532-q044i7ym	29	1	The	the	DT
cord-263532-q044i7ym	29	2	pneumonia	pneumonia	NN
cord-263532-q044i7ym	29	3	-	-	HYPH
cord-263532-q044i7ym	29	4	like	like	JJ
cord-263532-q044i7ym	29	5	illness	illness	NN
cord-263532-q044i7ym	29	6	caused	cause	VBN
cord-263532-q044i7ym	29	7	by	by	IN
cord-263532-q044i7ym	29	8	SARS	SARS	NNP
cord-263532-q044i7ym	29	9	-	-	HYPH
cord-263532-q044i7ym	29	10	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	29	11	was	be	VBD
cord-263532-q044i7ym	29	12	named	name	VBN
cord-263532-q044i7ym	29	13	as	as	IN
cord-263532-q044i7ym	29	14	COVID-19	COVID-19	NNP
cord-263532-q044i7ym	29	15	.	.	.
cord-263532-q044i7ym	30	1	Many	many	JJ
cord-263532-q044i7ym	30	2	patients	patient	NNS
cord-263532-q044i7ym	30	3	infected	infect	VBN
cord-263532-q044i7ym	30	4	with	with	IN
cord-263532-q044i7ym	30	5	COVID-19	covid-19	JJ
cord-263532-q044i7ym	30	6	suffer	suffer	NN
cord-263532-q044i7ym	30	7	from	from	IN
cord-263532-q044i7ym	30	8	fever	fever	NN
cord-263532-q044i7ym	30	9	,	,	,
cord-263532-q044i7ym	30	10	dry	dry	JJ
cord-263532-q044i7ym	30	11	cough	cough	NN
cord-263532-q044i7ym	30	12	,	,	,
cord-263532-q044i7ym	30	13	tiredness	tiredness	NN
cord-263532-q044i7ym	30	14	,	,	,
cord-263532-q044i7ym	30	15	and	and	CC
cord-263532-q044i7ym	30	16	breathing	breathe	VBG
cord-263532-q044i7ym	30	17	difficulty	difficulty	NN
cord-263532-q044i7ym	30	18	under	under	IN
cord-263532-q044i7ym	30	19	severe	severe	JJ
cord-263532-q044i7ym	30	20	conditions	condition	NNS
cord-263532-q044i7ym	30	21	;	;	:
cord-263532-q044i7ym	30	22	others	other	NNS
cord-263532-q044i7ym	30	23	may	may	MD
cord-263532-q044i7ym	30	24	be	be	VB
cord-263532-q044i7ym	30	25	just	just	RB
cord-263532-q044i7ym	30	26	silent	silent	JJ
cord-263532-q044i7ym	30	27	carriers	carrier	NNS
cord-263532-q044i7ym	30	28	of	of	IN
cord-263532-q044i7ym	30	29	the	the	DT
cord-263532-q044i7ym	30	30	virus	virus	NN
cord-263532-q044i7ym	30	31	.	.	.
cord-263532-q044i7ym	31	1	The	the	DT
cord-263532-q044i7ym	31	2	World	World	NNP
cord-263532-q044i7ym	31	3	Health	Health	NNP
cord-263532-q044i7ym	31	4	Organization	Organization	NNP
cord-263532-q044i7ym	31	5	(	(	-LRB-
cord-263532-q044i7ym	31	6	WHO	who	WP
cord-263532-q044i7ym	31	7	)	)	-RRB-
cord-263532-q044i7ym	31	8	declared	declare	VBD
cord-263532-q044i7ym	31	9	COVID-19	COVID-19	NNP
cord-263532-q044i7ym	31	10	a	a	DT
cord-263532-q044i7ym	31	11	pandemic	pandemic	NN
cord-263532-q044i7ym	31	12	on	on	IN
cord-263532-q044i7ym	31	13	March	March	NNP
cord-263532-q044i7ym	31	14	11	11	CD
cord-263532-q044i7ym	31	15	,	,	,
cord-263532-q044i7ym	31	16	2020	2020	CD
cord-263532-q044i7ym	31	17	.	.	.
cord-263532-q044i7ym	32	1	As	as	IN
cord-263532-q044i7ym	32	2	of	of	IN
cord-263532-q044i7ym	32	3	2:00	2:00	CD
cord-263532-q044i7ym	32	4	am	am	NN
cord-263532-q044i7ym	32	5	CEST	CEST	NNP
cord-263532-q044i7ym	32	6	,	,	,
cord-263532-q044i7ym	32	7	May	May	NNP
cord-263532-q044i7ym	32	8	6	6	CD
cord-263532-q044i7ym	32	9	,	,	,
cord-263532-q044i7ym	32	10	2020	2020	CD
cord-263532-q044i7ym	32	11	,	,	,
cord-263532-q044i7ym	32	12	there	there	EX
cord-263532-q044i7ym	32	13	were	be	VBD
cord-263532-q044i7ym	32	14	more	more	JJR
cord-263532-q044i7ym	32	15	than	than	IN
cord-263532-q044i7ym	32	16	3.5	3.5	CD
cord-263532-q044i7ym	32	17	million	million	CD
cord-263532-q044i7ym	32	18	confirmed	confirm	VBN
cord-263532-q044i7ym	32	19	cases	case	NNS
cord-263532-q044i7ym	32	20	globally	globally	RB
cord-263532-q044i7ym	32	21	with	with	IN
cord-263532-q044i7ym	32	22	245,150	245,150	CD
cord-263532-q044i7ym	32	23	deaths	death	NNS
cord-263532-q044i7ym	32	24	due	due	JJ
cord-263532-q044i7ym	32	25	to	to	IN
cord-263532-q044i7ym	32	26	the	the	DT
cord-263532-q044i7ym	32	27	SARS	SARS	NNP
cord-263532-q044i7ym	32	28	-	-	HYPH
cord-263532-q044i7ym	32	29	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	32	30	.	.	.
cord-263532-q044i7ym	33	1	8	8	CD
cord-263532-q044i7ym	34	1	The	the	DT
cord-263532-q044i7ym	34	2	figures	figure	NNS
cord-263532-q044i7ym	34	3	clearly	clearly	RB
cord-263532-q044i7ym	34	4	indicate	indicate	VBP
cord-263532-q044i7ym	34	5	that	that	IN
cord-263532-q044i7ym	34	6	COVID-19	COVID-19	NNP
cord-263532-q044i7ym	34	7	imposes	impose	VBZ
cord-263532-q044i7ym	34	8	a	a	DT
cord-263532-q044i7ym	34	9	huge	huge	JJ
cord-263532-q044i7ym	34	10	health	health	NN
cord-263532-q044i7ym	34	11	care	care	NN
cord-263532-q044i7ym	34	12	crisis	crisis	NN
cord-263532-q044i7ym	34	13	globally	globally	RB
cord-263532-q044i7ym	34	14	.	.	.
cord-263532-q044i7ym	35	1	The	the	DT
cord-263532-q044i7ym	35	2	scientific	scientific	JJ
cord-263532-q044i7ym	35	3	and	and	CC
cord-263532-q044i7ym	35	4	medical	medical	JJ
cord-263532-q044i7ym	35	5	fraternity	fraternity	NN
cord-263532-q044i7ym	35	6	across	across	IN
cord-263532-q044i7ym	35	7	the	the	DT
cord-263532-q044i7ym	35	8	world	world	NN
cord-263532-q044i7ym	35	9	have	have	VBP
cord-263532-q044i7ym	35	10	been	be	VBN
cord-263532-q044i7ym	35	11	working	work	VBG
cord-263532-q044i7ym	35	12	tirelessly	tirelessly	RB
cord-263532-q044i7ym	35	13	and	and	CC
cord-263532-q044i7ym	35	14	at	at	IN
cord-263532-q044i7ym	35	15	record	record	NN
cord-263532-q044i7ym	35	16	-	-	HYPH
cord-263532-q044i7ym	35	17	breaking	break	VBG
cord-263532-q044i7ym	35	18	speed	speed	NN
cord-263532-q044i7ym	35	19	to	to	TO
cord-263532-q044i7ym	35	20	find	find	VB
cord-263532-q044i7ym	35	21	a	a	DT
cord-263532-q044i7ym	35	22	solution	solution	NN
cord-263532-q044i7ym	35	23	to	to	TO
cord-263532-q044i7ym	35	24	bring	bring	VB
cord-263532-q044i7ym	35	25	this	this	DT
cord-263532-q044i7ym	35	26	virus	virus	NN
cord-263532-q044i7ym	35	27	outbreak	outbreak	NN
cord-263532-q044i7ym	35	28	under	under	IN
cord-263532-q044i7ym	35	29	control	control	NN
cord-263532-q044i7ym	35	30	;	;	:
cord-263532-q044i7ym	35	31	however	however	RB
cord-263532-q044i7ym	35	32	,	,	,
cord-263532-q044i7ym	35	33	no	no	DT
cord-263532-q044i7ym	35	34	success	success	NN
cord-263532-q044i7ym	35	35	has	have	VBZ
cord-263532-q044i7ym	35	36	been	be	VBN
cord-263532-q044i7ym	35	37	achieved	achieve	VBN
cord-263532-q044i7ym	35	38	at	at	IN
cord-263532-q044i7ym	35	39	the	the	DT
cord-263532-q044i7ym	35	40	time	time	NN
cord-263532-q044i7ym	35	41	of	of	IN
cord-263532-q044i7ym	35	42	publication	publication	NN
cord-263532-q044i7ym	35	43	of	of	IN
cord-263532-q044i7ym	35	44	this	this	DT
cord-263532-q044i7ym	35	45	review	review	NN
cord-263532-q044i7ym	35	46	.	.	.
cord-263532-q044i7ym	36	1	Similar	similar	JJ
cord-263532-q044i7ym	36	2	to	to	IN
cord-263532-q044i7ym	36	3	SARS	SARS	NNP
cord-263532-q044i7ym	36	4	and	and	CC
cord-263532-q044i7ym	36	5	MERS	MERS	NNP
cord-263532-q044i7ym	36	6	(	(	-LRB-
cord-263532-q044i7ym	36	7	Middle	Middle	NNP
cord-263532-q044i7ym	36	8	East	East	NNP
cord-263532-q044i7ym	36	9	respiratory	respiratory	JJ
cord-263532-q044i7ym	36	10	syndrome	syndrome	NN
cord-263532-q044i7ym	36	11	)	)	-RRB-
cord-263532-q044i7ym	36	12	,	,	,
cord-263532-q044i7ym	36	13	the	the	DT
cord-263532-q044i7ym	36	14	genome	genome	NN
cord-263532-q044i7ym	36	15	of	of	IN
cord-263532-q044i7ym	36	16	SARS	SARS	NNP
cord-263532-q044i7ym	36	17	-	-	HYPH
cord-263532-q044i7ym	36	18	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	36	19	encodes	encode	VBZ
cord-263532-q044i7ym	36	20	non	non	JJ
cord-263532-q044i7ym	36	21	-	-	JJ
cord-263532-q044i7ym	36	22	structural	structural	JJ
cord-263532-q044i7ym	36	23	proteins	protein	NNS
cord-263532-q044i7ym	36	24	[	[	-LRB-
cord-263532-q044i7ym	36	25	SARS	SARS	NNP
cord-263532-q044i7ym	36	26	-	-	HYPH
cord-263532-q044i7ym	36	27	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	36	28	M	M	NNP
cord-263532-q044i7ym	36	29	pro	pro	JJ
cord-263532-q044i7ym	36	30	(	(	-LRB-
cord-263532-q044i7ym	36	31	main	main	JJ
cord-263532-q044i7ym	36	32	protease	protease	NN
cord-263532-q044i7ym	36	33	)	)	-RRB-
cord-263532-q044i7ym	36	34	,	,	,
cord-263532-q044i7ym	36	35	also	also	RB
cord-263532-q044i7ym	36	36	known	know	VBN
cord-263532-q044i7ym	36	37	as	as	IN
cord-263532-q044i7ym	36	38	3chymotrypsin	3chymotrypsin	CD
cord-263532-q044i7ym	36	39	-	-	HYPH
cord-263532-q044i7ym	36	40	like	like	JJ
cord-263532-q044i7ym	36	41	cysteine	cysteine	NN
cord-263532-q044i7ym	36	42	protease	protease	NN
cord-263532-q044i7ym	36	43	(	(	-LRB-
cord-263532-q044i7ym	36	44	CCP	CCP	NNP
cord-263532-q044i7ym	36	45	or	or	CC
cord-263532-q044i7ym	36	46	3CL	3CL	NNP
cord-263532-q044i7ym	36	47	pro	pro	JJ
cord-263532-q044i7ym	36	48	)	)	-RRB-
cord-263532-q044i7ym	36	49	,	,	,
cord-263532-q044i7ym	36	50	papainlike	papainlike	JJ
cord-263532-q044i7ym	36	51	protease	protease	NN
cord-263532-q044i7ym	36	52	,	,	,
cord-263532-q044i7ym	36	53	and	and	CC
cord-263532-q044i7ym	36	54	RNA	RNA	NNP
cord-263532-q044i7ym	36	55	-	-	HYPH
cord-263532-q044i7ym	36	56	dependent	dependent	JJ
cord-263532-q044i7ym	36	57	RNA	RNA	NNP
cord-263532-q044i7ym	36	58	polymerase	polymerase	NN
cord-263532-q044i7ym	36	59	(	(	-LRB-
cord-263532-q044i7ym	36	60	RdRp	RdRp	NNP
cord-263532-q044i7ym	36	61	)	)	-RRB-
cord-263532-q044i7ym	36	62	]	]	-RRB-
cord-263532-q044i7ym	36	63	,	,	.
cord-263532-q044i7ym	37	1	helicase	helicase	NNP
cord-263532-q044i7ym	37	2	,	,	,
cord-263532-q044i7ym	37	3	structural	structural	JJ
cord-263532-q044i7ym	37	4	proteins	protein	NNS
cord-263532-q044i7ym	37	5	(	(	-LRB-
cord-263532-q044i7ym	37	6	spike	spike	NN
cord-263532-q044i7ym	37	7	glycoprotein	glycoprotein	NN
cord-263532-q044i7ym	37	8	)	)	-RRB-
cord-263532-q044i7ym	37	9	,	,	,
cord-263532-q044i7ym	37	10	and	and	CC
cord-263532-q044i7ym	37	11	accessory	accessory	NN
cord-263532-q044i7ym	37	12	proteins	protein	NNS
cord-263532-q044i7ym	37	13	.	.	.
cord-263532-q044i7ym	38	1	The	the	DT
cord-263532-q044i7ym	38	2	non	non	JJ
cord-263532-q044i7ym	38	3	-	-	JJ
cord-263532-q044i7ym	38	4	structural	structural	JJ
cord-263532-q044i7ym	38	5	proteins	protein	NNS
cord-263532-q044i7ym	38	6	play	play	VBP
cord-263532-q044i7ym	38	7	a	a	DT
cord-263532-q044i7ym	38	8	key	key	JJ
cord-263532-q044i7ym	38	9	role	role	NN
cord-263532-q044i7ym	38	10	during	during	IN
cord-263532-q044i7ym	38	11	the	the	DT
cord-263532-q044i7ym	38	12	virus	virus	NN
cord-263532-q044i7ym	38	13	's	's	POS
cord-263532-q044i7ym	38	14	life	life	NN
cord-263532-q044i7ym	38	15	cycle	cycle	NN
cord-263532-q044i7ym	38	16	,	,	,
cord-263532-q044i7ym	38	17	and	and	CC
cord-263532-q044i7ym	38	18	spike	spike	NN
cord-263532-q044i7ym	38	19	glycoprotein	glycoprotein	NN
cord-263532-q044i7ym	38	20	is	be	VBZ
cord-263532-q044i7ym	38	21	necessary	necessary	JJ
cord-263532-q044i7ym	38	22	for	for	IN
cord-263532-q044i7ym	38	23	the	the	DT
cord-263532-q044i7ym	38	24	interactions	interaction	NNS
cord-263532-q044i7ym	38	25	of	of	IN
cord-263532-q044i7ym	38	26	the	the	DT
cord-263532-q044i7ym	38	27	virus	virus	NN
cord-263532-q044i7ym	38	28	with	with	IN
cord-263532-q044i7ym	38	29	the	the	DT
cord-263532-q044i7ym	38	30	host	host	NN
cord-263532-q044i7ym	38	31	cell	cell	NN
cord-263532-q044i7ym	38	32	receptors	receptor	NNS
cord-263532-q044i7ym	38	33	during	during	IN
cord-263532-q044i7ym	38	34	viral	viral	JJ
cord-263532-q044i7ym	38	35	entry	entry	NN
cord-263532-q044i7ym	38	36	.	.	.
cord-263532-q044i7ym	39	1	3	3	LS
cord-263532-q044i7ym	40	1	The	the	DT
cord-263532-q044i7ym	40	2	non	non	JJ
cord-263532-q044i7ym	40	3	-	-	JJ
cord-263532-q044i7ym	40	4	structural	structural	JJ
cord-263532-q044i7ym	40	5	and	and	CC
cord-263532-q044i7ym	40	6	structural	structural	JJ
cord-263532-q044i7ym	40	7	proteins	protein	NNS
cord-263532-q044i7ym	40	8	were	be	VBD
cord-263532-q044i7ym	40	9	recognized	recognize	VBN
cord-263532-q044i7ym	40	10	as	as	IN
cord-263532-q044i7ym	40	11	promising	promising	JJ
cord-263532-q044i7ym	40	12	targets	target	NNS
cord-263532-q044i7ym	40	13	for	for	IN
cord-263532-q044i7ym	40	14	the	the	DT
cord-263532-q044i7ym	40	15	design	design	NN
cord-263532-q044i7ym	40	16	and	and	CC
cord-263532-q044i7ym	40	17	development	development	NN
cord-263532-q044i7ym	40	18	of	of	IN
cord-263532-q044i7ym	40	19	antiviral	antiviral	JJ
cord-263532-q044i7ym	40	20	agents	agent	NNS
cord-263532-q044i7ym	40	21	against	against	IN
cord-263532-q044i7ym	40	22	SARS	SARS	NNP
cord-263532-q044i7ym	40	23	and	and	CC
cord-263532-q044i7ym	40	24	MERS	MERS	NNP
cord-263532-q044i7ym	40	25	.	.	.
cord-263532-q044i7ym	41	1	3	3	CD
cord-263532-q044i7ym	41	2	SARS	SARS	NNP
cord-263532-q044i7ym	41	3	-	-	HYPH
cord-263532-q044i7ym	41	4	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	41	5	M	M	NNP
cord-263532-q044i7ym	41	6	pro	pro	NN
cord-263532-q044i7ym	41	7	plays	play	VBZ
cord-263532-q044i7ym	41	8	a	a	DT
cord-263532-q044i7ym	41	9	key	key	JJ
cord-263532-q044i7ym	41	10	role	role	NN
cord-263532-q044i7ym	41	11	in	in	IN
cord-263532-q044i7ym	41	12	polyprotein	polyprotein	JJ
cord-263532-q044i7ym	41	13	processing	processing	NN
cord-263532-q044i7ym	41	14	and	and	CC
cord-263532-q044i7ym	41	15	is	be	VBZ
cord-263532-q044i7ym	41	16	active	active	JJ
cord-263532-q044i7ym	41	17	in	in	IN
cord-263532-q044i7ym	41	18	a	a	DT
cord-263532-q044i7ym	41	19	dimeric	dimeric	JJ
cord-263532-q044i7ym	41	20	form	form	NN
cord-263532-q044i7ym	41	21	.	.	.
cord-263532-q044i7ym	42	1	9	9	CD
cord-263532-q044i7ym	43	1	The	the	DT
cord-263532-q044i7ym	43	2	M	M	NNP
cord-263532-q044i7ym	43	3	pro	pro	NN
cord-263532-q044i7ym	43	4	offers	offer	VBZ
cord-263532-q044i7ym	43	5	a	a	DT
cord-263532-q044i7ym	43	6	promising	promising	JJ
cord-263532-q044i7ym	43	7	target	target	NN
cord-263532-q044i7ym	43	8	for	for	IN
cord-263532-q044i7ym	43	9	the	the	DT
cord-263532-q044i7ym	43	10	development	development	NN
cord-263532-q044i7ym	43	11	of	of	IN
cord-263532-q044i7ym	43	12	broad	broad	JJ
cord-263532-q044i7ym	43	13	-	-	HYPH
cord-263532-q044i7ym	43	14	spectrum	spectrum	NN
cord-263532-q044i7ym	43	15	anti	anti	JJ
cord-263532-q044i7ym	43	16	-	-	JJ
cord-263532-q044i7ym	43	17	coronaviral	coronaviral	JJ
cord-263532-q044i7ym	43	18	therapeutic	therapeutic	JJ
cord-263532-q044i7ym	43	19	agents	agent	NNS
cord-263532-q044i7ym	43	20	due	due	JJ
cord-263532-q044i7ym	43	21	to	to	IN
cord-263532-q044i7ym	43	22	its	-PRON-	PRP$
cord-263532-q044i7ym	43	23	highly	highly	RB
cord-263532-q044i7ym	43	24	conserved	conserve	VBN
cord-263532-q044i7ym	43	25	three	three	CD
cord-263532-q044i7ym	43	26	-	-	HYPH
cord-263532-q044i7ym	43	27	dimensional	dimensional	JJ
cord-263532-q044i7ym	43	28	structure	structure	NN
cord-263532-q044i7ym	43	29	among	among	IN
cord-263532-q044i7ym	43	30	various	various	JJ
cord-263532-q044i7ym	43	31	CoVs	covs	NN
cord-263532-q044i7ym	43	32	(	(	-LRB-
cord-263532-q044i7ym	43	33	Figures	figure	NNS
cord-263532-q044i7ym	43	34	1	1	CD
cord-263532-q044i7ym	43	35	and	and	CC
cord-263532-q044i7ym	43	36	2	2	CD
cord-263532-q044i7ym	43	37	)	)	-RRB-
cord-263532-q044i7ym	43	38	.	.	.
cord-263532-q044i7ym	44	1	10	10	CD
cord-263532-q044i7ym	45	1	The	the	DT
cord-263532-q044i7ym	45	2	CoVs	cov	NNS
cord-263532-q044i7ym	45	3	are	be	VBP
cord-263532-q044i7ym	45	4	subject	subject	JJ
cord-263532-q044i7ym	45	5	to	to	IN
cord-263532-q044i7ym	45	6	extensive	extensive	JJ
cord-263532-q044i7ym	45	7	mutagenesis	mutagenesis	NN
cord-263532-q044i7ym	45	8	;	;	:
cord-263532-q044i7ym	45	9	however	however	RB
cord-263532-q044i7ym	45	10	,	,	,
cord-263532-q044i7ym	45	11	key	key	JJ
cord-263532-q044i7ym	45	12	proteins	protein	NNS
cord-263532-q044i7ym	45	13	are	be	VBP
cord-263532-q044i7ym	45	14	highly	highly	RB
cord-263532-q044i7ym	45	15	conserved	conserve	VBN
cord-263532-q044i7ym	45	16	,	,	,
cord-263532-q044i7ym	45	17	as	as	IN
cord-263532-q044i7ym	45	18	mutations	mutation	NNS
cord-263532-q044i7ym	45	19	in	in	IN
cord-263532-q044i7ym	45	20	key	key	JJ
cord-263532-q044i7ym	45	21	proteins	protein	NNS
cord-263532-q044i7ym	45	22	are	be	VBP
cord-263532-q044i7ym	45	23	often	often	RB
cord-263532-q044i7ym	45	24	lethal	lethal	JJ
cord-263532-q044i7ym	45	25	to	to	IN
cord-263532-q044i7ym	45	26	the	the	DT
cord-263532-q044i7ym	45	27	virus	virus	NN
cord-263532-q044i7ym	45	28	.	.	.
cord-263532-q044i7ym	45	29	11	11	CD
cord-263532-q044i7ym	46	1	Thus	thus	RB
cord-263532-q044i7ym	46	2	,	,	,
cord-263532-q044i7ym	46	3	drugs	drug	NNS
cord-263532-q044i7ym	46	4	targeting	target	VBG
cord-263532-q044i7ym	46	5	conserved	conserve	VBN
cord-263532-q044i7ym	46	6	M	M	NNP
cord-263532-q044i7ym	46	7	pro	pro	JJ
cord-263532-q044i7ym	46	8	are	be	VBP
cord-263532-q044i7ym	46	9	usually	usually	RB
cord-263532-q044i7ym	46	10	capable	capable	JJ
cord-263532-q044i7ym	46	11	of	of	IN
cord-263532-q044i7ym	46	12	preventing	prevent	VBG
cord-263532-q044i7ym	46	13	the	the	DT
cord-263532-q044i7ym	46	14	replication	replication	NN
cord-263532-q044i7ym	46	15	and	and	CC
cord-263532-q044i7ym	46	16	proliferation	proliferation	NN
cord-263532-q044i7ym	46	17	of	of	IN
cord-263532-q044i7ym	46	18	the	the	DT
cord-263532-q044i7ym	46	19	virus	virus	NN
cord-263532-q044i7ym	46	20	and	and	CC
cord-263532-q044i7ym	46	21	display	display	VB
cord-263532-q044i7ym	46	22	broad	broad	JJ
cord-263532-q044i7ym	46	23	-	-	HYPH
cord-263532-q044i7ym	46	24	spectrum	spectrum	NN
cord-263532-q044i7ym	46	25	antiviral	antiviral	JJ
cord-263532-q044i7ym	46	26	activity	activity	NN
cord-263532-q044i7ym	46	27	.	.	.
cord-263532-q044i7ym	47	1	In	in	IN
cord-263532-q044i7ym	47	2	addition	addition	NN
cord-263532-q044i7ym	47	3	,	,	,
cord-263532-q044i7ym	47	4	drugs	drug	NNS
cord-263532-q044i7ym	47	5	targeting	target	VBG
cord-263532-q044i7ym	47	6	M	M	NNP
cord-263532-q044i7ym	47	7	pro	pro	NN
cord-263532-q044i7ym	47	8	can	can	MD
cord-263532-q044i7ym	47	9	reduce	reduce	VB
cord-263532-q044i7ym	47	10	the	the	DT
cord-263532-q044i7ym	47	11	risk	risk	NN
cord-263532-q044i7ym	47	12	of	of	IN
cord-263532-q044i7ym	47	13	mutation	mutation	NN
cord-263532-q044i7ym	47	14	-	-	HYPH
cord-263532-q044i7ym	47	15	mediated	mediate	VBN
cord-263532-q044i7ym	47	16	drug	drug	NN
cord-263532-q044i7ym	47	17	resistance	resistance	NN
cord-263532-q044i7ym	47	18	in	in	IN
cord-263532-q044i7ym	47	19	future	future	JJ
cord-263532-q044i7ym	47	20	deadly	deadly	JJ
cord-263532-q044i7ym	47	21	viral	viral	JJ
cord-263532-q044i7ym	47	22	strains	strain	NNS
cord-263532-q044i7ym	47	23	.	.	.
cord-263532-q044i7ym	48	1	The	the	DT
cord-263532-q044i7ym	48	2	individual	individual	JJ
cord-263532-q044i7ym	48	3	monomers	monomer	NNS
cord-263532-q044i7ym	48	4	of	of	IN
cord-263532-q044i7ym	48	5	SARS	SARS	NNP
cord-263532-q044i7ym	48	6	-	-	HYPH
cord-263532-q044i7ym	48	7	CoV	CoV	NNP
cord-263532-q044i7ym	48	8	M	M	NNP
cord-263532-q044i7ym	48	9	pro	pro	NNP
cord-263532-q044i7ym	48	10	are	be	VBP
cord-263532-q044i7ym	48	11	enzymatically	enzymatically	RB
cord-263532-q044i7ym	48	12	inactive	inactive	JJ
cord-263532-q044i7ym	48	13	,	,	,
cord-263532-q044i7ym	48	14	and	and	CC
cord-263532-q044i7ym	48	15	two	two	CD
cord-263532-q044i7ym	48	16	strategies	strategy	NNS
cord-263532-q044i7ym	48	17	have	have	VBP
cord-263532-q044i7ym	48	18	been	be	VBN
cord-263532-q044i7ym	48	19	employed	employ	VBN
cord-263532-q044i7ym	48	20	to	to	TO
cord-263532-q044i7ym	48	21	develop	develop	VB
cord-263532-q044i7ym	48	22	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	48	23	against	against	IN
cord-263532-q044i7ym	48	24	this	this	DT
cord-263532-q044i7ym	48	25	enzyme	enzyme	NN
cord-263532-q044i7ym	48	26	:	:	:
cord-263532-q044i7ym	48	27	(	(	-LRB-
cord-263532-q044i7ym	48	28	i	i	NN
cord-263532-q044i7ym	48	29	)	)	-RRB-
cord-263532-q044i7ym	48	30	molecules	molecule	NNS
cord-263532-q044i7ym	48	31	targeting	target	VBG
cord-263532-q044i7ym	48	32	the	the	DT
cord-263532-q044i7ym	48	33	substrate	substrate	NN
cord-263532-q044i7ym	48	34	binding	bind	VBG
cord-263532-q044i7ym	48	35	pocket	pocket	NN
cord-263532-q044i7ym	48	36	to	to	TO
cord-263532-q044i7ym	48	37	block	block	VB
cord-263532-q044i7ym	48	38	the	the	DT
cord-263532-q044i7ym	48	39	catalytic	catalytic	JJ
cord-263532-q044i7ym	48	40	activity	activity	NN
cord-263532-q044i7ym	48	41	,	,	,
cord-263532-q044i7ym	48	42	and	and	CC
cord-263532-q044i7ym	48	43	(	(	-LRB-
cord-263532-q044i7ym	48	44	ii	ii	NN
cord-263532-q044i7ym	48	45	)	)	-RRB-
cord-263532-q044i7ym	48	46	dimerization	dimerization	NN
cord-263532-q044i7ym	48	47	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	48	48	.	.	.
cord-263532-q044i7ym	49	1	Numerous	numerous	JJ
cord-263532-q044i7ym	49	2	reports	report	NNS
cord-263532-q044i7ym	49	3	on	on	IN
cord-263532-q044i7ym	49	4	the	the	DT
cord-263532-q044i7ym	49	5	inhibitor	inhibitor	NN
cord-263532-q044i7ym	49	6	design	design	NN
cord-263532-q044i7ym	49	7	against	against	IN
cord-263532-q044i7ym	49	8	SARS	SARS	NNP
cord-263532-q044i7ym	49	9	-	-	HYPH
cord-263532-q044i7ym	49	10	CoV	CoV	NNP
cord-263532-q044i7ym	49	11	M	M	NNP
cord-263532-q044i7ym	49	12	pro	pro	NNP
cord-263532-q044i7ym	49	13	are	be	VBP
cord-263532-q044i7ym	49	14	based	base	VBN
cord-263532-q044i7ym	49	15	on	on	IN
cord-263532-q044i7ym	49	16	the	the	DT
cord-263532-q044i7ym	49	17	substrate	substrate	NN
cord-263532-q044i7ym	49	18	binding	bind	VBG
cord-263532-q044i7ym	49	19	pocket	pocket	NN
cord-263532-q044i7ym	49	20	.	.	.
cord-263532-q044i7ym	50	1	12	12	CD
cord-263532-q044i7ym	50	2	,	,	,
cord-263532-q044i7ym	50	3	13	13	CD
cord-263532-q044i7ym	51	1	However	however	RB
cord-263532-q044i7ym	51	2	,	,	,
cord-263532-q044i7ym	51	3	no	no	DT
cord-263532-q044i7ym	51	4	inhibitor	inhibitor	NN
cord-263532-q044i7ym	51	5	targeting	target	VBG
cord-263532-q044i7ym	51	6	the	the	DT
cord-263532-q044i7ym	51	7	substrate	substrate	NN
cord-263532-q044i7ym	51	8	binding	bind	VBG
cord-263532-q044i7ym	51	9	pocket	pocket	NN
cord-263532-q044i7ym	51	10	has	have	VBZ
cord-263532-q044i7ym	51	11	reached	reach	VBN
cord-263532-q044i7ym	51	12	clinical	clinical	JJ
cord-263532-q044i7ym	51	13	trials	trial	NNS
cord-263532-q044i7ym	51	14	to	to	IN
cord-263532-q044i7ym	51	15	date	date	NN
cord-263532-q044i7ym	51	16	.	.	.
cord-263532-q044i7ym	52	1	An	an	DT
cord-263532-q044i7ym	52	2	alternative	alternative	JJ
cord-263532-q044i7ym	52	3	potential	potential	JJ
cord-263532-q044i7ym	52	4	therapeutic	therapeutic	JJ
cord-263532-q044i7ym	52	5	strategy	strategy	NN
cord-263532-q044i7ym	52	6	is	be	VBZ
cord-263532-q044i7ym	52	7	to	to	TO
cord-263532-q044i7ym	52	8	inhibit	inhibit	VB
cord-263532-q044i7ym	52	9	the	the	DT
cord-263532-q044i7ym	52	10	dimerization	dimerization	NN
cord-263532-q044i7ym	52	11	of	of	IN
cord-263532-q044i7ym	52	12	M	M	NNP
cord-263532-q044i7ym	52	13	pro	pro	NN
cord-263532-q044i7ym	52	14	,	,	,
cord-263532-q044i7ym	52	15	and	and	CC
cord-263532-q044i7ym	52	16	there	there	EX
cord-263532-q044i7ym	52	17	are	be	VBP
cord-263532-q044i7ym	52	18	a	a	DT
cord-263532-q044i7ym	52	19	few	few	JJ
cord-263532-q044i7ym	52	20	reports	report	NNS
cord-263532-q044i7ym	52	21	on	on	IN
cord-263532-q044i7ym	52	22	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	52	23	targeting	target	VBG
cord-263532-q044i7ym	52	24	the	the	DT
cord-263532-q044i7ym	52	25	dimerization	dimerization	NN
cord-263532-q044i7ym	52	26	of	of	IN
cord-263532-q044i7ym	52	27	SARS	SARS	NNP
cord-263532-q044i7ym	52	28	-	-	HYPH
cord-263532-q044i7ym	52	29	CoV	CoV	NNP
cord-263532-q044i7ym	52	30	M	M	NNP
cord-263532-q044i7ym	52	31	pro	pro	NNP
cord-263532-q044i7ym	52	32	.	.	.
cord-263532-q044i7ym	53	1	14	14	CD
cord-263532-q044i7ym	53	2	,	,	,
cord-263532-q044i7ym	53	3	15	15	CD
cord-263532-q044i7ym	54	1	In	in	IN
cord-263532-q044i7ym	54	2	the	the	DT
cord-263532-q044i7ym	54	3	present	present	JJ
cord-263532-q044i7ym	54	4	review	review	NN
cord-263532-q044i7ym	54	5	,	,	,
cord-263532-q044i7ym	54	6	literature	literature	NN
cord-263532-q044i7ym	54	7	reports	report	NNS
cord-263532-q044i7ym	54	8	highlighting	highlight	VBG
cord-263532-q044i7ym	54	9	the	the	DT
cord-263532-q044i7ym	54	10	effect	effect	NN
cord-263532-q044i7ym	54	11	of	of	IN
cord-263532-q044i7ym	54	12	mutations	mutation	NNS
cord-263532-q044i7ym	54	13	and	and	CC
cord-263532-q044i7ym	54	14	N	n	CD
cord-263532-q044i7ym	54	15	-	-	HYPH
cord-263532-q044i7ym	54	16	terminal	terminal	JJ
cord-263532-q044i7ym	54	17	deletion	deletion	NN
cord-263532-q044i7ym	54	18	of	of	IN
cord-263532-q044i7ym	54	19	residues	residue	NNS
cord-263532-q044i7ym	54	20	of	of	IN
cord-263532-q044i7ym	54	21	SARS	SARS	NNP
cord-263532-q044i7ym	54	22	-	-	HYPH
cord-263532-q044i7ym	54	23	CoV	CoV	NNP
cord-263532-q044i7ym	54	24	M	M	NNP
cord-263532-q044i7ym	54	25	pro	pro	JJ
cord-263532-q044i7ym	54	26	on	on	IN
cord-263532-q044i7ym	54	27	its	-PRON-	PRP$
cord-263532-q044i7ym	54	28	dimerization	dimerization	NN
cord-263532-q044i7ym	54	29	and	and	CC
cord-263532-q044i7ym	54	30	,	,	,
cord-263532-q044i7ym	54	31	thus	thus	RB
cord-263532-q044i7ym	54	32	,	,	,
cord-263532-q044i7ym	54	33	catalytic	catalytic	JJ
cord-263532-q044i7ym	54	34	activity	activity	NN
cord-263532-q044i7ym	54	35	are	be	VBP
cord-263532-q044i7ym	54	36	compiled	compile	VBN
cord-263532-q044i7ym	54	37	.	.	.
cord-263532-q044i7ym	55	1	To	to	IN
cord-263532-q044i7ym	55	2	the	the	DT
cord-263532-q044i7ym	55	3	best	good	JJS
cord-263532-q044i7ym	55	4	of	of	IN
cord-263532-q044i7ym	55	5	our	-PRON-	PRP$
cord-263532-q044i7ym	55	6	knowledge	knowledge	NN
cord-263532-q044i7ym	55	7	,	,	,
cord-263532-q044i7ym	55	8	this	this	DT
cord-263532-q044i7ym	55	9	review	review	NN
cord-263532-q044i7ym	55	10	is	be	VBZ
cord-263532-q044i7ym	55	11	the	the	DT
cord-263532-q044i7ym	55	12	first	first	JJ
cord-263532-q044i7ym	55	13	compilation	compilation	NN
cord-263532-q044i7ym	55	14	of	of	IN
cord-263532-q044i7ym	55	15	the	the	DT
cord-263532-q044i7ym	55	16	various	various	JJ
cord-263532-q044i7ym	55	17	studies	study	NNS
cord-263532-q044i7ym	55	18	focusing	focus	VBG
cord-263532-q044i7ym	55	19	on	on	IN
cord-263532-q044i7ym	55	20	the	the	DT
cord-263532-q044i7ym	55	21	dimerization	dimerization	NN
cord-263532-q044i7ym	55	22	of	of	IN
cord-263532-q044i7ym	55	23	SARS	SARS	NNP
cord-263532-q044i7ym	55	24	-	-	HYPH
cord-263532-q044i7ym	55	25	CoV	CoV	NNP
cord-263532-q044i7ym	55	26	M	M	NNP
cord-263532-q044i7ym	55	27	pro	pro	NNP
cord-263532-q044i7ym	55	28	.	.	.
cord-263532-q044i7ym	56	1	A	a	DT
cord-263532-q044i7ym	56	2	number	number	NN
cord-263532-q044i7ym	56	3	of	of	IN
cord-263532-q044i7ym	56	4	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	56	5	targeting	target	VBG
cord-263532-q044i7ym	56	6	the	the	DT
cord-263532-q044i7ym	56	7	substrate	substrate	NN
cord-263532-q044i7ym	56	8	binding	bind	VBG
cord-263532-q044i7ym	56	9	pocket	pocket	NN
cord-263532-q044i7ym	56	10	of	of	IN
cord-263532-q044i7ym	56	11	SARS	SARS	NNP
cord-263532-q044i7ym	56	12	-	-	HYPH
cord-263532-q044i7ym	56	13	CoV	CoV	NNP
cord-263532-q044i7ym	56	14	M	M	NNP
cord-263532-q044i7ym	56	15	pro	pro	NNP
cord-263532-q044i7ym	56	16	are	be	VBP
cord-263532-q044i7ym	56	17	reported	report	VBN
cord-263532-q044i7ym	56	18	in	in	IN
cord-263532-q044i7ym	56	19	the	the	DT
cord-263532-q044i7ym	56	20	literature	literature	NN
cord-263532-q044i7ym	56	21	,	,	,
cord-263532-q044i7ym	56	22	and	and	CC
cord-263532-q044i7ym	56	23	they	-PRON-	PRP
cord-263532-q044i7ym	56	24	can	can	MD
cord-263532-q044i7ym	56	25	be	be	VB
cord-263532-q044i7ym	56	26	found	find	VBN
cord-263532-q044i7ym	56	27	discussed	discuss	VBN
cord-263532-q044i7ym	56	28	elsewhere	elsewhere	RB
cord-263532-q044i7ym	56	29	.	.	.
cord-263532-q044i7ym	57	1	12	12	CD
cord-263532-q044i7ym	57	2	,	,	,
cord-263532-q044i7ym	57	3	13	13	CD
cord-263532-q044i7ym	57	4	■	■	NFP
cord-263532-q044i7ym	57	5	STRUCTURAL	structural	NN
cord-263532-q044i7ym	57	6	AND	and	CC
cord-263532-q044i7ym	57	7	FUNCTIONAL	functional	JJ
cord-263532-q044i7ym	57	8	DETAILS	detail	NNS
cord-263532-q044i7ym	57	9	OF	of	IN
cord-263532-q044i7ym	57	10	SARS	SARS	NNP
cord-263532-q044i7ym	57	11	-	-	:
cord-263532-q044i7ym	57	12	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	57	13	M	M	NNP
cord-263532-q044i7ym	57	14	pro	pro	JJ
cord-263532-q044i7ym	57	15	ENZYME	enzyme	JJ
cord-263532-q044i7ym	57	16	SARS	SARS	NNP
cord-263532-q044i7ym	57	17	-	-	HYPH
cord-263532-q044i7ym	57	18	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	57	19	M	M	NNP
cord-263532-q044i7ym	57	20	pro	pro	NN
cord-263532-q044i7ym	57	21	is	be	VBZ
cord-263532-q044i7ym	57	22	a	a	DT
cord-263532-q044i7ym	57	23	dimer	dimer	NN
cord-263532-q044i7ym	57	24	consisting	consist	VBG
cord-263532-q044i7ym	57	25	of	of	IN
cord-263532-q044i7ym	57	26	two	two	CD
cord-263532-q044i7ym	57	27	monomers	monomer	NNS
cord-263532-q044i7ym	57	28	that	that	WDT
cord-263532-q044i7ym	57	29	are	be	VBP
cord-263532-q044i7ym	57	30	arranged	arrange	VBN
cord-263532-q044i7ym	57	31	almost	almost	RB
cord-263532-q044i7ym	57	32	perpendicular	perpendicular	JJ
cord-263532-q044i7ym	57	33	to	to	IN
cord-263532-q044i7ym	57	34	one	one	CD
cord-263532-q044i7ym	57	35	another	another	DT
cord-263532-q044i7ym	57	36	.	.	.
cord-263532-q044i7ym	58	1	9	9	CD
cord-263532-q044i7ym	59	1	Each	each	DT
cord-263532-q044i7ym	59	2	monomer	monomer	NN
cord-263532-q044i7ym	59	3	comprises	comprise	VBZ
cord-263532-q044i7ym	59	4	three	three	CD
cord-263532-q044i7ym	59	5	domains	domain	NNS
cord-263532-q044i7ym	59	6	and	and	CC
cord-263532-q044i7ym	59	7	possesses	possess	VBZ
cord-263532-q044i7ym	59	8	a	a	DT
cord-263532-q044i7ym	59	9	catalytic	catalytic	JJ
cord-263532-q044i7ym	59	10	dyad	dyad	NN
cord-263532-q044i7ym	59	11	(	(	-LRB-
cord-263532-q044i7ym	59	12	His41	His41	NNP
cord-263532-q044i7ym	59	13	and	and	CC
cord-263532-q044i7ym	59	14	Cys145	Cys145	NNP
cord-263532-q044i7ym	59	15	)	)	-RRB-
cord-263532-q044i7ym	59	16	situated	situate	VBN
cord-263532-q044i7ym	59	17	in	in	IN
cord-263532-q044i7ym	59	18	a	a	DT
cord-263532-q044i7ym	59	19	cleft	cleft	NN
cord-263532-q044i7ym	59	20	between	between	IN
cord-263532-q044i7ym	59	21	domains	domain	NNS
cord-263532-q044i7ym	59	22	I	-PRON-	PRP
cord-263532-q044i7ym	59	23	and	and	CC
cord-263532-q044i7ym	59	24	II	II	NNP
cord-263532-q044i7ym	59	25	(	(	-LRB-
cord-263532-q044i7ym	59	26	residues	residue	NNS
cord-263532-q044i7ym	59	27	10−99	10−99	CD
cord-263532-q044i7ym	59	28	and	and	CC
cord-263532-q044i7ym	59	29	100−182	100−182	CD
cord-263532-q044i7ym	59	30	,	,	,
cord-263532-q044i7ym	59	31	respectively	respectively	RB
cord-263532-q044i7ym	59	32	)	)	-RRB-
cord-263532-q044i7ym	59	33	.	.	.
cord-263532-q044i7ym	60	1	The	the	DT
cord-263532-q044i7ym	60	2	catalytic	catalytic	JJ
cord-263532-q044i7ym	60	3	residues	residue	NNS
cord-263532-q044i7ym	60	4	are	be	VBP
cord-263532-q044i7ym	60	5	situated	situate	VBN
cord-263532-q044i7ym	60	6	in	in	IN
cord-263532-q044i7ym	60	7	the	the	DT
cord-263532-q044i7ym	60	8	chymotrypsin	chymotrypsin	NN
cord-263532-q044i7ym	60	9	-	-	HYPH
cord-263532-q044i7ym	60	10	like	like	JJ
cord-263532-q044i7ym	60	11	double	double	JJ
cord-263532-q044i7ym	60	12	βbarrel	βbarrel	NN
cord-263532-q044i7ym	60	13	fold	fold	JJ
cord-263532-q044i7ym	60	14	consisting	consisting	NN
cord-263532-q044i7ym	60	15	of	of	IN
cord-263532-q044i7ym	60	16	domain	domain	NN
cord-263532-q044i7ym	60	17	I	i	NN
cord-263532-q044i7ym	60	18	and	and	CC
cord-263532-q044i7ym	60	19	II	II	NNP
cord-263532-q044i7ym	60	20	.	.	.
cord-263532-q044i7ym	61	1	The	the	DT
cord-263532-q044i7ym	61	2	catalytic	catalytic	JJ
cord-263532-q044i7ym	61	3	domains	domain	NNS
cord-263532-q044i7ym	61	4	are	be	VBP
cord-263532-q044i7ym	61	5	connected	connect	VBN
cord-263532-q044i7ym	61	6	by	by	IN
cord-263532-q044i7ym	61	7	a	a	DT
cord-263532-q044i7ym	61	8	long	long	JJ
cord-263532-q044i7ym	61	9	loop	loop	NN
cord-263532-q044i7ym	61	10	region	region	NN
cord-263532-q044i7ym	61	11	to	to	IN
cord-263532-q044i7ym	61	12	the	the	DT
cord-263532-q044i7ym	61	13	C	C	NNP
cord-263532-q044i7ym	61	14	-	-	HYPH
cord-263532-q044i7ym	61	15	terminal	terminal	NN
cord-263532-q044i7ym	61	16	domain	domain	NN
cord-263532-q044i7ym	61	17	III	III	NNP
cord-263532-q044i7ym	61	18	(	(	-LRB-
cord-263532-q044i7ym	61	19	residues	residue	NNS
cord-263532-q044i7ym	61	20	198−303	198−303	CD
cord-263532-q044i7ym	61	21	)	)	-RRB-
cord-263532-q044i7ym	61	22	composed	compose	VBN
cord-263532-q044i7ym	61	23	of	of	IN
cord-263532-q044i7ym	61	24	five	five	CD
cord-263532-q044i7ym	61	25	antiparallel	antiparallel	NN
cord-263532-q044i7ym	61	26	α	α	NN
cord-263532-q044i7ym	61	27	-	-	HYPH
cord-263532-q044i7ym	61	28	helices	helix	NNS
cord-263532-q044i7ym	61	29	.	.	.
cord-263532-q044i7ym	62	1	A	a	DT
cord-263532-q044i7ym	62	2	contact	contact	NN
cord-263532-q044i7ym	62	3	interface	interface	NN
cord-263532-q044i7ym	62	4	(	(	-LRB-
cord-263532-q044i7ym	62	5	∼1394	∼1394	NNP
cord-263532-q044i7ym	62	6	Å	å	NN
cord-263532-q044i7ym	62	7	2	2	CD
cord-263532-q044i7ym	62	8	)	)	-RRB-
cord-263532-q044i7ym	62	9	was	be	VBD
cord-263532-q044i7ym	62	10	formed	form	VBN
cord-263532-q044i7ym	62	11	between	between	IN
cord-263532-q044i7ym	62	12	domain	domain	NN
cord-263532-q044i7ym	62	13	II	ii	CD
cord-263532-q044i7ym	62	14	of	of	IN
cord-263532-q044i7ym	62	15	monomer	monomer	NN
cord-263532-q044i7ym	62	16	A	a	NN
cord-263532-q044i7ym	62	17	and	and	CC
cord-263532-q044i7ym	62	18	the	the	DT
cord-263532-q044i7ym	62	19	NH	NH	NNP
cord-263532-q044i7ym	62	20	2	2	CD
cord-263532-q044i7ym	62	21	-terminal	-terminal	JJ
cord-263532-q044i7ym	62	22	residues	residue	NNS
cord-263532-q044i7ym	62	23	(	(	-LRB-
cord-263532-q044i7ym	62	24	"	"	``
cord-263532-q044i7ym	62	25	N	n	NN
cord-263532-q044i7ym	62	26	-	-	HYPH
cord-263532-q044i7ym	62	27	finger	finger	NN
cord-263532-q044i7ym	62	28	"	"	''
cord-263532-q044i7ym	62	29	)	)	-RRB-
cord-263532-q044i7ym	62	30	of	of	IN
cord-263532-q044i7ym	62	31	monomer	monomer	NN
cord-263532-q044i7ym	62	32	B	b	NN
cord-263532-q044i7ym	62	33	in	in	IN
cord-263532-q044i7ym	62	34	the	the	DT
cord-263532-q044i7ym	62	35	dimeric	dimeric	JJ
cord-263532-q044i7ym	62	36	structure	structure	NN
cord-263532-q044i7ym	62	37	of	of	IN
cord-263532-q044i7ym	62	38	SARS	SARS	NNP
cord-263532-q044i7ym	62	39	-	-	HYPH
cord-263532-q044i7ym	62	40	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	62	41	M	M	NNP
cord-263532-q044i7ym	62	42	pro	pro	JJ
cord-263532-q044i7ym	62	43	.	.	.
cord-263532-q044i7ym	63	1	The	the	DT
cord-263532-q044i7ym	63	2	dimerization	dimerization	NN
cord-263532-q044i7ym	63	3	is	be	VBZ
cord-263532-q044i7ym	63	4	necessary	necessary	JJ
cord-263532-q044i7ym	63	5	for	for	IN
cord-263532-q044i7ym	63	6	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	63	7	activity	activity	NN
cord-263532-q044i7ym	63	8	as	as	IN
cord-263532-q044i7ym	63	9	the	the	DT
cord-263532-q044i7ym	63	10	N	n	NN
cord-263532-q044i7ym	63	11	-	-	HYPH
cord-263532-q044i7ym	63	12	finger	finger	NN
cord-263532-q044i7ym	63	13	of	of	IN
cord-263532-q044i7ym	63	14	each	each	DT
cord-263532-q044i7ym	63	15	of	of	IN
cord-263532-q044i7ym	63	16	the	the	DT
cord-263532-q044i7ym	63	17	two	two	CD
cord-263532-q044i7ym	63	18	monomers	monomer	NNS
cord-263532-q044i7ym	63	19	interact	interact	VBP
cord-263532-q044i7ym	63	20	with	with	IN
cord-263532-q044i7ym	63	21	Glu166	glu166	DT
cord-263532-q044i7ym	63	22	of	of	IN
cord-263532-q044i7ym	63	23	the	the	DT
cord-263532-q044i7ym	63	24	other	other	JJ
cord-263532-q044i7ym	63	25	monomer	monomer	NN
cord-263532-q044i7ym	63	26	,	,	,
cord-263532-q044i7ym	63	27	which	which	WDT
cord-263532-q044i7ym	63	28	assist	assist	VBP
cord-263532-q044i7ym	63	29	in	in	IN
cord-263532-q044i7ym	63	30	the	the	DT
cord-263532-q044i7ym	63	31	correct	correct	JJ
cord-263532-q044i7ym	63	32	orientation	orientation	NN
cord-263532-q044i7ym	63	33	of	of	IN
cord-263532-q044i7ym	63	34	the	the	DT
cord-263532-q044i7ym	63	35	S1	S1	NNP
cord-263532-q044i7ym	63	36	pocket	pocket	NN
cord-263532-q044i7ym	63	37	of	of	IN
cord-263532-q044i7ym	63	38	the	the	DT
cord-263532-q044i7ym	63	39	substrate	substrate	NN
cord-263532-q044i7ym	63	40	binding	bind	VBG
cord-263532-q044i7ym	63	41	site	site	NN
cord-263532-q044i7ym	63	42	.	.	.
cord-263532-q044i7ym	64	1	The	the	DT
cord-263532-q044i7ym	64	2	C	C	NNP
cord-263532-q044i7ym	64	3	-	-	HYPH
cord-263532-q044i7ym	64	4	and	and	CC
cord-263532-q044i7ym	64	5	N	n	CD
cord-263532-q044i7ym	64	6	-	-	HYPH
cord-263532-q044i7ym	64	7	terminus	terminus	NN
cord-263532-q044i7ym	64	8	of	of	IN
cord-263532-q044i7ym	64	9	the	the	DT
cord-263532-q044i7ym	64	10	monomers	monomer	NNS
cord-263532-q044i7ym	64	11	constitute	constitute	VBP
cord-263532-q044i7ym	64	12	the	the	DT
cord-263532-q044i7ym	64	13	dimer	dimer	NN
cord-263532-q044i7ym	64	14	interface	interface	NN
cord-263532-q044i7ym	64	15	and	and	CC
cord-263532-q044i7ym	64	16	are	be	VBP
cord-263532-q044i7ym	64	17	closely	closely	RB
cord-263532-q044i7ym	64	18	held	hold	VBN
cord-263532-q044i7ym	64	19	in	in	IN
cord-263532-q044i7ym	64	20	the	the	DT
cord-263532-q044i7ym	64	21	dimer	dimer	NN
cord-263532-q044i7ym	64	22	than	than	IN
cord-263532-q044i7ym	64	23	in	in	IN
cord-263532-q044i7ym	64	24	the	the	DT
cord-263532-q044i7ym	64	25	monomeric	monomeric	JJ
cord-263532-q044i7ym	64	26	state	state	NN
cord-263532-q044i7ym	64	27	where	where	WRB
cord-263532-q044i7ym	64	28	mobility	mobility	NN
cord-263532-q044i7ym	64	29	of	of	IN
cord-263532-q044i7ym	64	30	these	these	DT
cord-263532-q044i7ym	64	31	termini	terminus	NNS
cord-263532-q044i7ym	64	32	are	be	VBP
cord-263532-q044i7ym	64	33	higher	high	JJR
cord-263532-q044i7ym	64	34	.	.	.
cord-263532-q044i7ym	65	1	The	the	DT
cord-263532-q044i7ym	65	2	structural	structural	JJ
cord-263532-q044i7ym	65	3	design	design	NN
cord-263532-q044i7ym	65	4	of	of	IN
cord-263532-q044i7ym	65	5	SARS	SARS	NNP
cord-263532-q044i7ym	65	6	-	-	HYPH
cord-263532-q044i7ym	65	7	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	65	8	M	M	NNP
cord-263532-q044i7ym	65	9	pro	pro	NN
cord-263532-q044i7ym	65	10	was	be	VBD
cord-263532-q044i7ym	65	11	found	find	VBN
cord-263532-q044i7ym	65	12	to	to	TO
cord-263532-q044i7ym	65	13	be	be	VB
cord-263532-q044i7ym	65	14	similar	similar	JJ
cord-263532-q044i7ym	65	15	to	to	IN
cord-263532-q044i7ym	65	16	the	the	DT
cord-263532-q044i7ym	65	17	crystal	crystal	JJ
cord-263532-q044i7ym	65	18	structure	structure	NN
cord-263532-q044i7ym	65	19	of	of	IN
cord-263532-q044i7ym	65	20	SARS	SARS	NNP
cord-263532-q044i7ym	65	21	-	-	HYPH
cord-263532-q044i7ym	65	22	CoV	CoV	NNP
cord-263532-q044i7ym	65	23	M	M	NNP
cord-263532-q044i7ym	65	24	pro	pro	JJ
cord-263532-q044i7ym	65	25	(	(	-LRB-
cord-263532-q044i7ym	65	26	Figure	figure	NN
cord-263532-q044i7ym	65	27	1a	1a	NN
cord-263532-q044i7ym	65	28	,	,	,
cord-263532-q044i7ym	65	29	b	b	LS
cord-263532-q044i7ym	65	30	)	)	-RRB-
cord-263532-q044i7ym	65	31	.	.	.
cord-263532-q044i7ym	66	1	Only	only	RB
cord-263532-q044i7ym	66	2	12	12	CD
cord-263532-q044i7ym	66	3	out	out	IN
cord-263532-q044i7ym	66	4	of	of	IN
cord-263532-q044i7ym	66	5	306	306	CD
cord-263532-q044i7ym	66	6	residues	residue	NNS
cord-263532-q044i7ym	66	7	are	be	VBP
cord-263532-q044i7ym	67	1	The	the	DT
cord-263532-q044i7ym	67	2	homology	homology	NN
cord-263532-q044i7ym	67	3	models	model	NNS
cord-263532-q044i7ym	67	4	of	of	IN
cord-263532-q044i7ym	67	5	SARS	SARS	NNP
cord-263532-q044i7ym	67	6	-	-	HYPH
cord-263532-q044i7ym	67	7	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	67	8	M	M	NNP
cord-263532-q044i7ym	67	9	pro	pro	JJ
cord-263532-q044i7ym	67	10	were	be	VBD
cord-263532-q044i7ym	67	11	found	find	VBN
cord-263532-q044i7ym	67	12	to	to	TO
cord-263532-q044i7ym	67	13	be	be	VB
cord-263532-q044i7ym	67	14	very	very	RB
cord-263532-q044i7ym	67	15	much	much	RB
cord-263532-q044i7ym	67	16	similar	similar	JJ
cord-263532-q044i7ym	67	17	to	to	IN
cord-263532-q044i7ym	67	18	SARS	SARS	NNP
cord-263532-q044i7ym	67	19	-	-	HYPH
cord-263532-q044i7ym	67	20	CoV	CoV	NNP
cord-263532-q044i7ym	67	21	M	M	NNP
cord-263532-q044i7ym	67	22	pro	pro	NNP
cord-263532-q044i7ym	67	23	.	.	NNP
cord-263532-q044i7ym	67	24	16	16	CD
cord-263532-q044i7ym	68	1	Thus	thus	RB
cord-263532-q044i7ym	68	2	,	,	,
cord-263532-q044i7ym	68	3	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	68	4	targeting	target	VBG
cord-263532-q044i7ym	68	5	SARS	SARS	NNP
cord-263532-q044i7ym	68	6	-	-	HYPH
cord-263532-q044i7ym	68	7	CoV	CoV	NNP
cord-263532-q044i7ym	68	8	M	M	NNP
cord-263532-q044i7ym	68	9	pro	pro	NN
cord-263532-q044i7ym	68	10	may	may	MD
cord-263532-q044i7ym	68	11	also	also	RB
cord-263532-q044i7ym	68	12	block	block	VB
cord-263532-q044i7ym	68	13	the	the	DT
cord-263532-q044i7ym	68	14	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	68	15	activity	activity	NN
cord-263532-q044i7ym	68	16	of	of	IN
cord-263532-q044i7ym	68	17	SARS	SARS	NNP
cord-263532-q044i7ym	68	18	-	-	HYPH
cord-263532-q044i7ym	68	19	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	68	20	M	M	NNP
cord-263532-q044i7ym	68	21	pro	pro	JJ
cord-263532-q044i7ym	68	22	.	.	.
cord-263532-q044i7ym	69	1	Previous	previous	JJ
cord-263532-q044i7ym	69	2	studies	study	NNS
cord-263532-q044i7ym	69	3	highlighted	highlight	VBD
cord-263532-q044i7ym	69	4	that	that	IN
cord-263532-q044i7ym	69	5	many	many	JJ
cord-263532-q044i7ym	69	6	SARS	SARS	NNP
cord-263532-q044i7ym	69	7	-	-	HYPH
cord-263532-q044i7ym	69	8	CoV	CoV	NNP
cord-263532-q044i7ym	69	9	M	M	NNP
cord-263532-q044i7ym	69	10	pro	pro	NNP
cord-263532-q044i7ym	69	11	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	69	12	displayed	display	VBD
cord-263532-q044i7ym	69	13	efficacy	efficacy	NN
cord-263532-q044i7ym	69	14	against	against	IN
cord-263532-q044i7ym	69	15	MERS	MERS	NNP
cord-263532-q044i7ym	69	16	-	-	HYPH
cord-263532-q044i7ym	69	17	CoV.	CoV.	NNP
cord-263532-q044i7ym	69	18	17	17	CD
cord-263532-q044i7ym	69	19	,	,	,
cord-263532-q044i7ym	69	20	18	18	CD
cord-263532-q044i7ym	70	1	The	the	DT
cord-263532-q044i7ym	70	2	SARS	SARS	NNP
cord-263532-q044i7ym	70	3	-	-	HYPH
cord-263532-q044i7ym	70	4	CoV	CoV	NNP
cord-263532-q044i7ym	70	5	M	M	NNP
cord-263532-q044i7ym	70	6	pro	pro	JJ
cord-263532-q044i7ym	70	7	exists	exist	VBZ
cord-263532-q044i7ym	70	8	as	as	IN
cord-263532-q044i7ym	70	9	a	a	DT
cord-263532-q044i7ym	70	10	homodimer	homodimer	NN
cord-263532-q044i7ym	70	11	in	in	IN
cord-263532-q044i7ym	70	12	the	the	DT
cord-263532-q044i7ym	70	13	crystal	crystal	NN
cord-263532-q044i7ym	70	14	structure	structure	NN
cord-263532-q044i7ym	70	15	,	,	,
cord-263532-q044i7ym	70	16	19	19	CD
cord-263532-q044i7ym	70	17	and	and	CC
cord-263532-q044i7ym	70	18	the	the	DT
cord-263532-q044i7ym	70	19	important	important	JJ
cord-263532-q044i7ym	70	20	residues	residue	NNS
cord-263532-q044i7ym	70	21	along	along	IN
cord-263532-q044i7ym	70	22	with	with	IN
cord-263532-q044i7ym	70	23	their	-PRON-	PRP$
cord-263532-q044i7ym	70	24	key	key	JJ
cord-263532-q044i7ym	70	25	roles	role	NNS
cord-263532-q044i7ym	70	26	are	be	VBP
cord-263532-q044i7ym	70	27	listed	list	VBN
cord-263532-q044i7ym	70	28	in	in	IN
cord-263532-q044i7ym	70	29	Table	Table	NNP
cord-263532-q044i7ym	70	30	1	1	CD
cord-263532-q044i7ym	70	31	.	.	.
cord-263532-q044i7ym	71	1	The	the	DT
cord-263532-q044i7ym	71	2	key	key	JJ
cord-263532-q044i7ym	71	3	residues	residue	NNS
cord-263532-q044i7ym	71	4	that	that	WDT
cord-263532-q044i7ym	71	5	stabilize	stabilize	VBP
cord-263532-q044i7ym	71	6	the	the	DT
cord-263532-q044i7ym	71	7	dimeric	dimeric	JJ
cord-263532-q044i7ym	71	8	structure	structure	NN
cord-263532-q044i7ym	71	9	of	of	IN
cord-263532-q044i7ym	71	10	SARS	SARS	NNP
cord-263532-q044i7ym	71	11	-	-	HYPH
cord-263532-q044i7ym	71	12	CoV	CoV	NNP
cord-263532-q044i7ym	71	13	M	M	NNP
cord-263532-q044i7ym	71	14	pro	pro	NNP
cord-263532-q044i7ym	71	15	are	be	VBP
cord-263532-q044i7ym	71	16	shown	show	VBN
cord-263532-q044i7ym	71	17	in	in	IN
cord-263532-q044i7ym	71	18	Figure	Figure	NNP
cord-263532-q044i7ym	71	19	3	3	CD
cord-263532-q044i7ym	71	20	.	.	.
cord-263532-q044i7ym	72	1	The	the	DT
cord-263532-q044i7ym	72	2	M	M	NNP
cord-263532-q044i7ym	72	3	pro	pro	NN
cord-263532-q044i7ym	72	4	play	play	NN
cord-263532-q044i7ym	72	5	a	a	DT
cord-263532-q044i7ym	72	6	vital	vital	JJ
cord-263532-q044i7ym	72	7	role	role	NN
cord-263532-q044i7ym	72	8	in	in	IN
cord-263532-q044i7ym	72	9	cleaving	cleave	VBG
cord-263532-q044i7ym	72	10	the	the	DT
cord-263532-q044i7ym	72	11	polyproteins	polyprotein	NNS
cord-263532-q044i7ym	72	12	translated	translate	VBN
cord-263532-q044i7ym	72	13	by	by	IN
cord-263532-q044i7ym	72	14	the	the	DT
cord-263532-q044i7ym	72	15	virus	virus	NN
cord-263532-q044i7ym	72	16	RNA	RNA	NNP
cord-263532-q044i7ym	72	17	.	.	.
cord-263532-q044i7ym	73	1	32	32	CD
cord-263532-q044i7ym	74	1	The	the	DT
cord-263532-q044i7ym	74	2	M	M	NNP
cord-263532-q044i7ym	74	3	pro	pro	NN
cord-263532-q044i7ym	74	4	cleave	cleave	VB
cord-263532-q044i7ym	74	5	the	the	DT
cord-263532-q044i7ym	74	6	large	large	JJ
cord-263532-q044i7ym	74	7	polyprotein	polyprotein	JJ
cord-263532-q044i7ym	74	8	1ab	1ab	NN
cord-263532-q044i7ym	74	9	(	(	-LRB-
cord-263532-q044i7ym	74	10	replicase	replicase	NNP
cord-263532-q044i7ym	74	11	1ab	1ab	NNP
cord-263532-q044i7ym	74	12	,	,	,
cord-263532-q044i7ym	74	13	∼790	∼790	NNP
cord-263532-q044i7ym	74	14	kDa	kDa	NNP
cord-263532-q044i7ym	74	15	)	)	-RRB-
cord-263532-q044i7ym	74	16	at	at	IN
cord-263532-q044i7ym	74	17	11	11	CD
cord-263532-q044i7ym	74	18	different	different	JJ
cord-263532-q044i7ym	74	19	sites	site	NNS
cord-263532-q044i7ym	74	20	and	and	CC
cord-263532-q044i7ym	74	21	the	the	DT
cord-263532-q044i7ym	74	22	recognition	recognition	NN
cord-263532-q044i7ym	74	23	sequence	sequence	NN
cord-263532-q044i7ym	74	24	at	at	IN
cord-263532-q044i7ym	74	25	most	most	JJS
cord-263532-q044i7ym	74	26	sites	site	NNS
cord-263532-q044i7ym	74	27	was	be	VBD
cord-263532-q044i7ym	74	28	found	find	VBN
cord-263532-q044i7ym	74	29	to	to	TO
cord-263532-q044i7ym	74	30	be	be	VB
cord-263532-q044i7ym	74	31	Leu−	Leu−	VBN
cord-263532-q044i7ym	75	1	Gln↓(Ser	Gln↓(Ser	NNP
cord-263532-q044i7ym	75	2	/	/	SYM
cord-263532-q044i7ym	75	3	Ala	Ala	NNP
cord-263532-q044i7ym	75	4	/	/	SYM
cord-263532-q044i7ym	75	5	Gly	Gly	NNP
cord-263532-q044i7ym	75	6	)	)	-RRB-
cord-263532-q044i7ym	76	1	(	(	-LRB-
cord-263532-q044i7ym	76	2	↓	↓	NN
cord-263532-q044i7ym	76	3	shows	show	VBZ
cord-263532-q044i7ym	76	4	the	the	DT
cord-263532-q044i7ym	76	5	cleavage	cleavage	NN
cord-263532-q044i7ym	76	6	site	site	NN
cord-263532-q044i7ym	76	7	)	)	-RRB-
cord-263532-q044i7ym	76	8	.	.	.
cord-263532-q044i7ym	77	1	The	the	DT
cord-263532-q044i7ym	77	2	replication	replication	NN
cord-263532-q044i7ym	77	3	of	of	IN
cord-263532-q044i7ym	77	4	the	the	DT
cord-263532-q044i7ym	77	5	virus	virus	NN
cord-263532-q044i7ym	77	6	can	can	MD
cord-263532-q044i7ym	77	7	be	be	VB
cord-263532-q044i7ym	77	8	efficiently	efficiently	RB
cord-263532-q044i7ym	77	9	blocked	block	VBN
cord-263532-q044i7ym	77	10	by	by	IN
cord-263532-q044i7ym	77	11	inhibiting	inhibit	VBG
cord-263532-q044i7ym	77	12	M	M	NNP
cord-263532-q044i7ym	77	13	pro	pro	JJ
cord-263532-q044i7ym	77	14	activity	activity	NN
cord-263532-q044i7ym	77	15	.	.	.
cord-263532-q044i7ym	78	1	As	as	IN
cord-263532-q044i7ym	78	2	no	no	DT
cord-263532-q044i7ym	78	3	human	human	JJ
cord-263532-q044i7ym	78	4	proteases	protease	NNS
cord-263532-q044i7ym	78	5	with	with	IN
cord-263532-q044i7ym	78	6	an	an	DT
cord-263532-q044i7ym	78	7	analogous	analogous	JJ
cord-263532-q044i7ym	78	8	cleavage	cleavage	NN
cord-263532-q044i7ym	78	9	specificity	specificity	NN
cord-263532-q044i7ym	78	10	were	be	VBD
cord-263532-q044i7ym	78	11	reported	report	VBN
cord-263532-q044i7ym	78	12	,	,	,
cord-263532-q044i7ym	78	13	the	the	DT
cord-263532-q044i7ym	78	14	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	78	15	against	against	IN
cord-263532-q044i7ym	78	16	M	M	NNP
cord-263532-q044i7ym	78	17	pro	pro	NNP
cord-263532-q044i7ym	78	18	are	be	VBP
cord-263532-q044i7ym	78	19	not	not	RB
cord-263532-q044i7ym	78	20	likely	likely	JJ
cord-263532-q044i7ym	78	21	to	to	TO
cord-263532-q044i7ym	78	22	be	be	VB
cord-263532-q044i7ym	78	23	toxic	toxic	JJ
cord-263532-q044i7ym	78	24	.	.	.
cord-263532-q044i7ym	79	1	The	the	DT
cord-263532-q044i7ym	79	2	various	various	JJ
cord-263532-q044i7ym	79	3	mutation	mutation	NN
cord-263532-q044i7ym	79	4	analyses	analysis	NNS
cord-263532-q044i7ym	79	5	,	,	,
cord-263532-q044i7ym	79	6	N	n	CD
cord-263532-q044i7ym	79	7	-	-	HYPH
cord-263532-q044i7ym	79	8	terminal	terminal	JJ
cord-263532-q044i7ym	79	9	truncation	truncation	NN
cord-263532-q044i7ym	79	10	studies	study	NNS
cord-263532-q044i7ym	79	11	,	,	,
cord-263532-q044i7ym	79	12	and	and	CC
cord-263532-q044i7ym	79	13	MD	MD	NNP
cord-263532-q044i7ym	79	14	simulation	simulation	NN
cord-263532-q044i7ym	79	15	studies	study	NNS
cord-263532-q044i7ym	79	16	that	that	WDT
cord-263532-q044i7ym	79	17	highlighted	highlight	VBD
cord-263532-q044i7ym	79	18	key	key	JJ
cord-263532-q044i7ym	79	19	residues	residue	NNS
cord-263532-q044i7ym	79	20	of	of	IN
cord-263532-q044i7ym	79	21	SARS	SARS	NNP
cord-263532-q044i7ym	79	22	-	-	HYPH
cord-263532-q044i7ym	79	23	CoV	CoV	NNP
cord-263532-q044i7ym	79	24	M	M	NNP
cord-263532-q044i7ym	79	25	pro	pro	NNP
cord-263532-q044i7ym	79	26	involved	involve	VBN
cord-263532-q044i7ym	79	27	in	in	IN
cord-263532-q044i7ym	79	28	the	the	DT
cord-263532-q044i7ym	79	29	stabilization	stabilization	NN
cord-263532-q044i7ym	79	30	of	of	IN
cord-263532-q044i7ym	79	31	the	the	DT
cord-263532-q044i7ym	79	32	catalytically	catalytically	RB
cord-263532-q044i7ym	79	33	active	active	JJ
cord-263532-q044i7ym	79	34	dimeric	dimeric	JJ
cord-263532-q044i7ym	79	35	structure	structure	NN
cord-263532-q044i7ym	79	36	of	of	IN
cord-263532-q044i7ym	79	37	the	the	DT
cord-263532-q044i7ym	79	38	enzyme	enzyme	NN
cord-263532-q044i7ym	79	39	are	be	VBP
cord-263532-q044i7ym	79	40	listed	list	VBN
cord-263532-q044i7ym	79	41	in	in	IN
cord-263532-q044i7ym	79	42	Table	Table	NNP
cord-263532-q044i7ym	79	43	2	2	CD
cord-263532-q044i7ym	79	44	and	and	CC
cord-263532-q044i7ym	79	45	are	be	VBP
cord-263532-q044i7ym	79	46	arranged	arrange	VBN
cord-263532-q044i7ym	79	47	in	in	IN
cord-263532-q044i7ym	79	48	chronological	chronological	JJ
cord-263532-q044i7ym	79	49	order	order	NN
cord-263532-q044i7ym	79	50	.	.	.
cord-263532-q044i7ym	80	1	In	in	IN
cord-263532-q044i7ym	80	2	2004	2004	CD
cord-263532-q044i7ym	80	3	,	,	,
cord-263532-q044i7ym	80	4	Bacha	Bacha	NNP
cord-263532-q044i7ym	80	5	et	et	NNP
cord-263532-q044i7ym	80	6	al	al	NNP
cord-263532-q044i7ym	80	7	.	.	NNP
cord-263532-q044i7ym	80	8	identified	identify	VBD
cord-263532-q044i7ym	80	9	a	a	DT
cord-263532-q044i7ym	80	10	cluster	cluster	NN
cord-263532-q044i7ym	80	11	of	of	IN
cord-263532-q044i7ym	80	12	conserved	conserve	VBN
cord-263532-q044i7ym	80	13	serine	serine	NN
cord-263532-q044i7ym	80	14	residues	residue	NNS
cord-263532-q044i7ym	80	15	(	(	-LRB-
cord-263532-q044i7ym	80	16	Ser139	Ser139	NNP
cord-263532-q044i7ym	80	17	,	,	,
cord-263532-q044i7ym	80	18	Ser144	ser144	CD
cord-263532-q044i7ym	80	19	,	,	,
cord-263532-q044i7ym	80	20	and	and	CC
cord-263532-q044i7ym	80	21	Ser147	ser147	LS
cord-263532-q044i7ym	80	22	)	)	-RRB-
cord-263532-q044i7ym	80	23	situated	situate	VBN
cord-263532-q044i7ym	80	24	in	in	IN
cord-263532-q044i7ym	80	25	the	the	DT
cord-263532-q044i7ym	80	26	close	close	JJ
cord-263532-q044i7ym	80	27	proximity	proximity	NN
cord-263532-q044i7ym	80	28	of	of	IN
cord-263532-q044i7ym	80	29	the	the	DT
cord-263532-q044i7ym	80	30	active	active	JJ
cord-263532-q044i7ym	80	31	site	site	NN
cord-263532-q044i7ym	80	32	of	of	IN
cord-263532-q044i7ym	80	33	SARS	SARS	NNP
cord-263532-q044i7ym	80	34	-	-	HYPH
cord-263532-q044i7ym	80	35	CoV	CoV	NNP
cord-263532-q044i7ym	80	36	M	M	NNP
cord-263532-q044i7ym	80	37	pro	pro	JJ
cord-263532-q044i7ym	80	38	that	that	WDT
cord-263532-q044i7ym	80	39	can	can	MD
cord-263532-q044i7ym	80	40	be	be	VB
cord-263532-q044i7ym	80	41	targeted	target	VBN
cord-263532-q044i7ym	80	42	to	to	TO
cord-263532-q044i7ym	80	43	inhibit	inhibit	VB
cord-263532-q044i7ym	80	44	the	the	DT
cord-263532-q044i7ym	80	45	protease	protease	NN
cord-263532-q044i7ym	80	46	activity	activity	NN
cord-263532-q044i7ym	80	47	.	.	.
cord-263532-q044i7ym	81	1	33	33	CD
cord-263532-q044i7ym	82	1	The	the	DT
cord-263532-q044i7ym	82	2	alanine	alanine	JJ
cord-263532-q044i7ym	82	3	substitution	substitution	NN
cord-263532-q044i7ym	82	4	of	of	IN
cord-263532-q044i7ym	82	5	Ser139	ser139	CD
cord-263532-q044i7ym	82	6	,	,	,
cord-263532-q044i7ym	82	7	Ser144	ser144	CD
cord-263532-q044i7ym	82	8	,	,	,
cord-263532-q044i7ym	82	9	and	and	CC
cord-263532-q044i7ym	82	10	Ser147	ser147	CD
cord-263532-q044i7ym	82	11	had	have	VBD
cord-263532-q044i7ym	82	12	a	a	DT
cord-263532-q044i7ym	82	13	devastating	devastating	JJ
cord-263532-q044i7ym	82	14	impact	impact	NN
cord-263532-q044i7ym	82	15	on	on	IN
cord-263532-q044i7ym	82	16	the	the	DT
cord-263532-q044i7ym	82	17	SARS	SARS	NNP
cord-263532-q044i7ym	82	18	-	-	HYPH
cord-263532-q044i7ym	82	19	CoV	CoV	NNP
cord-263532-q044i7ym	82	20	M	M	NNP
cord-263532-q044i7ym	82	21	pro	pro	JJ
cord-263532-q044i7ym	82	22	catalytic	catalytic	JJ
cord-263532-q044i7ym	82	23	activity	activity	NN
cord-263532-q044i7ym	82	24	.	.	.
cord-263532-q044i7ym	83	1	The	the	DT
cord-263532-q044i7ym	83	2	serine	serine	NN
cord-263532-q044i7ym	83	3	cluster	cluster	NN
cord-263532-q044i7ym	83	4	(	(	-LRB-
cord-263532-q044i7ym	83	5	Ser139	Ser139	NNP
cord-263532-q044i7ym	83	6	,	,	,
cord-263532-q044i7ym	83	7	Ser144	ser144	CD
cord-263532-q044i7ym	83	8	,	,	,
cord-263532-q044i7ym	83	9	and	and	CC
cord-263532-q044i7ym	83	10	Ser147	ser147	LS
cord-263532-q044i7ym	83	11	)	)	-RRB-
cord-263532-q044i7ym	83	12	is	be	VBZ
cord-263532-q044i7ym	83	13	highly	highly	RB
cord-263532-q044i7ym	83	14	conserved	conserve	VBN
cord-263532-q044i7ym	83	15	in	in	IN
cord-263532-q044i7ym	83	16	proteases	protease	NNS
cord-263532-q044i7ym	83	17	among	among	IN
cord-263532-q044i7ym	83	18	various	various	JJ
cord-263532-q044i7ym	83	19	CoVs	covs	NN
cord-263532-q044i7ym	83	20	,	,	,
cord-263532-q044i7ym	83	21	which	which	WDT
cord-263532-q044i7ym	83	22	,	,	,
cord-263532-q044i7ym	83	23	in	in	IN
cord-263532-q044i7ym	83	24	turn	turn	NN
cord-263532-q044i7ym	83	25	,	,	,
cord-263532-q044i7ym	83	26	highlight	highlight	VBP
cord-263532-q044i7ym	83	27	that	that	IN
cord-263532-q044i7ym	83	28	targeting	target	VBG
cord-263532-q044i7ym	83	29	this	this	DT
cord-263532-q044i7ym	83	30	site	site	NN
cord-263532-q044i7ym	83	31	will	will	MD
cord-263532-q044i7ym	83	32	provide	provide	VB
cord-263532-q044i7ym	83	33	broad	broad	JJ
cord-263532-q044i7ym	83	34	-	-	HYPH
cord-263532-q044i7ym	83	35	spectrum	spectrum	NN
cord-263532-q044i7ym	83	36	therapeutic	therapeutic	JJ
cord-263532-q044i7ym	83	37	agents	agent	NNS
cord-263532-q044i7ym	83	38	against	against	IN
cord-263532-q044i7ym	83	39	CoV	CoV	NNP
cord-263532-q044i7ym	83	40	protease	protease	NN
cord-263532-q044i7ym	83	41	.	.	.
cord-263532-q044i7ym	84	1	In	in	IN
cord-263532-q044i7ym	84	2	a	a	DT
cord-263532-q044i7ym	84	3	later	later	JJ
cord-263532-q044i7ym	84	4	report	report	NN
cord-263532-q044i7ym	84	5	,	,	,
cord-263532-q044i7ym	84	6	Barrila	Barrila	NNP
cord-263532-q044i7ym	84	7	et	et	FW
cord-263532-q044i7ym	84	8	al	al	NNP
cord-263532-q044i7ym	84	9	.	.	NNP
cord-263532-q044i7ym	84	10	highlighted	highlight	VBD
cord-263532-q044i7ym	84	11	that	that	IN
cord-263532-q044i7ym	84	12	Ser147	ser147	CD
cord-263532-q044i7ym	84	13	of	of	IN
cord-263532-q044i7ym	84	14	SARS	SARS	NNP
cord-263532-q044i7ym	84	15	-	-	HYPH
cord-263532-q044i7ym	84	16	CoV	CoV	NNP
cord-263532-q044i7ym	84	17	M	M	NNP
cord-263532-q044i7ym	84	18	pro	pro	JJ
cord-263532-q044i7ym	84	19	play	play	NN
cord-263532-q044i7ym	84	20	a	a	DT
cord-263532-q044i7ym	84	21	key	key	JJ
cord-263532-q044i7ym	84	22	role	role	NN
cord-263532-q044i7ym	84	23	in	in	IN
cord-263532-q044i7ym	84	24	stabilizing	stabilize	VBG
cord-263532-q044i7ym	84	25	the	the	DT
cord-263532-q044i7ym	84	26	dimeric	dimeric	JJ
cord-263532-q044i7ym	84	27	structure	structure	NN
cord-263532-q044i7ym	84	28	and	and	CC
cord-263532-q044i7ym	84	29	mutation	mutation	NN
cord-263532-q044i7ym	84	30	of	of	IN
cord-263532-q044i7ym	84	31	conserved	conserve	VBN
cord-263532-q044i7ym	84	32	Ser147	Ser147	''
cord-263532-q044i7ym	84	33	to	to	IN
cord-263532-q044i7ym	84	34	Ala	Ala	NNP
cord-263532-q044i7ym	84	35	lead	lead	VB
cord-263532-q044i7ym	84	36	to	to	IN
cord-263532-q044i7ym	84	37	dimer	dimer	NN
cord-263532-q044i7ym	84	38	instability	instability	NN
cord-263532-q044i7ym	84	39	.	.	.
cord-263532-q044i7ym	85	1	25	25	CD
cord-263532-q044i7ym	86	1	The	the	DT
cord-263532-q044i7ym	86	2	backbone	backbone	NN
cord-263532-q044i7ym	86	3	of	of	IN
cord-263532-q044i7ym	86	4	Ser147	ser147	CD
cord-263532-q044i7ym	86	5	forms	form	NNS
cord-263532-q044i7ym	86	6	hydrogen	hydrogen	NN
cord-263532-q044i7ym	86	7	bonds	bond	NNS
cord-263532-q044i7ym	86	8	with	with	IN
cord-263532-q044i7ym	86	9	the	the	DT
cord-263532-q044i7ym	86	10	backbones	backbone	NNS
cord-263532-q044i7ym	86	11	of	of	IN
cord-263532-q044i7ym	86	12	Ser144	ser144	CD
cord-263532-q044i7ym	86	13	and	and	CC
cord-263532-q044i7ym	86	14	His163	his163	CD
cord-263532-q044i7ym	86	15	residues	residue	NNS
cord-263532-q044i7ym	86	16	.	.	.
cord-263532-q044i7ym	87	1	A	a	DT
cord-263532-q044i7ym	87	2	150-fold	150-fold	CD
cord-263532-q044i7ym	87	3	reduction	reduction	NN
cord-263532-q044i7ym	87	4	in	in	IN
cord-263532-q044i7ym	87	5	the	the	DT
cord-263532-q044i7ym	87	6	catalytic	catalytic	JJ
cord-263532-q044i7ym	87	7	efficiency	efficiency	NN
cord-263532-q044i7ym	87	8	and	and	CC
cord-263532-q044i7ym	87	9	complete	complete	JJ
cord-263532-q044i7ym	87	10	loss	loss	NN
cord-263532-q044i7ym	87	11	of	of	IN
cord-263532-q044i7ym	87	12	dimerization	dimerization	NN
cord-263532-q044i7ym	87	13	was	be	VBD
cord-263532-q044i7ym	87	14	observed	observe	VBN
cord-263532-q044i7ym	87	15	in	in	IN
cord-263532-q044i7ym	87	16	S147A	S147A	NNP
cord-263532-q044i7ym	87	17	mutant	mutant	JJ
cord-263532-q044i7ym	87	18	as	as	IN
cord-263532-q044i7ym	87	19	compared	compare	VBN
cord-263532-q044i7ym	87	20	to	to	IN
cord-263532-q044i7ym	87	21	wild	wild	JJ
cord-263532-q044i7ym	87	22	-	-	HYPH
cord-263532-q044i7ym	87	23	type	type	NN
cord-263532-q044i7ym	87	24	(	(	-LRB-
cord-263532-q044i7ym	87	25	wt	wt	NN
cord-263532-q044i7ym	87	26	)	)	-RRB-
cord-263532-q044i7ym	87	27	enzyme	enzyme	NN
cord-263532-q044i7ym	87	28	.	.	.
cord-263532-q044i7ym	88	1	In	in	IN
cord-263532-q044i7ym	88	2	another	another	DT
cord-263532-q044i7ym	88	3	study	study	NN
cord-263532-q044i7ym	88	4	,	,	,
cord-263532-q044i7ym	88	5	Chou	Chou	NNP
cord-263532-q044i7ym	88	6	et	et	NNP
cord-263532-q044i7ym	88	7	al	al	NNP
cord-263532-q044i7ym	88	8	.	.	NNP
cord-263532-q044i7ym	88	9	reported	report	VBD
cord-263532-q044i7ym	88	10	that	that	IN
cord-263532-q044i7ym	88	11	high	high	JJ
cord-263532-q044i7ym	88	12	salt	salt	NN
cord-263532-q044i7ym	88	13	concentration	concentration	NN
cord-263532-q044i7ym	88	14	and	and	CC
cord-263532-q044i7ym	88	15	low	low	JJ
cord-263532-q044i7ym	88	16	pH	ph	NN
cord-263532-q044i7ym	88	17	led	lead	VBD
cord-263532-q044i7ym	88	18	to	to	IN
cord-263532-q044i7ym	88	19	a	a	DT
cord-263532-q044i7ym	88	20	decrease	decrease	NN
cord-263532-q044i7ym	88	21	in	in	IN
cord-263532-q044i7ym	88	22	the	the	DT
cord-263532-q044i7ym	88	23	M	M	NNP
cord-263532-q044i7ym	88	24	pro	pro	JJ
cord-263532-q044i7ym	88	25	dimerization	dimerization	NN
cord-263532-q044i7ym	88	26	and	and	CC
cord-263532-q044i7ym	88	27	activity	activity	NN
cord-263532-q044i7ym	88	28	.	.	.
cord-263532-q044i7ym	89	1	24	24	CD
cord-263532-q044i7ym	90	1	The	the	DT
cord-263532-q044i7ym	90	2	observed	observed	JJ
cord-263532-q044i7ym	90	3	decrease	decrease	NN
cord-263532-q044i7ym	90	4	in	in	IN
cord-263532-q044i7ym	90	5	activity	activity	NN
cord-263532-q044i7ym	90	6	of	of	IN
cord-263532-q044i7ym	90	7	M	M	NNP
cord-263532-q044i7ym	90	8	pro	pro	NNP
cord-263532-q044i7ym	90	9	was	be	VBD
cord-263532-q044i7ym	90	10	attributed	attribute	VBN
cord-263532-q044i7ym	90	11	to	to	IN
cord-263532-q044i7ym	90	12	the	the	DT
cord-263532-q044i7ym	90	13	salt	salt	NN
cord-263532-q044i7ym	90	14	bridge	bridge	NN
cord-263532-q044i7ym	90	15	interaction	interaction	NN
cord-263532-q044i7ym	90	16	between	between	IN
cord-263532-q044i7ym	90	17	Arg4	Arg4	NNP
cord-263532-q044i7ym	90	18	and	and	CC
cord-263532-q044i7ym	90	19	Glu290	glu290	NN
cord-263532-q044i7ym	90	20	residues	residue	NNS
cord-263532-q044i7ym	90	21	.	.	.
cord-263532-q044i7ym	91	1	The	the	DT
cord-263532-q044i7ym	91	2	study	study	NN
cord-263532-q044i7ym	91	3	highlighted	highlight	VBD
cord-263532-q044i7ym	91	4	that	that	IN
cord-263532-q044i7ym	91	5	E290A	E290A	NNP
cord-263532-q044i7ym	91	6	mutation	mutation	NN
cord-263532-q044i7ym	91	7	led	lead	VBD
cord-263532-q044i7ym	91	8	to	to	IN
cord-263532-q044i7ym	91	9	a	a	DT
cord-263532-q044i7ym	91	10	complete	complete	JJ
cord-263532-q044i7ym	91	11	loss	loss	NN
cord-263532-q044i7ym	91	12	of	of	IN
cord-263532-q044i7ym	91	13	catalytic	catalytic	JJ
cord-263532-q044i7ym	91	14	activity	activity	NN
cord-263532-q044i7ym	91	15	and	and	CC
cord-263532-q044i7ym	91	16	22	22	CD
cord-263532-q044i7ym	91	17	Hsu	Hsu	NNP
cord-263532-q044i7ym	91	18	et	et	NNP
cord-263532-q044i7ym	91	19	al	al	NNP
cord-263532-q044i7ym	91	20	.	.	.
cord-263532-q044i7ym	92	1	23	23	CD
cord-263532-q044i7ym	92	2	Arg4	Arg4	NNP
cord-263532-q044i7ym	92	3	,	,	,
cord-263532-q044i7ym	92	4	Ser10	Ser10	NNP
cord-263532-q044i7ym	92	5	,	,	,
cord-263532-q044i7ym	92	6	Gly11	Gly11	NNP
cord-263532-q044i7ym	92	7	,	,	,
cord-263532-q044i7ym	92	8	Glu14	Glu14	NNP
cord-263532-q044i7ym	92	9	,	,	,
cord-263532-q044i7ym	92	10	Asn28	Asn28	NNP
cord-263532-q044i7ym	92	11	,	,	,
cord-263532-q044i7ym	92	12	Ser139	Ser139	NNP
cord-263532-q044i7ym	92	13	,	,	,
cord-263532-q044i7ym	92	14	Phe140	phe140	CD
cord-263532-q044i7ym	92	15	,	,	,
cord-263532-q044i7ym	92	16	Ser147	ser147	ADD
cord-263532-q044i7ym	92	17	,	,	,
cord-263532-q044i7ym	92	18	Glu290	glu290	CD
cord-263532-q044i7ym	92	19	,	,	,
cord-263532-q044i7ym	92	20	Arg298	arg298	DT
cord-263532-q044i7ym	92	21	dimerization	dimerization	NN
cord-263532-q044i7ym	93	1	Chou	Chou	NNP
cord-263532-q044i7ym	93	2	et	et	NNP
cord-263532-q044i7ym	93	3	al	al	NNP
cord-263532-q044i7ym	93	4	.	.	.
cord-263532-q044i7ym	94	1	,	,	,
cord-263532-q044i7ym	94	2	24	24	CD
cord-263532-q044i7ym	94	3	Barrila	Barrila	NNP
cord-263532-q044i7ym	94	4	et	et	FW
cord-263532-q044i7ym	94	5	al	al	NNP
cord-263532-q044i7ym	94	6	.	.	.
cord-263532-q044i7ym	95	1	,	,	,
cord-263532-q044i7ym	95	2	25	25	CD
cord-263532-q044i7ym	95	3	Chen	Chen	NNP
cord-263532-q044i7ym	95	4	et	et	NNP
cord-263532-q044i7ym	95	5	al	al	NNP
cord-263532-q044i7ym	95	6	.	.	.
cord-263532-q044i7ym	96	1	,	,	,
cord-263532-q044i7ym	96	2	26	26	CD
cord-263532-q044i7ym	96	3	Chen	Chen	NNP
cord-263532-q044i7ym	96	4	et	et	NNP
cord-263532-q044i7ym	96	5	al	al	NNP
cord-263532-q044i7ym	96	6	.	.	NNP
cord-263532-q044i7ym	96	7	,	,	,
cord-263532-q044i7ym	97	1	27	27	CD
cord-263532-q044i7ym	98	1	Lin	Lin	NNP
cord-263532-q044i7ym	98	2	et	et	NNP
cord-263532-q044i7ym	98	3	al	al	NNP
cord-263532-q044i7ym	98	4	.	.	NNP
cord-263532-q044i7ym	98	5	,	,	,
cord-263532-q044i7ym	98	6	28	28	CD
cord-263532-q044i7ym	98	7	Shiet	Shiet	NNP
cord-263532-q044i7ym	98	8	al	al	NNP
cord-263532-q044i7ym	98	9	.	.	.
cord-263532-q044i7ym	99	1	,	,	,
cord-263532-q044i7ym	99	2	29	29	CD
cord-263532-q044i7ym	100	1	Hu	Hu	NNP
cord-263532-q044i7ym	100	2	et	et	FW
cord-263532-q044i7ym	100	3	al	al	NNP
cord-263532-q044i7ym	100	4	.	.	.
cord-263532-q044i7ym	101	1	,	,	,
cord-263532-q044i7ym	101	2	30	30	CD
cord-263532-q044i7ym	101	3	Barrila	Barrila	NNP
cord-263532-q044i7ym	101	4	et	et	FW
cord-263532-q044i7ym	101	5	al	al	NNP
cord-263532-q044i7ym	101	6	.	.	.
cord-263532-q044i7ym	102	1	31	31	CD
cord-263532-q044i7ym	102	2	.	.	.
cord-263532-q044i7ym	103	1	S139A	S139A	NNS
cord-263532-q044i7ym	103	2	,	,	,
cord-263532-q044i7ym	103	3	S144A	S144A	NNPS
cord-263532-q044i7ym	103	4	,	,	,
cord-263532-q044i7ym	103	5	S147A	S147A	NNP
cord-263532-q044i7ym	103	6	S139A	S139A	NNP
cord-263532-q044i7ym	103	7	,	,	,
cord-263532-q044i7ym	103	8	S144A	S144A	NNPS
cord-263532-q044i7ym	103	9	,	,	,
cord-263532-q044i7ym	103	10	and	and	CC
cord-263532-q044i7ym	103	11	S147A	S147A	NNP
cord-263532-q044i7ym	103	12	mutations	mutation	NNS
cord-263532-q044i7ym	103	13	have	have	VBP
cord-263532-q044i7ym	103	14	a	a	DT
cord-263532-q044i7ym	103	15	devastating	devastating	JJ
cord-263532-q044i7ym	103	16	effect	effect	NN
cord-263532-q044i7ym	103	17	on	on	IN
cord-263532-q044i7ym	103	18	the	the	DT
cord-263532-q044i7ym	103	19	catalytic	catalytic	JJ
cord-263532-q044i7ym	103	20	activity	activity	NN
cord-263532-q044i7ym	103	21	of	of	IN
cord-263532-q044i7ym	103	22	SARS	SARS	NNP
cord-263532-q044i7ym	103	23	-	-	HYPH
cord-263532-q044i7ym	103	24	CoV	CoV	NNP
cord-263532-q044i7ym	103	25	M	M	NNP
cord-263532-q044i7ym	103	26	pro	pro	NNP
cord-263532-q044i7ym	103	27	.	.	.
cord-263532-q044i7ym	104	1	Bacha	Bacha	NNP
cord-263532-q044i7ym	104	2	et	et	NNP
cord-263532-q044i7ym	104	3	al	al	NNP
cord-263532-q044i7ym	104	4	.	.	.
cord-263532-q044i7ym	105	1	33	33	CD
cord-263532-q044i7ym	105	2	2	2	CD
cord-263532-q044i7ym	105	3	.	.	.
cord-263532-q044i7ym	106	1	A	a	DT
cord-263532-q044i7ym	106	2	150-fold	150-fold	CD
cord-263532-q044i7ym	106	3	reduction	reduction	NN
cord-263532-q044i7ym	106	4	in	in	IN
cord-263532-q044i7ym	106	5	the	the	DT
cord-263532-q044i7ym	106	6	catalytic	catalytic	JJ
cord-263532-q044i7ym	106	7	efficiency	efficiency	NN
cord-263532-q044i7ym	106	8	and	and	CC
cord-263532-q044i7ym	106	9	complete	complete	JJ
cord-263532-q044i7ym	106	10	loss	loss	NN
cord-263532-q044i7ym	106	11	of	of	IN
cord-263532-q044i7ym	106	12	dimerization	dimerization	NN
cord-263532-q044i7ym	106	13	were	be	VBD
cord-263532-q044i7ym	106	14	observed	observe	VBN
cord-263532-q044i7ym	106	15	in	in	IN
cord-263532-q044i7ym	106	16	S147A	S147A	NNP
cord-263532-q044i7ym	106	17	mutant	mutant	JJ
cord-263532-q044i7ym	106	18	as	as	IN
cord-263532-q044i7ym	106	19	compared	compare	VBN
cord-263532-q044i7ym	106	20	to	to	IN
cord-263532-q044i7ym	106	21	wild	wild	JJ
cord-263532-q044i7ym	106	22	-	-	HYPH
cord-263532-q044i7ym	106	23	type	type	NN
cord-263532-q044i7ym	106	24	(	(	-LRB-
cord-263532-q044i7ym	106	25	wt	wt	NN
cord-263532-q044i7ym	106	26	)	)	-RRB-
cord-263532-q044i7ym	106	27	enzyme	enzyme	NN
cord-263532-q044i7ym	106	28	.	.	.
cord-263532-q044i7ym	107	1	Barrila	Barrila	NNP
cord-263532-q044i7ym	107	2	et	et	FW
cord-263532-q044i7ym	107	3	al	al	NNP
cord-263532-q044i7ym	107	4	.	.	.
cord-263532-q044i7ym	108	1	25	25	CD
cord-263532-q044i7ym	108	2	3	3	CD
cord-263532-q044i7ym	108	3	.	.	.
cord-263532-q044i7ym	109	1	R4A	r4a	JJ
cord-263532-q044i7ym	109	2	,	,	,
cord-263532-q044i7ym	109	3	E290A	e290a	NN
cord-263532-q044i7ym	109	4	E290A	E290A	VBZ
cord-263532-q044i7ym	109	5	mutation	mutation	NN
cord-263532-q044i7ym	109	6	led	lead	VBD
cord-263532-q044i7ym	109	7	to	to	IN
cord-263532-q044i7ym	109	8	a	a	DT
cord-263532-q044i7ym	109	9	complete	complete	JJ
cord-263532-q044i7ym	109	10	loss	loss	NN
cord-263532-q044i7ym	109	11	of	of	IN
cord-263532-q044i7ym	109	12	catalytic	catalytic	JJ
cord-263532-q044i7ym	109	13	activity	activity	NN
cord-263532-q044i7ym	109	14	and	and	CC
cord-263532-q044i7ym	109	15	dimerization	dimerization	NN
cord-263532-q044i7ym	109	16	,	,	,
cord-263532-q044i7ym	109	17	whereas	whereas	IN
cord-263532-q044i7ym	109	18	R4A	r4a	NN
cord-263532-q044i7ym	109	19	mutation	mutation	NN
cord-263532-q044i7ym	109	20	resulted	result	VBD
cord-263532-q044i7ym	109	21	in	in	IN
cord-263532-q044i7ym	109	22	an	an	DT
cord-263532-q044i7ym	109	23	approximately	approximately	RB
cord-263532-q044i7ym	109	24	5-fold	5-fold	CD
cord-263532-q044i7ym	109	25	decrease	decrease	NN
cord-263532-q044i7ym	109	26	in	in	IN
cord-263532-q044i7ym	109	27	the	the	DT
cord-263532-q044i7ym	109	28	dimerization	dimerization	NN
cord-263532-q044i7ym	109	29	and	and	CC
cord-263532-q044i7ym	109	30	a	a	DT
cord-263532-q044i7ym	109	31	modest	modest	JJ
cord-263532-q044i7ym	109	32	loss	loss	NN
cord-263532-q044i7ym	109	33	in	in	IN
cord-263532-q044i7ym	109	34	the	the	DT
cord-263532-q044i7ym	109	35	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	109	36	activity	activity	NN
cord-263532-q044i7ym	109	37	.	.	.
cord-263532-q044i7ym	110	1	Chou	Chou	NNP
cord-263532-q044i7ym	110	2	et	et	NNP
cord-263532-q044i7ym	110	3	al	al	NNP
cord-263532-q044i7ym	110	4	.	.	.
cord-263532-q044i7ym	111	1	24	24	CD
cord-263532-q044i7ym	111	2	4	4	CD
cord-263532-q044i7ym	111	3	.	.	.
cord-263532-q044i7ym	112	1	N	n	CD
cord-263532-q044i7ym	112	2	-	-	HYPH
cord-263532-q044i7ym	112	3	terminal	terminal	NN
cord-263532-q044i7ym	112	4	truncated	truncate	VBN
cord-263532-q044i7ym	112	5	(	(	-LRB-
cord-263532-q044i7ym	112	6	residues	residue	NNS
cord-263532-q044i7ym	112	7	1−7	1−7	NNP
cord-263532-q044i7ym	112	8	)	)	-RRB-
cord-263532-q044i7ym	112	9	SARS	SARS	NNP
cord-263532-q044i7ym	112	10	-	-	HYPH
cord-263532-q044i7ym	112	11	CoV	CoV	NNP
cord-263532-q044i7ym	112	12	M	M	NNP
cord-263532-q044i7ym	112	13	pro	pro	NNP
cord-263532-q044i7ym	112	14	N	N	NNP
cord-263532-q044i7ym	112	15	-	-	HYPH
cord-263532-q044i7ym	112	16	terminal	terminal	JJ
cord-263532-q044i7ym	112	17	truncated	truncate	VBN
cord-263532-q044i7ym	112	18	protease	protease	NN
cord-263532-q044i7ym	112	19	dimer	dimer	NN
cord-263532-q044i7ym	112	20	adopts	adopt	VBZ
cord-263532-q044i7ym	112	21	a	a	DT
cord-263532-q044i7ym	112	22	different	different	JJ
cord-263532-q044i7ym	112	23	state	state	NN
cord-263532-q044i7ym	112	24	as	as	IN
cord-263532-q044i7ym	112	25	compared	compare	VBN
cord-263532-q044i7ym	112	26	to	to	IN
cord-263532-q044i7ym	112	27	the	the	DT
cord-263532-q044i7ym	112	28	full	full	JJ
cord-263532-q044i7ym	112	29	-	-	HYPH
cord-263532-q044i7ym	112	30	length	length	NN
cord-263532-q044i7ym	112	31	protease	protease	NN
cord-263532-q044i7ym	112	32	dimer	dimer	NN
cord-263532-q044i7ym	112	33	;	;	:
cord-263532-q044i7ym	112	34	MD	MD	NNP
cord-263532-q044i7ym	112	35	simulations	simulation	NNS
cord-263532-q044i7ym	112	36	depicted	depict	VBD
cord-263532-q044i7ym	112	37	that	that	IN
cord-263532-q044i7ym	112	38	the	the	DT
cord-263532-q044i7ym	112	39	angle	angle	NN
cord-263532-q044i7ym	112	40	between	between	IN
cord-263532-q044i7ym	112	41	the	the	DT
cord-263532-q044i7ym	112	42	two	two	CD
cord-263532-q044i7ym	112	43	monomers	monomer	NNS
cord-263532-q044i7ym	112	44	increased	increase	VBD
cord-263532-q044i7ym	112	45	and	and	CC
cord-263532-q044i7ym	112	46	the	the	DT
cord-263532-q044i7ym	112	47	dimension	dimension	NN
cord-263532-q044i7ym	112	48	of	of	IN
cord-263532-q044i7ym	112	49	the	the	DT
cord-263532-q044i7ym	112	50	substrate	substrate	NN
cord-263532-q044i7ym	112	51	binding	bind	VBG
cord-263532-q044i7ym	112	52	pocket	pocket	NN
cord-263532-q044i7ym	112	53	was	be	VBD
cord-263532-q044i7ym	112	54	reduced	reduce	VBN
cord-263532-q044i7ym	112	55	in	in	IN
cord-263532-q044i7ym	112	56	the	the	DT
cord-263532-q044i7ym	112	57	N	n	CD
cord-263532-q044i7ym	112	58	-	-	HYPH
cord-263532-q044i7ym	112	59	terminal	terminal	JJ
cord-263532-q044i7ym	112	60	truncated	truncate	VBN
cord-263532-q044i7ym	112	61	protease	protease	NN
cord-263532-q044i7ym	112	62	dimer	dimer	NN
cord-263532-q044i7ym	112	63	,	,	,
cord-263532-q044i7ym	112	64	which	which	WDT
cord-263532-q044i7ym	112	65	is	be	VBZ
cord-263532-q044i7ym	112	66	not	not	RB
cord-263532-q044i7ym	112	67	appropriate	appropriate	JJ
cord-263532-q044i7ym	112	68	for	for	IN
cord-263532-q044i7ym	112	69	the	the	DT
cord-263532-q044i7ym	112	70	substrate	substrate	NN
cord-263532-q044i7ym	112	71	binding	bind	VBG
cord-263532-q044i7ym	112	72	.	.	.
cord-263532-q044i7ym	113	1	Hsu	Hsu	NNP
cord-263532-q044i7ym	113	2	et	et	NNP
cord-263532-q044i7ym	113	3	al	al	NNP
cord-263532-q044i7ym	113	4	.	.	.
cord-263532-q044i7ym	114	1	35	35	CD
cord-263532-q044i7ym	114	2	6	6	CD
cord-263532-q044i7ym	114	3	.	.	.
cord-263532-q044i7ym	115	1	SARS	SARS	NNP
cord-263532-q044i7ym	115	2	-	-	HYPH
cord-263532-q044i7ym	115	3	CoV	CoV	NNP
cord-263532-q044i7ym	115	4	M	M	NNP
cord-263532-q044i7ym	115	5	pro	pro	NNP
cord-263532-q044i7ym	115	6	Size	Size	NNP
cord-263532-q044i7ym	115	7	and	and	CC
cord-263532-q044i7ym	115	8	conformation	conformation	NN
cord-263532-q044i7ym	115	9	of	of	IN
cord-263532-q044i7ym	115	10	the	the	DT
cord-263532-q044i7ym	115	11	substrate	substrate	NN
cord-263532-q044i7ym	115	12	binding	bind	VBG
cord-263532-q044i7ym	115	13	pocket	pocket	NN
cord-263532-q044i7ym	115	14	S1	S1	NNP
cord-263532-q044i7ym	115	15	are	be	VBP
cord-263532-q044i7ym	115	16	linked	link	VBN
cord-263532-q044i7ym	115	17	to	to	IN
cord-263532-q044i7ym	115	18	the	the	DT
cord-263532-q044i7ym	115	19	protonation	protonation	JJ
cord-263532-q044i7ym	115	20	states	state	NNS
cord-263532-q044i7ym	115	21	of	of	IN
cord-263532-q044i7ym	115	22	the	the	DT
cord-263532-q044i7ym	115	23	histidine	histidine	NN
cord-263532-q044i7ym	115	24	residues	residue	NNS
cord-263532-q044i7ym	115	25	(	(	-LRB-
cord-263532-q044i7ym	115	26	His163	his163	CD
cord-263532-q044i7ym	115	27	and	and	CC
cord-263532-q044i7ym	115	28	His172	his172	CD
cord-263532-q044i7ym	115	29	)	)	-RRB-
cord-263532-q044i7ym	115	30	comprising	comprise	VBG
cord-263532-q044i7ym	115	31	the	the	DT
cord-263532-q044i7ym	115	32	pocket	pocket	NN
cord-263532-q044i7ym	115	33	.	.	.
cord-263532-q044i7ym	116	1	The	the	DT
cord-263532-q044i7ym	116	2	N	N	NNP
cord-263532-q044i7ym	116	3	-	-	HYPH
cord-263532-q044i7ym	116	4	terminus	terminus	NN
cord-263532-q044i7ym	116	5	of	of	IN
cord-263532-q044i7ym	116	6	another	another	DT
cord-263532-q044i7ym	116	7	monomer	monomer	NN
cord-263532-q044i7ym	116	8	in	in	IN
cord-263532-q044i7ym	116	9	the	the	DT
cord-263532-q044i7ym	116	10	protease	protease	NN
cord-263532-q044i7ym	116	11	dimer	dimer	NN
cord-263532-q044i7ym	116	12	plays	play	VBZ
cord-263532-q044i7ym	116	13	a	a	DT
cord-263532-q044i7ym	116	14	critical	critical	JJ
cord-263532-q044i7ym	116	15	role	role	NN
cord-263532-q044i7ym	116	16	in	in	IN
cord-263532-q044i7ym	116	17	the	the	DT
cord-263532-q044i7ym	116	18	catalytic	catalytic	JJ
cord-263532-q044i7ym	116	19	activity	activity	NN
cord-263532-q044i7ym	116	20	by	by	IN
cord-263532-q044i7ym	116	21	sustaining	sustain	VBG
cord-263532-q044i7ym	116	22	the	the	DT
cord-263532-q044i7ym	116	23	correct	correct	JJ
cord-263532-q044i7ym	116	24	conformation	conformation	NN
cord-263532-q044i7ym	116	25	of	of	IN
cord-263532-q044i7ym	116	26	the	the	DT
cord-263532-q044i7ym	116	27	oxyanion	oxyanion	NN
cord-263532-q044i7ym	116	28	loop	loop	NN
cord-263532-q044i7ym	116	29	and	and	CC
cord-263532-q044i7ym	116	30	substrate	substrate	NN
cord-263532-q044i7ym	116	31	binding	bind	VBG
cord-263532-q044i7ym	116	32	pocket	pocket	NN
cord-263532-q044i7ym	116	33	S1	s1	NN
cord-263532-q044i7ym	116	34	through	through	IN
cord-263532-q044i7ym	116	35	hydrogen	hydrogen	NN
cord-263532-q044i7ym	116	36	bonds	bond	NNS
cord-263532-q044i7ym	116	37	.	.	.
cord-263532-q044i7ym	117	1	Tan	Tan	NNP
cord-263532-q044i7ym	117	2	et	et	FW
cord-263532-q044i7ym	117	3	al	al	NNP
cord-263532-q044i7ym	117	4	.	.	.
cord-263532-q044i7ym	118	1	36	36	CD
cord-263532-q044i7ym	118	2	7	7	CD
cord-263532-q044i7ym	118	3	.	.	.
cord-263532-q044i7ym	119	1	Analytical	analytical	JJ
cord-263532-q044i7ym	119	2	ultracentrifugation	ultracentrifugation	NN
cord-263532-q044i7ym	119	3	experiments	experiment	NNS
cord-263532-q044i7ym	119	4	depicted	depict	VBD
cord-263532-q044i7ym	119	5	that	that	IN
cord-263532-q044i7ym	119	6	a	a	DT
cord-263532-q044i7ym	119	7	tight	tight	JJ
cord-263532-q044i7ym	119	8	dimer	dimer	NN
cord-263532-q044i7ym	119	9	was	be	VBD
cord-263532-q044i7ym	119	10	formed	form	VBN
cord-263532-q044i7ym	119	11	in	in	IN
cord-263532-q044i7ym	119	12	the	the	DT
cord-263532-q044i7ym	119	13	mature	mature	JJ
cord-263532-q044i7ym	119	14	enzyme	enzyme	NN
cord-263532-q044i7ym	119	15	(	(	-LRB-
cord-263532-q044i7ym	119	16	K	K	NNP
cord-263532-q044i7ym	119	17	Wei	Wei	NNP
cord-263532-q044i7ym	119	18	et	et	NNP
cord-263532-q044i7ym	119	19	al	al	NNP
cord-263532-q044i7ym	119	20	.	.	.
cord-263532-q044i7ym	120	1	15	15	CD
cord-263532-q044i7ym	120	2	10	10	CD
cord-263532-q044i7ym	120	3	.	.	.
cord-263532-q044i7ym	121	1	hybrid	hybrid	JJ
cord-263532-q044i7ym	121	2	SARS	SARS	NNP
cord-263532-q044i7ym	121	3	-	-	HYPH
cord-263532-q044i7ym	121	4	CoV	CoV	NNP
cord-263532-q044i7ym	121	5	M	M	NNP
cord-263532-q044i7ym	121	6	pro	pro	NNP
cord-263532-q044i7ym	121	7	between	between	IN
cord-263532-q044i7ym	121	8	the	the	DT
cord-263532-q044i7ym	121	9	wt	wt	NN
cord-263532-q044i7ym	121	10	enzyme	enzyme	NN
cord-263532-q044i7ym	121	11	and	and	CC
cord-263532-q044i7ym	121	12	the	the	DT
cord-263532-q044i7ym	121	13	inactive	inactive	JJ
cord-263532-q044i7ym	121	14	mutant	mutant	NN
cord-263532-q044i7ym	121	15	C145A	C145A	NNP
cord-263532-q044i7ym	121	16	The	the	DT
cord-263532-q044i7ym	121	17	simulation	simulation	NN
cord-263532-q044i7ym	121	18	and	and	CC
cord-263532-q044i7ym	121	19	experimental	experimental	JJ
cord-263532-q044i7ym	121	20	results	result	NNS
cord-263532-q044i7ym	121	21	concluded	conclude	VBD
cord-263532-q044i7ym	121	22	that	that	IN
cord-263532-q044i7ym	121	23	(	(	-LRB-
cord-263532-q044i7ym	121	24	i	i	NN
cord-263532-q044i7ym	121	25	)	)	-RRB-
cord-263532-q044i7ym	121	26	dimerization	dimerization	NN
cord-263532-q044i7ym	121	27	was	be	VBD
cord-263532-q044i7ym	121	28	a	a	DT
cord-263532-q044i7ym	121	29	mandatory	mandatory	JJ
cord-263532-q044i7ym	121	30	requirement	requirement	NN
cord-263532-q044i7ym	121	31	for	for	IN
cord-263532-q044i7ym	121	32	the	the	DT
cord-263532-q044i7ym	121	33	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	121	34	activity	activity	NN
cord-263532-q044i7ym	121	35	of	of	IN
cord-263532-q044i7ym	121	36	the	the	DT
cord-263532-q044i7ym	121	37	protease	protease	NN
cord-263532-q044i7ym	121	38	,	,	,
cord-263532-q044i7ym	121	39	and	and	CC
cord-263532-q044i7ym	121	40	(	(	-LRB-
cord-263532-q044i7ym	121	41	ii	ii	NN
cord-263532-q044i7ym	121	42	)	)	-RRB-
cord-263532-q044i7ym	122	1	only	only	RB
cord-263532-q044i7ym	122	2	one	one	CD
cord-263532-q044i7ym	122	3	monomer	monomer	NN
cord-263532-q044i7ym	122	4	in	in	IN
cord-263532-q044i7ym	122	5	the	the	DT
cord-263532-q044i7ym	122	6	protease	protease	NN
cord-263532-q044i7ym	122	7	dimer	dimer	NN
cord-263532-q044i7ym	122	8	displayed	display	VBD
cord-263532-q044i7ym	122	9	catalytic	catalytic	JJ
cord-263532-q044i7ym	122	10	activity	activity	NN
cord-263532-q044i7ym	122	11	.	.	.
cord-263532-q044i7ym	123	1	Chen	Chen	NNP
cord-263532-q044i7ym	123	2	et	et	NNP
cord-263532-q044i7ym	123	3	al	al	NNP
cord-263532-q044i7ym	123	4	.	.	.
cord-263532-q044i7ym	124	1	37	37	CD
cord-263532-q044i7ym	124	2	11	11	CD
cord-263532-q044i7ym	124	3	.	.	.
cord-263532-q044i7ym	125	1	SARS	SARS	NNP
cord-263532-q044i7ym	125	2	CoV	CoV	NNP
cord-263532-q044i7ym	125	3	M	M	NNP
cord-263532-q044i7ym	126	1	pro	pro	NNP
cord-263532-q044i7ym	126	2	SARS	SARS	NNP
cord-263532-q044i7ym	126	3	CoV	CoV	NNP
cord-263532-q044i7ym	126	4	M	M	NNP
cord-263532-q044i7ym	126	5	pro	pro	NNP
cord-263532-q044i7ym	126	6	exists	exist	VBZ
cord-263532-q044i7ym	126	7	as	as	IN
cord-263532-q044i7ym	126	8	a	a	DT
cord-263532-q044i7ym	126	9	homodimer	homodimer	NN
cord-263532-q044i7ym	126	10	in	in	IN
cord-263532-q044i7ym	126	11	its	-PRON-	PRP$
cord-263532-q044i7ym	126	12	active	active	JJ
cord-263532-q044i7ym	126	13	form	form	NN
cord-263532-q044i7ym	126	14	.	.	.
cord-263532-q044i7ym	127	1	The	the	DT
cord-263532-q044i7ym	127	2	biochemical	biochemical	JJ
cord-263532-q044i7ym	127	3	and	and	CC
cord-263532-q044i7ym	127	4	biophysical	biophysical	JJ
cord-263532-q044i7ym	127	5	data	datum	NNS
cord-263532-q044i7ym	127	6	depicted	depict	VBD
cord-263532-q044i7ym	127	7	a	a	DT
cord-263532-q044i7ym	127	8	monomer−dimer	monomer−dimer	CD
cord-263532-q044i7ym	127	9	equilibrium	equilibrium	NN
cord-263532-q044i7ym	127	10	with	with	IN
cord-263532-q044i7ym	127	11	a	a	DT
cord-263532-q044i7ym	127	12	dissociation	dissociation	NN
cord-263532-q044i7ym	128	1	constant	constant	JJ
cord-263532-q044i7ym	128	2	K	K	NNP
cord-263532-q044i7ym	128	3	d	d	NN
cord-263532-q044i7ym	128	4	≈	≈	NNP
cord-263532-q044i7ym	128	5	6	6	CD
cord-263532-q044i7ym	129	1	μM.	μM.	NNP
cord-263532-q044i7ym	129	2	Graziano	Graziano	NNP
cord-263532-q044i7ym	129	3	et	et	NNP
cord-263532-q044i7ym	129	4	al	al	NNP
cord-263532-q044i7ym	129	5	.	.	.
cord-263532-q044i7ym	130	1	38	38	CD
cord-263532-q044i7ym	130	2	12	12	CD
cord-263532-q044i7ym	130	3	.	.	.
cord-263532-q044i7ym	131	1	MD	MD	NNP
cord-263532-q044i7ym	131	2	simulations	simulation	NNS
cord-263532-q044i7ym	131	3	of	of	IN
cord-263532-q044i7ym	131	4	dimeric	dimeric	JJ
cord-263532-q044i7ym	131	5	and	and	CC
cord-263532-q044i7ym	131	6	monomeric	monomeric	JJ
cord-263532-q044i7ym	131	7	forms	form	NNS
cord-263532-q044i7ym	131	8	of	of	IN
cord-263532-q044i7ym	131	9	SARS	SARS	NNP
cord-263532-q044i7ym	131	10	-	-	HYPH
cord-263532-q044i7ym	131	11	CoV	CoV	NNP
cord-263532-q044i7ym	131	12	M	M	NNP
cord-263532-q044i7ym	131	13	pro	pro	JJ
cord-263532-q044i7ym	131	14	MD	MD	NNP
cord-263532-q044i7ym	131	15	simulations	simulation	NNS
cord-263532-q044i7ym	131	16	highlighted	highlight	VBD
cord-263532-q044i7ym	131	17	that	that	IN
cord-263532-q044i7ym	131	18	the	the	DT
cord-263532-q044i7ym	131	19	interactions	interaction	NNS
cord-263532-q044i7ym	131	20	between	between	IN
cord-263532-q044i7ym	131	21	the	the	DT
cord-263532-q044i7ym	131	22	N	n	CD
cord-263532-q044i7ym	131	23	-	-	HYPH
cord-263532-q044i7ym	131	24	terminus	terminus	NN
cord-263532-q044i7ym	131	25	of	of	IN
cord-263532-q044i7ym	131	26	one	one	CD
cord-263532-q044i7ym	131	27	monomer	monomer	NN
cord-263532-q044i7ym	131	28	and	and	CC
cord-263532-q044i7ym	131	29	another	another	DT
cord-263532-q044i7ym	131	30	monomer	monomer	NN
cord-263532-q044i7ym	131	31	of	of	IN
cord-263532-q044i7ym	131	32	the	the	DT
cord-263532-q044i7ym	131	33	protease	protease	NN
cord-263532-q044i7ym	131	34	helped	help	VBD
cord-263532-q044i7ym	131	35	to	to	TO
cord-263532-q044i7ym	131	36	maintain	maintain	VB
cord-263532-q044i7ym	131	37	the	the	DT
cord-263532-q044i7ym	131	38	dimer	dimer	NN
cord-263532-q044i7ym	131	39	's	's	POS
cord-263532-q044i7ym	131	40	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	131	41	activity	activity	NN
cord-263532-q044i7ym	131	42	.	.	.
cord-263532-q044i7ym	132	1	Zheng	Zheng	NNP
cord-263532-q044i7ym	132	2	et	et	NNP
cord-263532-q044i7ym	132	3	al	al	NNP
cord-263532-q044i7ym	132	4	.	.	.
cord-263532-q044i7ym	133	1	39	39	CD
cord-263532-q044i7ym	133	2	13	13	CD
cord-263532-q044i7ym	133	3	.	.	.
cord-263532-q044i7ym	134	1	S1A	S1A	NNP
cord-263532-q044i7ym	134	2	,	,	,
cord-263532-q044i7ym	134	3	F2A	F2A	NNP
cord-263532-q044i7ym	134	4	,	,	,
cord-263532-q044i7ym	134	5	R4A	r4a	CC
cord-263532-q044i7ym	134	6	,	,	,
cord-263532-q044i7ym	134	7	S10A	s10a	NN
cord-263532-q044i7ym	134	8	,	,	,
cord-263532-q044i7ym	134	9	E14A	E14A	NNS
cord-263532-q044i7ym	134	10	,	,	,
cord-263532-q044i7ym	134	11	S139A	S139A	NNPS
cord-263532-q044i7ym	134	12	,	,	,
cord-263532-q044i7ym	134	13	F140A	F140A	NNP
cord-263532-q044i7ym	134	14	The	the	DT
cord-263532-q044i7ym	134	15	Ser10	Ser10	NNP
cord-263532-q044i7ym	134	16	and	and	CC
cord-263532-q044i7ym	134	17	Glu14	Glu14	NNP
cord-263532-q044i7ym	134	18	residues	residue	NNS
cord-263532-q044i7ym	134	19	located	locate	VBN
cord-263532-q044i7ym	134	20	in	in	IN
cord-263532-q044i7ym	134	21	the	the	DT
cord-263532-q044i7ym	134	22	α	α	NN
cord-263532-q044i7ym	134	23	-	-	HYPH
cord-263532-q044i7ym	134	24	helix	helix	NN
cord-263532-q044i7ym	134	25	A′	a′	CD
cord-263532-q044i7ym	134	26	of	of	IN
cord-263532-q044i7ym	134	27	domain	domain	NN
cord-263532-q044i7ym	135	1	I	-PRON-	PRP
cord-263532-q044i7ym	135	2	of	of	IN
cord-263532-q044i7ym	135	3	SARS	SARS	NNP
cord-263532-q044i7ym	135	4	-	-	HYPH
cord-263532-q044i7ym	135	5	CoV	CoV	NNP
cord-263532-q044i7ym	135	6	M	M	NNP
cord-263532-q044i7ym	135	7	pro	pro	JJ
cord-263532-q044i7ym	135	8	are	be	VBP
cord-263532-q044i7ym	135	9	highly	highly	RB
cord-263532-q044i7ym	135	10	conserved	conserve	VBN
cord-263532-q044i7ym	135	11	among	among	IN
cord-263532-q044i7ym	135	12	various	various	JJ
cord-263532-q044i7ym	135	13	CoVs	CoVs	NNP
cord-263532-q044i7ym	135	14	proteases	protease	NNS
cord-263532-q044i7ym	135	15	and	and	CC
cord-263532-q044i7ym	135	16	contribute	contribute	VBP
cord-263532-q044i7ym	135	17	significantly	significantly	RB
cord-263532-q044i7ym	135	18	in	in	IN
cord-263532-q044i7ym	135	19	the	the	DT
cord-263532-q044i7ym	135	20	monomer−	monomer−	NN
cord-263532-q044i7ym	135	21	monomer	monomer	NN
cord-263532-q044i7ym	135	22	interactions	interaction	NNS
cord-263532-q044i7ym	135	23	.	.	.
cord-263532-q044i7ym	136	1	The	the	DT
cord-263532-q044i7ym	136	2	individual	individual	JJ
cord-263532-q044i7ym	136	3	mutations	mutation	NNS
cord-263532-q044i7ym	136	4	of	of	IN
cord-263532-q044i7ym	136	5	Ser10	Ser10	NNP
cord-263532-q044i7ym	136	6	and	and	CC
cord-263532-q044i7ym	136	7	Glu14	Glu14	NNP
cord-263532-q044i7ym	136	8	to	to	IN
cord-263532-q044i7ym	136	9	Ala	Ala	NNP
cord-263532-q044i7ym	136	10	resulted	result	VBD
cord-263532-q044i7ym	136	11	in	in	IN
cord-263532-q044i7ym	136	12	weak	weak	JJ
cord-263532-q044i7ym	136	13	dimerization	dimerization	NN
cord-263532-q044i7ym	136	14	and	and	CC
cord-263532-q044i7ym	136	15	no	no	DT
cord-263532-q044i7ym	136	16	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	136	17	activity	activity	NN
cord-263532-q044i7ym	136	18	.	.	.
cord-263532-q044i7ym	137	1	al	al	NNP
cord-263532-q044i7ym	137	2	.	.	.
cord-263532-q044i7ym	138	1	26	26	CD
cord-263532-q044i7ym	138	2	14	14	CD
cord-263532-q044i7ym	138	3	.	.	.
cord-263532-q044i7ym	139	1	G11A	G11A	NNP
cord-263532-q044i7ym	139	2	G11A	G11A	NNP
cord-263532-q044i7ym	139	3	mutation	mutation	NN
cord-263532-q044i7ym	139	4	led	lead	VBD
cord-263532-q044i7ym	139	5	to	to	IN
cord-263532-q044i7ym	139	6	a	a	DT
cord-263532-q044i7ym	139	7	complete	complete	JJ
cord-263532-q044i7ym	139	8	loss	loss	NN
cord-263532-q044i7ym	139	9	in	in	IN
cord-263532-q044i7ym	139	10	the	the	DT
cord-263532-q044i7ym	139	11	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	139	12	activity	activity	NN
cord-263532-q044i7ym	139	13	of	of	IN
cord-263532-q044i7ym	139	14	SARS	SARS	NNP
cord-263532-q044i7ym	139	15	-	-	HYPH
cord-263532-q044i7ym	139	16	CoV	CoV	NNP
cord-263532-q044i7ym	139	17	M	M	NNP
cord-263532-q044i7ym	139	18	pro	pro	NNP
cord-263532-q044i7ym	139	19	.	.	.
cord-263532-q044i7ym	140	1	The	the	DT
cord-263532-q044i7ym	140	2	G11A	g11a	RB
cord-263532-q044i7ym	140	3	mutant	mutant	JJ
cord-263532-q044i7ym	140	4	structure	structure	NN
cord-263532-q044i7ym	140	5	was	be	VBD
cord-263532-q044i7ym	140	6	the	the	DT
cord-263532-q044i7ym	140	7	first	first	JJ
cord-263532-q044i7ym	140	8	reported	report	VBN
cord-263532-q044i7ym	140	9	crystal	crystal	NN
cord-263532-q044i7ym	140	10	structure	structure	NN
cord-263532-q044i7ym	140	11	of	of	IN
cord-263532-q044i7ym	140	12	the	the	DT
cord-263532-q044i7ym	140	13	monomeric	monomeric	JJ
cord-263532-q044i7ym	140	14	SARS	SARS	NNP
cord-263532-q044i7ym	140	15	-	-	HYPH
cord-263532-q044i7ym	140	16	CoV	CoV	NNP
cord-263532-q044i7ym	140	17	M	M	NNP
cord-263532-q044i7ym	140	18	pro	pro	NNP
cord-263532-q044i7ym	140	19	,	,	,
cord-263532-q044i7ym	140	20	and	and	CC
cord-263532-q044i7ym	140	21	the	the	DT
cord-263532-q044i7ym	140	22	structure	structure	NN
cord-263532-q044i7ym	140	23	provided	provide	VBD
cord-263532-q044i7ym	140	24	a	a	DT
cord-263532-q044i7ym	140	25	better	well	JJR
cord-263532-q044i7ym	140	26	understanding	understanding	NN
cord-263532-q044i7ym	140	27	of	of	IN
cord-263532-q044i7ym	140	28	the	the	DT
cord-263532-q044i7ym	140	29	dimerization	dimerization	NN
cord-263532-q044i7ym	140	30	and	and	CC
cord-263532-q044i7ym	140	31	catalytic	catalytic	JJ
cord-263532-q044i7ym	140	32	mechanism	mechanism	NN
cord-263532-q044i7ym	140	33	of	of	IN
cord-263532-q044i7ym	140	34	the	the	DT
cord-263532-q044i7ym	140	35	protease	protease	NN
cord-263532-q044i7ym	140	36	.	.	.
cord-263532-q044i7ym	141	1	Chen	Chen	NNP
cord-263532-q044i7ym	141	2	et	et	NNP
cord-263532-q044i7ym	141	3	al	al	NNP
cord-263532-q044i7ym	141	4	.	.	.
cord-263532-q044i7ym	142	1	27	27	CD
cord-263532-q044i7ym	142	2	15	15	CD
cord-263532-q044i7ym	142	3	.	.	.
cord-263532-q044i7ym	143	1	S123A	S123A	NNP
cord-263532-q044i7ym	143	2	,	,	,
cord-263532-q044i7ym	143	3	S123C	s123c	NN
cord-263532-q044i7ym	143	4	,	,	,
cord-263532-q044i7ym	143	5	S139A	S139A	NNPS
cord-263532-q044i7ym	143	6	,	,	,
cord-263532-q044i7ym	143	7	and	and	CC
cord-263532-q044i7ym	143	8	double	double	JJ
cord-263532-q044i7ym	143	9	mutants	mutant	NNS
cord-263532-q044i7ym	144	1	S123A	S123A	NNP
cord-263532-q044i7ym	145	1	/R298A	/r298a	RB
cord-263532-q044i7ym	145	2	,	,	,
cord-263532-q044i7ym	145	3	S139A	S139A	NNP
cord-263532-q044i7ym	145	4	/	/	SYM
cord-263532-q044i7ym	145	5	Q299A	Q299A	NNP
cord-263532-q044i7ym	145	6	Deletion	deletion	NN
cord-263532-q044i7ym	145	7	of	of	IN
cord-263532-q044i7ym	145	8	Gln299	gln299	CD
cord-263532-q044i7ym	145	9	or	or	CC
cord-263532-q044i7ym	145	10	Arg298	Arg298	,
cord-263532-q044i7ym	145	11	significantly	significantly	RB
cord-263532-q044i7ym	145	12	decreased	decrease	VBD
cord-263532-q044i7ym	145	13	the	the	DT
cord-263532-q044i7ym	145	14	catalytic	catalytic	JJ
cord-263532-q044i7ym	145	15	activity	activity	NN
cord-263532-q044i7ym	145	16	to	to	IN
cord-263532-q044i7ym	145	17	only	only	RB
cord-263532-q044i7ym	145	18	1−2	1−2	CD
cord-263532-q044i7ym	145	19	%	%	NN
cord-263532-q044i7ym	145	20	of	of	IN
cord-263532-q044i7ym	145	21	wt	wt	NN
cord-263532-q044i7ym	145	22	enzyme	enzyme	NN
cord-263532-q044i7ym	145	23	,	,	,
cord-263532-q044i7ym	145	24	and	and	CC
cord-263532-q044i7ym	145	25	the	the	DT
cord-263532-q044i7ym	145	26	enzyme	enzyme	NN
cord-263532-q044i7ym	145	27	existed	exist	VBD
cord-263532-q044i7ym	145	28	predominantly	predominantly	RB
cord-263532-q044i7ym	145	29	in	in	IN
cord-263532-q044i7ym	145	30	the	the	DT
cord-263532-q044i7ym	145	31	monomeric	monomeric	JJ
cord-263532-q044i7ym	145	32	form	form	NN
cord-263532-q044i7ym	145	33	.	.	.
cord-263532-q044i7ym	146	1	The	the	DT
cord-263532-q044i7ym	146	2	point	point	NN
cord-263532-q044i7ym	146	3	mutants	mutant	NNS
cord-263532-q044i7ym	146	4	of	of	IN
cord-263532-q044i7ym	146	5	Gln299	gln299	ADD
cord-263532-q044i7ym	146	6	and	and	CC
cord-263532-q044i7ym	146	7	Arg298	Arg298	,
cord-263532-q044i7ym	146	8	depicted	depict	VBD
cord-263532-q044i7ym	146	9	that	that	IN
cord-263532-q044i7ym	146	10	these	these	DT
cord-263532-q044i7ym	146	11	residues	residue	NNS
cord-263532-q044i7ym	146	12	are	be	VBP
cord-263532-q044i7ym	146	13	involved	involve	VBN
cord-263532-q044i7ym	146	14	in	in	IN
cord-263532-q044i7ym	146	15	dimerization	dimerization	NN
cord-263532-q044i7ym	146	16	and	and	CC
cord-263532-q044i7ym	146	17	play	play	VB
cord-263532-q044i7ym	146	18	a	a	DT
cord-263532-q044i7ym	146	19	key	key	JJ
cord-263532-q044i7ym	146	20	role	role	NN
cord-263532-q044i7ym	146	21	in	in	IN
cord-263532-q044i7ym	146	22	fixing	fix	VBG
cord-263532-q044i7ym	146	23	the	the	DT
cord-263532-q044i7ym	146	24	catalytically	catalytically	RB
cord-263532-q044i7ym	146	25	active	active	JJ
cord-263532-q044i7ym	146	26	conformation	conformation	NN
cord-263532-q044i7ym	146	27	of	of	IN
cord-263532-q044i7ym	146	28	the	the	DT
cord-263532-q044i7ym	146	29	enzyme	enzyme	NN
cord-263532-q044i7ym	146	30	.	.	.
cord-263532-q044i7ym	147	1	Lin	Lin	NNP
cord-263532-q044i7ym	147	2	et	et	NNP
cord-263532-q044i7ym	147	3	al	al	NNP
cord-263532-q044i7ym	147	4	.	.	.
cord-263532-q044i7ym	148	1	28	28	CD
cord-263532-q044i7ym	148	2	16	16	CD
cord-263532-q044i7ym	148	3	.	.	.
cord-263532-q044i7ym	149	1	R298A	R298A	NNP
cord-263532-q044i7ym	149	2	R298A	R298A	NNP
cord-263532-q044i7ym	149	3	mutation	mutation	NN
cord-263532-q044i7ym	149	4	leads	lead	VBZ
cord-263532-q044i7ym	149	5	to	to	IN
cord-263532-q044i7ym	149	6	disruption	disruption	NN
cord-263532-q044i7ym	149	7	of	of	IN
cord-263532-q044i7ym	149	8	the	the	DT
cord-263532-q044i7ym	149	9	dimeric	dimeric	JJ
cord-263532-q044i7ym	149	10	structure	structure	NN
cord-263532-q044i7ym	149	11	as	as	RB
cord-263532-q044i7ym	149	12	well	well	RB
cord-263532-q044i7ym	149	13	as	as	IN
cord-263532-q044i7ym	149	14	irreversible	irreversible	JJ
cord-263532-q044i7ym	149	15	inhibition	inhibition	NN
cord-263532-q044i7ym	149	16	of	of	IN
cord-263532-q044i7ym	149	17	the	the	DT
cord-263532-q044i7ym	149	18	catalytic	catalytic	JJ
cord-263532-q044i7ym	149	19	activity	activity	NN
cord-263532-q044i7ym	149	20	of	of	IN
cord-263532-q044i7ym	149	21	the	the	DT
cord-263532-q044i7ym	149	22	enzyme	enzyme	NN
cord-263532-q044i7ym	149	23	.	.	.
cord-263532-q044i7ym	150	1	Zhong	Zhong	NNP
cord-263532-q044i7ym	150	2	et	et	NNP
cord-263532-q044i7ym	150	3	al	al	NNP
cord-263532-q044i7ym	150	4	.	.	.
cord-263532-q044i7ym	151	1	41	41	CD
cord-263532-q044i7ym	151	2	,	,	,
cord-263532-q044i7ym	151	3	42	42	CD
cord-263532-q044i7ym	151	4	19	19	CD
cord-263532-q044i7ym	151	5	.	.	.
cord-263532-q044i7ym	152	1	S139A	S139A	NNP
cord-263532-q044i7ym	152	2	and	and	CC
cord-263532-q044i7ym	152	3	F140A	F140A	NNP
cord-263532-q044i7ym	152	4	S139A	S139A	NNPS
cord-263532-q044i7ym	152	5	and	and	CC
cord-263532-q044i7ym	152	6	F140A	F140A	NNP
cord-263532-q044i7ym	152	7	on	on	IN
cord-263532-q044i7ym	152	8	the	the	DT
cord-263532-q044i7ym	152	9	dimer	dimer	NN
cord-263532-q044i7ym	152	10	interface	interface	NN
cord-263532-q044i7ym	152	11	of	of	IN
cord-263532-q044i7ym	152	12	SARS	SARS	NNP
cord-263532-q044i7ym	152	13	-	-	HYPH
cord-263532-q044i7ym	152	14	CoV	CoV	NNP
cord-263532-q044i7ym	152	15	M	M	NNP
cord-263532-q044i7ym	152	16	pro	pro	NN
cord-263532-q044i7ym	152	17	resulted	result	VBD
cord-263532-q044i7ym	152	18	in	in	IN
cord-263532-q044i7ym	152	19	different	different	JJ
cord-263532-q044i7ym	152	20	conformational	conformational	JJ
cord-263532-q044i7ym	152	21	changes	change	NNS
cord-263532-q044i7ym	152	22	in	in	IN
cord-263532-q044i7ym	152	23	the	the	DT
cord-263532-q044i7ym	152	24	crystal	crystal	JJ
cord-263532-q044i7ym	152	25	structure	structure	NN
cord-263532-q044i7ym	152	26	of	of	IN
cord-263532-q044i7ym	152	27	the	the	DT
cord-263532-q044i7ym	152	28	enzyme	enzyme	NN
cord-263532-q044i7ym	152	29	.	.	.
cord-263532-q044i7ym	153	1	Ser139	ser139	CD
cord-263532-q044i7ym	153	2	of	of	IN
cord-263532-q044i7ym	153	3	monomer	monomer	NNP
cord-263532-q044i7ym	153	4	A	A	NNP
cord-263532-q044i7ym	153	5	was	be	VBD
cord-263532-q044i7ym	153	6	involved	involve	VBN
cord-263532-q044i7ym	153	7	in	in	IN
cord-263532-q044i7ym	153	8	the	the	DT
cord-263532-q044i7ym	153	9	hydrogen	hydrogen	NN
cord-263532-q044i7ym	153	10	-	-	HYPH
cord-263532-q044i7ym	153	11	bond	bond	NN
cord-263532-q044i7ym	153	12	interaction	interaction	NN
cord-263532-q044i7ym	153	13	with	with	IN
cord-263532-q044i7ym	153	14	Gln299	gln299	ADD
cord-263532-q044i7ym	153	15	of	of	IN
cord-263532-q044i7ym	153	16	monomer	monomer	NN
cord-263532-q044i7ym	153	17	B	b	NN
cord-263532-q044i7ym	153	18	,	,	,
cord-263532-q044i7ym	153	19	and	and	CC
cord-263532-q044i7ym	153	20	S139A	S139A	NNP
cord-263532-q044i7ym	153	21	mutation	mutation	NN
cord-263532-q044i7ym	153	22	resulted	result	VBD
cord-263532-q044i7ym	153	23	in	in	IN
cord-263532-q044i7ym	153	24	the	the	DT
cord-263532-q044i7ym	153	25	complete	complete	JJ
cord-263532-q044i7ym	153	26	loss	loss	NN
cord-263532-q044i7ym	153	27	of	of	IN
cord-263532-q044i7ym	153	28	dimerization	dimerization	NN
cord-263532-q044i7ym	153	29	.	.	.
cord-263532-q044i7ym	154	1	Hu	Hu	NNP
cord-263532-q044i7ym	154	2	et	et	FW
cord-263532-q044i7ym	154	3	al	al	NNP
cord-263532-q044i7ym	154	4	.	.	.
cord-263532-q044i7ym	155	1	30	30	CD
cord-263532-q044i7ym	155	2	20	20	CD
cord-263532-q044i7ym	155	3	.	.	.
cord-263532-q044i7ym	156	1	SARS	SARS	NNP
cord-263532-q044i7ym	156	2	-	-	HYPH
cord-263532-q044i7ym	156	3	CoV	CoV	NNP
cord-263532-q044i7ym	156	4	M	M	NNP
cord-263532-q044i7ym	156	5	pro	pro	JJ
cord-263532-q044i7ym	156	6	Substrate	Substrate	NNP
cord-263532-q044i7ym	156	7	-	-	HYPH
cord-263532-q044i7ym	156	8	induced	induce	VBN
cord-263532-q044i7ym	156	9	dimerization	dimerization	NN
cord-263532-q044i7ym	156	10	is	be	VBZ
cord-263532-q044i7ym	156	11	necessary	necessary	JJ
cord-263532-q044i7ym	156	12	for	for	IN
cord-263532-q044i7ym	156	13	the	the	DT
cord-263532-q044i7ym	156	14	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	156	15	activity	activity	NN
cord-263532-q044i7ym	156	16	of	of	IN
cord-263532-q044i7ym	156	17	SARS	SARS	NNP
cord-263532-q044i7ym	156	18	-	-	HYPH
cord-263532-q044i7ym	156	19	CoV	CoV	NNP
cord-263532-q044i7ym	156	20	M	M	NNP
cord-263532-q044i7ym	156	21	pro	pro	JJ
cord-263532-q044i7ym	156	22	in	in	IN
cord-263532-q044i7ym	156	23	the	the	DT
cord-263532-q044i7ym	156	24	polyprotein	polyprotein	NN
cord-263532-q044i7ym	156	25	.	.	.
cord-263532-q044i7ym	157	1	Li	Li	NNP
cord-263532-q044i7ym	157	2	et	et	NNP
cord-263532-q044i7ym	157	3	al	al	NNP
cord-263532-q044i7ym	157	4	.	.	.
cord-263532-q044i7ym	158	1	43	43	CD
cord-263532-q044i7ym	158	2	 	 	_SP
cord-263532-q044i7ym	159	1	The	the	DT
cord-263532-q044i7ym	159	2	mutagenesis	mutagenesis	NN
cord-263532-q044i7ym	159	3	studies	study	NNS
cord-263532-q044i7ym	159	4	highlighted	highlight	VBD
cord-263532-q044i7ym	159	5	that	that	IN
cord-263532-q044i7ym	159	6	Glu166	glu166	DT
cord-263532-q044i7ym	159	7	plays	play	VBZ
cord-263532-q044i7ym	159	8	a	a	DT
cord-263532-q044i7ym	159	9	linking	link	VBG
cord-263532-q044i7ym	159	10	role	role	NN
cord-263532-q044i7ym	159	11	between	between	IN
cord-263532-q044i7ym	159	12	the	the	DT
cord-263532-q044i7ym	159	13	dimer	dimer	NN
cord-263532-q044i7ym	159	14	interface	interface	NN
cord-263532-q044i7ym	159	15	and	and	CC
cord-263532-q044i7ym	159	16	substrate	substrate	NN
cord-263532-q044i7ym	159	17	binding	bind	VBG
cord-263532-q044i7ym	159	18	site	site	NN
cord-263532-q044i7ym	159	19	.	.	.
cord-263532-q044i7ym	160	1	34	34	CD
cord-263532-q044i7ym	160	2	MD	MD	NNP
cord-263532-q044i7ym	160	3	and	and	CC
cord-263532-q044i7ym	160	4	docking	docking	NN
cord-263532-q044i7ym	160	5	simulations	simulation	NNS
cord-263532-q044i7ym	160	6	highlighted	highlight	VBD
cord-263532-q044i7ym	160	7	that	that	IN
cord-263532-q044i7ym	160	8	Nterminal	Nterminal	NNP
cord-263532-q044i7ym	160	9	truncated	truncated	JJ
cord-263532-q044i7ym	160	10	protease	protease	NN
cord-263532-q044i7ym	160	11	dimer	dimer	NN
cord-263532-q044i7ym	160	12	adopts	adopt	VBZ
cord-263532-q044i7ym	160	13	a	a	DT
cord-263532-q044i7ym	160	14	different	different	JJ
cord-263532-q044i7ym	160	15	state	state	NN
cord-263532-q044i7ym	160	16	as	as	IN
cord-263532-q044i7ym	160	17	compared	compare	VBN
cord-263532-q044i7ym	160	18	to	to	IN
cord-263532-q044i7ym	160	19	the	the	DT
cord-263532-q044i7ym	160	20	full	full	JJ
cord-263532-q044i7ym	160	21	-	-	HYPH
cord-263532-q044i7ym	160	22	length	length	NN
cord-263532-q044i7ym	160	23	protease	protease	NN
cord-263532-q044i7ym	160	24	dimer	dimer	NN
cord-263532-q044i7ym	160	25	.	.	.
cord-263532-q044i7ym	161	1	MD	MD	NNP
cord-263532-q044i7ym	161	2	simulations	simulation	NNS
cord-263532-q044i7ym	161	3	depicted	depict	VBN
cord-263532-q044i7ym	161	4	that	that	DT
cord-263532-q044i7ym	161	5	angle	angle	NN
cord-263532-q044i7ym	161	6	between	between	IN
cord-263532-q044i7ym	161	7	the	the	DT
cord-263532-q044i7ym	161	8	two	two	CD
cord-263532-q044i7ym	161	9	monomers	monomer	NNS
cord-263532-q044i7ym	161	10	increased	increase	VBD
cord-263532-q044i7ym	161	11	and	and	CC
cord-263532-q044i7ym	161	12	the	the	DT
cord-263532-q044i7ym	161	13	dimension	dimension	NN
cord-263532-q044i7ym	161	14	of	of	IN
cord-263532-q044i7ym	161	15	the	the	DT
cord-263532-q044i7ym	161	16	substrate	substrate	NN
cord-263532-q044i7ym	161	17	binding	bind	VBG
cord-263532-q044i7ym	161	18	pocket	pocket	NN
cord-263532-q044i7ym	161	19	reduced	reduce	VBN
cord-263532-q044i7ym	161	20	in	in	IN
cord-263532-q044i7ym	161	21	the	the	DT
cord-263532-q044i7ym	161	22	Nterminal	Nterminal	NNP
cord-263532-q044i7ym	161	23	truncated	truncated	JJ
cord-263532-q044i7ym	161	24	protease	protease	NN
cord-263532-q044i7ym	161	25	dimer	dimer	NN
cord-263532-q044i7ym	161	26	,	,	,
cord-263532-q044i7ym	161	27	which	which	WDT
cord-263532-q044i7ym	161	28	is	be	VBZ
cord-263532-q044i7ym	161	29	not	not	RB
cord-263532-q044i7ym	161	30	appropriate	appropriate	JJ
cord-263532-q044i7ym	161	31	for	for	IN
cord-263532-q044i7ym	161	32	the	the	DT
cord-263532-q044i7ym	161	33	substrate	substrate	NN
cord-263532-q044i7ym	161	34	binding	bind	VBG
cord-263532-q044i7ym	161	35	.	.	.
cord-263532-q044i7ym	162	1	Additionally	additionally	RB
cord-263532-q044i7ym	162	2	,	,	,
cord-263532-q044i7ym	162	3	surface	surface	NN
cord-263532-q044i7ym	162	4	plasmon	plasmon	JJ
cord-263532-q044i7ym	162	5	resonance	resonance	NN
cord-263532-q044i7ym	162	6	highlighted	highlight	VBD
cord-263532-q044i7ym	162	7	that	that	IN
cord-263532-q044i7ym	162	8	N	n	CD
cord-263532-q044i7ym	162	9	-	-	HYPH
cord-263532-q044i7ym	162	10	terminal	terminal	NN
cord-263532-q044i7ym	162	11	truncated	truncated	JJ
cord-263532-q044i7ym	162	12	protease	protease	NN
cord-263532-q044i7ym	162	13	does	do	VBZ
cord-263532-q044i7ym	162	14	not	not	RB
cord-263532-q044i7ym	162	15	bind	bind	VB
cord-263532-q044i7ym	162	16	with	with	IN
cord-263532-q044i7ym	162	17	the	the	DT
cord-263532-q044i7ym	162	18	model	model	NN
cord-263532-q044i7ym	162	19	substrate	substrate	NN
cord-263532-q044i7ym	162	20	.	.	.
cord-263532-q044i7ym	163	1	In	in	IN
cord-263532-q044i7ym	163	2	2005	2005	CD
cord-263532-q044i7ym	163	3	,	,	,
cord-263532-q044i7ym	163	4	Hsu	Hsu	NNP
cord-263532-q044i7ym	163	5	et	et	NNP
cord-263532-q044i7ym	163	6	al	al	NNP
cord-263532-q044i7ym	163	7	.	.	NNP
cord-263532-q044i7ym	163	8	reported	report	VBD
cord-263532-q044i7ym	163	9	that	that	IN
cord-263532-q044i7ym	163	10	N	n	CD
cord-263532-q044i7ym	163	11	-	-	HYPH
cord-263532-q044i7ym	163	12	terminal	terminal	NN
cord-263532-q044i7ym	163	13	truncated	truncate	VBN
cord-263532-q044i7ym	163	14	(	(	-LRB-
cord-263532-q044i7ym	163	15	residues	residue	NNS
cord-263532-q044i7ym	163	16	1−3	1−3	CD
cord-263532-q044i7ym	163	17	)	)	-RRB-
cord-263532-q044i7ym	163	18	protease	protease	NN
cord-263532-q044i7ym	163	19	exists	exist	VBZ
cord-263532-q044i7ym	163	20	predominantly	predominantly	RB
cord-263532-q044i7ym	163	21	as	as	IN
cord-263532-q044i7ym	163	22	dimer	dimer	NN
cord-263532-q044i7ym	163	23	with	with	IN
cord-263532-q044i7ym	163	24	76	76	CD
cord-263532-q044i7ym	163	25	%	%	NN
cord-263532-q044i7ym	163	26	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	163	27	activity	activity	NN
cord-263532-q044i7ym	163	28	;	;	:
cord-263532-q044i7ym	163	29	however	however	RB
cord-263532-q044i7ym	163	30	,	,	,
cord-263532-q044i7ym	163	31	N	n	CD
cord-263532-q044i7ym	163	32	-	-	HYPH
cord-263532-q044i7ym	163	33	terminal	terminal	NN
cord-263532-q044i7ym	163	34	truncated	truncate	VBN
cord-263532-q044i7ym	163	35	(	(	-LRB-
cord-263532-q044i7ym	163	36	residues	residue	NNS
cord-263532-q044i7ym	163	37	1−	1−	CD
cord-263532-q044i7ym	163	38	4	4	CD
cord-263532-q044i7ym	163	39	)	)	-RRB-
cord-263532-q044i7ym	163	40	protease	protease	NN
cord-263532-q044i7ym	163	41	exists	exist	VBZ
cord-263532-q044i7ym	163	42	mostly	mostly	RB
cord-263532-q044i7ym	163	43	as	as	IN
cord-263532-q044i7ym	163	44	monomer	monomer	NN
cord-263532-q044i7ym	163	45	with	with	IN
cord-263532-q044i7ym	163	46	very	very	RB
cord-263532-q044i7ym	163	47	little	little	JJ
cord-263532-q044i7ym	163	48	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	163	49	activity	activity	NN
cord-263532-q044i7ym	163	50	.	.	.
cord-263532-q044i7ym	164	1	35	35	CD
cord-263532-q044i7ym	165	1	The	the	DT
cord-263532-q044i7ym	165	2	study	study	NN
cord-263532-q044i7ym	165	3	indicated	indicate	VBD
cord-263532-q044i7ym	165	4	that	that	IN
cord-263532-q044i7ym	165	5	Arg4	Arg4	NNP
cord-263532-q044i7ym	165	6	have	have	VB
cord-263532-q044i7ym	165	7	an	an	DT
cord-263532-q044i7ym	165	8	influential	influential	JJ
cord-263532-q044i7ym	165	9	effect	effect	NN
cord-263532-q044i7ym	165	10	on	on	IN
cord-263532-q044i7ym	165	11	the	the	DT
cord-263532-q044i7ym	165	12	catalytic	catalytic	JJ
cord-263532-q044i7ym	165	13	activity	activity	NN
cord-263532-q044i7ym	165	14	and	and	CC
cord-263532-q044i7ym	165	15	dimeric	dimeric	JJ
cord-263532-q044i7ym	165	16	structure	structure	NN
cord-263532-q044i7ym	165	17	of	of	IN
cord-263532-q044i7ym	165	18	the	the	DT
cord-263532-q044i7ym	165	19	protease	protease	NN
cord-263532-q044i7ym	165	20	.	.	.
cord-263532-q044i7ym	166	1	The	the	DT
cord-263532-q044i7ym	166	2	last	last	JJ
cord-263532-q044i7ym	166	3	C	c	NN
cord-263532-q044i7ym	166	4	-	-	HYPH
cord-263532-q044i7ym	166	5	terminal	terminal	NN
cord-263532-q044i7ym	166	6	helically	helically	RB
cord-263532-q044i7ym	166	7	truncated	truncate	VBN
cord-263532-q044i7ym	166	8	protease	protease	NN
cord-263532-q044i7ym	166	9	also	also	RB
cord-263532-q044i7ym	166	10	displayed	display	VBD
cord-263532-q044i7ym	166	11	a	a	DT
cord-263532-q044i7ym	166	12	higher	high	JJR
cord-263532-q044i7ym	166	13	tendency	tendency	NN
cord-263532-q044i7ym	166	14	to	to	TO
cord-263532-q044i7ym	166	15	exist	exist	VB
cord-263532-q044i7ym	166	16	as	as	IN
cord-263532-q044i7ym	166	17	a	a	DT
cord-263532-q044i7ym	166	18	monomer	monomer	NN
cord-263532-q044i7ym	166	19	and	and	CC
cord-263532-q044i7ym	166	20	displayed	display	VBD
cord-263532-q044i7ym	166	21	little	little	JJ
cord-263532-q044i7ym	166	22	activity	activity	NN
cord-263532-q044i7ym	166	23	.	.	.
cord-263532-q044i7ym	167	1	These	these	DT
cord-263532-q044i7ym	167	2	observations	observation	NNS
cord-263532-q044i7ym	167	3	highlighted	highlight	VBD
cord-263532-q044i7ym	167	4	that	that	IN
cord-263532-q044i7ym	167	5	both	both	DT
cord-263532-q044i7ym	167	6	N	N	NNP
cord-263532-q044i7ym	167	7	-	-	HYPH
cord-263532-q044i7ym	167	8	and	and	CC
cord-263532-q044i7ym	167	9	C	c	NN
cord-263532-q044i7ym	167	10	-	-	HYPH
cord-263532-q044i7ym	167	11	terminal	terminal	NN
cord-263532-q044i7ym	167	12	regions	region	NNS
cord-263532-q044i7ym	167	13	affect	affect	VBP
cord-263532-q044i7ym	167	14	the	the	DT
cord-263532-q044i7ym	167	15	dimerization	dimerization	NN
cord-263532-q044i7ym	167	16	and	and	CC
cord-263532-q044i7ym	167	17	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	167	18	activity	activity	NN
cord-263532-q044i7ym	167	19	of	of	IN
cord-263532-q044i7ym	167	20	the	the	DT
cord-263532-q044i7ym	167	21	SARS	SARS	NNP
cord-263532-q044i7ym	167	22	-	-	HYPH
cord-263532-q044i7ym	167	23	CoV	CoV	NNP
cord-263532-q044i7ym	167	24	M	M	NNP
cord-263532-q044i7ym	167	25	pro	pro	NNP
cord-263532-q044i7ym	167	26	.	.	.
cord-263532-q044i7ym	168	1	The	the	DT
cord-263532-q044i7ym	168	2	study	study	NN
cord-263532-q044i7ym	168	3	provided	provide	VBD
cord-263532-q044i7ym	168	4	key	key	JJ
cord-263532-q044i7ym	168	5	insights	insight	NNS
cord-263532-q044i7ym	168	6	for	for	IN
cord-263532-q044i7ym	168	7	the	the	DT
cord-263532-q044i7ym	168	8	novel	novel	JJ
cord-263532-q044i7ym	168	9	design	design	NN
cord-263532-q044i7ym	168	10	of	of	IN
cord-263532-q044i7ym	168	11	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	168	12	targeting	target	VBG
cord-263532-q044i7ym	168	13	the	the	DT
cord-263532-q044i7ym	168	14	dimer	dimer	NN
cord-263532-q044i7ym	168	15	interface	interface	NN
cord-263532-q044i7ym	168	16	of	of	IN
cord-263532-q044i7ym	168	17	SARS	SARS	NNP
cord-263532-q044i7ym	168	18	-	-	HYPH
cord-263532-q044i7ym	168	19	CoV	CoV	NNP
cord-263532-q044i7ym	168	20	M	M	NNP
cord-263532-q044i7ym	168	21	pro	pro	NNP
cord-263532-q044i7ym	168	22	.	.	.
cord-263532-q044i7ym	169	1	In	in	IN
cord-263532-q044i7ym	169	2	another	another	DT
cord-263532-q044i7ym	169	3	study	study	NN
cord-263532-q044i7ym	169	4	,	,	,
cord-263532-q044i7ym	169	5	the	the	DT
cord-263532-q044i7ym	169	6	conformational	conformational	JJ
cord-263532-q044i7ym	169	7	flexibility	flexibility	NN
cord-263532-q044i7ym	169	8	of	of	IN
cord-263532-q044i7ym	169	9	the	the	DT
cord-263532-q044i7ym	169	10	SARS	SARS	NNP
cord-263532-q044i7ym	169	11	-	-	HYPH
cord-263532-q044i7ym	169	12	CoV	CoV	NNP
cord-263532-q044i7ym	169	13	M	M	NNP
cord-263532-q044i7ym	169	14	pro	pro	NNP
cord-263532-q044i7ym	169	15	was	be	VBD
cord-263532-q044i7ym	169	16	investigated	investigate	VBN
cord-263532-q044i7ym	169	17	by	by	IN
cord-263532-q044i7ym	169	18	analyzing	analyze	VBG
cord-263532-q044i7ym	169	19	several	several	JJ
cord-263532-q044i7ym	169	20	crystal	crystal	NN
cord-263532-q044i7ym	169	21	structures	structure	NNS
cord-263532-q044i7ym	169	22	and	and	CC
cord-263532-q044i7ym	169	23	MD	MD	NNP
cord-263532-q044i7ym	169	24	simulations	simulation	NNS
cord-263532-q044i7ym	169	25	.	.	.
cord-263532-q044i7ym	170	1	36	36	CD
cord-263532-q044i7ym	171	1	The	the	DT
cord-263532-q044i7ym	171	2	size	size	NN
cord-263532-q044i7ym	171	3	and	and	CC
cord-263532-q044i7ym	171	4	conformation	conformation	NN
cord-263532-q044i7ym	171	5	of	of	IN
cord-263532-q044i7ym	171	6	the	the	DT
cord-263532-q044i7ym	171	7	substrate	substrate	NN
cord-263532-q044i7ym	171	8	binding	bind	VBG
cord-263532-q044i7ym	171	9	pocket	pocket	NN
cord-263532-q044i7ym	171	10	S1	S1	NNP
cord-263532-q044i7ym	171	11	are	be	VBP
cord-263532-q044i7ym	171	12	linked	link	VBN
cord-263532-q044i7ym	171	13	to	to	IN
cord-263532-q044i7ym	171	14	the	the	DT
cord-263532-q044i7ym	171	15	protonation	protonation	JJ
cord-263532-q044i7ym	171	16	state	state	NN
cord-263532-q044i7ym	171	17	of	of	IN
cord-263532-q044i7ym	171	18	His163	his163	CD
cord-263532-q044i7ym	171	19	and	and	CC
cord-263532-q044i7ym	171	20	His172	his172	NN
cord-263532-q044i7ym	171	21	comprising	comprise	VBG
cord-263532-q044i7ym	171	22	the	the	DT
cord-263532-q044i7ym	171	23	pocket	pocket	NN
cord-263532-q044i7ym	171	24	.	.	.
cord-263532-q044i7ym	172	1	The	the	DT
cord-263532-q044i7ym	172	2	study	study	NN
cord-263532-q044i7ym	172	3	highlighted	highlight	VBD
cord-263532-q044i7ym	172	4	that	that	IN
cord-263532-q044i7ym	172	5	the	the	DT
cord-263532-q044i7ym	172	6	N	n	CD
cord-263532-q044i7ym	172	7	-	-	HYPH
cord-263532-q044i7ym	172	8	terminus	terminus	NN
cord-263532-q044i7ym	172	9	of	of	IN
cord-263532-q044i7ym	172	10	another	another	DT
cord-263532-q044i7ym	172	11	monomer	monomer	NN
cord-263532-q044i7ym	172	12	in	in	IN
cord-263532-q044i7ym	172	13	the	the	DT
cord-263532-q044i7ym	172	14	protease	protease	NN
cord-263532-q044i7ym	172	15	dimer	dimer	NN
cord-263532-q044i7ym	172	16	plays	play	VBZ
cord-263532-q044i7ym	172	17	a	a	DT
cord-263532-q044i7ym	172	18	critical	critical	JJ
cord-263532-q044i7ym	172	19	role	role	NN
cord-263532-q044i7ym	172	20	in	in	IN
cord-263532-q044i7ym	172	21	the	the	DT
cord-263532-q044i7ym	172	22	catalytic	catalytic	JJ
cord-263532-q044i7ym	172	23	activity	activity	NN
cord-263532-q044i7ym	172	24	in	in	IN
cord-263532-q044i7ym	172	25	sustaining	sustain	VBG
cord-263532-q044i7ym	172	26	the	the	DT
cord-263532-q044i7ym	172	27	correct	correct	JJ
cord-263532-q044i7ym	172	28	conformation	conformation	NN
cord-263532-q044i7ym	172	29	of	of	IN
cord-263532-q044i7ym	172	30	the	the	DT
cord-263532-q044i7ym	172	31	oxyanion	oxyanion	NN
cord-263532-q044i7ym	172	32	loop	loop	NN
cord-263532-q044i7ym	172	33	and	and	CC
cord-263532-q044i7ym	172	34	substrate	substrate	NN
cord-263532-q044i7ym	172	35	binding	bind	VBG
cord-263532-q044i7ym	172	36	pocket	pocket	NN
cord-263532-q044i7ym	172	37	S1	s1	NN
cord-263532-q044i7ym	172	38	through	through	IN
cord-263532-q044i7ym	172	39	hydrogen	hydrogen	NN
cord-263532-q044i7ym	172	40	bonds	bond	NNS
cord-263532-q044i7ym	172	41	.	.	.
cord-263532-q044i7ym	173	1	In	in	IN
cord-263532-q044i7ym	173	2	2005	2005	CD
cord-263532-q044i7ym	173	3	,	,	,
cord-263532-q044i7ym	173	4	Hsu	Hsu	NNP
cord-263532-q044i7ym	173	5	et	et	NNP
cord-263532-q044i7ym	173	6	al	al	NNP
cord-263532-q044i7ym	173	7	.	.	NNP
cord-263532-q044i7ym	173	8	reported	report	VBD
cord-263532-q044i7ym	173	9	the	the	DT
cord-263532-q044i7ym	173	10	crystal	crystal	NN
cord-263532-q044i7ym	173	11	structure	structure	NN
cord-263532-q044i7ym	173	12	of	of	IN
cord-263532-q044i7ym	173	13	the	the	DT
cord-263532-q044i7ym	173	14	product	product	NN
cord-263532-q044i7ym	173	15	-	-	HYPH
cord-263532-q044i7ym	173	16	bound	bind	VBN
cord-263532-q044i7ym	173	17	C145A	C145A	NNP
cord-263532-q044i7ym	173	18	mutant	mutant	JJ
cord-263532-q044i7ym	173	19	protease	protease	NN
cord-263532-q044i7ym	173	20	and	and	CC
cord-263532-q044i7ym	173	21	suggested	suggest	VBD
cord-263532-q044i7ym	173	22	the	the	DT
cord-263532-q044i7ym	173	23	maturation	maturation	NN
cord-263532-q044i7ym	173	24	mechanism	mechanism	NN
cord-263532-q044i7ym	173	25	of	of	IN
cord-263532-q044i7ym	173	26	the	the	DT
cord-263532-q044i7ym	173	27	enzyme	enzyme	NN
cord-263532-q044i7ym	173	28	.	.	.
cord-263532-q044i7ym	174	1	23	23	CD
cord-263532-q044i7ym	175	1	The	the	DT
cord-263532-q044i7ym	175	2	analytical	analytical	JJ
cord-263532-q044i7ym	175	3	ultracentrifuge	ultracentrifuge	JJ
cord-263532-q044i7ym	175	4	experiments	experiment	NNS
cord-263532-q044i7ym	175	5	depicted	depict	VBD
cord-263532-q044i7ym	175	6	that	that	IN
cord-263532-q044i7ym	175	7	a	a	DT
cord-263532-q044i7ym	175	8	tight	tight	JJ
cord-263532-q044i7ym	175	9	dimer	dimer	NN
cord-263532-q044i7ym	175	10	was	be	VBD
cord-263532-q044i7ym	175	11	formed	form	VBN
cord-263532-q044i7ym	175	12	in	in	IN
cord-263532-q044i7ym	175	13	the	the	DT
cord-263532-q044i7ym	175	14	mature	mature	JJ
cord-263532-q044i7ym	175	15	enzyme	enzyme	NN
cord-263532-q044i7ym	175	16	(	(	-LRB-
cord-263532-q044i7ym	175	17	K	K	NNP
cord-263532-q044i7ym	175	18	d	d	NN
cord-263532-q044i7ym	175	19	=	=	SYM
cord-263532-q044i7ym	175	20	0.35	0.35	CD
cord-263532-q044i7ym	175	21	nM	nm	NN
cord-263532-q044i7ym	175	22	)	)	-RRB-
cord-263532-q044i7ym	175	23	as	as	IN
cord-263532-q044i7ym	175	24	compared	compare	VBN
cord-263532-q044i7ym	175	25	to	to	IN
cord-263532-q044i7ym	175	26	C145A	C145A	NNP
cord-263532-q044i7ym	175	27	mutant	mutant	JJ
cord-263532-q044i7ym	175	28	possessing	possess	VBG
cord-263532-q044i7ym	175	29	10	10	CD
cord-263532-q044i7ym	175	30	additional	additional	JJ
cord-263532-q044i7ym	175	31	N	n	CD
cord-263532-q044i7ym	175	32	-	-	HYPH
cord-263532-q044i7ym	175	33	terminal	terminal	NN
cord-263532-q044i7ym	175	34	(	(	-LRB-
cord-263532-q044i7ym	175	35	K	K	NNP
cord-263532-q044i7ym	175	36	d	d	NN
cord-263532-q044i7ym	175	37	=	=	SYM
cord-263532-q044i7ym	175	38	17.2	17.2	CD
cord-263532-q044i7ym	175	39	nM	nM	NNP
cord-263532-q044i7ym	175	40	)	)	-RRB-
cord-263532-q044i7ym	175	41	or	or	CC
cord-263532-q044i7ym	175	42	C	c	NN
cord-263532-q044i7ym	175	43	-	-	HYPH
cord-263532-q044i7ym	175	44	terminal	terminal	NN
cord-263532-q044i7ym	175	45	residues	residue	NNS
cord-263532-q044i7ym	175	46	(	(	-LRB-
cord-263532-q044i7ym	175	47	K	K	NNP
cord-263532-q044i7ym	175	48	d	d	NN
cord-263532-q044i7ym	175	49	=	=	SYM
cord-263532-q044i7ym	175	50	5.6	5.6	CD
cord-263532-q044i7ym	175	51	nM	nM	NNP
cord-263532-q044i7ym	175	52	)	)	-RRB-
cord-263532-q044i7ym	175	53	.	.	.
cord-263532-q044i7ym	176	1	The	the	DT
cord-263532-q044i7ym	176	2	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	176	3	targeting	target	VBG
cord-263532-q044i7ym	176	4	the	the	DT
cord-263532-q044i7ym	176	5	dimer	dimer	NN
cord-263532-q044i7ym	176	6	interface	interface	NN
cord-263532-q044i7ym	176	7	may	may	MD
cord-263532-q044i7ym	176	8	block	block	VB
cord-263532-q044i7ym	176	9	the	the	DT
cord-263532-q044i7ym	176	10	maturation	maturation	NN
cord-263532-q044i7ym	176	11	of	of	IN
cord-263532-q044i7ym	176	12	protease	protease	NN
cord-263532-q044i7ym	176	13	as	as	IN
cord-263532-q044i7ym	176	14	both	both	CC
cord-263532-q044i7ym	176	15	N	N	NNP
cord-263532-q044i7ym	176	16	and	and	CC
cord-263532-q044i7ym	176	17	C	C	NNP
cord-263532-q044i7ym	176	18	termini	terminus	NNS
cord-263532-q044i7ym	176	19	are	be	VBP
cord-263532-q044i7ym	176	20	near	near	JJ
cord-263532-q044i7ym	176	21	to	to	IN
cord-263532-q044i7ym	176	22	the	the	DT
cord-263532-q044i7ym	176	23	SARS	SARS	NNP
cord-263532-q044i7ym	176	24	-	-	HYPH
cord-263532-q044i7ym	176	25	CoV	CoV	NNP
cord-263532-q044i7ym	176	26	M	M	NNP
cord-263532-q044i7ym	176	27	pro	pro	JJ
cord-263532-q044i7ym	176	28	active	active	JJ
cord-263532-q044i7ym	176	29	site	site	NN
cord-263532-q044i7ym	176	30	in	in	IN
cord-263532-q044i7ym	176	31	the	the	DT
cord-263532-q044i7ym	176	32	product	product	NN
cord-263532-q044i7ym	176	33	-	-	HYPH
cord-263532-q044i7ym	176	34	bound	bind	VBN
cord-263532-q044i7ym	176	35	C145A	c145a	JJ
cord-263532-q044i7ym	176	36	structure	structure	NN
cord-263532-q044i7ym	176	37	.	.	.
cord-263532-q044i7ym	177	1	In	in	IN
cord-263532-q044i7ym	177	2	2005	2005	CD
cord-263532-q044i7ym	177	3	,	,	,
cord-263532-q044i7ym	177	4	Ding	Ding	NNP
cord-263532-q044i7ym	177	5	et	et	FW
cord-263532-q044i7ym	177	6	al	al	NNP
cord-263532-q044i7ym	177	7	.	.	NNP
cord-263532-q044i7ym	177	8	studied	study	VBD
cord-263532-q044i7ym	177	9	the	the	DT
cord-263532-q044i7ym	177	10	interaction	interaction	NN
cord-263532-q044i7ym	177	11	between	between	IN
cord-263532-q044i7ym	177	12	SARS	SARS	NNP
cord-263532-q044i7ym	177	13	-	-	HYPH
cord-263532-q044i7ym	177	14	CoV	CoV	NNP
cord-263532-q044i7ym	177	15	M	M	NNP
cord-263532-q044i7ym	177	16	pro	pro	NNP
cord-263532-q044i7ym	177	17	and	and	CC
cord-263532-q044i7ym	177	18	a	a	DT
cord-263532-q044i7ym	177	19	dimerization	dimerization	NN
cord-263532-q044i7ym	177	20	inhibitor	inhibitor	NN
cord-263532-q044i7ym	177	21	N8	n8	NN
cord-263532-q044i7ym	177	22	(	(	-LRB-
cord-263532-q044i7ym	177	23	SGFRKMAF	SGFRKMAF	NNP
cord-263532-q044i7ym	177	24	)	)	-RRB-
cord-263532-q044i7ym	177	25	by	by	IN
cord-263532-q044i7ym	177	26	affinity	affinity	NN
cord-263532-q044i7ym	177	27	capillary	capillary	JJ
cord-263532-q044i7ym	177	28	electrophoresis	electrophoresis	NN
cord-263532-q044i7ym	177	29	.	.	.
cord-263532-q044i7ym	178	1	14	14	CD
cord-263532-q044i7ym	179	1	The	the	DT
cord-263532-q044i7ym	179	2	thermodynamic	thermodynamic	JJ
cord-263532-q044i7ym	179	3	analysis	analysis	NN
cord-263532-q044i7ym	179	4	highlighted	highlight	VBD
cord-263532-q044i7ym	179	5	that	that	IN
cord-263532-q044i7ym	179	6	hydrophobic	hydrophobic	JJ
cord-263532-q044i7ym	179	7	contacts	contact	NNS
cord-263532-q044i7ym	179	8	and	and	CC
cord-263532-q044i7ym	179	9	electrostatic	electrostatic	JJ
cord-263532-q044i7ym	179	10	interactions	interaction	NNS
cord-263532-q044i7ym	179	11	play	play	VBP
cord-263532-q044i7ym	179	12	major	major	JJ
cord-263532-q044i7ym	179	13	roles	role	NNS
cord-263532-q044i7ym	179	14	in	in	IN
cord-263532-q044i7ym	179	15	the	the	DT
cord-263532-q044i7ym	179	16	binding	binding	NN
cord-263532-q044i7ym	179	17	of	of	IN
cord-263532-q044i7ym	179	18	dimerization	dimerization	NN
cord-263532-q044i7ym	179	19	inhibitor	inhibitor	NN
cord-263532-q044i7ym	179	20	with	with	IN
cord-263532-q044i7ym	179	21	SARS	SARS	NNP
cord-263532-q044i7ym	179	22	-	-	HYPH
cord-263532-q044i7ym	179	23	CoV	CoV	NNP
cord-263532-q044i7ym	179	24	M	M	NNP
cord-263532-q044i7ym	179	25	pro	pro	NNP
cord-263532-q044i7ym	179	26	.	.	.
cord-263532-q044i7ym	180	1	In	in	IN
cord-263532-q044i7ym	180	2	a	a	DT
cord-263532-q044i7ym	180	3	later	later	JJ
cord-263532-q044i7ym	180	4	report	report	NN
cord-263532-q044i7ym	180	5	by	by	IN
cord-263532-q044i7ym	180	6	the	the	DT
cord-263532-q044i7ym	180	7	same	same	JJ
cord-263532-q044i7ym	180	8	research	research	NN
cord-263532-q044i7ym	180	9	group	group	NN
cord-263532-q044i7ym	180	10	,	,	,
cord-263532-q044i7ym	180	11	N8	N8	NNP
cord-263532-q044i7ym	180	12	and	and	CC
cord-263532-q044i7ym	180	13	its	-PRON-	PRP$
cord-263532-q044i7ym	180	14	mutants	mutant	NNS
cord-263532-q044i7ym	180	15	were	be	VBD
cord-263532-q044i7ym	180	16	evaluated	evaluate	VBN
cord-263532-q044i7ym	180	17	for	for	IN
cord-263532-q044i7ym	180	18	their	-PRON-	PRP$
cord-263532-q044i7ym	180	19	ability	ability	NN
cord-263532-q044i7ym	180	20	to	to	TO
cord-263532-q044i7ym	180	21	act	act	VB
cord-263532-q044i7ym	180	22	as	as	IN
cord-263532-q044i7ym	180	23	dimerization	dimerization	NN
cord-263532-q044i7ym	180	24	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	180	25	of	of	IN
cord-263532-q044i7ym	180	26	SARS	SARS	NNP
cord-263532-q044i7ym	180	27	-	-	HYPH
cord-263532-q044i7ym	180	28	CoV	CoV	NNP
cord-263532-q044i7ym	180	29	M	M	NNP
cord-263532-q044i7ym	180	30	pro	pro	NNP
cord-263532-q044i7ym	180	31	.	.	NNP
cord-263532-q044i7ym	180	32	15	15	CD
cord-263532-q044i7ym	181	1	The	the	DT
cord-263532-q044i7ym	181	2	peptide	peptide	NN
cord-263532-q044i7ym	181	3	cleavage	cleavage	NN
cord-263532-q044i7ym	181	4	assay	assay	NN
cord-263532-q044i7ym	181	5	highlighted	highlight	VBD
cord-263532-q044i7ym	181	6	that	that	IN
cord-263532-q044i7ym	181	7	N8	N8	NNP
cord-263532-q044i7ym	181	8	inhibited	inhibit	VBD
cord-263532-q044i7ym	181	9	the	the	DT
cord-263532-q044i7ym	181	10	dimerization	dimerization	NN
cord-263532-q044i7ym	181	11	of	of	IN
cord-263532-q044i7ym	181	12	protease	protease	NN
cord-263532-q044i7ym	181	13	enzyme	enzyme	NN
cord-263532-q044i7ym	181	14	with	with	IN
cord-263532-q044i7ym	181	15	a	a	DT
cord-263532-q044i7ym	181	16	dimerization	dimerization	NN
cord-263532-q044i7ym	181	17	inhibition	inhibition	NN
cord-263532-q044i7ym	181	18	constant	constant	NN
cord-263532-q044i7ym	181	19	(	(	-LRB-
cord-263532-q044i7ym	181	20	K	K	NNP
cord-263532-q044i7ym	181	21	i	i	NNP
cord-263532-q044i7ym	181	22	)	)	-RRB-
cord-263532-q044i7ym	181	23	of	of	IN
cord-263532-q044i7ym	181	24	2.20	2.20	CD
cord-263532-q044i7ym	181	25	mM.	mm.	NN
cord-263532-q044i7ym	182	1	The	the	DT
cord-263532-q044i7ym	182	2	comparison	comparison	NN
cord-263532-q044i7ym	182	3	between	between	IN
cord-263532-q044i7ym	182	4	the	the	DT
cord-263532-q044i7ym	182	5	inhibitory	inhibitory	JJ
cord-263532-q044i7ym	182	6	activities	activity	NNS
cord-263532-q044i7ym	182	7	of	of	IN
cord-263532-q044i7ym	182	8	N8	N8	NNP
cord-263532-q044i7ym	182	9	and	and	CC
cord-263532-q044i7ym	182	10	its	-PRON-	PRP$
cord-263532-q044i7ym	182	11	mutants	mutant	NNS
cord-263532-q044i7ym	182	12	indicated	indicate	VBD
cord-263532-q044i7ym	182	13	that	that	IN
cord-263532-q044i7ym	182	14	hydrophobic	hydrophobic	JJ
cord-263532-q044i7ym	182	15	contact	contact	NN
cord-263532-q044i7ym	182	16	of	of	IN
cord-263532-q044i7ym	182	17	Met6	Met6	NNP
cord-263532-q044i7ym	182	18	and	and	CC
cord-263532-q044i7ym	182	19	electrostatic	electrostatic	JJ
cord-263532-q044i7ym	182	20	interaction	interaction	NN
cord-263532-q044i7ym	182	21	of	of	IN
cord-263532-q044i7ym	182	22	Arg4	Arg4	NNP
cord-263532-q044i7ym	182	23	of	of	IN
cord-263532-q044i7ym	182	24	N8	N8	NNP
cord-263532-q044i7ym	182	25	contributed	contribute	VBD
cord-263532-q044i7ym	182	26	significantly	significantly	RB
cord-263532-q044i7ym	182	27	in	in	IN
cord-263532-q044i7ym	182	28	its	-PRON-	PRP$
cord-263532-q044i7ym	182	29	binding	binding	NN
cord-263532-q044i7ym	182	30	with	with	IN
cord-263532-q044i7ym	182	31	the	the	DT
cord-263532-q044i7ym	182	32	enzyme	enzyme	NN
cord-263532-q044i7ym	182	33	.	.	.
cord-263532-q044i7ym	183	1	In	in	IN
cord-263532-q044i7ym	183	2	2006	2006	CD
cord-263532-q044i7ym	183	3	,	,	,
cord-263532-q044i7ym	183	4	Chen	Chen	NNP
cord-263532-q044i7ym	183	5	et	et	NNP
cord-263532-q044i7ym	183	6	al	al	NNP
cord-263532-q044i7ym	183	7	.	.	NNP
cord-263532-q044i7ym	183	8	employed	employ	VBD
cord-263532-q044i7ym	183	9	MD	MD	NNP
cord-263532-q044i7ym	183	10	simulations	simulation	NNS
cord-263532-q044i7ym	183	11	and	and	CC
cord-263532-q044i7ym	183	12	mutational	mutational	JJ
cord-263532-q044i7ym	183	13	studies	study	NNS
cord-263532-q044i7ym	183	14	to	to	TO
cord-263532-q044i7ym	183	15	investigate	investigate	VB
cord-263532-q044i7ym	183	16	that	that	IN
cord-263532-q044i7ym	183	17	why	why	WRB
cord-263532-q044i7ym	183	18	dimer	dimer	NN
cord-263532-q044i7ym	183	19	is	be	VBZ
cord-263532-q044i7ym	183	20	catalytically	catalytically	RB
cord-263532-q044i7ym	183	21	active	active	JJ
cord-263532-q044i7ym	183	22	as	as	IN
cord-263532-q044i7ym	183	23	compared	compare	VBN
cord-263532-q044i7ym	183	24	to	to	IN
cord-263532-q044i7ym	183	25	the	the	DT
cord-263532-q044i7ym	183	26	monomer	monomer	NN
cord-263532-q044i7ym	183	27	and	and	CC
cord-263532-q044i7ym	183	28	whether	whether	IN
cord-263532-q044i7ym	183	29	both	both	DT
cord-263532-q044i7ym	183	30	monomers	monomer	NNS
cord-263532-q044i7ym	183	31	in	in	IN
cord-263532-q044i7ym	183	32	the	the	DT
cord-263532-q044i7ym	183	33	dimer	dimer	NN
cord-263532-q044i7ym	183	34	are	be	VBP
cord-263532-q044i7ym	183	35	active	active	JJ
cord-263532-q044i7ym	183	36	.	.	.
cord-263532-q044i7ym	184	1	37	37	CD
cord-263532-q044i7ym	185	1	The	the	DT
cord-263532-q044i7ym	185	2	MD	MD	NNP
cord-263532-q044i7ym	185	3	simulations	simulation	NNS
cord-263532-q044i7ym	185	4	depicted	depict	VBN
cord-263532-q044i7ym	185	5	that	that	IN
cord-263532-q044i7ym	185	6	the	the	DT
cord-263532-q044i7ym	185	7	monomers	monomer	NNS
cord-263532-q044i7ym	185	8	are	be	VBP
cord-263532-q044i7ym	185	9	always	always	RB
cord-263532-q044i7ym	185	10	catalytically	catalytically	RB
cord-263532-q044i7ym	185	11	inactive	inactive	JJ
cord-263532-q044i7ym	185	12	,	,	,
cord-263532-q044i7ym	185	13	two	two	CD
cord-263532-q044i7ym	185	14	monomers	monomer	NNS
cord-263532-q044i7ym	185	15	comprising	comprise	VBG
cord-263532-q044i7ym	185	16	the	the	DT
cord-263532-q044i7ym	185	17	dimer	dimer	NN
cord-263532-q044i7ym	185	18	are	be	VBP
cord-263532-q044i7ym	185	19	asymmetric	asymmetric	JJ
cord-263532-q044i7ym	185	20	,	,	,
cord-263532-q044i7ym	185	21	and	and	CC
cord-263532-q044i7ym	185	22	only	only	RB
cord-263532-q044i7ym	185	23	one	one	CD
cord-263532-q044i7ym	185	24	monomer	monomer	NN
cord-263532-q044i7ym	185	25	display	display	NN
cord-263532-q044i7ym	185	26	catalytic	catalytic	JJ
cord-263532-q044i7ym	185	27	activity	activity	NN
cord-263532-q044i7ym	185	28	at	at	IN
cord-263532-q044i7ym	185	29	a	a	DT
cord-263532-q044i7ym	185	30	time	time	NN
cord-263532-q044i7ym	185	31	.	.	.
cord-263532-q044i7ym	186	1	MD	MD	NNP
cord-263532-q044i7ym	186	2	simulations	simulation	NNS
cord-263532-q044i7ym	186	3	also	also	RB
cord-263532-q044i7ym	186	4	highlighted	highlight	VBD
cord-263532-q044i7ym	186	5	that	that	IN
cord-263532-q044i7ym	186	6	the	the	DT
cord-263532-q044i7ym	186	7	correct	correct	JJ
cord-263532-q044i7ym	186	8	conformation	conformation	NN
cord-263532-q044i7ym	186	9	required	require	VBN
cord-263532-q044i7ym	186	10	for	for	IN
cord-263532-q044i7ym	186	11	the	the	DT
cord-263532-q044i7ym	186	12	catalytic	catalytic	JJ
cord-263532-q044i7ym	186	13	activity	activity	NN
cord-263532-q044i7ym	186	14	in	in	IN
cord-263532-q044i7ym	186	15	one	one	CD
cord-263532-q044i7ym	186	16	monomer	monomer	NN
cord-263532-q044i7ym	186	17	can	can	MD
cord-263532-q044i7ym	186	18	be	be	VB
cord-263532-q044i7ym	186	19	induced	induce	VBN
cord-263532-q044i7ym	186	20	by	by	IN
cord-263532-q044i7ym	186	21	the	the	DT
cord-263532-q044i7ym	186	22	formation	formation	NN
cord-263532-q044i7ym	186	23	of	of	IN
cord-263532-q044i7ym	186	24	dimer	dimer	NN
cord-263532-q044i7ym	186	25	.	.	.
cord-263532-q044i7ym	187	1	The	the	DT
cord-263532-q044i7ym	187	2	simulation	simulation	NN
cord-263532-q044i7ym	187	3	and	and	CC
cord-263532-q044i7ym	187	4	experimental	experimental	JJ
cord-263532-q044i7ym	187	5	results	result	NNS
cord-263532-q044i7ym	187	6	concluded	conclude	VBD
cord-263532-q044i7ym	187	7	that	that	IN
cord-263532-q044i7ym	187	8	(	(	-LRB-
cord-263532-q044i7ym	187	9	i	i	NN
cord-263532-q044i7ym	187	10	)	)	-RRB-
cord-263532-q044i7ym	187	11	dimerization	dimerization	NN
cord-263532-q044i7ym	187	12	was	be	VBD
cord-263532-q044i7ym	187	13	a	a	DT
cord-263532-q044i7ym	187	14	mandatory	mandatory	JJ
cord-263532-q044i7ym	187	15	requirement	requirement	NN
cord-263532-q044i7ym	187	16	for	for	IN
cord-263532-q044i7ym	187	17	the	the	DT
cord-263532-q044i7ym	187	18	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	187	19	activity	activity	NN
cord-263532-q044i7ym	187	20	of	of	IN
cord-263532-q044i7ym	187	21	the	the	DT
cord-263532-q044i7ym	187	22	protease	protease	NN
cord-263532-q044i7ym	187	23	,	,	,
cord-263532-q044i7ym	187	24	and	and	CC
cord-263532-q044i7ym	187	25	(	(	-LRB-
cord-263532-q044i7ym	187	26	ii	ii	NN
cord-263532-q044i7ym	187	27	)	)	-RRB-
cord-263532-q044i7ym	188	1	only	only	RB
cord-263532-q044i7ym	188	2	one	one	CD
cord-263532-q044i7ym	188	3	monomer	monomer	NN
cord-263532-q044i7ym	188	4	in	in	IN
cord-263532-q044i7ym	188	5	the	the	DT
cord-263532-q044i7ym	188	6	protease	protease	NN
cord-263532-q044i7ym	188	7	dimer	dimer	NN
cord-263532-q044i7ym	188	8	displayed	display	VBD
cord-263532-q044i7ym	188	9	catalytic	catalytic	JJ
cord-263532-q044i7ym	188	10	activity	activity	NN
cord-263532-q044i7ym	188	11	.	.	.
cord-263532-q044i7ym	189	1	In	in	IN
cord-263532-q044i7ym	189	2	another	another	DT
cord-263532-q044i7ym	189	3	study	study	NN
cord-263532-q044i7ym	189	4	,	,	,
cord-263532-q044i7ym	189	5	Graziano	Graziano	NNP
cord-263532-q044i7ym	189	6	et	et	NNP
cord-263532-q044i7ym	189	7	al	al	NNP
cord-263532-q044i7ym	189	8	.	.	NNP
cord-263532-q044i7ym	189	9	employed	employ	VBN
cord-263532-q044i7ym	189	10	chemical	chemical	NN
cord-263532-q044i7ym	189	11	crosslinking	crosslinking	NN
cord-263532-q044i7ym	189	12	,	,	,
cord-263532-q044i7ym	189	13	enzyme	enzyme	NN
cord-263532-q044i7ym	189	14	kinetics	kinetic	NNS
cord-263532-q044i7ym	189	15	and	and	CC
cord-263532-q044i7ym	189	16	small	small	JJ
cord-263532-q044i7ym	189	17	-	-	HYPH
cord-263532-q044i7ym	189	18	angle	angle	NN
cord-263532-q044i7ym	189	19	X	x	NN
cord-263532-q044i7ym	189	20	-	-	NN
cord-263532-q044i7ym	189	21	ray	ray	NN
cord-263532-q044i7ym	189	22	scattering	scattering	NN
cord-263532-q044i7ym	189	23	techniques	technique	NNS
cord-263532-q044i7ym	189	24	to	to	TO
cord-263532-q044i7ym	189	25	investigate	investigate	VB
cord-263532-q044i7ym	189	26	the	the	DT
cord-263532-q044i7ym	189	27	oligomeric	oligomeric	JJ
cord-263532-q044i7ym	189	28	state	state	NN
cord-263532-q044i7ym	189	29	of	of	IN
cord-263532-q044i7ym	189	30	SARS	SARS	NNP
cord-263532-q044i7ym	189	31	CoV	CoV	NNP
cord-263532-q044i7ym	189	32	M	M	NNP
cord-263532-q044i7ym	189	33	pro	pro	NNP
cord-263532-q044i7ym	189	34	.	.	NNP
cord-263532-q044i7ym	189	35	38	38	CD
cord-263532-q044i7ym	190	1	The	the	DT
cord-263532-q044i7ym	190	2	SARS	SARS	NNP
cord-263532-q044i7ym	190	3	CoV	cov	NN
cord-263532-q044i7ym	190	4	M	M	NNP
cord-263532-q044i7ym	190	5	pro	pro	NNP
cord-263532-q044i7ym	190	6	exists	exist	VBZ
cord-263532-q044i7ym	190	7	as	as	IN
cord-263532-q044i7ym	190	8	a	a	DT
cord-263532-q044i7ym	190	9	homodimer	homodimer	NN
cord-263532-q044i7ym	190	10	in	in	IN
cord-263532-q044i7ym	190	11	its	-PRON-	PRP$
cord-263532-q044i7ym	190	12	active	active	JJ
cord-263532-q044i7ym	190	13	form	form	NN
cord-263532-q044i7ym	190	14	.	.	.
cord-263532-q044i7ym	191	1	The	the	DT
cord-263532-q044i7ym	191	2	biochemical	biochemical	JJ
cord-263532-q044i7ym	191	3	and	and	CC
cord-263532-q044i7ym	191	4	biophysical	biophysical	JJ
cord-263532-q044i7ym	191	5	data	datum	NNS
cord-263532-q044i7ym	191	6	depicted	depict	VBD
cord-263532-q044i7ym	191	7	a	a	DT
cord-263532-q044i7ym	191	8	monomer−dimer	monomer−dimer	CD
cord-263532-q044i7ym	191	9	equilibrium	equilibrium	NN
cord-263532-q044i7ym	191	10	with	with	IN
cord-263532-q044i7ym	191	11	a	a	DT
cord-263532-q044i7ym	191	12	dissociation	dissociation	NN
cord-263532-q044i7ym	191	13	constant	constant	NN
cord-263532-q044i7ym	191	14	,	,	,
cord-263532-q044i7ym	191	15	K	K	NNP
cord-263532-q044i7ym	191	16	d	d	NNP
cord-263532-q044i7ym	191	17	,	,	,
cord-263532-q044i7ym	191	18	of	of	IN
cord-263532-q044i7ym	191	19	∼6	∼6	CD
cord-263532-q044i7ym	192	1	μM.	μM.	NNP
cord-263532-q044i7ym	193	1	In	in	IN
cord-263532-q044i7ym	193	2	2007	2007	CD
cord-263532-q044i7ym	193	3	,	,	,
cord-263532-q044i7ym	193	4	Zheng	Zheng	NNP
cord-263532-q044i7ym	193	5	et	et	NNP
cord-263532-q044i7ym	193	6	al	al	NNP
cord-263532-q044i7ym	193	7	.	.	NNP
cord-263532-q044i7ym	193	8	performed	perform	VBD
cord-263532-q044i7ym	193	9	MD	MD	NNP
cord-263532-q044i7ym	193	10	simulations	simulation	NNS
cord-263532-q044i7ym	193	11	of	of	IN
cord-263532-q044i7ym	193	12	the	the	DT
cord-263532-q044i7ym	193	13	dimeric	dimeric	JJ
cord-263532-q044i7ym	193	14	and	and	CC
cord-263532-q044i7ym	193	15	monomeric	monomeric	JJ
cord-263532-q044i7ym	193	16	form	form	NN
cord-263532-q044i7ym	193	17	of	of	IN
cord-263532-q044i7ym	193	18	a	a	DT
cord-263532-q044i7ym	193	19	SARS	SARS	NNP
cord-263532-q044i7ym	193	20	-	-	HYPH
cord-263532-q044i7ym	193	21	CoV	CoV	NNP
cord-263532-q044i7ym	193	22	M	M	NNP
cord-263532-q044i7ym	193	23	pro	pro	JJ
cord-263532-q044i7ym	193	24	to	to	TO
cord-263532-q044i7ym	193	25	get	get	VB
cord-263532-q044i7ym	193	26	insight	insight	NN
cord-263532-q044i7ym	193	27	into	into	IN
cord-263532-q044i7ym	193	28	the	the	DT
cord-263532-q044i7ym	193	29	activity	activity	NN
cord-263532-q044i7ym	193	30	of	of	IN
cord-263532-q044i7ym	193	31	the	the	DT
cord-263532-q044i7ym	193	32	enzyme	enzyme	NN
cord-263532-q044i7ym	193	33	.	.	.
cord-263532-q044i7ym	194	1	39	39	CD
cord-263532-q044i7ym	195	1	The	the	DT
cord-263532-q044i7ym	195	2	key	key	JJ
cord-263532-q044i7ym	195	3	interactions	interaction	NNS
cord-263532-q044i7ym	195	4	between	between	IN
cord-263532-q044i7ym	195	5	the	the	DT
cord-263532-q044i7ym	195	6	two	two	CD
cord-263532-q044i7ym	195	7	monomers	monomer	NNS
cord-263532-q044i7ym	195	8	in	in	IN
cord-263532-q044i7ym	195	9	the	the	DT
cord-263532-q044i7ym	195	10	dimer	dimer	NN
cord-263532-q044i7ym	195	11	were	be	VBD
cord-263532-q044i7ym	195	12	investigated	investigate	VBN
cord-263532-q044i7ym	195	13	and	and	CC
cord-263532-q044i7ym	195	14	how	how	WRB
cord-263532-q044i7ym	195	15	these	these	DT
cord-263532-q044i7ym	195	16	interactions	interaction	NNS
cord-263532-q044i7ym	195	17	help	help	VBP
cord-263532-q044i7ym	195	18	in	in	IN
cord-263532-q044i7ym	195	19	maintaining	maintain	VBG
cord-263532-q044i7ym	195	20	the	the	DT
cord-263532-q044i7ym	195	21	function	function	NN
cord-263532-q044i7ym	195	22	of	of	IN
cord-263532-q044i7ym	195	23	the	the	DT
cord-263532-q044i7ym	195	24	dimer	dimer	NN
cord-263532-q044i7ym	195	25	was	be	VBD
cord-263532-q044i7ym	195	26	studied	study	VBN
cord-263532-q044i7ym	195	27	.	.	.
cord-263532-q044i7ym	196	1	The	the	DT
cord-263532-q044i7ym	196	2	study	study	NN
cord-263532-q044i7ym	196	3	highlighted	highlight	VBD
cord-263532-q044i7ym	196	4	that	that	IN
cord-263532-q044i7ym	196	5	the	the	DT
cord-263532-q044i7ym	196	6	interactions	interaction	NNS
cord-263532-q044i7ym	196	7	between	between	IN
cord-263532-q044i7ym	196	8	the	the	DT
cord-263532-q044i7ym	196	9	N	n	CD
cord-263532-q044i7ym	196	10	-	-	HYPH
cord-263532-q044i7ym	196	11	terminus	terminus	NN
cord-263532-q044i7ym	196	12	of	of	IN
cord-263532-q044i7ym	196	13	one	one	CD
cord-263532-q044i7ym	196	14	monomer	monomer	NN
cord-263532-q044i7ym	196	15	with	with	IN
cord-263532-q044i7ym	196	16	another	another	DT
cord-263532-q044i7ym	196	17	monomer	monomer	NN
cord-263532-q044i7ym	196	18	of	of	IN
cord-263532-q044i7ym	196	19	the	the	DT
cord-263532-q044i7ym	196	20	protease	protease	NN
cord-263532-q044i7ym	196	21	helped	help	VBD
cord-263532-q044i7ym	196	22	to	to	TO
cord-263532-q044i7ym	196	23	maintain	maintain	VB
cord-263532-q044i7ym	196	24	the	the	DT
cord-263532-q044i7ym	196	25	dimer	dimer	NN
cord-263532-q044i7ym	196	26	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	196	27	activity	activity	NN
cord-263532-q044i7ym	196	28	.	.	.
cord-263532-q044i7ym	197	1	The	the	DT
cord-263532-q044i7ym	197	2	key	key	JJ
cord-263532-q044i7ym	197	3	insights	insight	NNS
cord-263532-q044i7ym	197	4	obtained	obtain	VBN
cord-263532-q044i7ym	197	5	from	from	IN
cord-263532-q044i7ym	197	6	MD	MD	NNP
cord-263532-q044i7ym	197	7	simulations	simulation	NNS
cord-263532-q044i7ym	197	8	will	will	MD
cord-263532-q044i7ym	197	9	be	be	VB
cord-263532-q044i7ym	197	10	beneficial	beneficial	JJ
cord-263532-q044i7ym	197	11	in	in	IN
cord-263532-q044i7ym	197	12	the	the	DT
cord-263532-q044i7ym	197	13	design	design	NN
cord-263532-q044i7ym	197	14	of	of	IN
cord-263532-q044i7ym	197	15	specific	specific	JJ
cord-263532-q044i7ym	197	16	protease	protease	NN
cord-263532-q044i7ym	197	17	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	197	18	targeting	target	VBG
cord-263532-q044i7ym	197	19	the	the	DT
cord-263532-q044i7ym	197	20	dimer	dimer	NN
cord-263532-q044i7ym	197	21	interface	interface	NN
cord-263532-q044i7ym	197	22	of	of	IN
cord-263532-q044i7ym	197	23	SARS	SARS	NNP
cord-263532-q044i7ym	197	24	-	-	HYPH
cord-263532-q044i7ym	197	25	CoV	CoV	NNP
cord-263532-q044i7ym	197	26	M	M	NNP
cord-263532-q044i7ym	197	27	pro	pro	JJ
cord-263532-q044i7ym	197	28	enzyme	enzyme	NN
cord-263532-q044i7ym	197	29	.	.	.
cord-263532-q044i7ym	198	1	Chen	Chen	NNP
cord-263532-q044i7ym	198	2	et	et	NNP
cord-263532-q044i7ym	198	3	al	al	NNP
cord-263532-q044i7ym	198	4	.	.	NNP
cord-263532-q044i7ym	198	5	identified	identify	VBD
cord-263532-q044i7ym	198	6	critical	critical	JJ
cord-263532-q044i7ym	198	7	residues	residue	NNS
cord-263532-q044i7ym	198	8	involved	involve	VBN
cord-263532-q044i7ym	198	9	in	in	IN
cord-263532-q044i7ym	198	10	the	the	DT
cord-263532-q044i7ym	198	11	SARS	SARS	NNP
cord-263532-q044i7ym	198	12	-	-	HYPH
cord-263532-q044i7ym	198	13	CoV	CoV	NNP
cord-263532-q044i7ym	198	14	M	M	NNP
cord-263532-q044i7ym	198	15	pro	pro	JJ
cord-263532-q044i7ym	198	16	dimerization	dimerization	NN
cord-263532-q044i7ym	198	17	and	and	CC
cord-263532-q044i7ym	198	18	activity	activity	NN
cord-263532-q044i7ym	198	19	by	by	IN
cord-263532-q044i7ym	198	20	systematic	systematic	JJ
cord-263532-q044i7ym	198	21	mutation	mutation	NN
cord-263532-q044i7ym	198	22	analysis	analysis	NN
cord-263532-q044i7ym	198	23	.	.	.
cord-263532-q044i7ym	199	1	26	26	CD
cord-263532-q044i7ym	200	1	A	a	DT
cord-263532-q044i7ym	200	2	total	total	NN
cord-263532-q044i7ym	200	3	of	of	IN
cord-263532-q044i7ym	200	4	seven	seven	CD
cord-263532-q044i7ym	200	5	residues	residue	NNS
cord-263532-q044i7ym	200	6	on	on	IN
cord-263532-q044i7ym	200	7	the	the	DT
cord-263532-q044i7ym	200	8	dimer	dimer	NN
cord-263532-q044i7ym	200	9	interface	interface	NN
cord-263532-q044i7ym	200	10	of	of	IN
cord-263532-q044i7ym	200	11	the	the	DT
cord-263532-q044i7ym	200	12	enzyme	enzyme	NN
cord-263532-q044i7ym	200	13	were	be	VBD
cord-263532-q044i7ym	200	14	selected	select	VBN
cord-263532-q044i7ym	200	15	to	to	TO
cord-263532-q044i7ym	200	16	assess	assess	VB
cord-263532-q044i7ym	200	17	their	-PRON-	PRP$
cord-263532-q044i7ym	200	18	influence	influence	NN
cord-263532-q044i7ym	200	19	on	on	IN
cord-263532-q044i7ym	200	20	the	the	DT
cord-263532-q044i7ym	200	21	catalytic	catalytic	JJ
cord-263532-q044i7ym	200	22	activity	activity	NN
cord-263532-q044i7ym	200	23	and	and	CC
cord-263532-q044i7ym	200	24	dimer	dimer	NN
cord-263532-q044i7ym	200	25	stability	stability	NN
cord-263532-q044i7ym	200	26	by	by	IN
cord-263532-q044i7ym	200	27	employing	employ	VBG
cord-263532-q044i7ym	200	28	biophysical	biophysical	JJ
cord-263532-q044i7ym	200	29	and	and	CC
cord-263532-q044i7ym	200	30	biochemical	biochemical	JJ
cord-263532-q044i7ym	200	31	techniques	technique	NNS
cord-263532-q044i7ym	200	32	.	.	.
cord-263532-q044i7ym	201	1	The	the	DT
cord-263532-q044i7ym	201	2	Ser10	Ser10	NNP
cord-263532-q044i7ym	201	3	and	and	CC
cord-263532-q044i7ym	201	4	Glu14	Glu14	NNP
cord-263532-q044i7ym	201	5	residues	residue	NNS
cord-263532-q044i7ym	201	6	located	locate	VBN
cord-263532-q044i7ym	201	7	in	in	IN
cord-263532-q044i7ym	201	8	the	the	DT
cord-263532-q044i7ym	201	9	α	α	NN
cord-263532-q044i7ym	201	10	-	-	HYPH
cord-263532-q044i7ym	201	11	helix	helix	NN
cord-263532-q044i7ym	201	12	A′	a′	CD
cord-263532-q044i7ym	201	13	of	of	IN
cord-263532-q044i7ym	201	14	domain	domain	NN
cord-263532-q044i7ym	202	1	I	-PRON-	PRP
cord-263532-q044i7ym	202	2	of	of	IN
cord-263532-q044i7ym	202	3	SARS	SARS	NNP
cord-263532-q044i7ym	202	4	-	-	HYPH
cord-263532-q044i7ym	202	5	CoV	CoV	NNP
cord-263532-q044i7ym	202	6	M	M	NNP
cord-263532-q044i7ym	202	7	pro	pro	JJ
cord-263532-q044i7ym	202	8	are	be	VBP
cord-263532-q044i7ym	202	9	highly	highly	RB
cord-263532-q044i7ym	202	10	conserved	conserve	VBN
cord-263532-q044i7ym	202	11	among	among	IN
cord-263532-q044i7ym	202	12	various	various	JJ
cord-263532-q044i7ym	202	13	CoVs	CoVs	NNP
cord-263532-q044i7ym	202	14	proteases	protease	NNS
cord-263532-q044i7ym	202	15	and	and	CC
cord-263532-q044i7ym	202	16	contribute	contribute	VBP
cord-263532-q044i7ym	202	17	significantly	significantly	RB
cord-263532-q044i7ym	202	18	in	in	IN
cord-263532-q044i7ym	202	19	the	the	DT
cord-263532-q044i7ym	202	20	monomer−monomer	monomer−monomer	CD
cord-263532-q044i7ym	202	21	interactions	interaction	NNS
cord-263532-q044i7ym	202	22	.	.	.
cord-263532-q044i7ym	203	1	The	the	DT
cord-263532-q044i7ym	203	2	individual	individual	JJ
cord-263532-q044i7ym	203	3	mutations	mutation	NNS
cord-263532-q044i7ym	203	4	of	of	IN
cord-263532-q044i7ym	203	5	Ser10	Ser10	NNP
cord-263532-q044i7ym	203	6	and	and	CC
cord-263532-q044i7ym	203	7	Glu14	Glu14	NNP
cord-263532-q044i7ym	203	8	to	to	IN
cord-263532-q044i7ym	203	9	Ala	Ala	NNP
cord-263532-q044i7ym	203	10	resulted	result	VBD
cord-263532-q044i7ym	203	11	in	in	IN
cord-263532-q044i7ym	203	12	weak	weak	JJ
cord-263532-q044i7ym	203	13	dimerization	dimerization	NN
cord-263532-q044i7ym	203	14	and	and	CC
cord-263532-q044i7ym	203	15	no	no	DT
cord-263532-q044i7ym	203	16	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	203	17	activity	activity	NN
cord-263532-q044i7ym	203	18	.	.	.
cord-263532-q044i7ym	204	1	The	the	DT
cord-263532-q044i7ym	204	2	results	result	NNS
cord-263532-q044i7ym	204	3	of	of	IN
cord-263532-q044i7ym	204	4	the	the	DT
cord-263532-q044i7ym	204	5	study	study	NN
cord-263532-q044i7ym	204	6	will	will	MD
cord-263532-q044i7ym	204	7	be	be	VB
cord-263532-q044i7ym	204	8	beneficial	beneficial	JJ
cord-263532-q044i7ym	204	9	in	in	IN
cord-263532-q044i7ym	204	10	the	the	DT
cord-263532-q044i7ym	204	11	better	well	JJR
cord-263532-q044i7ym	204	12	understanding	understanding	NN
cord-263532-q044i7ym	204	13	of	of	IN
cord-263532-q044i7ym	204	14	the	the	DT
cord-263532-q044i7ym	204	15	dimerization	dimerization	NN
cord-263532-q044i7ym	204	16	activity	activity	NN
cord-263532-q044i7ym	204	17	relationship	relationship	NN
cord-263532-q044i7ym	204	18	of	of	IN
cord-263532-q044i7ym	204	19	SARS	SARS	NNP
cord-263532-q044i7ym	204	20	-	-	HYPH
cord-263532-q044i7ym	204	21	CoV	CoV	NNP
cord-263532-q044i7ym	204	22	M	M	NNP
cord-263532-q044i7ym	204	23	pro	pro	JJ
cord-263532-q044i7ym	204	24	and	and	CC
cord-263532-q044i7ym	204	25	will	will	MD
cord-263532-q044i7ym	204	26	provide	provide	VB
cord-263532-q044i7ym	204	27	key	key	JJ
cord-263532-q044i7ym	204	28	insights	insight	NNS
cord-263532-q044i7ym	204	29	for	for	IN
cord-263532-q044i7ym	204	30	the	the	DT
cord-263532-q044i7ym	204	31	design	design	NN
cord-263532-q044i7ym	204	32	of	of	IN
cord-263532-q044i7ym	204	33	antiviral	antiviral	JJ
cord-263532-q044i7ym	204	34	compounds	compound	NNS
cord-263532-q044i7ym	204	35	targeting	target	VBG
cord-263532-q044i7ym	204	36	the	the	DT
cord-263532-q044i7ym	204	37	dimer	dimer	NN
cord-263532-q044i7ym	204	38	interface	interface	NN
cord-263532-q044i7ym	204	39	of	of	IN
cord-263532-q044i7ym	204	40	the	the	DT
cord-263532-q044i7ym	204	41	SARS	SARS	NNP
cord-263532-q044i7ym	204	42	-	-	HYPH
cord-263532-q044i7ym	204	43	CoV	CoV	NNP
cord-263532-q044i7ym	204	44	M	M	NNP
cord-263532-q044i7ym	204	45	pro	pro	NNP
cord-263532-q044i7ym	204	46	.	.	.
cord-263532-q044i7ym	205	1	Further	further	RB
cord-263532-q044i7ym	205	2	Chen	Chen	NNP
cord-263532-q044i7ym	205	3	et	et	NNP
cord-263532-q044i7ym	205	4	al	al	NNP
cord-263532-q044i7ym	205	5	.	.	NNP
cord-263532-q044i7ym	205	6	reported	report	VBD
cord-263532-q044i7ym	205	7	that	that	IN
cord-263532-q044i7ym	205	8	mutation	mutation	NN
cord-263532-q044i7ym	205	9	of	of	IN
cord-263532-q044i7ym	205	10	Gly11	Gly11	NNP
cord-263532-q044i7ym	205	11	residue	residue	NN
cord-263532-q044i7ym	205	12	situated	situate	VBN
cord-263532-q044i7ym	205	13	at	at	IN
cord-263532-q044i7ym	205	14	the	the	DT
cord-263532-q044i7ym	205	15	dimer	dimer	NN
cord-263532-q044i7ym	205	16	interface	interface	NN
cord-263532-q044i7ym	205	17	to	to	IN
cord-263532-q044i7ym	205	18	Ala	Ala	NNP
cord-263532-q044i7ym	205	19	led	lead	VBD
cord-263532-q044i7ym	205	20	to	to	IN
cord-263532-q044i7ym	205	21	a	a	DT
cord-263532-q044i7ym	205	22	complete	complete	JJ
cord-263532-q044i7ym	205	23	loss	loss	NN
cord-263532-q044i7ym	205	24	in	in	IN
cord-263532-q044i7ym	205	25	the	the	DT
cord-263532-q044i7ym	205	26	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	205	27	activity	activity	NN
cord-263532-q044i7ym	205	28	of	of	IN
cord-263532-q044i7ym	205	29	SARS	SARS	NNP
cord-263532-q044i7ym	205	30	-	-	HYPH
cord-263532-q044i7ym	205	31	CoV	CoV	NNP
cord-263532-q044i7ym	205	32	M	M	NNP
cord-263532-q044i7ym	205	33	pro	pro	NNP
cord-263532-q044i7ym	205	34	.	.	.
cord-263532-q044i7ym	206	1	27	27	CD
cord-263532-q044i7ym	207	1	A	a	DT
cord-263532-q044i7ym	207	2	complete	complete	JJ
cord-263532-q044i7ym	207	3	dimer	dimer	NN
cord-263532-q044i7ym	207	4	dissociation	dissociation	NN
cord-263532-q044i7ym	207	5	in	in	IN
cord-263532-q044i7ym	207	6	the	the	DT
cord-263532-q044i7ym	207	7	crystal	crystal	JJ
cord-263532-q044i7ym	207	8	structure	structure	NN
cord-263532-q044i7ym	207	9	of	of	IN
cord-263532-q044i7ym	207	10	G11A	G11A	NNP
cord-263532-q044i7ym	207	11	mutant	mutant	JJ
cord-263532-q044i7ym	207	12	was	be	VBD
cord-263532-q044i7ym	207	13	observed	observe	VBN
cord-263532-q044i7ym	207	14	.	.	.
cord-263532-q044i7ym	208	1	The	the	DT
cord-263532-q044i7ym	208	2	G11A	G11A	NNP
cord-263532-q044i7ym	208	3	mutation	mutation	NN
cord-263532-q044i7ym	208	4	might	may	MD
cord-263532-q044i7ym	208	5	shorten	shorten	VB
cord-263532-q044i7ym	208	6	the	the	DT
cord-263532-q044i7ym	208	7	α	α	NN
cord-263532-q044i7ym	208	8	-	-	HYPH
cord-263532-q044i7ym	208	9	helix	helix	NN
cord-263532-q044i7ym	208	10	A′	a′	CD
cord-263532-q044i7ym	208	11	(	(	-LRB-
cord-263532-q044i7ym	208	12	Ser10−Gly15	Ser10−Gly15	NNP
cord-263532-q044i7ym	208	13	)	)	-RRB-
cord-263532-q044i7ym	208	14	of	of	IN
cord-263532-q044i7ym	208	15	domain	domain	NN
cord-263532-q044i7ym	208	16	I	-PRON-	PRP
cord-263532-q044i7ym	208	17	,	,	,
cord-263532-q044i7ym	208	18	which	which	WDT
cord-263532-q044i7ym	208	19	led	lead	VBD
cord-263532-q044i7ym	208	20	to	to	IN
cord-263532-q044i7ym	208	21	the	the	DT
cord-263532-q044i7ym	208	22	misorientation	misorientation	NN
cord-263532-q044i7ym	208	23	of	of	IN
cord-263532-q044i7ym	208	24	the	the	DT
cord-263532-q044i7ym	208	25	N	N	NNP
cord-263532-q044i7ym	208	26	-	-	HYPH
cord-263532-q044i7ym	208	27	finger	finger	NN
cord-263532-q044i7ym	208	28	of	of	IN
cord-263532-q044i7ym	208	29	the	the	DT
cord-263532-q044i7ym	208	30	enzyme	enzyme	NN
cord-263532-q044i7ym	208	31	.	.	.
cord-263532-q044i7ym	209	1	As	as	IN
cord-263532-q044i7ym	209	2	a	a	DT
cord-263532-q044i7ym	209	3	result	result	NN
cord-263532-q044i7ym	209	4	,	,	,
cord-263532-q044i7ym	209	5	N	n	CD
cord-263532-q044i7ym	209	6	-	-	HYPH
cord-263532-q044i7ym	209	7	finger	finger	NN
cord-263532-q044i7ym	209	8	could	could	MD
cord-263532-q044i7ym	209	9	not	not	RB
cord-263532-q044i7ym	209	10	properly	properly	RB
cord-263532-q044i7ym	209	11	squeeze	squeeze	VB
cord-263532-q044i7ym	209	12	into	into	IN
cord-263532-q044i7ym	209	13	another	another	DT
cord-263532-q044i7ym	209	14	monomer	monomer	NN
cord-263532-q044i7ym	209	15	pocket	pocket	NN
cord-263532-q044i7ym	209	16	during	during	IN
cord-263532-q044i7ym	209	17	dimerization	dimerization	NN
cord-263532-q044i7ym	209	18	;	;	:
cord-263532-q044i7ym	209	19	thus	thus	RB
cord-263532-q044i7ym	209	20	resulting	result	VBG
cord-263532-q044i7ym	209	21	in	in	IN
cord-263532-q044i7ym	209	22	the	the	DT
cord-263532-q044i7ym	209	23	destabilization	destabilization	NN
cord-263532-q044i7ym	209	24	of	of	IN
cord-263532-q044i7ym	209	25	the	the	DT
cord-263532-q044i7ym	209	26	dimer	dimer	NN
cord-263532-q044i7ym	209	27	structure	structure	NN
cord-263532-q044i7ym	209	28	.	.	.
cord-263532-q044i7ym	210	1	The	the	DT
cord-263532-q044i7ym	210	2	hydrogen	hydrogen	NN
cord-263532-q044i7ym	210	3	bond	bond	NN
cord-263532-q044i7ym	210	4	interactions	interaction	NNS
cord-263532-q044i7ym	210	5	between	between	IN
cord-263532-q044i7ym	210	6	two	two	CD
cord-263532-q044i7ym	210	7	helices	helix	NNS
cord-263532-q044i7ym	210	8	A′	a′	CD
cord-263532-q044i7ym	211	1	[	[	-LRB-
cord-263532-q044i7ym	211	2	Ser10A···Ser10B	ser10a···ser10b	NN
cord-263532-q044i7ym	211	3	and	and	CC
cord-263532-q044i7ym	211	4	Gly11A	Gly11A	NNP
cord-263532-q044i7ym	212	1	/B···Glu14B	/B···Glu14B	NNP
cord-263532-q044i7ym	212	2	/	/	NFP
cord-263532-q044i7ym	212	3	A	a	NN
cord-263532-q044i7ym	213	1	(	(	-LRB-
cord-263532-q044i7ym	213	2	Ser10A	Ser10A	NNP
cord-263532-q044i7ym	213	3	and	and	CC
cord-263532-q044i7ym	213	4	Ser10B	Ser10B	NNP
cord-263532-q044i7ym	213	5	indicate	indicate	VB
cord-263532-q044i7ym	213	6	Ser10	Ser10	NNP
cord-263532-q044i7ym	213	7	of	of	IN
cord-263532-q044i7ym	213	8	monomer	monomer	NN
cord-263532-q044i7ym	213	9	A	a	NN
cord-263532-q044i7ym	213	10	and	and	CC
cord-263532-q044i7ym	213	11	B	b	NN
cord-263532-q044i7ym	213	12	,	,	,
cord-263532-q044i7ym	213	13	respectively	respectively	RB
cord-263532-q044i7ym	213	14	)	)	-RRB-
cord-263532-q044i7ym	213	15	]	]	-RRB-
cord-263532-q044i7ym	213	16	play	play	VBP
cord-263532-q044i7ym	213	17	a	a	DT
cord-263532-q044i7ym	213	18	major	major	JJ
cord-263532-q044i7ym	213	19	role	role	NN
cord-263532-q044i7ym	213	20	in	in	IN
cord-263532-q044i7ym	213	21	the	the	DT
cord-263532-q044i7ym	213	22	stability	stability	NN
cord-263532-q044i7ym	213	23	of	of	IN
cord-263532-q044i7ym	213	24	the	the	DT
cord-263532-q044i7ym	213	25	dimer	dimer	NN
cord-263532-q044i7ym	213	26	interface	interface	NN
cord-263532-q044i7ym	213	27	.	.	.
cord-263532-q044i7ym	214	1	The	the	DT
cord-263532-q044i7ym	214	2	G11A	g11a	RB
cord-263532-q044i7ym	214	3	mutant	mutant	JJ
cord-263532-q044i7ym	214	4	structure	structure	NN
cord-263532-q044i7ym	214	5	was	be	VBD
cord-263532-q044i7ym	214	6	the	the	DT
cord-263532-q044i7ym	214	7	first	first	JJ
cord-263532-q044i7ym	214	8	reported	report	VBN
cord-263532-q044i7ym	214	9	crystal	crystal	NN
cord-263532-q044i7ym	214	10	structure	structure	NN
cord-263532-q044i7ym	214	11	of	of	IN
cord-263532-q044i7ym	214	12	the	the	DT
cord-263532-q044i7ym	214	13	monomeric	monomeric	JJ
cord-263532-q044i7ym	214	14	SARS	SARS	NNP
cord-263532-q044i7ym	214	15	-	-	HYPH
cord-263532-q044i7ym	214	16	CoV	CoV	NNP
cord-263532-q044i7ym	214	17	M	M	NNP
cord-263532-q044i7ym	214	18	pro	pro	JJ
cord-263532-q044i7ym	214	19	and	and	CC
cord-263532-q044i7ym	214	20	provided	provide	VBD
cord-263532-q044i7ym	214	21	a	a	DT
cord-263532-q044i7ym	214	22	better	well	JJR
cord-263532-q044i7ym	214	23	understanding	understanding	NN
cord-263532-q044i7ym	214	24	of	of	IN
cord-263532-q044i7ym	214	25	the	the	DT
cord-263532-q044i7ym	214	26	dimerization	dimerization	NN
cord-263532-q044i7ym	214	27	and	and	CC
cord-263532-q044i7ym	214	28	catalytic	catalytic	JJ
cord-263532-q044i7ym	214	29	mechanism	mechanism	NN
cord-263532-q044i7ym	214	30	of	of	IN
cord-263532-q044i7ym	214	31	the	the	DT
cord-263532-q044i7ym	214	32	protease	protease	NN
cord-263532-q044i7ym	214	33	.	.	.
cord-263532-q044i7ym	215	1	In	in	IN
cord-263532-q044i7ym	215	2	2008	2008	CD
cord-263532-q044i7ym	215	3	,	,	,
cord-263532-q044i7ym	215	4	Grum	Grum	NNP
cord-263532-q044i7ym	215	5	-	-	HYPH
cord-263532-q044i7ym	215	6	Tokars	Tokars	NNP
cord-263532-q044i7ym	215	7	et	et	NNP
cord-263532-q044i7ym	215	8	al	al	NNP
cord-263532-q044i7ym	215	9	.	.	NNP
cord-263532-q044i7ym	215	10	reviewed	review	VBD
cord-263532-q044i7ym	215	11	the	the	DT
cord-263532-q044i7ym	215	12	literature	literature	NN
cord-263532-q044i7ym	215	13	related	relate	VBN
cord-263532-q044i7ym	215	14	to	to	IN
cord-263532-q044i7ym	215	15	different	different	JJ
cord-263532-q044i7ym	215	16	SARS	SARS	NNP
cord-263532-q044i7ym	215	17	-	-	HYPH
cord-263532-q044i7ym	215	18	CoV	CoV	NNP
cord-263532-q044i7ym	215	19	M	M	NNP
cord-263532-q044i7ym	215	20	pro	pro	JJ
cord-263532-q044i7ym	215	21	expression	expression	NN
cord-263532-q044i7ym	215	22	constructs	construct	NNS
cord-263532-q044i7ym	215	23	and	and	CC
cord-263532-q044i7ym	215	24	assays	assay	NNS
cord-263532-q044i7ym	215	25	used	use	VBN
cord-263532-q044i7ym	215	26	to	to	TO
cord-263532-q044i7ym	215	27	calculate	calculate	VB
cord-263532-q044i7ym	215	28	the	the	DT
cord-263532-q044i7ym	215	29	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	215	30	activity	activity	NN
cord-263532-q044i7ym	215	31	.	.	.
cord-263532-q044i7ym	216	1	45	45	CD
cord-263532-q044i7ym	217	1	The	the	DT
cord-263532-q044i7ym	217	2	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	217	3	activity	activity	NN
cord-263532-q044i7ym	217	4	of	of	IN
cord-263532-q044i7ym	217	5	SARS	SARS	NNP
cord-263532-q044i7ym	217	6	-	-	HYPH
cord-263532-q044i7ym	217	7	CoV	CoV	NNP
cord-263532-q044i7ym	217	8	M	M	NNP
cord-263532-q044i7ym	217	9	pro	pro	NNP
cord-263532-q044i7ym	217	10	was	be	VBD
cord-263532-q044i7ym	217	11	significantly	significantly	RB
cord-263532-q044i7ym	217	12	reduced	reduce	VBN
cord-263532-q044i7ym	217	13	in	in	IN
cord-263532-q044i7ym	217	14	two	two	CD
cord-263532-q044i7ym	217	15	cases	case	NNS
cord-263532-q044i7ym	217	16	:	:	:
cord-263532-q044i7ym	217	17	(	(	-LRB-
cord-263532-q044i7ym	217	18	i	i	NN
cord-263532-q044i7ym	217	19	)	)	-RRB-
cord-263532-q044i7ym	217	20	on	on	IN
cord-263532-q044i7ym	217	21	adding	add	VBG
cord-263532-q044i7ym	217	22	affinity	affinity	NN
cord-263532-q044i7ym	217	23	-	-	HYPH
cord-263532-q044i7ym	217	24	tags	tag	NNS
cord-263532-q044i7ym	217	25	or	or	CC
cord-263532-q044i7ym	217	26	non	non	JJ
cord-263532-q044i7ym	217	27	-	-	JJ
cord-263532-q044i7ym	217	28	native	native	JJ
cord-263532-q044i7ym	217	29	sequences	sequence	NNS
cord-263532-q044i7ym	217	30	to	to	IN
cord-263532-q044i7ym	217	31	the	the	DT
cord-263532-q044i7ym	217	32	N	N	NNP
cord-263532-q044i7ym	217	33	-	-	:
cord-263532-q044i7ym	217	34	or	or	CC
cord-263532-q044i7ym	217	35	Cterminus	Cterminus	NNP
cord-263532-q044i7ym	217	36	of	of	IN
cord-263532-q044i7ym	217	37	the	the	DT
cord-263532-q044i7ym	217	38	protease	protease	NN
cord-263532-q044i7ym	217	39	enzyme	enzyme	NN
cord-263532-q044i7ym	217	40	,	,	,
cord-263532-q044i7ym	217	41	and	and	CC
cord-263532-q044i7ym	217	42	(	(	-LRB-
cord-263532-q044i7ym	217	43	ii	ii	NN
cord-263532-q044i7ym	217	44	)	)	-RRB-
cord-263532-q044i7ym	217	45	when	when	WRB
cord-263532-q044i7ym	217	46	the	the	DT
cord-263532-q044i7ym	217	47	concentration	concentration	NN
cord-263532-q044i7ym	217	48	of	of	IN
cord-263532-q044i7ym	217	49	the	the	DT
cord-263532-q044i7ym	217	50	enzyme	enzyme	NN
cord-263532-q044i7ym	217	51	used	use	VBN
cord-263532-q044i7ym	217	52	in	in	IN
cord-263532-q044i7ym	217	53	assays	assay	NNS
cord-263532-q044i7ym	217	54	was	be	VBD
cord-263532-q044i7ym	217	55	below	below	IN
cord-263532-q044i7ym	217	56	the	the	DT
cord-263532-q044i7ym	217	57	equilibrium	equilibrium	NN
cord-263532-q044i7ym	217	58	dissociation	dissociation	NN
cord-263532-q044i7ym	217	59	constant	constant	JJ
cord-263532-q044i7ym	217	60	of	of	IN
cord-263532-q044i7ym	217	61	the	the	DT
cord-263532-q044i7ym	217	62	SARS	SARS	NNP
cord-263532-q044i7ym	217	63	-	-	HYPH
cord-263532-q044i7ym	217	64	CoV	CoV	NNP
cord-263532-q044i7ym	217	65	M	M	NNP
cord-263532-q044i7ym	217	66	pro	pro	JJ
cord-263532-q044i7ym	217	67	dimer	dimer	NN
cord-263532-q044i7ym	217	68	.	.	.
cord-263532-q044i7ym	218	1	In	in	IN
cord-263532-q044i7ym	218	2	2008	2008	CD
cord-263532-q044i7ym	218	3	,	,	,
cord-263532-q044i7ym	218	4	Lin	Lin	NNP
cord-263532-q044i7ym	218	5	et	et	NNP
cord-263532-q044i7ym	218	6	al	al	NNP
cord-263532-q044i7ym	218	7	.	.	.
cord-263532-q044i7ym	218	8	analyzed	analyze	VBD
cord-263532-q044i7ym	218	9	the	the	DT
cord-263532-q044i7ym	218	10	quaternary	quaternary	JJ
cord-263532-q044i7ym	218	11	structure	structure	NN
cord-263532-q044i7ym	218	12	of	of	IN
cord-263532-q044i7ym	218	13	the	the	DT
cord-263532-q044i7ym	218	14	Cterminal	Cterminal	NNP
cord-263532-q044i7ym	218	15	truncated	truncated	JJ
cord-263532-q044i7ym	218	16	mutants	mutant	NNS
cord-263532-q044i7ym	218	17	of	of	IN
cord-263532-q044i7ym	218	18	SARS	SARS	NNP
cord-263532-q044i7ym	218	19	-	-	HYPH
cord-263532-q044i7ym	218	20	CoV	CoV	NNP
cord-263532-q044i7ym	218	21	-	-	HYPH
cord-263532-q044i7ym	218	22	M	M	NNP
cord-263532-q044i7ym	218	23	pro	pro	JJ
cord-263532-q044i7ym	218	24	enzyme	enzyme	NN
cord-263532-q044i7ym	218	25	by	by	IN
cord-263532-q044i7ym	218	26	employing	employ	VBG
cord-263532-q044i7ym	218	27	sedimentation	sedimentation	NN
cord-263532-q044i7ym	218	28	velocity	velocity	NN
cord-263532-q044i7ym	218	29	and	and	CC
cord-263532-q044i7ym	218	30	sedimentation	sedimentation	NN
cord-263532-q044i7ym	218	31	equilibrium	equilibrium	NN
cord-263532-q044i7ym	218	32	analytical	analytical	JJ
cord-263532-q044i7ym	218	33	ultracentrifugation	ultracentrifugation	NN
cord-263532-q044i7ym	218	34	techniques	technique	NNS
cord-263532-q044i7ym	218	35	.	.	.
cord-263532-q044i7ym	219	1	28	28	CD
cord-263532-q044i7ym	220	1	The	the	DT
cord-263532-q044i7ym	220	2	deletion	deletion	NN
cord-263532-q044i7ym	220	3	of	of	IN
cord-263532-q044i7ym	220	4	C	c	NN
cord-263532-q044i7ym	220	5	-	-	HYPH
cord-263532-q044i7ym	220	6	terminus	terminus	NN
cord-263532-q044i7ym	220	7	from	from	IN
cord-263532-q044i7ym	220	8	306	306	CD
cord-263532-q044i7ym	220	9	to	to	IN
cord-263532-q044i7ym	220	10	300	300	CD
cord-263532-q044i7ym	220	11	does	do	VBZ
cord-263532-q044i7ym	220	12	not	not	RB
cord-263532-q044i7ym	220	13	affect	affect	VB
cord-263532-q044i7ym	220	14	the	the	DT
cord-263532-q044i7ym	220	15	structure	structure	NN
cord-263532-q044i7ym	220	16	and	and	CC
cord-263532-q044i7ym	220	17	catalytic	catalytic	JJ
cord-263532-q044i7ym	220	18	activity	activity	NN
cord-263532-q044i7ym	220	19	of	of	IN
cord-263532-q044i7ym	220	20	the	the	DT
cord-263532-q044i7ym	220	21	enzyme	enzyme	NN
cord-263532-q044i7ym	220	22	.	.	.
cord-263532-q044i7ym	221	1	However	however	RB
cord-263532-q044i7ym	221	2	,	,	,
cord-263532-q044i7ym	221	3	deletion	deletion	NN
cord-263532-q044i7ym	221	4	of	of	IN
cord-263532-q044i7ym	221	5	Gln299	gln299	CD
cord-263532-q044i7ym	221	6	or	or	CC
cord-263532-q044i7ym	221	7	Arg298	Arg298	,
cord-263532-q044i7ym	221	8	significantly	significantly	RB
cord-263532-q044i7ym	221	9	decreased	decrease	VBD
cord-263532-q044i7ym	221	10	the	the	DT
cord-263532-q044i7ym	221	11	catalytic	catalytic	JJ
cord-263532-q044i7ym	221	12	activity	activity	NN
cord-263532-q044i7ym	221	13	to	to	IN
cord-263532-q044i7ym	221	14	only	only	RB
cord-263532-q044i7ym	221	15	1−	1−	CD
cord-263532-q044i7ym	221	16	2	2	CD
cord-263532-q044i7ym	221	17	%	%	NN
cord-263532-q044i7ym	221	18	of	of	IN
cord-263532-q044i7ym	221	19	wt	wt	NN
cord-263532-q044i7ym	221	20	enzyme	enzyme	NN
cord-263532-q044i7ym	221	21	,	,	,
cord-263532-q044i7ym	221	22	and	and	CC
cord-263532-q044i7ym	221	23	the	the	DT
cord-263532-q044i7ym	221	24	enzyme	enzyme	NN
cord-263532-q044i7ym	221	25	existed	exist	VBD
cord-263532-q044i7ym	221	26	predominantly	predominantly	RB
cord-263532-q044i7ym	221	27	in	in	IN
cord-263532-q044i7ym	221	28	the	the	DT
cord-263532-q044i7ym	221	29	monomeric	monomeric	JJ
cord-263532-q044i7ym	221	30	form	form	NN
cord-263532-q044i7ym	221	31	.	.	.
cord-263532-q044i7ym	222	1	The	the	DT
cord-263532-q044i7ym	222	2	point	point	NN
cord-263532-q044i7ym	222	3	mutants	mutant	NNS
cord-263532-q044i7ym	222	4	of	of	IN
cord-263532-q044i7ym	222	5	Gln299	gln299	ADD
cord-263532-q044i7ym	222	6	and	and	CC
cord-263532-q044i7ym	222	7	Arg298	Arg298	,
cord-263532-q044i7ym	222	8	depicted	depict	VBD
cord-263532-q044i7ym	222	9	that	that	IN
cord-263532-q044i7ym	222	10	these	these	DT
cord-263532-q044i7ym	222	11	residues	residue	NNS
cord-263532-q044i7ym	222	12	are	be	VBP
cord-263532-q044i7ym	222	13	involved	involve	VBN
cord-263532-q044i7ym	222	14	in	in	IN
cord-263532-q044i7ym	222	15	dimerization	dimerization	NN
cord-263532-q044i7ym	222	16	and	and	CC
cord-263532-q044i7ym	222	17	played	play	VBD
cord-263532-q044i7ym	222	18	a	a	DT
cord-263532-q044i7ym	222	19	key	key	JJ
cord-263532-q044i7ym	222	20	role	role	NN
cord-263532-q044i7ym	222	21	in	in	IN
cord-263532-q044i7ym	222	22	fixing	fix	VBG
cord-263532-q044i7ym	222	23	the	the	DT
cord-263532-q044i7ym	222	24	catalytically	catalytically	RB
cord-263532-q044i7ym	222	25	active	active	JJ
cord-263532-q044i7ym	222	26	conformation	conformation	NN
cord-263532-q044i7ym	222	27	of	of	IN
cord-263532-q044i7ym	222	28	the	the	DT
cord-263532-q044i7ym	222	29	enzyme	enzyme	NN
cord-263532-q044i7ym	222	30	.	.	.
cord-263532-q044i7ym	223	1	The	the	DT
cord-263532-q044i7ym	223	2	monomeric	monomeric	JJ
cord-263532-q044i7ym	223	3	crystal	crystal	NN
cord-263532-q044i7ym	223	4	structure	structure	NN
cord-263532-q044i7ym	223	5	of	of	IN
cord-263532-q044i7ym	223	6	the	the	DT
cord-263532-q044i7ym	223	7	SARS	SARS	NNP
cord-263532-q044i7ym	223	8	-	-	HYPH
cord-263532-q044i7ym	223	9	CoV	CoV	NNP
cord-263532-q044i7ym	223	10	M	M	NNP
cord-263532-q044i7ym	223	11	pro	pro	JJ
cord-263532-q044i7ym	223	12	R298A	R298A	NNP
cord-263532-q044i7ym	223	13	mutant	mutant	NN
cord-263532-q044i7ym	223	14	was	be	VBD
cord-263532-q044i7ym	223	15	reported	report	VBN
cord-263532-q044i7ym	223	16	by	by	IN
cord-263532-q044i7ym	223	17	Shi	Shi	NNP
cord-263532-q044i7ym	223	18	et	et	FW
cord-263532-q044i7ym	223	19	al	al	NNP
cord-263532-q044i7ym	223	20	.	.	.
cord-263532-q044i7ym	224	1	29	29	CD
cord-263532-q044i7ym	225	1	The	the	DT
cord-263532-q044i7ym	225	2	study	study	NN
cord-263532-q044i7ym	225	3	highlighted	highlight	VBD
cord-263532-q044i7ym	225	4	that	that	IN
cord-263532-q044i7ym	225	5	Arg298	arg298	TO
cord-263532-q044i7ym	225	6	play	play	VB
cord-263532-q044i7ym	225	7	an	an	DT
cord-263532-q044i7ym	225	8	important	important	JJ
cord-263532-q044i7ym	225	9	role	role	NN
cord-263532-q044i7ym	225	10	in	in	IN
cord-263532-q044i7ym	225	11	maintaining	maintain	VBG
cord-263532-q044i7ym	225	12	the	the	DT
cord-263532-q044i7ym	225	13	dimer	dimer	JJ
cord-263532-q044i7ym	225	14	structure	structure	NN
cord-263532-q044i7ym	225	15	of	of	IN
cord-263532-q044i7ym	225	16	the	the	DT
cord-263532-q044i7ym	225	17	enzyme	enzyme	NN
cord-263532-q044i7ym	225	18	.	.	.
cord-263532-q044i7ym	226	1	The	the	DT
cord-263532-q044i7ym	226	2	authors	author	NNS
cord-263532-q044i7ym	226	3	tried	try	VBD
cord-263532-q044i7ym	226	4	to	to	TO
cord-263532-q044i7ym	226	5	solve	solve	VB
cord-263532-q044i7ym	226	6	two	two	CD
cord-263532-q044i7ym	226	7	puzzles	puzzle	NNS
cord-263532-q044i7ym	226	8	:	:	:
cord-263532-q044i7ym	227	1	(	(	-LRB-
cord-263532-q044i7ym	227	2	i	i	NN
cord-263532-q044i7ym	227	3	)	)	-RRB-
cord-263532-q044i7ym	227	4	how	how	WRB
cord-263532-q044i7ym	227	5	the	the	DT
cord-263532-q044i7ym	227	6	dimer−monomer	dimer−monomer	CD
cord-263532-q044i7ym	227	7	switch	switch	NN
cord-263532-q044i7ym	227	8	was	be	VBD
cord-263532-q044i7ym	227	9	controlled	control	VBN
cord-263532-q044i7ym	227	10	,	,	,
cord-263532-q044i7ym	227	11	and	and	CC
cord-263532-q044i7ym	227	12	(	(	-LRB-
cord-263532-q044i7ym	227	13	ii	ii	NN
cord-263532-q044i7ym	227	14	)	)	-RRB-
cord-263532-q044i7ym	228	1	why	why	WRB
cord-263532-q044i7ym	228	2	dimerization	dimerization	NN
cord-263532-q044i7ym	228	3	was	be	VBD
cord-263532-q044i7ym	228	4	necessary	necessary	JJ
cord-263532-q044i7ym	228	5	for	for	IN
cord-263532-q044i7ym	228	6	the	the	DT
cord-263532-q044i7ym	228	7	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	228	8	activity	activity	NN
cord-263532-q044i7ym	228	9	.	.	.
cord-263532-q044i7ym	229	1	The	the	DT
cord-263532-q044i7ym	229	2	results	result	NNS
cord-263532-q044i7ym	229	3	highlighted	highlight	VBD
cord-263532-q044i7ym	229	4	that	that	IN
cord-263532-q044i7ym	229	5	R298A	R298A	NNP
cord-263532-q044i7ym	229	6	mutation	mutation	NN
cord-263532-q044i7ym	229	7	leads	lead	VBZ
cord-263532-q044i7ym	229	8	to	to	IN
cord-263532-q044i7ym	229	9	disruption	disruption	NN
cord-263532-q044i7ym	229	10	of	of	IN
cord-263532-q044i7ym	229	11	the	the	DT
cord-263532-q044i7ym	229	12	dimeric	dimeric	JJ
cord-263532-q044i7ym	229	13	structure	structure	NN
cord-263532-q044i7ym	229	14	as	as	RB
cord-263532-q044i7ym	229	15	well	well	RB
cord-263532-q044i7ym	229	16	as	as	IN
cord-263532-q044i7ym	229	17	irreversible	irreversible	JJ
cord-263532-q044i7ym	229	18	inhibition	inhibition	NN
cord-263532-q044i7ym	229	19	of	of	IN
cord-263532-q044i7ym	229	20	the	the	DT
cord-263532-q044i7ym	229	21	catalytic	catalytic	JJ
cord-263532-q044i7ym	229	22	activity	activity	NN
cord-263532-q044i7ym	229	23	of	of	IN
cord-263532-q044i7ym	229	24	the	the	DT
cord-263532-q044i7ym	229	25	enzyme	enzyme	NN
cord-263532-q044i7ym	229	26	.	.	.
cord-263532-q044i7ym	230	1	In	in	IN
cord-263532-q044i7ym	230	2	2013	2013	CD
cord-263532-q044i7ym	230	3	,	,	,
cord-263532-q044i7ym	230	4	Wu	Wu	NNP
cord-263532-q044i7ym	230	5	et	et	NNP
cord-263532-q044i7ym	230	6	al	al	NNP
cord-263532-q044i7ym	230	7	.	.	NNP
cord-263532-q044i7ym	230	8	presented	present	VBD
cord-263532-q044i7ym	230	9	the	the	DT
cord-263532-q044i7ym	230	10	crystal	crystal	NN
cord-263532-q044i7ym	230	11	structure	structure	NN
cord-263532-q044i7ym	230	12	of	of	IN
cord-263532-q044i7ym	230	13	R298A	R298A	NNP
cord-263532-q044i7ym	230	14	mutant	mutant	NN
cord-263532-q044i7ym	230	15	of	of	IN
cord-263532-q044i7ym	230	16	SARS	SARS	NNP
cord-263532-q044i7ym	230	17	-	-	HYPH
cord-263532-q044i7ym	230	18	CoV	CoV	NNP
cord-263532-q044i7ym	230	19	M	M	NNP
cord-263532-q044i7ym	230	20	pro	pro	JJ
cord-263532-q044i7ym	230	21	in	in	IN
cord-263532-q044i7ym	230	22	the	the	DT
cord-263532-q044i7ym	230	23	presence	presence	NN
cord-263532-q044i7ym	230	24	of	of	IN
cord-263532-q044i7ym	230	25	a	a	DT
cord-263532-q044i7ym	230	26	peptide	peptide	NN
cord-263532-q044i7ym	230	27	substrate	substrate	NN
cord-263532-q044i7ym	230	28	.	.	.
cord-263532-q044i7ym	231	1	40	40	CD
cord-263532-q044i7ym	232	1	The	the	DT
cord-263532-q044i7ym	232	2	R298A	R298A	NNP
cord-263532-q044i7ym	232	3	mutant	mutant	NN
cord-263532-q044i7ym	232	4	undergoes	undergo	VBZ
cord-263532-q044i7ym	232	5	a	a	DT
cord-263532-q044i7ym	232	6	reversible	reversible	JJ
cord-263532-q044i7ym	232	7	substrate	substrate	NN
cord-263532-q044i7ym	232	8	induced	induce	VBN
cord-263532-q044i7ym	232	9	dimerization	dimerization	NN
cord-263532-q044i7ym	232	10	with	with	IN
cord-263532-q044i7ym	232	11	minute	minute	NN
cord-263532-q044i7ym	232	12	changes	change	NNS
cord-263532-q044i7ym	232	13	in	in	IN
cord-263532-q044i7ym	232	14	the	the	DT
cord-263532-q044i7ym	232	15	relative	relative	JJ
cord-263532-q044i7ym	232	16	position	position	NN
cord-263532-q044i7ym	232	17	of	of	IN
cord-263532-q044i7ym	232	18	the	the	DT
cord-263532-q044i7ym	232	19	domain	domain	NN
cord-263532-q044i7ym	232	20	III	iii	CD
cord-263532-q044i7ym	232	21	of	of	IN
cord-263532-q044i7ym	232	22	each	each	DT
cord-263532-q044i7ym	232	23	monomer	monomer	NN
cord-263532-q044i7ym	232	24	as	as	IN
cord-263532-q044i7ym	232	25	compared	compare	VBN
cord-263532-q044i7ym	232	26	to	to	IN
cord-263532-q044i7ym	232	27	wt	wt	NN
cord-263532-q044i7ym	232	28	M	M	NNP
cord-263532-q044i7ym	232	29	pro	pro	NNP
cord-263532-q044i7ym	232	30	.	.	.
cord-263532-q044i7ym	233	1	As	as	IN
cord-263532-q044i7ym	233	2	indicated	indicate	VBN
cord-263532-q044i7ym	233	3	by	by	IN
cord-263532-q044i7ym	233	4	active	active	JJ
cord-263532-q044i7ym	233	5	enzyme	enzyme	NN
cord-263532-q044i7ym	233	6	centrifugation	centrifugation	NN
cord-263532-q044i7ym	233	7	(	(	-LRB-
cord-263532-q044i7ym	233	8	AEC	AEC	NNP
cord-263532-q044i7ym	233	9	)	)	-RRB-
cord-263532-q044i7ym	233	10	experiments	experiment	NNS
cord-263532-q044i7ym	233	11	,	,	,
cord-263532-q044i7ym	233	12	the	the	DT
cord-263532-q044i7ym	233	13	kinetic	kinetic	JJ
cord-263532-q044i7ym	233	14	parameters	parameter	NNS
cord-263532-q044i7ym	233	15	of	of	IN
cord-263532-q044i7ym	233	16	the	the	DT
cord-263532-q044i7ym	233	17	R298A	R298A	NNP
cord-263532-q044i7ym	233	18	mutant	mutant	NN
cord-263532-q044i7ym	233	19	were	be	VBD
cord-263532-q044i7ym	233	20	identical	identical	JJ
cord-263532-q044i7ym	233	21	with	with	IN
cord-263532-q044i7ym	233	22	that	that	DT
cord-263532-q044i7ym	233	23	of	of	IN
cord-263532-q044i7ym	233	24	wt	wt	NN
cord-263532-q044i7ym	233	25	M	M	NNP
cord-263532-q044i7ym	233	26	pro	pro	NNP
cord-263532-q044i7ym	233	27	.	.	.
cord-263532-q044i7ym	234	1	The	the	DT
cord-263532-q044i7ym	234	2	study	study	NN
cord-263532-q044i7ym	234	3	provided	provide	VBD
cord-263532-q044i7ym	234	4	key	key	JJ
cord-263532-q044i7ym	234	5	insights	insight	NNS
cord-263532-q044i7ym	234	6	into	into	IN
cord-263532-q044i7ym	234	7	the	the	DT
cord-263532-q044i7ym	234	8	mechanisms	mechanism	NNS
cord-263532-q044i7ym	234	9	that	that	WDT
cord-263532-q044i7ym	234	10	governed	govern	VBD
cord-263532-q044i7ym	234	11	monomer−dimer	monomer−dimer	CD
cord-263532-q044i7ym	234	12	switch	switch	NN
cord-263532-q044i7ym	234	13	during	during	IN
cord-263532-q044i7ym	234	14	M	M	NNP
cord-263532-q044i7ym	234	15	pro	pro	JJ
cord-263532-q044i7ym	234	16	maturation	maturation	NN
cord-263532-q044i7ym	234	17	process	process	NN
cord-263532-q044i7ym	234	18	.	.	.
cord-263532-q044i7ym	235	1	In	in	IN
cord-263532-q044i7ym	235	2	2008	2008	CD
cord-263532-q044i7ym	235	3	,	,	,
cord-263532-q044i7ym	235	4	Zhong	Zhong	NNP
cord-263532-q044i7ym	235	5	et	et	NNP
cord-263532-q044i7ym	235	6	al	al	NNP
cord-263532-q044i7ym	235	7	.	.	NNP
cord-263532-q044i7ym	235	8	reported	report	VBD
cord-263532-q044i7ym	235	9	that	that	IN
cord-263532-q044i7ym	235	10	C	c	NN
cord-263532-q044i7ym	235	11	-	-	HYPH
cord-263532-q044i7ym	235	12	terminal	terminal	NN
cord-263532-q044i7ym	235	13	domain	domain	NN
cord-263532-q044i7ym	235	14	[	[	-LRB-
cord-263532-q044i7ym	235	15	M	M	NNP
cord-263532-q044i7ym	235	16	pro	pro	FW
cord-263532-q044i7ym	235	17	-C	-C	VBZ
cord-263532-q044i7ym	236	1	(	(	-LRB-
cord-263532-q044i7ym	236	2	residues	residue	NNS
cord-263532-q044i7ym	236	3	187−306	187−306	CD
cord-263532-q044i7ym	236	4	)	)	-RRB-
cord-263532-q044i7ym	236	5	]	]	-RRB-
cord-263532-q044i7ym	236	6	of	of	IN
cord-263532-q044i7ym	236	7	SARS	SARS	NNP
cord-263532-q044i7ym	236	8	-	-	HYPH
cord-263532-q044i7ym	236	9	CoV	CoV	NNP
cord-263532-q044i7ym	236	10	M	M	NNP
cord-263532-q044i7ym	236	11	pro	pro	JJ
cord-263532-q044i7ym	236	12	exist	exist	VBP
cord-263532-q044i7ym	236	13	as	as	IN
cord-263532-q044i7ym	236	14	a	a	DT
cord-263532-q044i7ym	236	15	monomer	monomer	NN
cord-263532-q044i7ym	236	16	and	and	CC
cord-263532-q044i7ym	236	17	dimer	dimer	NN
cord-263532-q044i7ym	236	18	,	,	,
cord-263532-q044i7ym	236	19	and	and	CC
cord-263532-q044i7ym	236	20	M	M	NNP
cord-263532-q044i7ym	236	21	pro	pro	JJ
cord-263532-q044i7ym	236	22	-C	-C	VBZ
cord-263532-q044i7ym	236	23	dimer	dimer	JJ
cord-263532-q044i7ym	237	1	possess	possess	VB
cord-263532-q044i7ym	237	2	a	a	DT
cord-263532-q044i7ym	237	3	novel	novel	JJ
cord-263532-q044i7ym	237	4	dimerization	dimerization	NN
cord-263532-q044i7ym	237	5	interface	interface	NN
cord-263532-q044i7ym	237	6	.	.	.
cord-263532-q044i7ym	238	1	41	41	CD
cord-263532-q044i7ym	239	1	The	the	DT
cord-263532-q044i7ym	239	2	N	N	NNP
cord-263532-q044i7ym	239	3	-	-	HYPH
cord-263532-q044i7ym	239	4	finger	finger	NN
cord-263532-q044i7ym	239	5	deleted	delete	VBN
cord-263532-q044i7ym	239	6	SARS	SARS	NNP
cord-263532-q044i7ym	239	7	-	-	HYPH
cord-263532-q044i7ym	239	8	CoV	CoV	NNP
cord-263532-q044i7ym	239	9	M	M	NNP
cord-263532-q044i7ym	239	10	pro	pro	JJ
cord-263532-q044i7ym	239	11	does	do	VBZ
cord-263532-q044i7ym	239	12	not	not	RB
cord-263532-q044i7ym	239	13	maintain	maintain	VB
cord-263532-q044i7ym	239	14	the	the	DT
cord-263532-q044i7ym	239	15	active	active	JJ
cord-263532-q044i7ym	239	16	dimer	dimer	NN
cord-263532-q044i7ym	239	17	structure	structure	NN
cord-263532-q044i7ym	239	18	;	;	:
cord-263532-q044i7ym	239	19	however	however	RB
cord-263532-q044i7ym	239	20	,	,	,
cord-263532-q044i7ym	239	21	form	form	VB
cord-263532-q044i7ym	239	22	a	a	DT
cord-263532-q044i7ym	239	23	new	new	JJ
cord-263532-q044i7ym	239	24	dimer	dimer	NN
cord-263532-q044i7ym	239	25	that	that	WDT
cord-263532-q044i7ym	239	26	is	be	VBZ
cord-263532-q044i7ym	239	27	not	not	RB
cord-263532-q044i7ym	239	28	active	active	JJ
cord-263532-q044i7ym	239	29	.	.	.
cord-263532-q044i7ym	240	1	Thus	thus	RB
cord-263532-q044i7ym	240	2	,	,	,
cord-263532-q044i7ym	240	3	the	the	DT
cord-263532-q044i7ym	240	4	N	n	NN
cord-263532-q044i7ym	240	5	-	-	HYPH
cord-263532-q044i7ym	240	6	finger	finger	NN
cord-263532-q044i7ym	240	7	of	of	IN
cord-263532-q044i7ym	240	8	SARS	SARS	NNP
cord-263532-q044i7ym	240	9	-	-	HYPH
cord-263532-q044i7ym	240	10	CoV	CoV	NNP
cord-263532-q044i7ym	240	11	M	M	NNP
cord-263532-q044i7ym	240	12	pro	pro	JJ
cord-263532-q044i7ym	240	13	play	play	VBP
cord-263532-q044i7ym	240	14	a	a	DT
cord-263532-q044i7ym	240	15	critical	critical	JJ
cord-263532-q044i7ym	240	16	role	role	NN
cord-263532-q044i7ym	240	17	in	in	IN
cord-263532-q044i7ym	240	18	the	the	DT
cord-263532-q044i7ym	240	19	formation	formation	NN
cord-263532-q044i7ym	240	20	of	of	IN
cord-263532-q044i7ym	240	21	catalytically	catalytically	RB
cord-263532-q044i7ym	240	22	active	active	JJ
cord-263532-q044i7ym	240	23	dimer	dimer	NN
cord-263532-q044i7ym	240	24	of	of	IN
cord-263532-q044i7ym	240	25	SARS	SARS	NNP
cord-263532-q044i7ym	240	26	-	-	HYPH
cord-263532-q044i7ym	240	27	CoV	CoV	NNP
cord-263532-q044i7ym	240	28	M	M	NNP
cord-263532-q044i7ym	240	29	pro	pro	NNP
cord-263532-q044i7ym	240	30	.	.	.
cord-263532-q044i7ym	241	1	Later	later	RB
cord-263532-q044i7ym	241	2	in	in	IN
cord-263532-q044i7ym	241	3	2009	2009	CD
cord-263532-q044i7ym	241	4	,	,	,
cord-263532-q044i7ym	241	5	the	the	DT
cord-263532-q044i7ym	241	6	authors	author	NNS
cord-263532-q044i7ym	241	7	reported	report	VBD
cord-263532-q044i7ym	241	8	stable	stable	JJ
cord-263532-q044i7ym	241	9	M	M	NNP
cord-263532-q044i7ym	241	10	pro	pro	JJ
cord-263532-q044i7ym	241	11	-C	-C	NNS
cord-263532-q044i7ym	241	12	dimer	dimer	JJ
cord-263532-q044i7ym	241	13	as	as	IN
cord-263532-q044i7ym	241	14	the	the	DT
cord-263532-q044i7ym	241	15	3D	3d	JJ
cord-263532-q044i7ym	241	16	domain	domain	NN
cord-263532-q044i7ym	241	17	-	-	HYPH
cord-263532-q044i7ym	241	18	swapped	swap	VBN
cord-263532-q044i7ym	241	19	dimer	dimer	NN
cord-263532-q044i7ym	241	20	.	.	.
cord-263532-q044i7ym	242	1	42	42	CD
cord-263532-q044i7ym	243	1	The	the	DT
cord-263532-q044i7ym	243	2	N	N	NNP
cord-263532-q044i7ym	243	3	-	-	HYPH
cord-263532-q044i7ym	243	4	finger	finger	NN
cord-263532-q044i7ym	243	5	deleted	delete	VBD
cord-263532-q044i7ym	243	6	M	M	NNP
cord-263532-q044i7ym	243	7	pro	pro	NNP
cord-263532-q044i7ym	243	8	also	also	RB
cord-263532-q044i7ym	243	9	undergo	undergo	VBP
cord-263532-q044i7ym	243	10	3D	3d	JJ
cord-263532-q044i7ym	243	11	domain	domain	NN
cord-263532-q044i7ym	243	12	swapping	swapping	NN
cord-263532-q044i7ym	243	13	of	of	IN
cord-263532-q044i7ym	243	14	the	the	DT
cord-263532-q044i7ym	243	15	Cterminal	Cterminal	NNP
cord-263532-q044i7ym	243	16	domains	domain	NNS
cord-263532-q044i7ym	243	17	and	and	CC
cord-263532-q044i7ym	243	18	form	form	VB
cord-263532-q044i7ym	243	19	a	a	DT
cord-263532-q044i7ym	243	20	stable	stable	JJ
cord-263532-q044i7ym	243	21	dimer	dimer	NN
cord-263532-q044i7ym	243	22	.	.	.
cord-263532-q044i7ym	244	1	Next	next	RB
cord-263532-q044i7ym	244	2	,	,	,
cord-263532-q044i7ym	244	3	Hu	Hu	NNP
cord-263532-q044i7ym	244	4	et	et	FW
cord-263532-q044i7ym	244	5	al	al	NNP
cord-263532-q044i7ym	244	6	.	.	NNP
cord-263532-q044i7ym	244	7	reported	report	VBD
cord-263532-q044i7ym	244	8	that	that	IN
cord-263532-q044i7ym	244	9	two	two	CD
cord-263532-q044i7ym	244	10	adjacent	adjacent	JJ
cord-263532-q044i7ym	244	11	mutations	mutation	NNS
cord-263532-q044i7ym	244	12	(	(	-LRB-
cord-263532-q044i7ym	244	13	S139A	S139A	NNS
cord-263532-q044i7ym	244	14	and	and	CC
cord-263532-q044i7ym	244	15	F140A	F140A	NNP
cord-263532-q044i7ym	244	16	)	)	-RRB-
cord-263532-q044i7ym	244	17	on	on	IN
cord-263532-q044i7ym	244	18	the	the	DT
cord-263532-q044i7ym	244	19	dimer	dimer	NN
cord-263532-q044i7ym	244	20	interface	interface	NN
cord-263532-q044i7ym	244	21	of	of	IN
cord-263532-q044i7ym	244	22	SARS	SARS	NNP
cord-263532-q044i7ym	244	23	-	-	HYPH
cord-263532-q044i7ym	244	24	CoV	CoV	NNP
cord-263532-q044i7ym	244	25	M	M	NNP
cord-263532-q044i7ym	244	26	pro	pro	NN
cord-263532-q044i7ym	244	27	resulted	result	VBD
cord-263532-q044i7ym	244	28	in	in	IN
cord-263532-q044i7ym	244	29	the	the	DT
cord-263532-q044i7ym	244	30	different	different	JJ
cord-263532-q044i7ym	244	31	conformational	conformational	JJ
cord-263532-q044i7ym	244	32	changes	change	NNS
cord-263532-q044i7ym	244	33	in	in	IN
cord-263532-q044i7ym	244	34	crystal	crystal	JJ
cord-263532-q044i7ym	244	35	structure	structure	NN
cord-263532-q044i7ym	244	36	of	of	IN
cord-263532-q044i7ym	244	37	the	the	DT
cord-263532-q044i7ym	244	38	enzyme	enzyme	NN
cord-263532-q044i7ym	244	39	.	.	.
cord-263532-q044i7ym	245	1	30	30	CD
cord-263532-q044i7ym	246	1	The	the	DT
cord-263532-q044i7ym	246	2	S139A	S139A	NNPS
cord-263532-q044i7ym	246	3	mutation	mutation	NN
cord-263532-q044i7ym	246	4	resulted	result	VBD
cord-263532-q044i7ym	246	5	in	in	IN
cord-263532-q044i7ym	246	6	the	the	DT
cord-263532-q044i7ym	246	7	complete	complete	JJ
cord-263532-q044i7ym	246	8	loss	loss	NN
cord-263532-q044i7ym	246	9	of	of	IN
cord-263532-q044i7ym	246	10	dimerization	dimerization	NN
cord-263532-q044i7ym	246	11	.	.	.
cord-263532-q044i7ym	247	1	The	the	DT
cord-263532-q044i7ym	247	2	Ser139	ser139	CD
cord-263532-q044i7ym	247	3	of	of	IN
cord-263532-q044i7ym	247	4	monomer	monomer	NNP
cord-263532-q044i7ym	247	5	A	A	NNP
cord-263532-q044i7ym	247	6	was	be	VBD
cord-263532-q044i7ym	247	7	involved	involve	VBN
cord-263532-q044i7ym	247	8	in	in	IN
cord-263532-q044i7ym	247	9	the	the	DT
cord-263532-q044i7ym	247	10	hydrogen	hydrogen	NN
cord-263532-q044i7ym	247	11	bond	bond	NN
cord-263532-q044i7ym	247	12	interaction	interaction	NN
cord-263532-q044i7ym	247	13	with	with	IN
cord-263532-q044i7ym	247	14	Gln299	gln299	ADD
cord-263532-q044i7ym	247	15	of	of	IN
cord-263532-q044i7ym	247	16	monomer	monomer	NN
cord-263532-q044i7ym	248	1	B.	B.	NNP
cord-263532-q044i7ym	249	1	The	the	DT
cord-263532-q044i7ym	249	2	study	study	NN
cord-263532-q044i7ym	249	3	suggested	suggest	VBD
cord-263532-q044i7ym	249	4	that	that	IN
cord-263532-q044i7ym	249	5	the	the	DT
cord-263532-q044i7ym	249	6	cooperativity	cooperativity	NN
cord-263532-q044i7ym	249	7	among	among	IN
cord-263532-q044i7ym	249	8	all	all	PDT
cord-263532-q044i7ym	249	9	the	the	DT
cord-263532-q044i7ym	249	10	key	key	JJ
cord-263532-q044i7ym	249	11	elements	element	NNS
cord-263532-q044i7ym	249	12	control	control	VBP
cord-263532-q044i7ym	249	13	the	the	DT
cord-263532-q044i7ym	249	14	dimerization	dimerization	NN
cord-263532-q044i7ym	249	15	of	of	IN
cord-263532-q044i7ym	249	16	SARS	SARS	NNP
cord-263532-q044i7ym	249	17	-	-	HYPH
cord-263532-q044i7ym	249	18	CoV	CoV	NNP
cord-263532-q044i7ym	249	19	M	M	NNP
cord-263532-q044i7ym	249	20	pro	pro	JJ
cord-263532-q044i7ym	249	21	and	and	CC
cord-263532-q044i7ym	249	22	the	the	DT
cord-263532-q044i7ym	249	23	stability	stability	NN
cord-263532-q044i7ym	249	24	of	of	IN
cord-263532-q044i7ym	249	25	the	the	DT
cord-263532-q044i7ym	249	26	dimer	dimer	NN
cord-263532-q044i7ym	249	27	greatly	greatly	RB
cord-263532-q044i7ym	249	28	depends	depend	VBZ
cord-263532-q044i7ym	249	29	on	on	IN
cord-263532-q044i7ym	249	30	the	the	DT
cord-263532-q044i7ym	249	31	integrity	integrity	NN
cord-263532-q044i7ym	249	32	of	of	IN
cord-263532-q044i7ym	249	33	the	the	DT
cord-263532-q044i7ym	249	34	dimer	dimer	NN
cord-263532-q044i7ym	249	35	interface	interface	NN
cord-263532-q044i7ym	249	36	.	.	.
cord-263532-q044i7ym	250	1	In	in	IN
cord-263532-q044i7ym	250	2	2010	2010	CD
cord-263532-q044i7ym	250	3	,	,	,
cord-263532-q044i7ym	250	4	Li	Li	NNP
cord-263532-q044i7ym	250	5	et	et	NNP
cord-263532-q044i7ym	250	6	al	al	NNP
cord-263532-q044i7ym	250	7	.	.	NNP
cord-263532-q044i7ym	250	8	presented	present	VBD
cord-263532-q044i7ym	250	9	the	the	DT
cord-263532-q044i7ym	250	10	maturation	maturation	NN
cord-263532-q044i7ym	250	11	mechanism	mechanism	NN
cord-263532-q044i7ym	250	12	of	of	IN
cord-263532-q044i7ym	250	13	SARS	SARS	NNP
cord-263532-q044i7ym	250	14	-	-	HYPH
cord-263532-q044i7ym	250	15	CoV	CoV	NNP
cord-263532-q044i7ym	250	16	M	M	NNP
cord-263532-q044i7ym	250	17	pro	pro	JJ
cord-263532-q044i7ym	250	18	and	and	CC
cord-263532-q044i7ym	250	19	concluded	conclude	VBD
cord-263532-q044i7ym	250	20	that	that	IN
cord-263532-q044i7ym	250	21	substrate	substrate	NN
cord-263532-q044i7ym	250	22	-	-	HYPH
cord-263532-q044i7ym	250	23	induced	induce	VBN
cord-263532-q044i7ym	250	24	dimerization	dimerization	NN
cord-263532-q044i7ym	250	25	is	be	VBZ
cord-263532-q044i7ym	250	26	essential	essential	JJ
cord-263532-q044i7ym	250	27	for	for	IN
cord-263532-q044i7ym	250	28	the	the	DT
cord-263532-q044i7ym	250	29	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	250	30	activity	activity	NN
cord-263532-q044i7ym	250	31	of	of	IN
cord-263532-q044i7ym	250	32	SARS	SARS	NNP
cord-263532-q044i7ym	250	33	-	-	HYPH
cord-263532-q044i7ym	250	34	CoV	CoV	NNP
cord-263532-q044i7ym	250	35	M	M	NNP
cord-263532-q044i7ym	250	36	pro	pro	JJ
cord-263532-q044i7ym	250	37	in	in	IN
cord-263532-q044i7ym	250	38	the	the	DT
cord-263532-q044i7ym	250	39	polyprotein	polyprotein	NN
cord-263532-q044i7ym	250	40	.	.	.
cord-263532-q044i7ym	251	1	43	43	CD
cord-263532-q044i7ym	252	1	A	a	DT
cord-263532-q044i7ym	252	2	modified	modified	JJ
cord-263532-q044i7ym	252	3	model	model	NN
cord-263532-q044i7ym	252	4	for	for	IN
cord-263532-q044i7ym	252	5	the	the	DT
cord-263532-q044i7ym	252	6	M	M	NNP
cord-263532-q044i7ym	252	7	pro	pro	JJ
cord-263532-q044i7ym	252	8	maturation	maturation	NN
cord-263532-q044i7ym	252	9	process	process	NN
cord-263532-q044i7ym	252	10	was	be	VBD
cord-263532-q044i7ym	252	11	proposed	propose	VBN
cord-263532-q044i7ym	252	12	in	in	IN
cord-263532-q044i7ym	252	13	the	the	DT
cord-263532-q044i7ym	252	14	study	study	NN
cord-263532-q044i7ym	252	15	.	.	.
cord-263532-q044i7ym	253	1	In	in	IN
cord-263532-q044i7ym	253	2	2010	2010	CD
cord-263532-q044i7ym	253	3	,	,	,
cord-263532-q044i7ym	253	4	Cheng	Cheng	NNP
cord-263532-q044i7ym	253	5	et	et	NNP
cord-263532-q044i7ym	253	6	al	al	NNP
cord-263532-q044i7ym	253	7	.	.	NNP
cord-263532-q044i7ym	253	8	demonstrated	demonstrate	VBD
cord-263532-q044i7ym	253	9	the	the	DT
cord-263532-q044i7ym	253	10	significance	significance	NN
cord-263532-q044i7ym	253	11	of	of	IN
cord-263532-q044i7ym	253	12	substrate	substrate	NN
cord-263532-q044i7ym	253	13	-	-	HYPH
cord-263532-q044i7ym	253	14	induced	induce	VBN
cord-263532-q044i7ym	253	15	dimerization	dimerization	NN
cord-263532-q044i7ym	253	16	of	of	IN
cord-263532-q044i7ym	253	17	M	M	NNP
cord-263532-q044i7ym	253	18	pro	pro	JJ
cord-263532-q044i7ym	253	19	to	to	IN
cord-263532-q044i7ym	253	20	its	-PRON-	PRP$
cord-263532-q044i7ym	253	21	catalytic	catalytic	JJ
cord-263532-q044i7ym	253	22	mechanism	mechanism	NN
cord-263532-q044i7ym	253	23	.	.	.
cord-263532-q044i7ym	254	1	44	44	CD
cord-263532-q044i7ym	255	1	The	the	DT
cord-263532-q044i7ym	255	2	results	result	NNS
cord-263532-q044i7ym	255	3	of	of	IN
cord-263532-q044i7ym	255	4	the	the	DT
cord-263532-q044i7ym	255	5	experimental	experimental	JJ
cord-263532-q044i7ym	255	6	studies	study	NNS
cord-263532-q044i7ym	255	7	highlighted	highlight	VBD
cord-263532-q044i7ym	255	8	that	that	IN
cord-263532-q044i7ym	255	9	dimerization	dimerization	NN
cord-263532-q044i7ym	255	10	of	of	IN
cord-263532-q044i7ym	255	11	M	M	NNP
cord-263532-q044i7ym	255	12	pro	pro	JJ
cord-263532-q044i7ym	255	13	was	be	VBD
cord-263532-q044i7ym	255	14	necessary	necessary	JJ
cord-263532-q044i7ym	255	15	for	for	IN
cord-263532-q044i7ym	255	16	the	the	DT
cord-263532-q044i7ym	255	17	protease	protease	NN
cord-263532-q044i7ym	255	18	activity	activity	NN
cord-263532-q044i7ym	255	19	.	.	.
cord-263532-q044i7ym	256	1	The	the	DT
cord-263532-q044i7ym	256	2	mutagenesis	mutagenesis	NN
cord-263532-q044i7ym	256	3	studies	study	NNS
cord-263532-q044i7ym	256	4	highlighted	highlight	VBD
cord-263532-q044i7ym	256	5	that	that	IN
cord-263532-q044i7ym	256	6	Glu166	glu166	DT
cord-263532-q044i7ym	256	7	plays	play	VBZ
cord-263532-q044i7ym	256	8	a	a	DT
cord-263532-q044i7ym	256	9	linking	link	VBG
cord-263532-q044i7ym	256	10	role	role	NN
cord-263532-q044i7ym	256	11	between	between	IN
cord-263532-q044i7ym	256	12	dimer	dimer	NN
cord-263532-q044i7ym	256	13	interface	interface	NN
cord-263532-q044i7ym	256	14	and	and	CC
cord-263532-q044i7ym	256	15	substrate	substrate	NN
cord-263532-q044i7ym	256	16	binding	bind	VBG
cord-263532-q044i7ym	256	17	site	site	NN
cord-263532-q044i7ym	256	18	.	.	.
cord-263532-q044i7ym	257	1	The	the	DT
cord-263532-q044i7ym	257	2	authors	author	NNS
cord-263532-q044i7ym	257	3	mentioned	mention	VBD
cord-263532-q044i7ym	257	4	that	that	IN
cord-263532-q044i7ym	257	5	the	the	DT
cord-263532-q044i7ym	257	6	connection	connection	NN
cord-263532-q044i7ym	257	7	between	between	IN
cord-263532-q044i7ym	257	8	dimer	dimer	NN
cord-263532-q044i7ym	257	9	interface	interface	NN
cord-263532-q044i7ym	257	10	and	and	CC
cord-263532-q044i7ym	257	11	substrate	substrate	NN
cord-263532-q044i7ym	257	12	binding	bind	VBG
cord-263532-q044i7ym	257	13	site	site	NN
cord-263532-q044i7ym	257	14	by	by	IN
cord-263532-q044i7ym	257	15	Glu166	Glu166	NNP
cord-263532-q044i7ym	257	16	may	may	MD
cord-263532-q044i7ym	257	17	be	be	VB
cord-263532-q044i7ym	257	18	universal	universal	JJ
cord-263532-q044i7ym	257	19	in	in	IN
cord-263532-q044i7ym	257	20	all	all	DT
cord-263532-q044i7ym	257	21	proteases	protease	NNS
cord-263532-q044i7ym	257	22	among	among	IN
cord-263532-q044i7ym	257	23	various	various	JJ
cord-263532-q044i7ym	257	24	CoVs	covs	NN
cord-263532-q044i7ym	257	25	.	.	.
cord-263532-q044i7ym	258	1	The	the	DT
cord-263532-q044i7ym	258	2	another	another	DT
cord-263532-q044i7ym	258	3	study	study	NN
cord-263532-q044i7ym	258	4	highlighted	highlight	VBD
cord-263532-q044i7ym	258	5	that	that	IN
cord-263532-q044i7ym	258	6	Asn28	Asn28	NNP
cord-263532-q044i7ym	258	7	was	be	VBD
cord-263532-q044i7ym	258	8	essential	essential	JJ
cord-263532-q044i7ym	258	9	for	for	IN
cord-263532-q044i7ym	258	10	the	the	DT
cord-263532-q044i7ym	258	11	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	258	12	activity	activity	NN
cord-263532-q044i7ym	258	13	and	and	CC
cord-263532-q044i7ym	258	14	dimerization	dimerization	NN
cord-263532-q044i7ym	258	15	of	of	IN
cord-263532-q044i7ym	258	16	SARS	SARS	NNP
cord-263532-q044i7ym	258	17	-	-	HYPH
cord-263532-q044i7ym	258	18	CoV	CoV	NNP
cord-263532-q044i7ym	258	19	M	M	NNP
cord-263532-q044i7ym	258	20	pro	pro	NNP
cord-263532-q044i7ym	258	21	.	.	NNP
cord-263532-q044i7ym	258	22	31	31	CD
cord-263532-q044i7ym	259	1	The	the	DT
cord-263532-q044i7ym	259	2	N28A	n28a	NN
cord-263532-q044i7ym	259	3	mutation	mutation	NN
cord-263532-q044i7ym	259	4	led	lead	VBD
cord-263532-q044i7ym	259	5	to	to	IN
cord-263532-q044i7ym	259	6	a	a	DT
cord-263532-q044i7ym	259	7	complete	complete	JJ
cord-263532-q044i7ym	259	8	inactivation	inactivation	NN
cord-263532-q044i7ym	259	9	of	of	IN
cord-263532-q044i7ym	259	10	the	the	DT
cord-263532-q044i7ym	259	11	enzyme	enzyme	NN
cord-263532-q044i7ym	259	12	and	and	CC
cord-263532-q044i7ym	259	13	a	a	DT
cord-263532-q044i7ym	259	14	decrease	decrease	NN
cord-263532-q044i7ym	259	15	of	of	IN
cord-263532-q044i7ym	259	16	19.2-fold	19.2-fold	CD
cord-263532-q044i7ym	259	17	in	in	IN
cord-263532-q044i7ym	259	18	the	the	DT
cord-263532-q044i7ym	259	19	dimerization	dimerization	NN
cord-263532-q044i7ym	259	20	K	K	NNP
cord-263532-q044i7ym	259	21	d	d	NNP
cord-263532-q044i7ym	259	22	.	.	.
cord-263532-q044i7ym	260	1	The	the	DT
cord-263532-q044i7ym	260	2	interactions	interaction	NNS
cord-263532-q044i7ym	260	3	between	between	IN
cord-263532-q044i7ym	260	4	Asn28	Asn28	NNP
cord-263532-q044i7ym	260	5	and	and	CC
cord-263532-q044i7ym	260	6	Cys117	Cys117	.
cord-263532-q044i7ym	260	7	play	play	VB
cord-263532-q044i7ym	260	8	a	a	DT
cord-263532-q044i7ym	260	9	key	key	JJ
cord-263532-q044i7ym	260	10	role	role	NN
cord-263532-q044i7ym	260	11	in	in	IN
cord-263532-q044i7ym	260	12	the	the	DT
cord-263532-q044i7ym	260	13	dimer	dimer	NN
cord-263532-q044i7ym	260	14	stability	stability	NN
cord-263532-q044i7ym	260	15	and	and	CC
cord-263532-q044i7ym	260	16	enzymatic	enzymatic	JJ
cord-263532-q044i7ym	260	17	activity	activity	NN
cord-263532-q044i7ym	260	18	of	of	IN
cord-263532-q044i7ym	260	19	SARS	SARS	NNP
cord-263532-q044i7ym	260	20	-	-	HYPH
cord-263532-q044i7ym	260	21	CoV	CoV	NNP
cord-263532-q044i7ym	260	22	M	M	NNP
cord-263532-q044i7ym	260	23	pro	pro	NNP
cord-263532-q044i7ym	260	24	.	.	.
cord-263532-q044i7ym	261	1	The	the	DT
cord-263532-q044i7ym	261	2	residue	residue	NN
cord-263532-q044i7ym	261	3	Asn28	Asn28	NNP
cord-263532-q044i7ym	261	4	,	,	,
cord-263532-q044i7ym	261	5	a	a	DT
cord-263532-q044i7ym	261	6	buried	bury	VBN
cord-263532-q044i7ym	261	7	residue	residue	NN
cord-263532-q044i7ym	261	8	,	,	,
cord-263532-q044i7ym	261	9	display	display	NN
cord-263532-q044i7ym	261	10	interactions	interaction	NNS
cord-263532-q044i7ym	261	11	with	with	IN
cord-263532-q044i7ym	261	12	catalytic	catalytic	JJ
cord-263532-q044i7ym	261	13	loop	loop	NN
cord-263532-q044i7ym	261	14	and	and	CC
cord-263532-q044i7ym	261	15	βsheet	βsheet	NNP
cord-263532-q044i7ym	261	16	region	region	NN
cord-263532-q044i7ym	261	17	of	of	IN
cord-263532-q044i7ym	261	18	SARS	SARS	NNP
cord-263532-q044i7ym	261	19	-	-	HYPH
cord-263532-q044i7ym	261	20	CoV	CoV	NNP
cord-263532-q044i7ym	261	21	M	M	NNP
cord-263532-q044i7ym	261	22	pro	pro	NNP
cord-263532-q044i7ym	261	23	where	where	WRB
cord-263532-q044i7ym	261	24	Cys117	Cys117	-LRB-
cord-263532-q044i7ym	261	25	is	be	VBZ
cord-263532-q044i7ym	261	26	present	present	JJ
cord-263532-q044i7ym	261	27	.	.	.
cord-263532-q044i7ym	262	1	The	the	DT
cord-263532-q044i7ym	262	2	conformational	conformational	JJ
cord-263532-q044i7ym	262	3	switch	switch	NN
cord-263532-q044i7ym	262	4	of	of	IN
cord-263532-q044i7ym	262	5	residues	residue	NNS
cord-263532-q044i7ym	262	6	(	(	-LRB-
cord-263532-q044i7ym	262	7	Ser139	Ser139	NNP
cord-263532-q044i7ym	262	8	,	,	,
cord-263532-q044i7ym	262	9	Phe140	phe140	CD
cord-263532-q044i7ym	262	10	,	,	,
cord-263532-q044i7ym	262	11	and	and	CC
cord-263532-q044i7ym	262	12	Leu141	leu141	CD
cord-263532-q044i7ym	262	13	)	)	-RRB-
cord-263532-q044i7ym	262	14	in	in	IN
cord-263532-q044i7ym	262	15	the	the	DT
cord-263532-q044i7ym	262	16	catalytic	catalytic	JJ
cord-263532-q044i7ym	262	17	loop	loop	NN
cord-263532-q044i7ym	262	18	region	region	NN
cord-263532-q044i7ym	262	19	from	from	IN
cord-263532-q044i7ym	262	20	standard	standard	JJ
cord-263532-q044i7ym	262	21	loop	loop	NN
cord-263532-q044i7ym	262	22	conformation	conformation	NN
cord-263532-q044i7ym	262	23	to	to	IN
cord-263532-q044i7ym	262	24	a	a	DT
cord-263532-q044i7ym	262	25	short	short	JJ
cord-263532-q044i7ym	262	26	3	3	CD
cord-263532-q044i7ym	262	27	10	10	CD
cord-263532-q044i7ym	262	28	-helical	-helical	JJ
cord-263532-q044i7ym	262	29	conformation	conformation	NN
cord-263532-q044i7ym	262	30	lead	lead	NN
cord-263532-q044i7ym	262	31	to	to	IN
cord-263532-q044i7ym	262	32	a	a	DT
cord-263532-q044i7ym	262	33	diminished	diminished	JJ
cord-263532-q044i7ym	262	34	dimerization	dimerization	NN
cord-263532-q044i7ym	262	35	of	of	IN
cord-263532-q044i7ym	262	36	M	M	NNP
cord-263532-q044i7ym	262	37	pro	pro	JJ
cord-263532-q044i7ym	262	38	.	.	.
cord-263532-q044i7ym	263	1	The	the	DT
cord-263532-q044i7ym	263	2	N28A	n28a	NN
cord-263532-q044i7ym	263	3	mutant	mutant	JJ
cord-263532-q044i7ym	263	4	crystal	crystal	NN
cord-263532-q044i7ym	263	5	structure	structure	NN
cord-263532-q044i7ym	263	6	revealed	reveal	VBD
cord-263532-q044i7ym	263	7	about	about	IN
cord-263532-q044i7ym	263	8	the	the	DT
cord-263532-q044i7ym	263	9	critical	critical	JJ
cord-263532-q044i7ym	263	10	role	role	NN
cord-263532-q044i7ym	263	11	of	of	IN
cord-263532-q044i7ym	263	12	Asn28	Asn28	NNP
cord-263532-q044i7ym	263	13	in	in	IN
cord-263532-q044i7ym	263	14	preserving	preserve	VBG
cord-263532-q044i7ym	263	15	the	the	DT
cord-263532-q044i7ym	263	16	structural	structural	JJ
cord-263532-q044i7ym	263	17	integrity	integrity	NN
cord-263532-q044i7ym	263	18	of	of	IN
cord-263532-q044i7ym	263	19	the	the	DT
cord-263532-q044i7ym	263	20	active	active	JJ
cord-263532-q044i7ym	263	21	site	site	NN
cord-263532-q044i7ym	263	22	and	and	CC
cord-263532-q044i7ym	263	23	in	in	IN
cord-263532-q044i7ym	263	24	positioning	position	VBG
cord-263532-q044i7ym	263	25	critical	critical	JJ
cord-263532-q044i7ym	263	26	residues	residue	NNS
cord-263532-q044i7ym	263	27	that	that	WDT
cord-263532-q044i7ym	263	28	are	be	VBP
cord-263532-q044i7ym	263	29	involved	involve	VBN
cord-263532-q044i7ym	263	30	in	in	IN
cord-263532-q044i7ym	263	31	binding	bind	VBG
cord-263532-q044i7ym	263	32	at	at	IN
cord-263532-q044i7ym	263	33	the	the	DT
cord-263532-q044i7ym	263	34	dimer	dimer	NN
cord-263532-q044i7ym	263	35	interface	interface	NN
cord-263532-q044i7ym	263	36	and	and	CC
cord-263532-q044i7ym	263	37	substrate	substrate	NN
cord-263532-q044i7ym	263	38	catalysis	catalysis	NN
cord-263532-q044i7ym	263	39	.	.	.
cord-263532-q044i7ym	264	1	COVID-19	COVID-19	NNP
cord-263532-q044i7ym	264	2	,	,	,
cord-263532-q044i7ym	264	3	a	a	DT
cord-263532-q044i7ym	264	4	novel	novel	JJ
cord-263532-q044i7ym	264	5	infectious	infectious	JJ
cord-263532-q044i7ym	264	6	disease	disease	NN
cord-263532-q044i7ym	264	7	caused	cause	VBN
cord-263532-q044i7ym	264	8	by	by	IN
cord-263532-q044i7ym	264	9	a	a	DT
cord-263532-q044i7ym	264	10	singlestranded	singlestranded	JJ
cord-263532-q044i7ym	264	11	positive	positive	JJ
cord-263532-q044i7ym	264	12	-	-	HYPH
cord-263532-q044i7ym	264	13	sense	sense	NN
cord-263532-q044i7ym	264	14	RNA	RNA	NNP
cord-263532-q044i7ym	264	15	virus	virus	NN
cord-263532-q044i7ym	264	16	,	,	,
cord-263532-q044i7ym	264	17	has	have	VBZ
cord-263532-q044i7ym	264	18	presented	present	VBN
cord-263532-q044i7ym	264	19	a	a	DT
cord-263532-q044i7ym	264	20	serious	serious	JJ
cord-263532-q044i7ym	264	21	worldwide	worldwide	JJ
cord-263532-q044i7ym	264	22	public	public	JJ
cord-263532-q044i7ym	264	23	health	health	NN
cord-263532-q044i7ym	264	24	care	care	NN
cord-263532-q044i7ym	264	25	emergency	emergency	NN
cord-263532-q044i7ym	264	26	.	.	.
cord-263532-q044i7ym	265	1	The	the	DT
cord-263532-q044i7ym	265	2	whole	whole	JJ
cord-263532-q044i7ym	265	3	world	world	NN
cord-263532-q044i7ym	265	4	remains	remain	VBZ
cord-263532-q044i7ym	265	5	unprepared	unprepared	JJ
cord-263532-q044i7ym	265	6	to	to	TO
cord-263532-q044i7ym	265	7	efficiently	efficiently	RB
cord-263532-q044i7ym	265	8	control	control	VB
cord-263532-q044i7ym	265	9	this	this	DT
cord-263532-q044i7ym	265	10	infectious	infectious	JJ
cord-263532-q044i7ym	265	11	disease	disease	NN
cord-263532-q044i7ym	265	12	,	,	,
cord-263532-q044i7ym	265	13	despite	despite	IN
cord-263532-q044i7ym	265	14	the	the	DT
cord-263532-q044i7ym	265	15	lessons	lesson	NNS
cord-263532-q044i7ym	265	16	learned	learn	VBN
cord-263532-q044i7ym	265	17	from	from	IN
cord-263532-q044i7ym	265	18	the	the	DT
cord-263532-q044i7ym	265	19	previous	previous	JJ
cord-263532-q044i7ym	265	20	coronavirus	coronavirus	NN
cord-263532-q044i7ym	265	21	(	(	-LRB-
cord-263532-q044i7ym	265	22	CoV	CoV	NNP
cord-263532-q044i7ym	265	23	)	)	-RRB-
cord-263532-q044i7ym	265	24	infections	infection	NNS
cord-263532-q044i7ym	265	25	that	that	WDT
cord-263532-q044i7ym	265	26	caused	cause	VBD
cord-263532-q044i7ym	265	27	SARS	SARS	NNP
cord-263532-q044i7ym	265	28	and	and	CC
cord-263532-q044i7ym	265	29	MERS	MERS	NNP
cord-263532-q044i7ym	265	30	.	.	.
cord-263532-q044i7ym	266	1	Scientists	scientist	NNS
cord-263532-q044i7ym	266	2	around	around	IN
cord-263532-q044i7ym	266	3	the	the	DT
cord-263532-q044i7ym	266	4	world	world	NN
cord-263532-q044i7ym	266	5	are	be	VBP
cord-263532-q044i7ym	266	6	looking	look	VBG
cord-263532-q044i7ym	266	7	for	for	IN
cord-263532-q044i7ym	266	8	effective	effective	JJ
cord-263532-q044i7ym	266	9	and	and	CC
cord-263532-q044i7ym	266	10	promising	promising	JJ
cord-263532-q044i7ym	266	11	therapeutic	therapeutic	JJ
cord-263532-q044i7ym	266	12	antiviral	antiviral	JJ
cord-263532-q044i7ym	266	13	agents	agent	NNS
cord-263532-q044i7ym	266	14	as	as	RB
cord-263532-q044i7ym	266	15	well	well	RB
cord-263532-q044i7ym	266	16	as	as	IN
cord-263532-q044i7ym	266	17	vaccine	vaccine	NN
cord-263532-q044i7ym	266	18	candidates	candidate	NNS
cord-263532-q044i7ym	266	19	for	for	IN
cord-263532-q044i7ym	266	20	combating	combat	VBG
cord-263532-q044i7ym	266	21	COVID-19	COVID-19	NNP
cord-263532-q044i7ym	266	22	.	.	.
cord-263532-q044i7ym	267	1	However	however	RB
cord-263532-q044i7ym	267	2	,	,	,
cord-263532-q044i7ym	267	3	no	no	DT
cord-263532-q044i7ym	267	4	specific	specific	JJ
cord-263532-q044i7ym	267	5	antiviral	antiviral	JJ
cord-263532-q044i7ym	267	6	drugs	drug	NNS
cord-263532-q044i7ym	267	7	or	or	CC
cord-263532-q044i7ym	267	8	effective	effective	JJ
cord-263532-q044i7ym	267	9	vaccines	vaccine	NNS
cord-263532-q044i7ym	267	10	for	for	IN
cord-263532-q044i7ym	267	11	COVID-19	covid-19	CD
cord-263532-q044i7ym	267	12	have	have	VBP
cord-263532-q044i7ym	267	13	been	be	VBN
cord-263532-q044i7ym	267	14	discovered	discover	VBN
cord-263532-q044i7ym	267	15	to	to	IN
cord-263532-q044i7ym	267	16	date	date	NN
cord-263532-q044i7ym	267	17	.	.	.
cord-263532-q044i7ym	268	1	The	the	DT
cord-263532-q044i7ym	268	2	genetic	genetic	JJ
cord-263532-q044i7ym	268	3	reshuffling	reshuffling	NN
cord-263532-q044i7ym	268	4	,	,	,
cord-263532-q044i7ym	268	5	mutations	mutation	NNS
cord-263532-q044i7ym	268	6	,	,	,
cord-263532-q044i7ym	268	7	and	and	CC
cord-263532-q044i7ym	268	8	interspecies	interspecies	NN
cord-263532-q044i7ym	268	9	transmission	transmission	NN
cord-263532-q044i7ym	268	10	of	of	IN
cord-263532-q044i7ym	268	11	the	the	DT
cord-263532-q044i7ym	268	12	RNA	RNA	NNP
cord-263532-q044i7ym	268	13	viruses	virus	NNS
cord-263532-q044i7ym	268	14	highlight	highlight	VBP
cord-263532-q044i7ym	268	15	the	the	DT
cord-263532-q044i7ym	268	16	urgent	urgent	JJ
cord-263532-q044i7ym	268	17	need	need	NN
cord-263532-q044i7ym	268	18	for	for	IN
cord-263532-q044i7ym	268	19	the	the	DT
cord-263532-q044i7ym	268	20	design	design	NN
cord-263532-q044i7ym	268	21	and	and	CC
cord-263532-q044i7ym	268	22	development	development	NN
cord-263532-q044i7ym	268	23	of	of	IN
cord-263532-q044i7ym	268	24	broad	broad	JJ
cord-263532-q044i7ym	268	25	-	-	HYPH
cord-263532-q044i7ym	268	26	spectrum	spectrum	NN
cord-263532-q044i7ym	268	27	antiviral	antiviral	JJ
cord-263532-q044i7ym	268	28	drugs	drug	NNS
cord-263532-q044i7ym	268	29	.	.	.
cord-263532-q044i7ym	269	1	Thus	thus	RB
cord-263532-q044i7ym	269	2	,	,	,
cord-263532-q044i7ym	269	3	a	a	DT
cord-263532-q044i7ym	269	4	coherent	coherent	JJ
cord-263532-q044i7ym	269	5	effort	effort	NN
cord-263532-q044i7ym	269	6	is	be	VBZ
cord-263532-q044i7ym	269	7	required	require	VBN
cord-263532-q044i7ym	269	8	to	to	TO
cord-263532-q044i7ym	269	9	develop	develop	VB
cord-263532-q044i7ym	269	10	effective	effective	JJ
cord-263532-q044i7ym	269	11	drugs	drug	NNS
cord-263532-q044i7ym	269	12	and	and	CC
cord-263532-q044i7ym	269	13	vaccines	vaccine	NNS
cord-263532-q044i7ym	269	14	against	against	IN
cord-263532-q044i7ym	269	15	CoV	cov	NN
cord-263532-q044i7ym	269	16	infections	infection	NNS
cord-263532-q044i7ym	269	17	and	and	CC
cord-263532-q044i7ym	269	18	other	other	JJ
cord-263532-q044i7ym	269	19	highly	highly	RB
cord-263532-q044i7ym	269	20	pathogenic	pathogenic	JJ
cord-263532-q044i7ym	269	21	viruses	virus	NNS
cord-263532-q044i7ym	269	22	to	to	TO
cord-263532-q044i7ym	269	23	decrease	decrease	VB
cord-263532-q044i7ym	269	24	the	the	DT
cord-263532-q044i7ym	269	25	devastating	devastating	JJ
cord-263532-q044i7ym	269	26	impact	impact	NN
cord-263532-q044i7ym	269	27	on	on	IN
cord-263532-q044i7ym	269	28	human	human	JJ
cord-263532-q044i7ym	269	29	life	life	NN
cord-263532-q044i7ym	269	30	.	.	.
cord-263532-q044i7ym	270	1	As	as	IN
cord-263532-q044i7ym	270	2	the	the	DT
cord-263532-q044i7ym	270	3	clinical	clinical	JJ
cord-263532-q044i7ym	270	4	drug	drug	NN
cord-263532-q044i7ym	270	5	discovery	discovery	NN
cord-263532-q044i7ym	270	6	and	and	CC
cord-263532-q044i7ym	270	7	development	development	NN
cord-263532-q044i7ym	270	8	process	process	NN
cord-263532-q044i7ym	270	9	is	be	VBZ
cord-263532-q044i7ym	270	10	costly	costly	JJ
cord-263532-q044i7ym	270	11	,	,	,
cord-263532-q044i7ym	270	12	time	time	NN
cord-263532-q044i7ym	270	13	extensive	extensive	JJ
cord-263532-q044i7ym	270	14	,	,	,
cord-263532-q044i7ym	270	15	and	and	CC
cord-263532-q044i7ym	270	16	difficult	difficult	JJ
cord-263532-q044i7ym	270	17	,	,	,
cord-263532-q044i7ym	270	18	the	the	DT
cord-263532-q044i7ym	270	19	design	design	NN
cord-263532-q044i7ym	270	20	and	and	CC
cord-263532-q044i7ym	270	21	development	development	NN
cord-263532-q044i7ym	270	22	of	of	IN
cord-263532-q044i7ym	270	23	broadspectrum	broadspectrum	NNP
cord-263532-q044i7ym	270	24	antiviral	antiviral	JJ
cord-263532-q044i7ym	270	25	drugs	drug	NNS
cord-263532-q044i7ym	270	26	are	be	VBP
cord-263532-q044i7ym	270	27	of	of	IN
cord-263532-q044i7ym	270	28	paramount	paramount	JJ
cord-263532-q044i7ym	270	29	importance	importance	NN
cord-263532-q044i7ym	270	30	.	.	.
cord-263532-q044i7ym	271	1	Thus	thus	RB
cord-263532-q044i7ym	271	2	,	,	,
cord-263532-q044i7ym	271	3	drugs	drug	NNS
cord-263532-q044i7ym	271	4	targeting	target	VBG
cord-263532-q044i7ym	271	5	highly	highly	RB
cord-263532-q044i7ym	271	6	conserved	conserve	VBN
cord-263532-q044i7ym	271	7	proteins	protein	NNS
cord-263532-q044i7ym	271	8	such	such	JJ
cord-263532-q044i7ym	271	9	as	as	IN
cord-263532-q044i7ym	271	10	main	main	JJ
cord-263532-q044i7ym	271	11	protease	protease	NN
cord-263532-q044i7ym	271	12	(	(	-LRB-
cord-263532-q044i7ym	271	13	M	M	NNP
cord-263532-q044i7ym	271	14	pro	pro	FW
cord-263532-q044i7ym	271	15	)	)	-RRB-
cord-263532-q044i7ym	271	16	among	among	IN
cord-263532-q044i7ym	271	17	various	various	JJ
cord-263532-q044i7ym	271	18	CoVs	CoVs	NNP
cord-263532-q044i7ym	271	19	will	will	MD
cord-263532-q044i7ym	271	20	provide	provide	VB
cord-263532-q044i7ym	271	21	two	two	CD
cord-263532-q044i7ym	271	22	advantages	advantage	NNS
cord-263532-q044i7ym	271	23	:	:	:
cord-263532-q044i7ym	271	24	(	(	-LRB-
cord-263532-q044i7ym	271	25	i	i	NN
cord-263532-q044i7ym	271	26	)	)	-RRB-
cord-263532-q044i7ym	272	1	the	the	DT
cord-263532-q044i7ym	272	2	potential	potential	NN
cord-263532-q044i7ym	272	3	for	for	IN
cord-263532-q044i7ym	272	4	broad	broad	JJ
cord-263532-q044i7ym	272	5	-	-	HYPH
cord-263532-q044i7ym	272	6	spectrum	spectrum	NN
cord-263532-q044i7ym	272	7	antiviral	antiviral	JJ
cord-263532-q044i7ym	272	8	activity	activity	NN
cord-263532-q044i7ym	272	9	,	,	,
cord-263532-q044i7ym	272	10	and	and	CC
cord-263532-q044i7ym	272	11	(	(	-LRB-
cord-263532-q044i7ym	272	12	ii	ii	NN
cord-263532-q044i7ym	272	13	)	)	-RRB-
cord-263532-q044i7ym	272	14	reduced	reduce	VBN
cord-263532-q044i7ym	272	15	risk	risk	NN
cord-263532-q044i7ym	272	16	of	of	IN
cord-263532-q044i7ym	272	17	mutation	mutation	NN
cord-263532-q044i7ym	272	18	-	-	HYPH
cord-263532-q044i7ym	272	19	mediated	mediate	VBN
cord-263532-q044i7ym	272	20	drug	drug	NN
cord-263532-q044i7ym	272	21	resistance	resistance	NN
cord-263532-q044i7ym	272	22	.	.	.
cord-263532-q044i7ym	273	1	The	the	DT
cord-263532-q044i7ym	273	2	CAS	CAS	NNP
cord-263532-q044i7ym	273	3	data	datum	NNS
cord-263532-q044i7ym	273	4	highlighted	highlight	VBD
cord-263532-q044i7ym	273	5	that	that	IN
cord-263532-q044i7ym	273	6	SARS	SARS	NNP
cord-263532-q044i7ym	273	7	-	-	HYPH
cord-263532-q044i7ym	273	8	CoV	CoV	NNP
cord-263532-q044i7ym	273	9	M	M	NNP
cord-263532-q044i7ym	273	10	pro	pro	NNP
cord-263532-q044i7ym	273	11	has	have	VBZ
cord-263532-q044i7ym	273	12	drawn	draw	VBN
cord-263532-q044i7ym	273	13	significantly	significantly	RB
cord-263532-q044i7ym	273	14	more	more	JJR
cord-263532-q044i7ym	273	15	attention	attention	NN
cord-263532-q044i7ym	273	16	than	than	IN
cord-263532-q044i7ym	273	17	other	other	JJ
cord-263532-q044i7ym	273	18	targets	target	NNS
cord-263532-q044i7ym	273	19	,	,	,
cord-263532-q044i7ym	273	20	and	and	CC
cord-263532-q044i7ym	273	21	a	a	DT
cord-263532-q044i7ym	273	22	large	large	JJ
cord-263532-q044i7ym	273	23	number	number	NN
cord-263532-q044i7ym	273	24	of	of	IN
cord-263532-q044i7ym	273	25	compounds	compound	NNS
cord-263532-q044i7ym	273	26	with	with	IN
cord-263532-q044i7ym	273	27	therapeutic	therapeutic	JJ
cord-263532-q044i7ym	273	28	potential	potential	NN
cord-263532-q044i7ym	273	29	have	have	VBP
cord-263532-q044i7ym	273	30	been	be	VBN
cord-263532-q044i7ym	273	31	identified	identify	VBN
cord-263532-q044i7ym	273	32	against	against	IN
cord-263532-q044i7ym	273	33	SARS	SARS	NNP
cord-263532-q044i7ym	273	34	-	-	HYPH
cord-263532-q044i7ym	273	35	CoV	CoV	NNP
cord-263532-q044i7ym	273	36	M	M	NNP
cord-263532-q044i7ym	273	37	pro	pro	NNP
cord-263532-q044i7ym	273	38	.	.	.
cord-263532-q044i7ym	274	1	A	a	DT
cord-263532-q044i7ym	274	2	total	total	JJ
cord-263532-q044i7ym	274	3	number	number	NN
cord-263532-q044i7ym	274	4	of	of	IN
cord-263532-q044i7ym	274	5	49	49	CD
cord-263532-q044i7ym	274	6	patents	patent	NNS
cord-263532-q044i7ym	274	7	and	and	CC
cord-263532-q044i7ym	274	8	2178	2178	CD
cord-263532-q044i7ym	274	9	potential	potential	JJ
cord-263532-q044i7ym	274	10	drug	drug	NN
cord-263532-q044i7ym	274	11	candidates	candidate	NNS
cord-263532-q044i7ym	274	12	have	have	VBP
cord-263532-q044i7ym	274	13	been	be	VBN
cord-263532-q044i7ym	274	14	listed	list	VBN
cord-263532-q044i7ym	274	15	in	in	IN
cord-263532-q044i7ym	274	16	the	the	DT
cord-263532-q044i7ym	274	17	CAS	CAS	NNP
cord-263532-q044i7ym	274	18	Registry	Registry	NNP
cord-263532-q044i7ym	274	19	of	of	IN
cord-263532-q044i7ym	274	20	Chemical	Chemical	NNP
cord-263532-q044i7ym	274	21	Substances	Substances	NNPS
cord-263532-q044i7ym	274	22	for	for	IN
cord-263532-q044i7ym	274	23	M	M	NNP
cord-263532-q044i7ym	275	1	pro	pro	NNP
cord-263532-q044i7ym	275	2	.	.	NNP
cord-263532-q044i7ym	275	3	CoV	CoV	NNP
cord-263532-q044i7ym	275	4	-	-	HYPH
cord-263532-q044i7ym	275	5	infected	infect	VBN
cord-263532-q044i7ym	275	6	patients	patient	NNS
cord-263532-q044i7ym	275	7	administered	administer	VBN
cord-263532-q044i7ym	275	8	with	with	IN
cord-263532-q044i7ym	275	9	the	the	DT
cord-263532-q044i7ym	275	10	HIV	HIV	NNP
cord-263532-q044i7ym	275	11	drug	drug	NN
cord-263532-q044i7ym	275	12	combination	combination	NN
cord-263532-q044i7ym	275	13	of	of	IN
cord-263532-q044i7ym	275	14	lopinavir/	lopinavir/	CD
cord-263532-q044i7ym	275	15	ritonavir	ritonavir	NNS
cord-263532-q044i7ym	275	16	(	(	-LRB-
cord-263532-q044i7ym	275	17	Kaletra	Kaletra	NNP
cord-263532-q044i7ym	275	18	)	)	-RRB-
cord-263532-q044i7ym	275	19	,	,	,
cord-263532-q044i7ym	275	20	a	a	DT
cord-263532-q044i7ym	275	21	M	M	NNP
cord-263532-q044i7ym	275	22	pro	pro	JJ
cord-263532-q044i7ym	275	23	inhibitor	inhibitor	NN
cord-263532-q044i7ym	275	24	,	,	,
cord-263532-q044i7ym	275	25	have	have	VBP
cord-263532-q044i7ym	275	26	shown	show	VBN
cord-263532-q044i7ym	275	27	considerable	considerable	JJ
cord-263532-q044i7ym	275	28	improvement	improvement	NN
cord-263532-q044i7ym	275	29	(	(	-LRB-
cord-263532-q044i7ym	275	30	NCT04307693	NCT04307693	NNP
cord-263532-q044i7ym	275	31	46	46	CD
cord-263532-q044i7ym	275	32	and	and	CC
cord-263532-q044i7ym	275	33	NCT04255017	NCT04255017	NNP
cord-263532-q044i7ym	275	34	47	47	CD
cord-263532-q044i7ym	275	35	)	)	-RRB-
cord-263532-q044i7ym	275	36	,	,	,
cord-263532-q044i7ym	275	37	highlighting	highlight	VBG
cord-263532-q044i7ym	275	38	M	M	NNP
cord-263532-q044i7ym	275	39	pro	pro	NNP
cord-263532-q044i7ym	275	40	as	as	IN
cord-263532-q044i7ym	275	41	a	a	DT
cord-263532-q044i7ym	275	42	high	high	JJ
cord-263532-q044i7ym	275	43	-	-	HYPH
cord-263532-q044i7ym	275	44	value	value	NN
cord-263532-q044i7ym	275	45	target	target	NN
cord-263532-q044i7ym	275	46	for	for	IN
cord-263532-q044i7ym	275	47	the	the	DT
cord-263532-q044i7ym	275	48	development	development	NN
cord-263532-q044i7ym	275	49	of	of	IN
cord-263532-q044i7ym	275	50	drug	drug	NN
cord-263532-q044i7ym	275	51	candidates	candidate	NNS
cord-263532-q044i7ym	275	52	against	against	IN
cord-263532-q044i7ym	275	53	CoVs	CoVs	NNP
cord-263532-q044i7ym	275	54	.	.	.
cord-263532-q044i7ym	276	1	3	3	CD
cord-263532-q044i7ym	276	2	,	,	,
cord-263532-q044i7ym	276	3	48	48	CD
cord-263532-q044i7ym	277	1	Another	another	DT
cord-263532-q044i7ym	277	2	clinical	clinical	JJ
cord-263532-q044i7ym	277	3	trial	trial	NN
cord-263532-q044i7ym	277	4	study	study	NN
cord-263532-q044i7ym	277	5	on	on	IN
cord-263532-q044i7ym	277	6	ACS	ACS	NNP
cord-263532-q044i7ym	277	7	Combinatorial	Combinatorial	NNP
cord-263532-q044i7ym	277	8	Science	Science	NNP
cord-263532-q044i7ym	277	9	pubs.acs.org/acscombsci	pubs.acs.org/acscombsci	NNP
cord-263532-q044i7ym	277	10	Review	Review	NNP
cord-263532-q044i7ym	277	11	different	different	JJ
cord-263532-q044i7ym	277	12	combinations	combination	NNS
cord-263532-q044i7ym	277	13	of	of	IN
cord-263532-q044i7ym	277	14	protease	protease	NN
cord-263532-q044i7ym	277	15	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	277	16	such	such	JJ
cord-263532-q044i7ym	277	17	as	as	IN
cord-263532-q044i7ym	277	18	oseltamivir	oseltamivir	NNP
cord-263532-q044i7ym	277	19	,	,	,
cord-263532-q044i7ym	277	20	favipiravir	favipiravir	NNP
cord-263532-q044i7ym	277	21	,	,	,
cord-263532-q044i7ym	277	22	and	and	CC
cord-263532-q044i7ym	277	23	hydroxychloroquine	hydroxychloroquine	NNP
cord-263532-q044i7ym	277	24	(	(	-LRB-
cord-263532-q044i7ym	277	25	HCQ	HCQ	NNP
cord-263532-q044i7ym	277	26	)	)	-RRB-
cord-263532-q044i7ym	277	27	49	49	CD
cord-263532-q044i7ym	277	28	is	be	VBZ
cord-263532-q044i7ym	277	29	presently	presently	RB
cord-263532-q044i7ym	277	30	underway	underway	JJ
cord-263532-q044i7ym	277	31	for	for	IN
cord-263532-q044i7ym	277	32	treatment	treatment	NN
cord-263532-q044i7ym	277	33	of	of	IN
cord-263532-q044i7ym	277	34	COVID-19	COVID-19	NNP
cord-263532-q044i7ym	277	35	.	.	.
cord-263532-q044i7ym	278	1	50	50	CD
cord-263532-q044i7ym	279	1	Twenty	twenty	CD
cord-263532-q044i7ym	279	2	-	-	HYPH
cord-263532-q044i7ym	279	3	seven	seven	CD
cord-263532-q044i7ym	279	4	clinical	clinical	JJ
cord-263532-q044i7ym	279	5	trial	trial	NN
cord-263532-q044i7ym	279	6	studies	study	NNS
cord-263532-q044i7ym	279	7	registered	register	VBN
cord-263532-q044i7ym	279	8	with	with	IN
cord-263532-q044i7ym	279	9	the	the	DT
cord-263532-q044i7ym	279	10	U.S.	U.S.	NNP
cord-263532-q044i7ym	279	11	National	National	NNP
cord-263532-q044i7ym	279	12	Library	Library	NNP
cord-263532-q044i7ym	279	13	of	of	IN
cord-263532-q044i7ym	279	14	Medicine	Medicine	NNP
cord-263532-q044i7ym	279	15	database	database	NN
cord-263532-q044i7ym	279	16	were	be	VBD
cord-263532-q044i7ym	279	17	underway	underway	JJ
cord-263532-q044i7ym	279	18	on	on	IN
cord-263532-q044i7ym	279	19	the	the	DT
cord-263532-q044i7ym	279	20	protease	protease	NN
cord-263532-q044i7ym	279	21	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	279	22	in	in	IN
cord-263532-q044i7ym	279	23	CoV	cov	NN
cord-263532-q044i7ym	279	24	infections	infection	NNS
cord-263532-q044i7ym	279	25	as	as	IN
cord-263532-q044i7ym	279	26	of	of	IN
cord-263532-q044i7ym	279	27	May	May	NNP
cord-263532-q044i7ym	279	28	6	6	CD
cord-263532-q044i7ym	279	29	,	,	,
cord-263532-q044i7ym	279	30	2020	2020	CD
cord-263532-q044i7ym	279	31	.	.	.
cord-263532-q044i7ym	280	1	51	51	CD
cord-263532-q044i7ym	281	1	A	a	DT
cord-263532-q044i7ym	281	2	number	number	NN
cord-263532-q044i7ym	281	3	of	of	IN
cord-263532-q044i7ym	281	4	reports	report	NNS
cord-263532-q044i7ym	281	5	have	have	VBP
cord-263532-q044i7ym	281	6	been	be	VBN
cord-263532-q044i7ym	281	7	published	publish	VBN
cord-263532-q044i7ym	281	8	on	on	IN
cord-263532-q044i7ym	281	9	the	the	DT
cord-263532-q044i7ym	281	10	design	design	NN
cord-263532-q044i7ym	281	11	of	of	IN
cord-263532-q044i7ym	281	12	small	small	JJ
cord-263532-q044i7ym	281	13	-	-	HYPH
cord-263532-q044i7ym	281	14	molecule	molecule	NN
cord-263532-q044i7ym	281	15	and	and	CC
cord-263532-q044i7ym	281	16	peptidomimetic	peptidomimetic	NNP
cord-263532-q044i7ym	281	17	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	281	18	targeting	target	VBG
cord-263532-q044i7ym	281	19	the	the	DT
cord-263532-q044i7ym	281	20	substrate	substrate	NN
cord-263532-q044i7ym	281	21	binding	bind	VBG
cord-263532-q044i7ym	281	22	pocket	pocket	NN
cord-263532-q044i7ym	281	23	of	of	IN
cord-263532-q044i7ym	281	24	SARS	SARS	NNP
cord-263532-q044i7ym	281	25	-	-	HYPH
cord-263532-q044i7ym	281	26	CoV	CoV	NNP
cord-263532-q044i7ym	281	27	M	M	NNP
cord-263532-q044i7ym	281	28	pro	pro	NNP
cord-263532-q044i7ym	281	29	.	.	.
cord-263532-q044i7ym	282	1	12	12	CD
cord-263532-q044i7ym	282	2	,	,	,
cord-263532-q044i7ym	282	3	13	13	CD
cord-263532-q044i7ym	283	1	However	however	RB
cord-263532-q044i7ym	283	2	,	,	,
cord-263532-q044i7ym	283	3	no	no	DT
cord-263532-q044i7ym	283	4	such	such	JJ
cord-263532-q044i7ym	283	5	inhibitor	inhibitor	NN
cord-263532-q044i7ym	283	6	has	have	VBZ
cord-263532-q044i7ym	283	7	advanced	advance	VBN
cord-263532-q044i7ym	283	8	to	to	IN
cord-263532-q044i7ym	283	9	clinical	clinical	JJ
cord-263532-q044i7ym	283	10	trials	trial	NNS
cord-263532-q044i7ym	283	11	to	to	IN
cord-263532-q044i7ym	283	12	date	date	NN
cord-263532-q044i7ym	283	13	.	.	.
cord-263532-q044i7ym	284	1	An	an	DT
cord-263532-q044i7ym	284	2	alternative	alternative	JJ
cord-263532-q044i7ym	284	3	approach	approach	NN
cord-263532-q044i7ym	284	4	includes	include	VBZ
cord-263532-q044i7ym	284	5	the	the	DT
cord-263532-q044i7ym	284	6	combinatorial	combinatorial	JJ
cord-263532-q044i7ym	284	7	design	design	NN
cord-263532-q044i7ym	284	8	of	of	IN
cord-263532-q044i7ym	284	9	peptide	peptide	NN
cord-263532-q044i7ym	284	10	-	-	HYPH
cord-263532-q044i7ym	284	11	based	base	VBN
cord-263532-q044i7ym	284	12	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	284	13	that	that	WDT
cord-263532-q044i7ym	284	14	target	target	VBP
cord-263532-q044i7ym	284	15	the	the	DT
cord-263532-q044i7ym	284	16	dimerization	dimerization	NN
cord-263532-q044i7ym	284	17	of	of	IN
cord-263532-q044i7ym	284	18	SARS	SARS	NNP
cord-263532-q044i7ym	284	19	-	-	HYPH
cord-263532-q044i7ym	284	20	CoV	CoV	NNP
cord-263532-q044i7ym	284	21	M	M	NNP
cord-263532-q044i7ym	284	22	pro	pro	NNP
cord-263532-q044i7ym	284	23	as	as	IN
cord-263532-q044i7ym	284	24	a	a	DT
cord-263532-q044i7ym	284	25	potential	potential	JJ
cord-263532-q044i7ym	284	26	therapeutic	therapeutic	JJ
cord-263532-q044i7ym	284	27	strategy	strategy	NN
cord-263532-q044i7ym	284	28	.	.	.
cord-263532-q044i7ym	285	1	Dimerization	Dimerization	NNP
cord-263532-q044i7ym	285	2	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	285	3	have	have	VBP
cord-263532-q044i7ym	285	4	been	be	VBN
cord-263532-q044i7ym	285	5	successfully	successfully	RB
cord-263532-q044i7ym	285	6	employed	employ	VBN
cord-263532-q044i7ym	285	7	against	against	IN
cord-263532-q044i7ym	285	8	HIV	HIV	NNP
cord-263532-q044i7ym	285	9	protease	protease	NN
cord-263532-q044i7ym	285	10	and	and	CC
cord-263532-q044i7ym	285	11	other	other	JJ
cord-263532-q044i7ym	285	12	viral	viral	JJ
cord-263532-q044i7ym	285	13	enzymes	enzyme	NNS
cord-263532-q044i7ym	285	14	.	.	.
cord-263532-q044i7ym	286	1	52−57	52−57	CD
cord-263532-q044i7ym	287	1	The	the	DT
cord-263532-q044i7ym	287	2	various	various	JJ
cord-263532-q044i7ym	287	3	mutation	mutation	NN
cord-263532-q044i7ym	287	4	analyses	analysis	NNS
cord-263532-q044i7ym	287	5	listed	list	VBN
cord-263532-q044i7ym	287	6	in	in	IN
cord-263532-q044i7ym	287	7	the	the	DT
cord-263532-q044i7ym	287	8	present	present	JJ
cord-263532-q044i7ym	287	9	review	review	NN
cord-263532-q044i7ym	287	10	highlight	highlight	VBP
cord-263532-q044i7ym	287	11	the	the	DT
cord-263532-q044i7ym	287	12	key	key	JJ
cord-263532-q044i7ym	287	13	residues	residue	NNS
cord-263532-q044i7ym	287	14	of	of	IN
cord-263532-q044i7ym	287	15	SARS	SARS	NNP
cord-263532-q044i7ym	287	16	-	-	HYPH
cord-263532-q044i7ym	287	17	CoV	CoV	NNP
cord-263532-q044i7ym	287	18	M	M	NNP
cord-263532-q044i7ym	287	19	pro	pro	JJ
cord-263532-q044i7ym	287	20	that	that	WDT
cord-263532-q044i7ym	287	21	are	be	VBP
cord-263532-q044i7ym	287	22	crucial	crucial	JJ
cord-263532-q044i7ym	287	23	for	for	IN
cord-263532-q044i7ym	287	24	the	the	DT
cord-263532-q044i7ym	287	25	dimerization	dimerization	NN
cord-263532-q044i7ym	287	26	and	and	CC
cord-263532-q044i7ym	287	27	thus	thus	RB
cord-263532-q044i7ym	287	28	catalytic	catalytic	JJ
cord-263532-q044i7ym	287	29	activity	activity	NN
cord-263532-q044i7ym	287	30	of	of	IN
cord-263532-q044i7ym	287	31	the	the	DT
cord-263532-q044i7ym	287	32	enzyme	enzyme	NN
cord-263532-q044i7ym	287	33	.	.	.
cord-263532-q044i7ym	288	1	The	the	DT
cord-263532-q044i7ym	288	2	studies	study	NNS
cord-263532-q044i7ym	288	3	provide	provide	VBP
cord-263532-q044i7ym	288	4	future	future	JJ
cord-263532-q044i7ym	288	5	directions	direction	NNS
cord-263532-q044i7ym	288	6	for	for	IN
cord-263532-q044i7ym	288	7	the	the	DT
cord-263532-q044i7ym	288	8	design	design	NN
cord-263532-q044i7ym	288	9	of	of	IN
cord-263532-q044i7ym	288	10	potential	potential	JJ
cord-263532-q044i7ym	288	11	dimerization	dimerization	NN
cord-263532-q044i7ym	288	12	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	288	13	against	against	IN
cord-263532-q044i7ym	288	14	M	M	NNP
cord-263532-q044i7ym	288	15	pro	pro	NNP
cord-263532-q044i7ym	288	16	.	.	.
cord-263532-q044i7ym	289	1	The	the	DT
cord-263532-q044i7ym	289	2	MD	MD	NNP
cord-263532-q044i7ym	289	3	studies	study	NNS
cord-263532-q044i7ym	289	4	of	of	IN
cord-263532-q044i7ym	289	5	M	M	NNP
cord-263532-q044i7ym	289	6	pro	pro	NNP
cord-263532-q044i7ym	289	7	compiled	compile	VBN
cord-263532-q044i7ym	289	8	in	in	IN
cord-263532-q044i7ym	289	9	the	the	DT
cord-263532-q044i7ym	289	10	review	review	NN
cord-263532-q044i7ym	289	11	will	will	MD
cord-263532-q044i7ym	289	12	act	act	VB
cord-263532-q044i7ym	289	13	as	as	IN
cord-263532-q044i7ym	289	14	molecular	molecular	JJ
cord-263532-q044i7ym	289	15	guide	guide	NN
cord-263532-q044i7ym	289	16	for	for	IN
cord-263532-q044i7ym	289	17	the	the	DT
cord-263532-q044i7ym	289	18	structure	structure	NN
cord-263532-q044i7ym	289	19	-	-	HYPH
cord-263532-q044i7ym	289	20	based	base	VBN
cord-263532-q044i7ym	289	21	design	design	NN
cord-263532-q044i7ym	289	22	of	of	IN
cord-263532-q044i7ym	289	23	potent	potent	JJ
cord-263532-q044i7ym	289	24	dimerization	dimerization	NN
cord-263532-q044i7ym	289	25	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	289	26	.	.	.
cord-263532-q044i7ym	290	1	In	in	IN
cord-263532-q044i7ym	290	2	addition	addition	NN
cord-263532-q044i7ym	290	3	,	,	,
cord-263532-q044i7ym	290	4	the	the	DT
cord-263532-q044i7ym	290	5	already	already	RB
cord-263532-q044i7ym	290	6	reported	report	VBN
cord-263532-q044i7ym	290	7	dimerization	dimerization	NN
cord-263532-q044i7ym	290	8	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	290	9	of	of	IN
cord-263532-q044i7ym	290	10	M	M	NNP
cord-263532-q044i7ym	290	11	pro	pro	NNP
cord-263532-q044i7ym	290	12	will	will	MD
cord-263532-q044i7ym	290	13	provide	provide	VB
cord-263532-q044i7ym	290	14	the	the	DT
cord-263532-q044i7ym	290	15	framework	framework	NN
cord-263532-q044i7ym	290	16	for	for	IN
cord-263532-q044i7ym	290	17	further	further	JJ
cord-263532-q044i7ym	290	18	modifications	modification	NNS
cord-263532-q044i7ym	290	19	to	to	TO
cord-263532-q044i7ym	290	20	design	design	VB
cord-263532-q044i7ym	290	21	potent	potent	JJ
cord-263532-q044i7ym	290	22	antiviral	antiviral	JJ
cord-263532-q044i7ym	290	23	agents	agent	NNS
cord-263532-q044i7ym	290	24	.	.	.
cord-263532-q044i7ym	291	1	The	the	DT
cord-263532-q044i7ym	291	2	peptide	peptide	NN
cord-263532-q044i7ym	291	3	-	-	HYPH
cord-263532-q044i7ym	291	4	based	base	VBN
cord-263532-q044i7ym	291	5	interface	interface	NN
cord-263532-q044i7ym	291	6	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	291	7	may	may	MD
cord-263532-q044i7ym	291	8	provide	provide	VB
cord-263532-q044i7ym	291	9	better	well	JJR
cord-263532-q044i7ym	291	10	therapeutic	therapeutic	JJ
cord-263532-q044i7ym	291	11	options	option	NNS
cord-263532-q044i7ym	291	12	than	than	IN
cord-263532-q044i7ym	291	13	small	small	JJ
cord-263532-q044i7ym	291	14	molecules	molecule	NNS
cord-263532-q044i7ym	291	15	,	,	,
cord-263532-q044i7ym	291	16	as	as	IN
cord-263532-q044i7ym	291	17	the	the	DT
cord-263532-q044i7ym	291	18	large	large	JJ
cord-263532-q044i7ym	291	19	surface	surface	NN
cord-263532-q044i7ym	291	20	area	area	NN
cord-263532-q044i7ym	291	21	of	of	IN
cord-263532-q044i7ym	291	22	the	the	DT
cord-263532-q044i7ym	291	23	dimer	dimer	NN
cord-263532-q044i7ym	291	24	interface	interface	NN
cord-263532-q044i7ym	291	25	of	of	IN
cord-263532-q044i7ym	291	26	M	M	NNP
cord-263532-q044i7ym	291	27	pro	pro	NN
cord-263532-q044i7ym	291	28	will	will	MD
cord-263532-q044i7ym	291	29	be	be	VB
cord-263532-q044i7ym	291	30	better	well	RBR
cord-263532-q044i7ym	291	31	targeted	target	VBN
cord-263532-q044i7ym	291	32	with	with	IN
cord-263532-q044i7ym	291	33	peptide	peptide	NN
cord-263532-q044i7ym	291	34	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	291	35	.	.	.
cord-263532-q044i7ym	292	1	The	the	DT
cord-263532-q044i7ym	292	2	peptide	peptide	NN
cord-263532-q044i7ym	292	3	-	-	HYPH
cord-263532-q044i7ym	292	4	based	base	VBN
cord-263532-q044i7ym	292	5	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	292	6	have	have	VBP
cord-263532-q044i7ym	292	7	additional	additional	JJ
cord-263532-q044i7ym	292	8	advantages	advantage	NNS
cord-263532-q044i7ym	292	9	over	over	IN
cord-263532-q044i7ym	292	10	small	small	JJ
cord-263532-q044i7ym	292	11	molecules	molecule	NNS
cord-263532-q044i7ym	292	12	as	as	IN
cord-263532-q044i7ym	292	13	drug	drug	NN
cord-263532-q044i7ym	292	14	candidates	candidate	NNS
cord-263532-q044i7ym	292	15	due	due	JJ
cord-263532-q044i7ym	292	16	to	to	IN
cord-263532-q044i7ym	292	17	their	-PRON-	PRP$
cord-263532-q044i7ym	292	18	greater	great	JJR
cord-263532-q044i7ym	292	19	chemical	chemical	NN
cord-263532-q044i7ym	292	20	diversity	diversity	NN
cord-263532-q044i7ym	292	21	,	,	,
cord-263532-q044i7ym	292	22	high	high	JJ
cord-263532-q044i7ym	292	23	specificity	specificity	NN
cord-263532-q044i7ym	292	24	,	,	,
cord-263532-q044i7ym	292	25	low	low	JJ
cord-263532-q044i7ym	292	26	toxicity	toxicity	NN
cord-263532-q044i7ym	292	27	,	,	,
cord-263532-q044i7ym	292	28	possibility	possibility	NN
cord-263532-q044i7ym	292	29	of	of	IN
cord-263532-q044i7ym	292	30	rational	rational	JJ
cord-263532-q044i7ym	292	31	design	design	NN
cord-263532-q044i7ym	292	32	,	,	,
cord-263532-q044i7ym	292	33	low	low	JJ
cord-263532-q044i7ym	292	34	accumulation	accumulation	NN
cord-263532-q044i7ym	292	35	in	in	IN
cord-263532-q044i7ym	292	36	tissues	tissue	NNS
cord-263532-q044i7ym	292	37	,	,	,
cord-263532-q044i7ym	292	38	and	and	CC
cord-263532-q044i7ym	292	39	stability	stability	NN
cord-263532-q044i7ym	292	40	toward	toward	IN
cord-263532-q044i7ym	292	41	proteolytic	proteolytic	JJ
cord-263532-q044i7ym	292	42	cleavage	cleavage	NN
cord-263532-q044i7ym	292	43	(	(	-LRB-
cord-263532-q044i7ym	292	44	peptidomimetics	peptidomimetic	NNS
cord-263532-q044i7ym	292	45	)	)	-RRB-
cord-263532-q044i7ym	292	46	.	.	.
cord-263532-q044i7ym	293	1	54,56,58−60	54,56,58−60	CD
cord-263532-q044i7ym	294	1	In	in	IN
cord-263532-q044i7ym	294	2	parallel	parallel	NN
cord-263532-q044i7ym	294	3	with	with	IN
cord-263532-q044i7ym	294	4	the	the	DT
cord-263532-q044i7ym	294	5	drug	drug	NN
cord-263532-q044i7ym	294	6	development	development	NN
cord-263532-q044i7ym	294	7	,	,	,
cord-263532-q044i7ym	294	8	scientists	scientist	NNS
cord-263532-q044i7ym	294	9	around	around	IN
cord-263532-q044i7ym	294	10	the	the	DT
cord-263532-q044i7ym	294	11	globe	globe	NN
cord-263532-q044i7ym	294	12	are	be	VBP
cord-263532-q044i7ym	294	13	actively	actively	RB
cord-263532-q044i7ym	294	14	involved	involve	VBN
cord-263532-q044i7ym	294	15	in	in	IN
cord-263532-q044i7ym	294	16	developing	develop	VBG
cord-263532-q044i7ym	294	17	rapid	rapid	JJ
cord-263532-q044i7ym	294	18	point	point	NN
cord-263532-q044i7ym	294	19	-	-	HYPH
cord-263532-q044i7ym	294	20	of	of	IN
cord-263532-q044i7ym	294	21	-	-	HYPH
cord-263532-q044i7ym	294	22	care	care	NN
cord-263532-q044i7ym	294	23	diagnostic	diagnostic	JJ
cord-263532-q044i7ym	294	24	methods	method	NNS
cord-263532-q044i7ym	294	25	for	for	IN
cord-263532-q044i7ym	294	26	SARS	SARS	NNP
cord-263532-q044i7ym	294	27	-	-	HYPH
cord-263532-q044i7ym	294	28	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	294	29	.	.	.
cord-263532-q044i7ym	295	1	We	-PRON-	PRP
cord-263532-q044i7ym	295	2	believe	believe	VBP
cord-263532-q044i7ym	295	3	that	that	IN
cord-263532-q044i7ym	295	4	the	the	DT
cord-263532-q044i7ym	295	5	combinational	combinational	JJ
cord-263532-q044i7ym	295	6	design	design	NN
cord-263532-q044i7ym	295	7	of	of	IN
cord-263532-q044i7ym	295	8	peptide	peptide	NN
cord-263532-q044i7ym	295	9	-	-	HYPH
cord-263532-q044i7ym	295	10	based	base	VBN
cord-263532-q044i7ym	295	11	dimerization	dimerization	NN
cord-263532-q044i7ym	295	12	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	295	13	of	of	IN
cord-263532-q044i7ym	295	14	M	M	NNP
cord-263532-q044i7ym	295	15	pro	pro	NN
cord-263532-q044i7ym	295	16	provide	provide	VBP
cord-263532-q044i7ym	295	17	an	an	DT
cord-263532-q044i7ym	295	18	attractive	attractive	JJ
cord-263532-q044i7ym	295	19	approach	approach	NN
cord-263532-q044i7ym	295	20	to	to	TO
cord-263532-q044i7ym	295	21	combat	combat	VB
cord-263532-q044i7ym	295	22	CoVs	CoVs	NNP
cord-263532-q044i7ym	295	23	and	and	CC
cord-263532-q044i7ym	295	24	that	that	IN
cord-263532-q044i7ym	295	25	this	this	DT
cord-263532-q044i7ym	295	26	review	review	NN
cord-263532-q044i7ym	295	27	will	will	MD
cord-263532-q044i7ym	295	28	stimulate	stimulate	VB
cord-263532-q044i7ym	295	29	research	research	NN
cord-263532-q044i7ym	295	30	in	in	IN
cord-263532-q044i7ym	295	31	this	this	DT
cord-263532-q044i7ym	295	32	less	less	RBR
cord-263532-q044i7ym	295	33	explored	explore	VBN
cord-263532-q044i7ym	295	34	yet	yet	CC
cord-263532-q044i7ym	295	35	highly	highly	RB
cord-263532-q044i7ym	295	36	relevant	relevant	JJ
cord-263532-q044i7ym	295	37	area	area	NN
cord-263532-q044i7ym	295	38	.	.	.
cord-263532-q044i7ym	296	1	The	the	DT
cord-263532-q044i7ym	296	2	previous	previous	JJ
cord-263532-q044i7ym	296	3	research	research	NN
cord-263532-q044i7ym	296	4	efforts	effort	NNS
cord-263532-q044i7ym	296	5	toward	toward	IN
cord-263532-q044i7ym	296	6	the	the	DT
cord-263532-q044i7ym	296	7	design	design	NN
cord-263532-q044i7ym	296	8	of	of	IN
cord-263532-q044i7ym	296	9	potent	potent	JJ
cord-263532-q044i7ym	296	10	antiviral	antiviral	JJ
cord-263532-q044i7ym	296	11	agents	agent	NNS
cord-263532-q044i7ym	296	12	against	against	IN
cord-263532-q044i7ym	296	13	SARS	SARS	NNP
cord-263532-q044i7ym	296	14	and	and	CC
cord-263532-q044i7ym	296	15	MERS	MERS	NNP
cord-263532-q044i7ym	296	16	should	should	MD
cord-263532-q044i7ym	296	17	be	be	VB
cord-263532-q044i7ym	296	18	used	use	VBN
cord-263532-q044i7ym	296	19	to	to	TO
cord-263532-q044i7ym	296	20	draw	draw	VB
cord-263532-q044i7ym	296	21	the	the	DT
cord-263532-q044i7ym	296	22	line	line	NN
cord-263532-q044i7ym	296	23	of	of	IN
cord-263532-q044i7ym	296	24	defense	defense	NN
cord-263532-q044i7ym	296	25	more	more	RBR
cord-263532-q044i7ym	296	26	quickly	quickly	RB
cord-263532-q044i7ym	296	27	against	against	IN
cord-263532-q044i7ym	296	28	the	the	DT
cord-263532-q044i7ym	296	29	novel	novel	JJ
cord-263532-q044i7ym	296	30	deadly	deadly	JJ
cord-263532-q044i7ym	296	31	SARS	SARS	NNP
cord-263532-q044i7ym	296	32	-	-	HYPH
cord-263532-q044i7ym	296	33	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	296	34	.	.	.
cord-263532-q044i7ym	297	1	The	the	DT
cord-263532-q044i7ym	297	2	present	present	JJ
cord-263532-q044i7ym	297	3	review	review	NN
cord-263532-q044i7ym	297	4	provides	provide	VBZ
cord-263532-q044i7ym	297	5	strong	strong	JJ
cord-263532-q044i7ym	297	6	groundwork	groundwork	NN
cord-263532-q044i7ym	297	7	for	for	IN
cord-263532-q044i7ym	297	8	the	the	DT
cord-263532-q044i7ym	297	9	design	design	NN
cord-263532-q044i7ym	297	10	and	and	CC
cord-263532-q044i7ym	297	11	development	development	NN
cord-263532-q044i7ym	297	12	of	of	IN
cord-263532-q044i7ym	297	13	novel	novel	JJ
cord-263532-q044i7ym	297	14	dimerization	dimerization	NN
cord-263532-q044i7ym	297	15	inhibitors	inhibitor	NNS
cord-263532-q044i7ym	297	16	of	of	IN
cord-263532-q044i7ym	297	17	SARS	SARS	NNP
cord-263532-q044i7ym	297	18	-	-	HYPH
cord-263532-q044i7ym	297	19	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	297	20	M	M	NNP
cord-263532-q044i7ym	297	21	pro	pro	JJ
cord-263532-q044i7ym	297	22	for	for	IN
cord-263532-q044i7ym	297	23	combating	combat	VBG
cord-263532-q044i7ym	297	24	this	this	DT
cord-263532-q044i7ym	297	25	mysterious	mysterious	JJ
cord-263532-q044i7ym	297	26	and	and	CC
cord-263532-q044i7ym	297	27	rapidly	rapidly	RB
cord-263532-q044i7ym	297	28	evolving	evolve	VBG
cord-263532-q044i7ym	297	29	virus	virus	NN
cord-263532-q044i7ym	297	30	on	on	IN
cord-263532-q044i7ym	297	31	an	an	DT
cord-263532-q044i7ym	297	32	invisible	invisible	JJ
cord-263532-q044i7ym	297	33	battlefield	battlefield	NN
cord-263532-q044i7ym	297	34	.	.	.
cord-263532-q044i7ym	298	1	Chemical	Chemical	NNP
cord-263532-q044i7ym	298	2	Abstracts	Abstracts	NNPS
cord-263532-q044i7ym	298	3	Service	Service	NNP
cord-263532-q044i7ym	298	4	;	;	:
cord-263532-q044i7ym	298	5	CCP	CCP	NNP
cord-263532-q044i7ym	298	6	,	,	,
cord-263532-q044i7ym	298	7	3-chymotrypsin	3-chymotrypsin	CD
cord-263532-q044i7ym	298	8	-	-	HYPH
cord-263532-q044i7ym	298	9	like	like	JJ
cord-263532-q044i7ym	298	10	cysteine	cysteine	NN
cord-263532-q044i7ym	298	11	protease	protease	NN
cord-263532-q044i7ym	298	12	;	;	:
cord-263532-q044i7ym	298	13	CEST	CEST	NNP
cord-263532-q044i7ym	298	14	CoV	CoV	NNP
cord-263532-q044i7ym	298	15	,	,	,
cord-263532-q044i7ym	298	16	coronavirus	coronavirus	NN
cord-263532-q044i7ym	298	17	;	;	.
cord-263532-q044i7ym	299	1	COVID-19	COVID-19	NNP
cord-263532-q044i7ym	299	2	,	,	,
cord-263532-q044i7ym	299	3	coronavirus	coronavirus	NN
cord-263532-q044i7ym	299	4	disease	disease	NN
cord-263532-q044i7ym	299	5	HIV	HIV	NNP
cord-263532-q044i7ym	299	6	,	,	,
cord-263532-q044i7ym	299	7	human	human	JJ
cord-263532-q044i7ym	299	8	immunodeficiency	immunodeficiency	NN
cord-263532-q044i7ym	299	9	virus	virus	NN
cord-263532-q044i7ym	299	10	K	K	NNP
cord-263532-q044i7ym	299	11	d	d	NNP
cord-263532-q044i7ym	299	12	,	,	,
cord-263532-q044i7ym	299	13	dissociation	dissociation	NN
cord-263532-q044i7ym	299	14	constant	constant	NN
cord-263532-q044i7ym	299	15	;	;	:
cord-263532-q044i7ym	299	16	K	K	NNP
cord-263532-q044i7ym	299	17	i	i	NNP
cord-263532-q044i7ym	299	18	,	,	,
cord-263532-q044i7ym	299	19	dimerization	dimerization	NN
cord-263532-q044i7ym	299	20	inhibition	inhibition	NN
cord-263532-q044i7ym	299	21	constant	constant	NN
cord-263532-q044i7ym	299	22	;	;	:
cord-263532-q044i7ym	299	23	MERS	MERS	NNP
cord-263532-q044i7ym	299	24	-	-	HYPH
cord-263532-q044i7ym	299	25	CoV	CoV	NNP
cord-263532-q044i7ym	299	26	,	,	,
cord-263532-q044i7ym	299	27	Middle	Middle	NNP
cord-263532-q044i7ym	299	28	East	East	NNP
cord-263532-q044i7ym	299	29	respiratory	respiratory	JJ
cord-263532-q044i7ym	299	30	syndrome	syndrome	NN
cord-263532-q044i7ym	299	31	coronavirus	coronavirus	NN
cord-263532-q044i7ym	299	32	MD	MD	NNP
cord-263532-q044i7ym	299	33	,	,	,
cord-263532-q044i7ym	299	34	molecular	molecular	JJ
cord-263532-q044i7ym	299	35	dynamics	dynamic	NNS
cord-263532-q044i7ym	299	36	;	;	:
cord-263532-q044i7ym	300	1	M	M	NNP
cord-263532-q044i7ym	300	2	pro	pro	NNP
cord-263532-q044i7ym	300	3	RNA	RNA	NNP
cord-263532-q044i7ym	300	4	-	-	HYPH
cord-263532-q044i7ym	300	5	dependent	dependent	JJ
cord-263532-q044i7ym	300	6	RNA	RNA	NNP
cord-263532-q044i7ym	300	7	polymerase	polymerase	NN
cord-263532-q044i7ym	300	8	;	;	:
cord-263532-q044i7ym	300	9	SARS	SARS	NNP
cord-263532-q044i7ym	300	10	-	-	HYPH
cord-263532-q044i7ym	300	11	CoV	CoV	NNP
cord-263532-q044i7ym	300	12	,	,	,
cord-263532-q044i7ym	300	13	severe	severe	JJ
cord-263532-q044i7ym	300	14	acute	acute	JJ
cord-263532-q044i7ym	300	15	respiratory	respiratory	JJ
cord-263532-q044i7ym	300	16	syndrome	syndrome	NN
cord-263532-q044i7ym	300	17	coronavirus	coronavirus	NN
cord-263532-q044i7ym	300	18	;	;	:
cord-263532-q044i7ym	300	19	SARS	SARS	NNP
cord-263532-q044i7ym	300	20	-	-	HYPH
cord-263532-q044i7ym	300	21	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	300	22	,	,	,
cord-263532-q044i7ym	300	23	severe	severe	JJ
cord-263532-q044i7ym	300	24	acute	acute	JJ
cord-263532-q044i7ym	300	25	respiratory	respiratory	JJ
cord-263532-q044i7ym	300	26	syndrome	syndrome	NN
cord-263532-q044i7ym	300	27	coronavirus-2	coronavirus-2	VBZ
cord-263532-q044i7ym	300	28	World	World	NNP
cord-263532-q044i7ym	300	29	Health	Health	NNP
cord-263532-q044i7ym	300	30	Organization	Organization	NNP
cord-263532-q044i7ym	300	31	;	;	:
cord-263532-q044i7ym	300	32	wt	wt	NN
cord-263532-q044i7ym	300	33	,	,	,
cord-263532-q044i7ym	300	34	wild	wild	JJ
cord-263532-q044i7ym	300	35	-	-	HYPH
cord-263532-q044i7ym	300	36	type	type	NN
cord-263532-q044i7ym	300	37	■	■	NFP
cord-263532-q044i7ym	300	38	REFERENCES	reference	VBG
cord-263532-q044i7ym	300	39	A	a	DT
cord-263532-q044i7ym	300	40	Murine	Murine	NNP
cord-263532-q044i7ym	300	41	Virus	virus	NN
cord-263532-q044i7ym	300	42	(	(	-LRB-
cord-263532-q044i7ym	300	43	JHM	JHM	NNP
cord-263532-q044i7ym	300	44	)	)	-RRB-
cord-263532-q044i7ym	301	1	Causing	cause	VBG
cord-263532-q044i7ym	301	2	Disseminated	disseminate	VBN
cord-263532-q044i7ym	301	3	Encephalomyelitis	Encephalomyelitis	NNP
cord-263532-q044i7ym	301	4	with	with	IN
cord-263532-q044i7ym	301	5	Extensive	extensive	JJ
cord-263532-q044i7ym	301	6	Destruction	destruction	NN
cord-263532-q044i7ym	301	7	of	of	IN
cord-263532-q044i7ym	301	8	Myelin	Myelin	NNP
cord-263532-q044i7ym	301	9	:	:	:
cord-263532-q044i7ym	301	10	I.	I.	NNP
cord-263532-q044i7ym	301	11	Isolation	Isolation	NNP
cord-263532-q044i7ym	301	12	and	and	CC
cord-263532-q044i7ym	301	13	Biological	Biological	NNP
cord-263532-q044i7ym	301	14	Properties	Properties	NNPS
cord-263532-q044i7ym	301	15	of	of	IN
cord-263532-q044i7ym	301	16	the	the	DT
cord-263532-q044i7ym	301	17	Virus	Virus	NNP
cord-263532-q044i7ym	301	18	A	A	NNP
cord-263532-q044i7ym	301	19	Murine	Murine	NNP
cord-263532-q044i7ym	301	20	Virus	virus	NN
cord-263532-q044i7ym	302	1	(	(	-LRB-
cord-263532-q044i7ym	302	2	JHM	JHM	NNP
cord-263532-q044i7ym	302	3	)	)	-RRB-
cord-263532-q044i7ym	303	1	Causing	cause	VBG
cord-263532-q044i7ym	303	2	Disseminated	disseminate	VBN
cord-263532-q044i7ym	303	3	Encephalomyelitis	Encephalomyelitis	NNP
cord-263532-q044i7ym	303	4	with	with	IN
cord-263532-q044i7ym	303	5	Extensive	extensive	JJ
cord-263532-q044i7ym	303	6	Destruction	destruction	NN
cord-263532-q044i7ym	303	7	of	of	IN
cord-263532-q044i7ym	303	8	Myelin	Myelin	NNP
cord-263532-q044i7ym	303	9	:	:	:
cord-263532-q044i7ym	303	10	II	II	NNP
cord-263532-q044i7ym	303	11	.	.	.
cord-263532-q044i7ym	304	1	Pathology	Pathology	NNP
cord-263532-q044i7ym	304	2	Coronaviruses	Coronaviruses	NNP
cord-263532-q044i7ym	304	3	-	-	HYPH
cord-263532-q044i7ym	304	4	Drug	Drug	NNP
cord-263532-q044i7ym	304	5	Discovery	Discovery	NNP
cord-263532-q044i7ym	304	6	and	and	CC
cord-263532-q044i7ym	304	7	Therapeutic	Therapeutic	NNP
cord-263532-q044i7ym	304	8	Options	Options	NNPS
cord-263532-q044i7ym	304	9	Recent	Recent	NNP
cord-263532-q044i7ym	304	10	Insights	Insights	NNPS
cord-263532-q044i7ym	304	11	into	into	IN
cord-263532-q044i7ym	304	12	Emerging	Emerging	NNP
cord-263532-q044i7ym	304	13	Coronaviruses	Coronaviruses	NNP
cord-263532-q044i7ym	305	1	A	a	DT
cord-263532-q044i7ym	305	2	New	New	NNP
cord-263532-q044i7ym	305	3	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	305	4	Associated	Associated	NNP
cord-263532-q044i7ym	305	5	with	with	IN
cord-263532-q044i7ym	305	6	Human	Human	NNP
cord-263532-q044i7ym	305	7	Respiratory	Respiratory	NNP
cord-263532-q044i7ym	305	8	Disease	Disease	NNP
cord-263532-q044i7ym	305	9	in	in	IN
cord-263532-q044i7ym	305	10	China	China	NNP
cord-263532-q044i7ym	305	11	Sidorov	Sidorov	NNP
cord-263532-q044i7ym	305	12	,	,	,
cord-263532-q044i7ym	305	13	I.	I.	NNP
cord-263532-q044i7ym	305	14	A.	a.	NN
cord-263532-q044i7ym	305	15	;	;	:
cord-263532-q044i7ym	305	16	Sola	Sola	NNP
cord-263532-q044i7ym	305	17	,	,	,
cord-263532-q044i7ym	305	18	I.	i.	NN
cord-263532-q044i7ym	305	19	;	;	:
cord-263532-q044i7ym	305	20	Ziebuhr	Ziebuhr	NNP
cord-263532-q044i7ym	305	21	,	,	,
cord-263532-q044i7ym	305	22	J.	J.	NNP
cord-263532-q044i7ym	305	23	Severe	Severe	NNP
cord-263532-q044i7ym	305	24	Acute	Acute	NNP
cord-263532-q044i7ym	305	25	Respiratory	Respiratory	NNP
cord-263532-q044i7ym	305	26	Syndrome	syndrome	NN
cord-263532-q044i7ym	305	27	-	-	HYPH
cord-263532-q044i7ym	305	28	Related	relate	VBN
cord-263532-q044i7ym	305	29	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	305	30	:	:	:
cord-263532-q044i7ym	306	1	The	the	DT
cord-263532-q044i7ym	306	2	Species	Species	NNPS
cord-263532-q044i7ym	306	3	and	and	CC
cord-263532-q044i7ym	306	4	its	-PRON-	PRP$
cord-263532-q044i7ym	306	5	Viruses−A	Viruses−A	NNP
cord-263532-q044i7ym	306	6	Statement	Statement	NNP
cord-263532-q044i7ym	306	7	of	of	IN
cord-263532-q044i7ym	306	8	the	the	DT
cord-263532-q044i7ym	306	9	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	306	10	Study	Study	NNP
cord-263532-q044i7ym	306	11	Group	Group	NNP
cord-263532-q044i7ym	306	12	Main	Main	NNP
cord-263532-q044i7ym	306	13	Protease	Protease	NNP
cord-263532-q044i7ym	306	14	Provides	provide	VBZ
cord-263532-q044i7ym	306	15	a	a	DT
cord-263532-q044i7ym	306	16	Basis	basis	NN
cord-263532-q044i7ym	306	17	for	for	IN
cord-263532-q044i7ym	306	18	Design	Design	NNP
cord-263532-q044i7ym	306	19	of	of	IN
cord-263532-q044i7ym	306	20	Improved	Improved	NNP
cord-263532-q044i7ym	306	21	α	α	NNP
cord-263532-q044i7ym	306	22	-	-	HYPH
cord-263532-q044i7ym	306	23	Ketoamide	Ketoamide	NNP
cord-263532-q044i7ym	306	24	Inhibitors	Inhibitors	NNP
cord-263532-q044i7ym	306	25	Learning	learn	VBG
cord-263532-q044i7ym	306	26	from	from	IN
cord-263532-q044i7ym	306	27	the	the	DT
cord-263532-q044i7ym	306	28	Past	past	NN
cord-263532-q044i7ym	306	29	:	:	:
cord-263532-q044i7ym	307	1	Possible	possible	JJ
cord-263532-q044i7ym	307	2	Urgent	Urgent	NNP
cord-263532-q044i7ym	307	3	Prevention	Prevention	NNP
cord-263532-q044i7ym	307	4	and	and	CC
cord-263532-q044i7ym	307	5	Treatment	Treatment	NNP
cord-263532-q044i7ym	307	6	Options	Options	NNPS
cord-263532-q044i7ym	307	7	for	for	IN
cord-263532-q044i7ym	307	8	Severe	severe	JJ
cord-263532-q044i7ym	307	9	Acute	acute	JJ
cord-263532-q044i7ym	307	10	Respiratory	respiratory	JJ
cord-263532-q044i7ym	307	11	Infections	infection	NNS
cord-263532-q044i7ym	307	12	Caused	cause	VBN
cord-263532-q044i7ym	307	13	by	by	IN
cord-263532-q044i7ym	308	1	2019-nCoV	2019-ncov	CD
cord-263532-q044i7ym	308	2	Evolutionary	Evolutionary	NNP
cord-263532-q044i7ym	308	3	Selection	selection	NN
cord-263532-q044i7ym	308	4	Associated	associate	VBN
cord-263532-q044i7ym	308	5	with	with	IN
cord-263532-q044i7ym	308	6	the	the	DT
cord-263532-q044i7ym	308	7	Multi	Multi	NNP
cord-263532-q044i7ym	308	8	-	-	HYPH
cord-263532-q044i7ym	308	9	Function	Function	NNP
cord-263532-q044i7ym	308	10	of	of	IN
cord-263532-q044i7ym	308	11	Overlapping	Overlapping	NNP
cord-263532-q044i7ym	308	12	Genes	Genes	NNPS
cord-263532-q044i7ym	308	13	in	in	IN
cord-263532-q044i7ym	309	1	the	the	DT
cord-263532-q044i7ym	309	2	Hepatitis	Hepatitis	NNP
cord-263532-q044i7ym	309	3	B	B	NNP
cord-263532-q044i7ym	309	4	Virus	Virus	NNP
cord-263532-q044i7ym	309	5	An	An	NNP
cord-263532-q044i7ym	309	6	Overview	Overview	NNP
cord-263532-q044i7ym	309	7	of	of	IN
cord-263532-q044i7ym	309	8	Severe	severe	JJ
cord-263532-q044i7ym	309	9	Acute	acute	JJ
cord-263532-q044i7ym	309	10	Respiratory	Respiratory	NNP
cord-263532-q044i7ym	309	11	Syndrome	Syndrome	NNP
cord-263532-q044i7ym	309	12	-	-	HYPH
cord-263532-q044i7ym	309	13	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	309	14	(	(	-LRB-
cord-263532-q044i7ym	309	15	SARS	SARS	NNP
cord-263532-q044i7ym	309	16	-	-	HYPH
cord-263532-q044i7ym	309	17	CoV	CoV	NNP
cord-263532-q044i7ym	309	18	)	)	-RRB-
cord-263532-q044i7ym	309	19	3CL	3CL	NNP
cord-263532-q044i7ym	309	20	Protease	Protease	NNP
cord-263532-q044i7ym	309	21	Inhibitors	Inhibitors	NNP
cord-263532-q044i7ym	309	22	:	:	:
cord-263532-q044i7ym	309	23	Peptidomimetics	Peptidomimetics	NNP
cord-263532-q044i7ym	309	24	and	and	CC
cord-263532-q044i7ym	309	25	Small	Small	NNP
cord-263532-q044i7ym	309	26	Molecule	Molecule	NNP
cord-263532-q044i7ym	309	27	Chemotherapy	Chemotherapy	NNP
cord-263532-q044i7ym	309	28	Characterization	Characterization	NNP
cord-263532-q044i7ym	309	29	and	and	CC
cord-263532-q044i7ym	309	30	Inhibition	inhibition	NN
cord-263532-q044i7ym	309	31	of	of	IN
cord-263532-q044i7ym	309	32	the	the	DT
cord-263532-q044i7ym	309	33	Main	Main	NNP
cord-263532-q044i7ym	309	34	Protease	Protease	NNP
cord-263532-q044i7ym	309	35	of	of	IN
cord-263532-q044i7ym	309	36	Severe	severe	JJ
cord-263532-q044i7ym	309	37	Acute	acute	JJ
cord-263532-q044i7ym	309	38	Respiratory	Respiratory	NNP
cord-263532-q044i7ym	309	39	Syndrome	Syndrome	NNP
cord-263532-q044i7ym	309	40	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	309	41	.	.	.
cord-263532-q044i7ym	310	1	ChemBioEng	ChemBioEng	NNP
cord-263532-q044i7ym	310	2	Rev	Rev	NNP
cord-263532-q044i7ym	310	3	The	the	DT
cord-263532-q044i7ym	310	4	Interaction	Interaction	NNP
cord-263532-q044i7ym	310	5	Between	between	IN
cord-263532-q044i7ym	310	6	Severe	severe	JJ
cord-263532-q044i7ym	310	7	Acute	acute	JJ
cord-263532-q044i7ym	310	8	Respiratory	Respiratory	NNP
cord-263532-q044i7ym	310	9	Syndrome	Syndrome	NNP
cord-263532-q044i7ym	310	10	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	310	11	3C	3c	NN
cord-263532-q044i7ym	310	12	-	-	HYPH
cord-263532-q044i7ym	310	13	like	like	JJ
cord-263532-q044i7ym	310	14	Proteinase	Proteinase	NNP
cord-263532-q044i7ym	310	15	and	and	CC
cord-263532-q044i7ym	310	16	a	a	DT
cord-263532-q044i7ym	310	17	Dimeric	Dimeric	NNP
cord-263532-q044i7ym	310	18	Inhibitor	Inhibitor	NNP
cord-263532-q044i7ym	310	19	by	by	IN
cord-263532-q044i7ym	310	20	Capillary	Capillary	NNP
cord-263532-q044i7ym	310	21	Electrophoresis	Electrophoresis	NNP
cord-263532-q044i7ym	311	1	The	the	DT
cord-263532-q044i7ym	311	2	N	N	NNP
cord-263532-q044i7ym	311	3	-	-	HYPH
cord-263532-q044i7ym	311	4	Terminal	Terminal	NNP
cord-263532-q044i7ym	311	5	Octapeptide	Octapeptide	NNP
cord-263532-q044i7ym	311	6	Acts	act	VBZ
cord-263532-q044i7ym	311	7	as	as	IN
cord-263532-q044i7ym	311	8	a	a	DT
cord-263532-q044i7ym	311	9	Dimerization	Dimerization	NNP
cord-263532-q044i7ym	311	10	Inhibitor	Inhibitor	NNP
cord-263532-q044i7ym	311	11	of	of	IN
cord-263532-q044i7ym	311	12	SARS	SARS	NNP
cord-263532-q044i7ym	312	1	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	312	2	3C	3c	NN
cord-263532-q044i7ym	312	3	-	-	HYPH
cord-263532-q044i7ym	312	4	like	like	JJ
cord-263532-q044i7ym	313	1	Proteinase	Proteinase	NNP
cord-263532-q044i7ym	313	2	Middle	Middle	NNP
cord-263532-q044i7ym	313	3	East	East	NNP
cord-263532-q044i7ym	313	4	Respiratory	Respiratory	NNP
cord-263532-q044i7ym	313	5	Syndrome	Syndrome	NNP
cord-263532-q044i7ym	313	6	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	313	7	(	(	-LRB-
cord-263532-q044i7ym	313	8	MERS	MERS	NNP
cord-263532-q044i7ym	313	9	-	-	HYPH
cord-263532-q044i7ym	313	10	CoV	CoV	NNP
cord-263532-q044i7ym	313	11	)	)	-RRB-
cord-263532-q044i7ym	313	12	:	:	:
cord-263532-q044i7ym	314	1	An	an	DT
cord-263532-q044i7ym	314	2	Updated	Updated	NNP
cord-263532-q044i7ym	314	3	Overview	Overview	NNP
cord-263532-q044i7ym	314	4	and	and	CC
cord-263532-q044i7ym	314	5	Pharmacotherapeutics	Pharmacotherapeutics	NNP
cord-263532-q044i7ym	314	6	Repurposing	Repurposing	NNP
cord-263532-q044i7ym	314	7	of	of	IN
cord-263532-q044i7ym	314	8	Clinically	clinically	RB
cord-263532-q044i7ym	314	9	Developed	develop	VBN
cord-263532-q044i7ym	314	10	Drugs	drug	NNS
cord-263532-q044i7ym	314	11	for	for	IN
cord-263532-q044i7ym	314	12	Treatment	Treatment	NNP
cord-263532-q044i7ym	314	13	of	of	IN
cord-263532-q044i7ym	314	14	Middle	Middle	NNP
cord-263532-q044i7ym	314	15	East	East	NNP
cord-263532-q044i7ym	314	16	Respiratory	Respiratory	NNP
cord-263532-q044i7ym	314	17	Syndrome	Syndrome	NNP
cord-263532-q044i7ym	314	18	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	314	19	Infection	infection	NN
cord-263532-q044i7ym	314	20	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	314	21	Main	Main	NNP
cord-263532-q044i7ym	314	22	Proteinase	Proteinase	NNP
cord-263532-q044i7ym	314	23	(	(	-LRB-
cord-263532-q044i7ym	314	24	3CL	3CL	NNP
cord-263532-q044i7ym	314	25	pro	pro	JJ
cord-263532-q044i7ym	314	26	)	)	-RRB-
cord-263532-q044i7ym	314	27	Structure	structure	NN
cord-263532-q044i7ym	314	28	:	:	:
cord-263532-q044i7ym	314	29	Basis	basis	NN
cord-263532-q044i7ym	314	30	for	for	IN
cord-263532-q044i7ym	314	31	Design	Design	NNP
cord-263532-q044i7ym	314	32	of	of	IN
cord-263532-q044i7ym	314	33	Anti	Anti	NNP
cord-263532-q044i7ym	314	34	-	-	NNP
cord-263532-q044i7ym	314	35	SARS	SARS	NNP
cord-263532-q044i7ym	314	36	Drugs	Drugs	NNPS
cord-263532-q044i7ym	314	37	3C	3c	NN
cord-263532-q044i7ym	314	38	-	-	HYPH
cord-263532-q044i7ym	314	39	like	like	JJ
cord-263532-q044i7ym	314	40	Proteinase	Proteinase	NNP
cord-263532-q044i7ym	314	41	from	from	IN
cord-263532-q044i7ym	314	42	SARS	SARS	NNP
cord-263532-q044i7ym	314	43	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	314	44	Catalyzes	Catalyzes	NNP
cord-263532-q044i7ym	314	45	Substrate	Substrate	NNP
cord-263532-q044i7ym	314	46	Hydrolysis	Hydrolysis	NNP
cord-263532-q044i7ym	314	47	by	by	IN
cord-263532-q044i7ym	314	48	a	a	DT
cord-263532-q044i7ym	314	49	General	General	NNP
cord-263532-q044i7ym	314	50	Base	Base	NNP
cord-263532-q044i7ym	314	51	Mechanism	Mechanism	NNP
cord-263532-q044i7ym	314	52	A	A	NNP
cord-263532-q044i7ym	314	53	Novel	Novel	NNP
cord-263532-q044i7ym	314	54	Auto	Auto	NNP
cord-263532-q044i7ym	314	55	-	-	HYPH
cord-263532-q044i7ym	314	56	Cleavage	Cleavage	NNP
cord-263532-q044i7ym	314	57	Assay	Assay	NNP
cord-263532-q044i7ym	314	58	for	for	IN
cord-263532-q044i7ym	314	59	Studying	study	VBG
cord-263532-q044i7ym	314	60	Mutational	Mutational	NNP
cord-263532-q044i7ym	314	61	Effects	effect	NNS
cord-263532-q044i7ym	314	62	on	on	IN
cord-263532-q044i7ym	314	63	the	the	DT
cord-263532-q044i7ym	314	64	Active	Active	NNP
cord-263532-q044i7ym	314	65	Site	Site	NNP
cord-263532-q044i7ym	314	66	of	of	IN
cord-263532-q044i7ym	314	67	Severe	severe	JJ
cord-263532-q044i7ym	314	68	Acute	acute	JJ
cord-263532-q044i7ym	314	69	Respiratory	Respiratory	NNP
cord-263532-q044i7ym	314	70	Syndrome	Syndrome	NNP
cord-263532-q044i7ym	314	71	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	315	1	3C	3C	NNP
cord-263532-q044i7ym	315	2	-	-	HYPH
cord-263532-q044i7ym	315	3	like	like	JJ
cord-263532-q044i7ym	315	4	Protease	Protease	NNP
cord-263532-q044i7ym	315	5	SARS	SARS	NNP
cord-263532-q044i7ym	315	6	-	-	HYPH
cord-263532-q044i7ym	315	7	CoV	CoV	NNP
cord-263532-q044i7ym	315	8	3CL	3CL	NNP
cord-263532-q044i7ym	315	9	Protease	Protease	NNP
cord-263532-q044i7ym	315	10	Cleaves	cleave	VBZ
cord-263532-q044i7ym	315	11	its	-PRON-	PRP$
cord-263532-q044i7ym	315	12	C	C	NNP
cord-263532-q044i7ym	315	13	-	-	HYPH
cord-263532-q044i7ym	315	14	Terminal	Terminal	NNP
cord-263532-q044i7ym	315	15	Autoprocessing	Autoprocessing	NNP
cord-263532-q044i7ym	315	16	Site	site	NN
cord-263532-q044i7ym	315	17	by	by	IN
cord-263532-q044i7ym	315	18	Novel	Novel	NNP
cord-263532-q044i7ym	315	19	Subsite	Subsite	NNP
cord-263532-q044i7ym	315	20	Cooperativity	Cooperativity	NNP
cord-263532-q044i7ym	315	21	Mechanism	Mechanism	NNP
cord-263532-q044i7ym	315	22	of	of	IN
cord-263532-q044i7ym	315	23	the	the	DT
cord-263532-q044i7ym	315	24	Maturation	Maturation	NNP
cord-263532-q044i7ym	315	25	Process	Process	NNP
cord-263532-q044i7ym	315	26	of	of	IN
cord-263532-q044i7ym	315	27	SARS	SARS	NNP
cord-263532-q044i7ym	315	28	-	-	HYPH
cord-263532-q044i7ym	315	29	CoV	CoV	NNP
cord-263532-q044i7ym	315	30	3CL	3CL	NNP
cord-263532-q044i7ym	315	31	Protease	Protease	NNP
cord-263532-q044i7ym	315	32	Quaternary	Quaternary	NNP
cord-263532-q044i7ym	315	33	Structure	Structure	NNP
cord-263532-q044i7ym	315	34	of	of	IN
cord-263532-q044i7ym	315	35	the	the	DT
cord-263532-q044i7ym	315	36	Severe	severe	JJ
cord-263532-q044i7ym	315	37	Acute	acute	JJ
cord-263532-q044i7ym	315	38	Respiratory	Respiratory	NNP
cord-263532-q044i7ym	315	39	Syndrome	Syndrome	NNP
cord-263532-q044i7ym	315	40	(	(	-LRB-
cord-263532-q044i7ym	315	41	SARS	SARS	NNP
cord-263532-q044i7ym	315	42	)	)	-RRB-
cord-263532-q044i7ym	316	1	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	316	2	Main	Main	NNP
cord-263532-q044i7ym	316	3	Protease	Protease	NNP
cord-263532-q044i7ym	317	1	Long	long	JJ
cord-263532-q044i7ym	317	2	-	-	HYPH
cord-263532-q044i7ym	317	3	Range	Range	NNP
cord-263532-q044i7ym	317	4	Cooperative	Cooperative	NNP
cord-263532-q044i7ym	317	5	Interactions	Interactions	NNPS
cord-263532-q044i7ym	317	6	Modulate	modulate	VBP
cord-263532-q044i7ym	317	7	Dimerization	Dimerization	NNP
cord-263532-q044i7ym	317	8	in	in	IN
cord-263532-q044i7ym	317	9	SARS	SARS	NNP
cord-263532-q044i7ym	317	10	3CL	3CL	NNP
cord-263532-q044i7ym	317	11	pro	pro	NNP
cord-263532-q044i7ym	317	12	Residues	residue	NNS
cord-263532-q044i7ym	317	13	on	on	IN
cord-263532-q044i7ym	317	14	the	the	DT
cord-263532-q044i7ym	317	15	Dimer	Dimer	NNP
cord-263532-q044i7ym	317	16	Interface	Interface	NNP
cord-263532-q044i7ym	317	17	of	of	IN
cord-263532-q044i7ym	317	18	SARS	SARS	NNP
cord-263532-q044i7ym	318	1	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	318	2	3C	3c	NN
cord-263532-q044i7ym	318	3	-	-	HYPH
cord-263532-q044i7ym	318	4	like	like	JJ
cord-263532-q044i7ym	318	5	Protease	protease	NN
cord-263532-q044i7ym	318	6	:	:	:
cord-263532-q044i7ym	318	7	Dimer	Dimer	NNP
cord-263532-q044i7ym	318	8	Stability	Stability	NNP
cord-263532-q044i7ym	318	9	Characterization	Characterization	NNP
cord-263532-q044i7ym	318	10	and	and	CC
cord-263532-q044i7ym	318	11	Enzyme	Enzyme	NNP
cord-263532-q044i7ym	318	12	Catalytic	Catalytic	NNP
cord-263532-q044i7ym	318	13	Activity	Activity	NNP
cord-263532-q044i7ym	318	14	Analysis	Analysis	NNP
cord-263532-q044i7ym	318	15	Mutation	Mutation	NNP
cord-263532-q044i7ym	318	16	of	of	IN
cord-263532-q044i7ym	318	17	Gly-11	Gly-11	NNP
cord-263532-q044i7ym	318	18	on	on	IN
cord-263532-q044i7ym	318	19	the	the	DT
cord-263532-q044i7ym	318	20	Dimer	Dimer	NNP
cord-263532-q044i7ym	318	21	Interface	Interface	NNP
cord-263532-q044i7ym	318	22	Results	Results	NNPS
cord-263532-q044i7ym	318	23	in	in	IN
cord-263532-q044i7ym	318	24	the	the	DT
cord-263532-q044i7ym	318	25	Complete	Complete	NNP
cord-263532-q044i7ym	318	26	Crystallographic	Crystallographic	NNP
cord-263532-q044i7ym	318	27	Dimer	Dimer	NNP
cord-263532-q044i7ym	318	28	Dissociation	Dissociation	NNP
cord-263532-q044i7ym	318	29	of	of	IN
cord-263532-q044i7ym	318	30	Severe	severe	JJ
cord-263532-q044i7ym	318	31	Acute	acute	JJ
cord-263532-q044i7ym	318	32	Respiratory	Respiratory	NNP
cord-263532-q044i7ym	318	33	Syndrome	Syndrome	NNP
cord-263532-q044i7ym	318	34	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	318	35	3C	3c	NN
cord-263532-q044i7ym	318	36	-	-	HYPH
cord-263532-q044i7ym	318	37	like	like	JJ
cord-263532-q044i7ym	318	38	Protease	Protease	NNP
cord-263532-q044i7ym	318	39	:	:	:
cord-263532-q044i7ym	318	40	Crystal	Crystal	NNP
cord-263532-q044i7ym	318	41	Structure	Structure	NNP
cord-263532-q044i7ym	318	42	with	with	IN
cord-263532-q044i7ym	318	43	Molecular	Molecular	NNP
cord-263532-q044i7ym	318	44	Dynamics	Dynamics	NNPS
cord-263532-q044i7ym	318	45	Simulations	Simulations	NNPS
cord-263532-q044i7ym	318	46	Correlation	Correlation	NNP
cord-263532-q044i7ym	318	47	Between	between	IN
cord-263532-q044i7ym	318	48	Dissociation	Dissociation	NNP
cord-263532-q044i7ym	318	49	and	and	CC
cord-263532-q044i7ym	318	50	Catalysis	Catalysis	NNP
cord-263532-q044i7ym	318	51	of	of	IN
cord-263532-q044i7ym	318	52	SARS	SARS	NNP
cord-263532-q044i7ym	318	53	-	-	HYPH
cord-263532-q044i7ym	318	54	CoV	CoV	NNP
cord-263532-q044i7ym	318	55	Main	Main	NNP
cord-263532-q044i7ym	318	56	Protease	Protease	NNP
cord-263532-q044i7ym	318	57	Mechanism	Mechanism	NNP
cord-263532-q044i7ym	318	58	for	for	IN
cord-263532-q044i7ym	318	59	Controlling	control	VBG
cord-263532-q044i7ym	318	60	the	the	DT
cord-263532-q044i7ym	318	61	Dimer	Dimer	NNP
cord-263532-q044i7ym	318	62	-	-	HYPH
cord-263532-q044i7ym	318	63	Monomer	Monomer	NNP
cord-263532-q044i7ym	318	64	Switch	Switch	NNP
cord-263532-q044i7ym	318	65	and	and	CC
cord-263532-q044i7ym	318	66	Coupling	Coupling	NNP
cord-263532-q044i7ym	318	67	Dimerization	Dimerization	NNP
cord-263532-q044i7ym	318	68	to	to	IN
cord-263532-q044i7ym	318	69	Catalysis	Catalysis	NNP
cord-263532-q044i7ym	318	70	of	of	IN
cord-263532-q044i7ym	318	71	the	the	DT
cord-263532-q044i7ym	318	72	Severe	severe	JJ
cord-263532-q044i7ym	318	73	Acute	acute	JJ
cord-263532-q044i7ym	318	74	Respiratory	Respiratory	NNP
cord-263532-q044i7ym	318	75	Syndrome	Syndrome	NNP
cord-263532-q044i7ym	318	76	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	319	1	3C	3C	NNP
cord-263532-q044i7ym	319	2	-	-	HYPH
cord-263532-q044i7ym	319	3	like	like	JJ
cord-263532-q044i7ym	319	4	Protease	Protease	NNP
cord-263532-q044i7ym	319	5	Two	Two	NNP
cord-263532-q044i7ym	319	6	Adjacent	Adjacent	NNP
cord-263532-q044i7ym	319	7	Mutations	Mutations	NNPS
cord-263532-q044i7ym	319	8	on	on	IN
cord-263532-q044i7ym	319	9	the	the	DT
cord-263532-q044i7ym	319	10	Dimer	Dimer	NNP
cord-263532-q044i7ym	319	11	Interface	Interface	NNP
cord-263532-q044i7ym	319	12	of	of	IN
cord-263532-q044i7ym	319	13	SARS	SARS	NNP
cord-263532-q044i7ym	320	1	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	320	2	3C	3c	NN
cord-263532-q044i7ym	320	3	-	-	HYPH
cord-263532-q044i7ym	320	4	like	like	JJ
cord-263532-q044i7ym	320	5	Protease	protease	NN
cord-263532-q044i7ym	321	1	Cause	cause	VB
cord-263532-q044i7ym	322	1	Different	different	JJ
cord-263532-q044i7ym	322	2	Conformational	Conformational	NNP
cord-263532-q044i7ym	322	3	Changes	Changes	NNPS
cord-263532-q044i7ym	322	4	in	in	IN
cord-263532-q044i7ym	322	5	Crystal	Crystal	NNP
cord-263532-q044i7ym	322	6	Structure	Structure	NNP
cord-263532-q044i7ym	322	7	Mutation	Mutation	NNP
cord-263532-q044i7ym	322	8	of	of	IN
cord-263532-q044i7ym	322	9	Asn28	Asn28	NNP
cord-263532-q044i7ym	322	10	Disrupts	disrupt	VBZ
cord-263532-q044i7ym	322	11	the	the	DT
cord-263532-q044i7ym	322	12	Dimerization	Dimerization	NNP
cord-263532-q044i7ym	322	13	and	and	CC
cord-263532-q044i7ym	322	14	Enzymatic	Enzymatic	NNP
cord-263532-q044i7ym	322	15	Activity	Activity	NNP
cord-263532-q044i7ym	322	16	of	of	IN
cord-263532-q044i7ym	322	17	SARS	SARS	NNP
cord-263532-q044i7ym	322	18	3CL	3CL	NNP
cord-263532-q044i7ym	322	19	pro	pro	NNP
cord-263532-q044i7ym	322	20	Crystallographic	Crystallographic	NNP
cord-263532-q044i7ym	322	21	Studies	Studies	NNPS
cord-263532-q044i7ym	322	22	on	on	IN
cord-263532-q044i7ym	322	23	Coronaviral	Coronaviral	NNP
cord-263532-q044i7ym	322	24	Proteases	Proteases	NNP
cord-263532-q044i7ym	323	1	Enable	enable	VB
cord-263532-q044i7ym	323	2	Antiviral	Antiviral	NNP
cord-263532-q044i7ym	323	3	Drug	Drug	NNP
cord-263532-q044i7ym	323	4	Design	Design	NNP
cord-263532-q044i7ym	323	5	Identification	Identification	NNP
cord-263532-q044i7ym	323	6	of	of	IN
cord-263532-q044i7ym	323	7	Novel	Novel	NNP
cord-263532-q044i7ym	323	8	Inhibitors	Inhibitors	NNPS
cord-263532-q044i7ym	323	9	of	of	IN
cord-263532-q044i7ym	323	10	the	the	DT
cord-263532-q044i7ym	323	11	SARS	SARS	NNP
cord-263532-q044i7ym	323	12	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	323	13	Main	Main	NNP
cord-263532-q044i7ym	323	14	Protease	Protease	NNP
cord-263532-q044i7ym	323	15	3CL	3CL	NNP
cord-263532-q044i7ym	323	16	pro	pro	JJ
cord-263532-q044i7ym	323	17	Severe	severe	JJ
cord-263532-q044i7ym	323	18	Acute	acute	JJ
cord-263532-q044i7ym	323	19	Respiratory	Respiratory	NNP
cord-263532-q044i7ym	323	20	Syndrome	Syndrome	NNP
cord-263532-q044i7ym	323	21	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	323	22	3C	3c	NN
cord-263532-q044i7ym	323	23	-	-	HYPH
cord-263532-q044i7ym	323	24	like	like	JJ
cord-263532-q044i7ym	323	25	Proteinase	Proteinase	NNP
cord-263532-q044i7ym	323	26	N	N	NNP
cord-263532-q044i7ym	323	27	Terminus	Terminus	NNP
cord-263532-q044i7ym	323	28	Is	be	VBZ
cord-263532-q044i7ym	323	29	Indispensable	indispensable	JJ
cord-263532-q044i7ym	323	30	for	for	IN
cord-263532-q044i7ym	323	31	Proteolytic	Proteolytic	NNP
cord-263532-q044i7ym	323	32	Activity	Activity	NNP
cord-263532-q044i7ym	324	1	but	but	CC
cord-263532-q044i7ym	324	2	Not	not	RB
cord-263532-q044i7ym	324	3	for	for	IN
cord-263532-q044i7ym	324	4	Enzyme	Enzyme	NNP
cord-263532-q044i7ym	324	5	Dimerization	Dimerization	NNP
cord-263532-q044i7ym	324	6	:	:	:
cord-263532-q044i7ym	324	7	Biochemical	Biochemical	NNP
cord-263532-q044i7ym	324	8	and	and	CC
cord-263532-q044i7ym	324	9	Thermodynamic	Thermodynamic	NNP
cord-263532-q044i7ym	324	10	Investigation	Investigation	NNP
cord-263532-q044i7ym	324	11	in	in	IN
cord-263532-q044i7ym	324	12	Conjunction	Conjunction	NNP
cord-263532-q044i7ym	324	13	with	with	IN
cord-263532-q044i7ym	324	14	Molecular	Molecular	NNP
cord-263532-q044i7ym	324	15	Dynamics	Dynamics	NNPS
cord-263532-q044i7ym	324	16	Simulations	Simulations	NNPS
cord-263532-q044i7ym	324	17	Critical	Critical	NNP
cord-263532-q044i7ym	324	18	Assessment	Assessment	NNP
cord-263532-q044i7ym	324	19	of	of	IN
cord-263532-q044i7ym	324	20	Important	Important	NNP
cord-263532-q044i7ym	324	21	Regions	Regions	NNPS
cord-263532-q044i7ym	324	22	in	in	IN
cord-263532-q044i7ym	324	23	the	the	DT
cord-263532-q044i7ym	324	24	Subunit	Subunit	NNP
cord-263532-q044i7ym	324	25	Association	Association	NNP
cord-263532-q044i7ym	324	26	and	and	CC
cord-263532-q044i7ym	324	27	Catalytic	Catalytic	NNP
cord-263532-q044i7ym	324	28	Action	Action	NNP
cord-263532-q044i7ym	324	29	of	of	IN
cord-263532-q044i7ym	324	30	the	the	DT
cord-263532-q044i7ym	324	31	Severe	severe	JJ
cord-263532-q044i7ym	324	32	Acute	acute	JJ
cord-263532-q044i7ym	324	33	Respiratory	respiratory	JJ
cord-263532-q044i7ym	324	34	Syndrome	syndrome	NN
cord-263532-q044i7ym	325	1	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	325	2	Main	Main	NNP
cord-263532-q044i7ym	325	3	Protease	Protease	NNP
cord-263532-q044i7ym	325	4	Hilgenfeld	Hilgenfeld	NNP
cord-263532-q044i7ym	325	5	,	,	,
cord-263532-q044i7ym	325	6	R.	R.	NNP
cord-263532-q044i7ym	325	7	pH	ph	NN
cord-263532-q044i7ym	325	8	-	-	HYPH
cord-263532-q044i7ym	325	9	dependent	dependent	JJ
cord-263532-q044i7ym	325	10	conformational	conformational	JJ
cord-263532-q044i7ym	325	11	flexibility	flexibility	NN
cord-263532-q044i7ym	325	12	of	of	IN
cord-263532-q044i7ym	325	13	the	the	DT
cord-263532-q044i7ym	325	14	SARS	SARS	NNP
cord-263532-q044i7ym	325	15	-	-	HYPH
cord-263532-q044i7ym	325	16	CoV	CoV	NNP
cord-263532-q044i7ym	325	17	main	main	JJ
cord-263532-q044i7ym	325	18	proteinase	proteinase	NN
cord-263532-q044i7ym	325	19	(	(	-LRB-
cord-263532-q044i7ym	325	20	M	M	NNP
cord-263532-q044i7ym	325	21	pro	pro	JJ
cord-263532-q044i7ym	325	22	)	)	-RRB-
cord-263532-q044i7ym	325	23	dimer	dimer	NNP
cord-263532-q044i7ym	325	24	:	:	:
cord-263532-q044i7ym	325	25	molecular	molecular	JJ
cord-263532-q044i7ym	325	26	dynamics	dynamic	NNS
cord-263532-q044i7ym	325	27	simulations	simulation	NNS
cord-263532-q044i7ym	325	28	and	and	CC
cord-263532-q044i7ym	325	29	multiple	multiple	JJ
cord-263532-q044i7ym	325	30	X	x	NN
cord-263532-q044i7ym	325	31	-	-	NN
cord-263532-q044i7ym	325	32	ray	ray	NN
cord-263532-q044i7ym	325	33	structure	structure	NN
cord-263532-q044i7ym	325	34	analyses	analyse	VBZ
cord-263532-q044i7ym	325	35	Only	only	RB
cord-263532-q044i7ym	325	36	One	one	CD
cord-263532-q044i7ym	325	37	Protomer	Protomer	NNP
cord-263532-q044i7ym	325	38	Is	be	VBZ
cord-263532-q044i7ym	325	39	Active	active	JJ
cord-263532-q044i7ym	325	40	in	in	IN
cord-263532-q044i7ym	325	41	the	the	DT
cord-263532-q044i7ym	325	42	Dimer	Dimer	NNP
cord-263532-q044i7ym	325	43	of	of	IN
cord-263532-q044i7ym	325	44	SARS	SARS	NNP
cord-263532-q044i7ym	326	1	3C	3C	NNP
cord-263532-q044i7ym	326	2	-	-	HYPH
cord-263532-q044i7ym	326	3	like	like	JJ
cord-263532-q044i7ym	326	4	Proteinase	Proteinase	NNP
cord-263532-q044i7ym	326	5	CoV	cov	NN
cord-263532-q044i7ym	326	6	Main	Main	NNP
cord-263532-q044i7ym	326	7	Proteinase	Proteinase	NNP
cord-263532-q044i7ym	326	8	:	:	:
cord-263532-q044i7ym	327	1	The	the	DT
cord-263532-q044i7ym	327	2	Monomer	Monomer	NNP
cord-263532-q044i7ym	327	3	-	-	HYPH
cord-263532-q044i7ym	327	4	Dimer	Dimer	NNP
cord-263532-q044i7ym	327	5	Equilibrium	Equilibrium	NNP
cord-263532-q044i7ym	327	6	Dissociation	Dissociation	NNP
cord-263532-q044i7ym	327	7	Constant	Constant	NNP
cord-263532-q044i7ym	327	8	Insight	Insight	NNP
cord-263532-q044i7ym	327	9	into	into	IN
cord-263532-q044i7ym	327	10	the	the	DT
cord-263532-q044i7ym	327	11	Activity	Activity	NNP
cord-263532-q044i7ym	327	12	of	of	IN
cord-263532-q044i7ym	327	13	SARS	SARS	NNP
cord-263532-q044i7ym	327	14	Main	Main	NNP
cord-263532-q044i7ym	327	15	Protease	Protease	NNP
cord-263532-q044i7ym	327	16	:	:	:
cord-263532-q044i7ym	327	17	Molecular	Molecular	NNP
cord-263532-q044i7ym	327	18	Dynamics	Dynamics	NNPS
cord-263532-q044i7ym	327	19	Study	Study	NNP
cord-263532-q044i7ym	327	20	of	of	IN
cord-263532-q044i7ym	327	21	Dimeric	Dimeric	NNP
cord-263532-q044i7ym	327	22	and	and	CC
cord-263532-q044i7ym	327	23	Monomeric	Monomeric	NNP
cord-263532-q044i7ym	327	24	Form	Form	NNP
cord-263532-q044i7ym	327	25	of	of	IN
cord-263532-q044i7ym	327	26	Enzyme	Enzyme	NNP
cord-263532-q044i7ym	327	27	Mechanism	Mechanism	NNP
cord-263532-q044i7ym	328	1	For	for	IN
cord-263532-q044i7ym	328	2	Controlling	control	VBG
cord-263532-q044i7ym	328	3	the	the	DT
cord-263532-q044i7ym	328	4	Monomer	Monomer	NNP
cord-263532-q044i7ym	328	5	-	-	HYPH
cord-263532-q044i7ym	328	6	Dimer	Dimer	NNP
cord-263532-q044i7ym	328	7	Conversion	Conversion	NNP
cord-263532-q044i7ym	328	8	of	of	IN
cord-263532-q044i7ym	328	9	SARS	SARS	NNP
cord-263532-q044i7ym	328	10	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	328	11	Main	Main	NNP
cord-263532-q044i7ym	328	12	Protease	Protease	NNP
cord-263532-q044i7ym	329	1	Without	without	IN
cord-263532-q044i7ym	329	2	Its	-PRON-	PRP$
cord-263532-q044i7ym	329	3	N	N	NNP
cord-263532-q044i7ym	329	4	-	-	HYPH
cord-263532-q044i7ym	329	5	Finger	Finger	NNP
cord-263532-q044i7ym	329	6	,	,	,
cord-263532-q044i7ym	329	7	the	the	DT
cord-263532-q044i7ym	329	8	Main	Main	NNP
cord-263532-q044i7ym	329	9	Protease	Protease	NNP
cord-263532-q044i7ym	329	10	of	of	IN
cord-263532-q044i7ym	329	11	Severe	severe	JJ
cord-263532-q044i7ym	329	12	Acute	acute	JJ
cord-263532-q044i7ym	329	13	Respiratory	respiratory	JJ
cord-263532-q044i7ym	329	14	Syndrome	syndrome	NN
cord-263532-q044i7ym	329	15	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	329	16	Can	Can	MD
cord-263532-q044i7ym	329	17	Form	form	VB
cord-263532-q044i7ym	329	18	a	a	DT
cord-263532-q044i7ym	329	19	Novel	Novel	NNP
cord-263532-q044i7ym	329	20	Dimer	Dimer	NNP
cord-263532-q044i7ym	329	21	through	through	IN
cord-263532-q044i7ym	329	22	Its	-PRON-	PRP$
cord-263532-q044i7ym	329	23	C	C	NNP
cord-263532-q044i7ym	329	24	-	-	HYPH
cord-263532-q044i7ym	329	25	Terminal	Terminal	NNP
cord-263532-q044i7ym	329	26	Domain	Domain	NNP
cord-263532-q044i7ym	329	27	Xia	Xia	NNP
cord-263532-q044i7ym	329	28	,	,	,
cord-263532-q044i7ym	329	29	B.	B.	NNP
cord-263532-q044i7ym	329	30	C	C	NNP
cord-263532-q044i7ym	329	31	-	-	HYPH
cord-263532-q044i7ym	329	32	Terminal	Terminal	NNP
cord-263532-q044i7ym	329	33	Domain	Domain	NNP
cord-263532-q044i7ym	329	34	of	of	IN
cord-263532-q044i7ym	329	35	SARS	SARS	NNP
cord-263532-q044i7ym	329	36	-	-	HYPH
cord-263532-q044i7ym	329	37	CoV	CoV	NNP
cord-263532-q044i7ym	329	38	Main	Main	NNP
cord-263532-q044i7ym	329	39	Protease	Protease	NNP
cord-263532-q044i7ym	329	40	can	can	MD
cord-263532-q044i7ym	329	41	form	form	VB
cord-263532-q044i7ym	329	42	a	a	DT
cord-263532-q044i7ym	329	43	3D	3d	JJ
cord-263532-q044i7ym	329	44	Domain	domain	NN
cord-263532-q044i7ym	329	45	-	-	HYPH
cord-263532-q044i7ym	329	46	Swapped	Swapped	NNP
cord-263532-q044i7ym	329	47	Dimer	Dimer	NNP
cord-263532-q044i7ym	329	48	Maturation	Maturation	NNP
cord-263532-q044i7ym	329	49	Mechanism	Mechanism	NNP
cord-263532-q044i7ym	329	50	of	of	IN
cord-263532-q044i7ym	329	51	Severe	severe	JJ
cord-263532-q044i7ym	329	52	Acute	acute	JJ
cord-263532-q044i7ym	329	53	Respiratory	Respiratory	NNP
cord-263532-q044i7ym	329	54	Syndrome	Syndrome	NNP
cord-263532-q044i7ym	329	55	(	(	-LRB-
cord-263532-q044i7ym	329	56	SARS	SARS	NNP
cord-263532-q044i7ym	329	57	)	)	-RRB-
cord-263532-q044i7ym	330	1	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	330	2	3C	3c	NN
cord-263532-q044i7ym	330	3	-	-	HYPH
cord-263532-q044i7ym	330	4	like	like	JJ
cord-263532-q044i7ym	331	1	Proteinase	Proteinase	NNP
cord-263532-q044i7ym	331	2	Blocks	Blocks	NNP
cord-263532-q044i7ym	331	3	the	the	DT
cord-263532-q044i7ym	331	4	Substrate	Substrate	NNP
cord-263532-q044i7ym	331	5	-	-	HYPH
cord-263532-q044i7ym	331	6	Induced	Induced	NNP
cord-263532-q044i7ym	331	7	Dimerization	Dimerization	NNP
cord-263532-q044i7ym	331	8	of	of	IN
cord-263532-q044i7ym	331	9	SARS	SARS	NNP
cord-263532-q044i7ym	331	10	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	331	11	Main	Main	NNP
cord-263532-q044i7ym	331	12	Protease	Protease	NNP
cord-263532-q044i7ym	332	1	Evaluating	evaluate	VBG
cord-263532-q044i7ym	332	2	the	the	DT
cord-263532-q044i7ym	332	3	3C	3c	NN
cord-263532-q044i7ym	332	4	-	-	HYPH
cord-263532-q044i7ym	332	5	like	like	JJ
cord-263532-q044i7ym	332	6	Protease	Protease	NNP
cord-263532-q044i7ym	332	7	Activity	Activity	NNP
cord-263532-q044i7ym	332	8	of	of	IN
cord-263532-q044i7ym	332	9	SARS	SARS	NNP
cord-263532-q044i7ym	332	10	-	-	HYPH
cord-263532-q044i7ym	332	11	Coronavirus	Coronavirus	NNP
cord-263532-q044i7ym	333	1	:	:	:
cord-263532-q044i7ym	333	2	Recommendations	recommendation	NNS
cord-263532-q044i7ym	333	3	for	for	IN
cord-263532-q044i7ym	333	4	Standardized	Standardized	NNP
cord-263532-q044i7ym	333	5	Assays	Assays	NNP
cord-263532-q044i7ym	333	6	for	for	IN
cord-263532-q044i7ym	333	7	Drug	Drug	NNP
cord-263532-q044i7ym	333	8	Discovery	Discovery	NNP
cord-263532-q044i7ym	333	9	Role	role	NN
cord-263532-q044i7ym	333	10	of	of	IN
cord-263532-q044i7ym	333	11	Lopinavir/	Lopinavir/	NNP
cord-263532-q044i7ym	333	12	Ritonavir	Ritonavir	NNPS
cord-263532-q044i7ym	333	13	in	in	IN
cord-263532-q044i7ym	333	14	the	the	DT
cord-263532-q044i7ym	333	15	Treatment	Treatment	NNP
cord-263532-q044i7ym	333	16	of	of	IN
cord-263532-q044i7ym	333	17	SARS	SARS	NNP
cord-263532-q044i7ym	333	18	:	:	:
cord-263532-q044i7ym	334	1	Initial	Initial	NNP
cord-263532-q044i7ym	334	2	Virological	Virological	NNP
cord-263532-q044i7ym	334	3	and	and	CC
cord-263532-q044i7ym	334	4	Clinical	Clinical	NNP
cord-263532-q044i7ym	334	5	Findings	Findings	NNP
cord-263532-q044i7ym	334	6	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-263532-q044i7ym	334	7	,	,	,
cord-263532-q044i7ym	334	8	a	a	DT
cord-263532-q044i7ym	334	9	Less	less	RBR
cord-263532-q044i7ym	334	10	Toxic	toxic	JJ
cord-263532-q044i7ym	334	11	Derivative	derivative	NN
cord-263532-q044i7ym	334	12	of	of	IN
cord-263532-q044i7ym	334	13	Chloroquine	Chloroquine	NNP
cord-263532-q044i7ym	334	14	,	,	,
cord-263532-q044i7ym	334	15	Is	be	VBZ
cord-263532-q044i7ym	334	16	Effective	effective	JJ
cord-263532-q044i7ym	334	17	in	in	IN
cord-263532-q044i7ym	334	18	Inhibiting	inhibit	VBG
cord-263532-q044i7ym	334	19	SARS	SARS	NNP
cord-263532-q044i7ym	334	20	-	-	HYPH
cord-263532-q044i7ym	334	21	CoV-2	CoV-2	NNP
cord-263532-q044i7ym	334	22	Infection	infection	NN
cord-263532-q044i7ym	335	1	In	in	IN
cord-263532-q044i7ym	335	2	Vitro	Vitro	NNP
cord-263532-q044i7ym	335	3	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-263532-q044i7ym	335	4	for	for	IN
cord-263532-q044i7ym	335	5	Treatment	Treatment	NNP
cord-263532-q044i7ym	335	6	of	of	IN
cord-263532-q044i7ym	335	7	COVID-19	COVID-19	NNP
cord-263532-q044i7ym	335	8	:	:	:
cord-263532-q044i7ym	336	1	A	a	DT
cord-263532-q044i7ym	336	2	Randomized	Randomized	NNP
cord-263532-q044i7ym	336	3	Control	Control	NNP
cord-263532-q044i7ym	336	4	Trial	trial	NN
cord-263532-q044i7ym	337	1	(	(	-LRB-
cord-263532-q044i7ym	337	2	THDMS	THDMS	NNP
cord-263532-q044i7ym	337	3	-	-	HYPH
cord-263532-q044i7ym	337	4	COVID-19).https://	COVID-19).https://	NNP
cord-263532-q044i7ym	337	5	d	d	NN
cord-263532-q044i7ym	337	6	=	=	SYM
cord-263532-q044i7ym	337	7	protease+inhibitors+covid-19&draw=2&rank=1	protease+inhibitors+covid-19&draw=2&rank=1	VBN
cord-263532-q044i7ym	337	8	(	(	-LRB-
cord-263532-q044i7ym	337	9	accessed	access	VBN
cord-263532-q044i7ym	337	10	2020	2020	CD
cord-263532-q044i7ym	337	11	-	-	SYM
cord-263532-q044i7ym	337	12	05	05	CD
cord-263532-q044i7ym	337	13	-	-	HYPH
cord-263532-q044i7ym	337	14	06	06	CD
cord-263532-q044i7ym	337	15	)	)	-RRB-
cord-263532-q044i7ym	337	16	.	.	.
cord-263532-q044i7ym	338	1	(	(	-LRB-
cord-263532-q044i7ym	338	2	51	51	CD
cord-263532-q044i7ym	338	3	)	)	-RRB-
cord-263532-q044i7ym	338	4	31	31	CD
cord-263532-q044i7ym	338	5	Studies	study	NNS
cord-263532-q044i7ym	338	6	found	find	VBD
cord-263532-q044i7ym	338	7	for	for	IN
cord-263532-q044i7ym	338	8	:	:	:
cord-263532-q044i7ym	338	9	lopinavir	lopinavir	NNP
cord-263532-q044i7ym	338	10	/	/	SYM
cord-263532-q044i7ym	338	11	ritonavir	ritonavir	NNP
cord-263532-q044i7ym	338	12	|	|	NNP
cord-263532-q044i7ym	338	13	coronavirus	coronavirus	NN
cord-263532-q044i7ym	338	14	.	.	.
cord-263532-q044i7ym	339	1	https://	https://	NNP
cord-263532-q044i7ym	339	2	cli	cli	NNP
cord-263532-q044i7ym	339	3	nical	nical	NNP
cord-263532-q044i7ym	339	4	tri	tri	NNP
cord-263532-q044i7ym	339	5	als	als	NNP
cord-263532-q044i7ym	340	1	.gov	.gov	NNP
cord-263532-q044i7ym	340	2	/	/	SYM
cord-263532-q044i7ym	340	3	ct	ct	NN
cord-263532-q044i7ym	340	4	2	2	CD
cord-263532-q044i7ym	341	1	/res	/res	.
cord-263532-q044i7ym	342	1	ult	ult	NNP
cord-263532-q044i7ym	342	2	s	s	NNP
cord-263532-q044i7ym	342	3	?	?	.
cord-263532-q044i7ym	343	1	Structure	structure	NN
cord-263532-q044i7ym	343	2	-	-	HYPH
cord-263532-q044i7ym	343	3	Based	Based	NNP
cord-263532-q044i7ym	343	4	Discovery	Discovery	NNP
cord-263532-q044i7ym	343	5	of	of	IN
cord-263532-q044i7ym	343	6	Antiviral	Antiviral	NNP
cord-263532-q044i7ym	343	7	Inhibitors	Inhibitors	NNP
cord-263532-q044i7ym	343	8	Targeting	target	VBG
cord-263532-q044i7ym	343	9	the	the	DT
cord-263532-q044i7ym	343	10	E	E	NNP
cord-263532-q044i7ym	343	11	Dimer	Dimer	NNP
cord-263532-q044i7ym	343	12	Interface	Interface	NNP
cord-263532-q044i7ym	343	13	of	of	IN
cord-263532-q044i7ym	343	14	Japanese	japanese	JJ
cord-263532-q044i7ym	343	15	Encephalitis	Encephalitis	NNP
cord-263532-q044i7ym	343	16	Virus	Virus	NNP
cord-263532-q044i7ym	343	17	Dimer	Dimer	NNP
cord-263532-q044i7ym	343	18	Disruption	Disruption	NNP
cord-263532-q044i7ym	343	19	and	and	CC
cord-263532-q044i7ym	343	20	Monomer	Monomer	NNP
cord-263532-q044i7ym	343	21	Sequestration	Sequestration	NNP
cord-263532-q044i7ym	343	22	by	by	IN
cord-263532-q044i7ym	343	23	Alkyl	Alkyl	NNP
cord-263532-q044i7ym	343	24	Tripeptides	tripeptide	NNS
cord-263532-q044i7ym	343	25	Are	be	VBP
cord-263532-q044i7ym	343	26	Successful	successful	JJ
cord-263532-q044i7ym	343	27	Strategies	strategy	NNS
cord-263532-q044i7ym	343	28	for	for	IN
cord-263532-q044i7ym	343	29	Inhibiting	inhibit	VBG
cord-263532-q044i7ym	343	30	Wild	Wild	NNP
cord-263532-q044i7ym	343	31	-	-	HYPH
cord-263532-q044i7ym	343	32	Type	Type	NNP
cord-263532-q044i7ym	343	33	and	and	CC
cord-263532-q044i7ym	343	34	Multidrug	Multidrug	NNP
cord-263532-q044i7ym	343	35	-	-	HYPH
cord-263532-q044i7ym	343	36	Resistant	Resistant	NNP
cord-263532-q044i7ym	343	37	Mutated	mutate	VBD
cord-263532-q044i7ym	343	38	HIV-1	HIV-1	NNP
cord-263532-q044i7ym	343	39	Proteases	Proteases	NNP
cord-263532-q044i7ym	343	40	Strategies	Strategies	NNPS
cord-263532-q044i7ym	343	41	in	in	IN
cord-263532-q044i7ym	343	42	the	the	DT
cord-263532-q044i7ym	343	43	Design	Design	NNP
cord-263532-q044i7ym	343	44	of	of	IN
cord-263532-q044i7ym	343	45	Antiviral	antiviral	JJ
cord-263532-q044i7ym	343	46	Drugs	drug	NNS
cord-263532-q044i7ym	344	1	Targeting	target	VBG
cord-263532-q044i7ym	344	2	the	the	DT
cord-263532-q044i7ym	344	3	Dimerization	Dimerization	NNP
cord-263532-q044i7ym	344	4	Interface	Interface	NNP
cord-263532-q044i7ym	344	5	of	of	IN
cord-263532-q044i7ym	344	6	HIV-1	HIV-1	NNP
cord-263532-q044i7ym	344	7	Protease	Protease	NNP
cord-263532-q044i7ym	344	8	:	:	:
cord-263532-q044i7ym	345	1	Inhibition	inhibition	NN
cord-263532-q044i7ym	345	2	with	with	IN
cord-263532-q044i7ym	345	3	Cross	Cross	NNP
cord-263532-q044i7ym	345	4	-	-	HYPH
cord-263532-q044i7ym	345	5	Linked	link	VBN
cord-263532-q044i7ym	345	6	Interfacial	Interfacial	NNP
cord-263532-q044i7ym	345	7	Peptides	Peptides	NNP
cord-263532-q044i7ym	345	8	HIV-1	HIV-1	NNP
cord-263532-q044i7ym	345	9	Reproduction	Reproduction	NNP
cord-263532-q044i7ym	345	10	Is	be	VBZ
cord-263532-q044i7ym	345	11	Inhibited	inhibit	VBN
cord-263532-q044i7ym	345	12	by	by	IN
cord-263532-q044i7ym	346	1	Peptides	peptide	NNS
cord-263532-q044i7ym	346	2	Derived	derive	VBN
cord-263532-q044i7ym	346	3	from	from	IN
cord-263532-q044i7ym	346	4	the	the	DT
cord-263532-q044i7ym	346	5	N	N	NNP
cord-263532-q044i7ym	346	6	-	-	:
cord-263532-q044i7ym	346	7	And	and	CC
cord-263532-q044i7ym	346	8	C	C	NNP
cord-263532-q044i7ym	346	9	-	-	HYPH
cord-263532-q044i7ym	346	10	Termini	Termini	NNP
cord-263532-q044i7ym	346	11	of	of	IN
cord-263532-q044i7ym	346	12	HIV-1	HIV-1	NNP
cord-263532-q044i7ym	346	13	Protease	Protease	NNP
cord-263532-q044i7ym	346	14	Peptide	Peptide	NNP
cord-263532-q044i7ym	346	15	-	-	HYPH
cord-263532-q044i7ym	346	16	Based	base	VBN
cord-263532-q044i7ym	346	17	Molecular	Molecular	NNP
cord-263532-q044i7ym	346	18	Strategies	Strategies	NNPS
cord-263532-q044i7ym	347	1	To	to	TO
cord-263532-q044i7ym	347	2	Interfere	interfere	VB
cord-263532-q044i7ym	347	3	with	with	IN
cord-263532-q044i7ym	347	4	Protein	Protein	NNP
cord-263532-q044i7ym	347	5	Misfolding	Misfolding	NNP
cord-263532-q044i7ym	347	6	,	,	,
cord-263532-q044i7ym	347	7	Aggregation	Aggregation	NNP
cord-263532-q044i7ym	347	8	and	and	CC
cord-263532-q044i7ym	347	9	Cell	Cell	NNP
cord-263532-q044i7ym	347	10	Degeneration	Degeneration	NNP
cord-263532-q044i7ym	348	1	The	the	DT
cord-263532-q044i7ym	348	2	Current	Current	NNP
cord-263532-q044i7ym	348	3	State	State	NNP
cord-263532-q044i7ym	348	4	of	of	IN
cord-263532-q044i7ym	348	5	Peptide	Peptide	NNP
cord-263532-q044i7ym	348	6	Drug	Drug	NNP
cord-263532-q044i7ym	348	7	Discovery	Discovery	NNP
cord-263532-q044i7ym	348	8	:	:	:
cord-263532-q044i7ym	349	1	Back	back	RB
cord-263532-q044i7ym	349	2	to	to	IN
cord-263532-q044i7ym	349	3	the	the	DT
cord-263532-q044i7ym	349	4	Future	future	NN
cord-263532-q044i7ym	349	5	?	?	.
cord-263532-q044i7ym	350	1	Rationally	rationally	RB
cord-263532-q044i7ym	350	2	Designed	design	VBN
cord-263532-q044i7ym	350	3	Peptides	Peptides	NNPS
cord-263532-q044i7ym	350	4	and	and	CC
cord-263532-q044i7ym	350	5	Peptidomimetics	Peptidomimetics	NNPS
cord-263532-q044i7ym	350	6	as	as	IN
cord-263532-q044i7ym	350	7	Inhibitors	Inhibitors	NNP
cord-263532-q044i7ym	350	8	of	of	IN
cord-263532-q044i7ym	351	1	Amyloid	Amyloid	NNP
cord-263532-q044i7ym	351	2	-	-	HYPH
cord-263532-q044i7ym	351	3	β	β	NN
cord-263532-q044i7ym	351	4	(	(	-LRB-
cord-263532-q044i7ym	351	5	Aβ	Aβ	NNP
cord-263532-q044i7ym	351	6	)	)	-RRB-
cord-263532-q044i7ym	351	7	Aggregation	aggregation	NN
cord-263532-q044i7ym	351	8	:	:	:
cord-263532-q044i7ym	351	9	Potential	potential	JJ
cord-263532-q044i7ym	351	10	Therapeutics	therapeutic	NNS
cord-263532-q044i7ym	351	11	of	of	IN
cord-263532-q044i7ym	351	12	Alzheimer	Alzheimer	NNP
cord-263532-q044i7ym	351	13	's	's	POS
cord-263532-q044i7ym	351	14	Disease	Disease	NNP
cord-263532-q044i7ym	351	15	ACS	ACS	NNP
cord-263532-q044i7ym	351	16	Combinatorial	Combinatorial	NNP
cord-263532-q044i7ym	351	17	Science	Science	NNP
cord-263532-q044i7ym	351	18	pubs.acs.org/acscombsci	pubs.acs.org/acscombsci	NNP
cord-263532-q044i7ym	351	19	Review	Review	NNP