id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012897-n5ujh4qg	Barrett, Tessa J.	Platelet and Vascular Biomarkers Associate With Thrombosis and Death in Coronavirus Disease	2020-08-06		.txt	text/plain	1032	66	45	Following adjustment for age, sex, race/ethnicity, antiplatelet therapy, platelet count, and chronic obstructive pulmonary disease, TxB 2 (P=0.006), P-selectin (P=0.005), sCD40L (P=0.016), and MPV (P=0.012) were independently associated with the composite of thrombosis or death. Of the 24 patients who died TxB 2 (P=0.006), P-selectin (P=0.005), sCD40L (P=0.016), and MPV (P=0.012) were associated with all-cause mortality after multivariable adjustment (Table 2) . We report for the first time that biomarkers of platelet activity and vascular health, are significantly associated with the composite outcome of thrombosis or death in hospitalized patients with COVID-19. Our current study does not characterize the cellular source of measured biomarkers, thus in addition to platelets, plasma P-selectin and sCD40L may originate from alternate sources including endothelial cells and T OR from logistic regression analysis per SD increase for biomarker levels adjusted for age, sex, race, antiplatelet therapy, platelet count, and COPD. 3 We extend those finding and demonstrate that biomarkers of platelet activation are associated with thrombosis or death in patients hospitalized with COVID-19.	./cache/cord-012897-n5ujh4qg.txt	./txt/cord-012897-n5ujh4qg.txt