id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-034156-adcnahpn	Kim, Michael G.	Fatal Cerebral Edema in a Child with COVID-19	2020-10-22		.txt	text/plain	837	62	51	Many patients with the pediatric multisystem inflammatory syndrome (PMIS) associated with COVID-19 present without respiratory symptoms. [1, 2] We present a pediatric patient with COVID-19 who experienced rapid neurologic deterioration, diffuse cerebral edema, and ultimately brain death secondary to PMIS. His serum inflammatory labs showed a normal procalcitonin, ferritin, and white blood cell count, but had an elevated C-reactive protein of 13 mg/dL (0.00-0.50 mg/dL), erythrocyte sedimentation rate of 38 mm/hr (0-15 mm/hr), and Ddimer of 6.54 mg/L (<0.59 mg/L). [3, 4] An overproduction of pro-inflammatory cytokines can cause vascular injury, cell death, and increased vascular permeability, which could account for the cerebral edema in our patient. It is unclear why PMIS presents in a delayed fashion in pediatric patients who otherwise J o u r n a l P r e -p r o o f Kim 4 did not manifest the early stages of COVID-19. Pediatric COVID-associated Multi-system Inflammatory Syndrome (PMIS)	./cache/cord-034156-adcnahpn.txt	./txt/cord-034156-adcnahpn.txt