id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-206006-8l7hrany	Wang, Rui	Mutations on COVID-19 diagnostic targets	2020-05-05		.txt	text/plain	1605	94	56	Effective, sensitive, and reliable diagnostic reagents are of paramount importance for combating the ongoing coronavirus disease 2019 (COVID-19) pandemic at a time there is no preventive vaccine nor specific drug available for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Based on the genotyping of 7818 SARS-CoV-2 genome samples collected up to May 1, 2020, we reveal that essentially all of the current COVID-19 diagnostic targets have had mutations. We further show that SARS-CoV-2 has the most devastating mutations on the targets of various nucleocapsid (N) gene primers and probes, which have been unfortunately used by countries around the world to diagnose COVID-19. It is interesting to note that N-China-F [10] is the most inefficient reagent among all primers/probes and its SARS-CoV-2 target has eight mutations involving samples in all five clusters, which may explain many media reports about the inefficiency of certain COVID-19 diagnostic kits made in China.	./cache/cord-206006-8l7hrany.txt	./txt/cord-206006-8l7hrany.txt