id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-241686-bzt6jsyi	Srivastava, Ambrish Kumar	In Silico Investigations on the Potential Inhibitors for COVID-19 Protease	2020-03-24		.txt	text/plain	1355	80	56	This prompted us to perform a preliminary in silico study on the COVID-19 protease with anti-malarial compounds in the search of potential inhibitor. Among the seven studied compounds, mepacrine appears as the potential inhibitor of the COVID-19 followed by chloroquine, hydroxychloroquine and phomarin. Based on the results of some clinical trials, it has been reported [11] that chloroquine phosphate, an anti-malarial drug, has a certain curative effect on the COVID-19. This motivated us to perform a systematic study on some anti-malarial drugs using molecular docking and reinvestigate their biological activities and pharmacological effects. To identify the potential binding sites for anti-malarial compounds, we have been performed an automated in silico molecular-docking procedure using the SwissDock web server [14, 15] , which is based on the docking algorithm EADock ESS. We have performed a systematic study on anti-malarial compounds in the search of potential inhibitors for novel coronavirus, COVID-19 protease.	./cache/cord-241686-bzt6jsyi.txt	./txt/cord-241686-bzt6jsyi.txt