id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-253958-8lhzgqfr	Clark, T. W.	Diagnostic accuracy of a host response point-of-care test for identifying COVID-19	2020-06-02		.txt	text/plain	4067	270	62	The sample size for this sub-study was driven by consideration for estimating sensitivity of FebriDx MxA for the identification of COVID-19 (as defined by the reference standard of detection of SARS-CoV-2 by PCR on respiratory samples) and of the methods proposed by Riley et al 12 for multivariable predictive models. As the antiviral host response to SARS-CoV-2 would be expected to wane over time, but detection of viral RNA by PCR may persist for several weeks, a secondary analysis was pre-specified to assess diagnostic accuracy in those who have had duration of less than seven days. Although direct comparison of accuracy was not possible due to samples size, the sensitivity, specificity and positive and negative predictive values of FebriDx appeared comparable for patients presenting before and after 7 days of symptom duration. In this large, real-world study we have shown that that the detection of the antiviral host response protein MxA using the FebriDx point-of-care test had high sensitivity for the identification of COVID-19 during the first wave of the pandemic.	./cache/cord-253958-8lhzgqfr.txt	./txt/cord-253958-8lhzgqfr.txt