id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-253993-ynrthadj	Belhassan, Assia	Assessment of effective imidazole derivatives against SARS-CoV-2 main protease through computational approach	2020-09-18		.txt	text/plain	1766	94	46	The result indicate that Molecules N° 3, 7 and 14 have more binding energy with SARS-CoV-2 main protease recently crystallized (pdb code 6LU7) in comparison with the other imidazole derivatives and the two drug; Chloroquine and hydroxychloroquine. Based on all these effects, the study of interactions between chloroquine, hydroxychloroquine and the eighteen imidazole derivatives against the SARS-CoV-2 main protease are recommended. In this paper, the modeling interaction of eighteen imidazole derivatives against novel Coronavirus are performed using the molecular docking method followed by comparison with chloroquine, hydroxychloroquine interactions formed in the same binding site of SARS-CoV-2 main protease. In this study, we have tried to carry out a docking study of chemical compounds reported as potent Antiplasmodial inhibitors of imidazole derivatives based on 7-chloro-4-aminoquinoline and analogues in the active site of SARS-Cov-2 main protease, flowed by comparison with two drugs; chloroquine and hydroxychloroquine.	./cache/cord-253993-ynrthadj.txt	./txt/cord-253993-ynrthadj.txt