id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-254715-4dt8aqof	Kander, Thomas	Coagulation disorder in COVID-19	2020-07-10		.txt	text/plain	873	48	31	In severe cases, the host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to sepsis or septic shock as defined by the international consensus definitions for sepsis and septic shock (sepsis-3), including life-threatening organ dysfunction. 2 In COVID-19-induced sepsis or septic shock, the respiratory manifestations such as severe dyspnoea and hypoxaemia are particularly obvious and pertinent and are also the basis for the grading of mild, moderate, severe, and critical COVID-19 infection, as suggested by the diagnosis and treatment protocol for novel coronavirus pneumonia published by National Health Commission in China. Pending the results of several randomised controlled trials (NCT04345848, NCT04366960, NCT04367831 and NCT04372589), the opinion of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis on thrombosis prophylaxis is that "a change of anticoagulant regimen from prophylactic low molecular weight heparin or intermediate-dose to treatment-dose regimen can be considered in patients without established venous thromboembolism, but deteriorating pulmonary status or acute respiratory distress syndrome".	./cache/cord-254715-4dt8aqof.txt	./txt/cord-254715-4dt8aqof.txt