id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-254993-bndl93qr	Sonnweber, Thomas	Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study	2020-10-21		.txt	text/plain	3684	192	41	To shed light on the regulation of iron metabolism and its impact on monocyte immune effector functions at the cellular level, we investigated the mRNA expression of key mediators of iron homeostasis as well as cytokine expression in PBMCs. In line with serum hepcidin measurements, we also found increased hepcidin mRNA (HAMP, for hepcidin antimicrobial peptide) expression in PBMCs isolated from subjects who previously had severe to critical COVID-19 as compared to those who suffered from milder disease (Fig. 2) . In contrast, the immune effector function of PBMCs was related to COVID-19 severity, as mononuclear cells obtained from patients, who suffered from severe to critical disease, demonstrated higher levels of interleukin 10 (IL10, p = 0.044) and tumour necrosis factor (TNF, p = 0.024) mRNA expression as compared to subjects with a milder course of COVID-19 (Fig. 2) .	./cache/cord-254993-bndl93qr.txt	./txt/cord-254993-bndl93qr.txt