id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-256226-hzgvioq6	Sehgal, Vishal	Sex, Sleep, Steroids, and Lifestyle: Unraveling the Coronavirus Disease 2019 Conundrum	2020-09-25		.txt	text/plain	1773	129	52	[6] Obesity being a state of chronic inflammation has been known to induce the alteration of the immune system with proinflammatory M1 macrophages being activated and anti-inflammatory M2 macrophages being suppressed. [7] Aging of the immune system is accompanied by a proinflammatory state with a marked increase in cytokines, namely IL-1, IL-6, IL-18, and tumor necrosis factor (TNF). [12] In fact, individuals with any proinflammatory state would potentially be at risk for COVID-19 related complications. The proinflammatory state may be related to hypothyroidism, [13] hyperthyroidism, [14] or any common chronic autoimmune pathology like rheumatoid arthritis, inflammatory bowel disease, or gout. [20] A metanalysis of 20 randomized controlled trials reported that mindfulness meditation is associated with reduced inflammation as shown by reduced CRP, improved CD4+ T-cell count, and increased telomerase activity. The anti-inflammatory monoclonal antibodies work by predominantly limiting the proinflammatory state and potentially reducing the cytokine storm, which could be fatal.	./cache/cord-256226-hzgvioq6.txt	./txt/cord-256226-hzgvioq6.txt