id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-256696-leqakx22	Sherratt, K.	Evaluating the use of the reproduction number as an epidemiological tool, using spatio-temporal trends of the Covid-19 outbreak in England	2020-10-20		.txt	text/plain	5759	299	55	We estimated Rt using a model that mapped unobserved infections to observed test-positive cases, hospital admissions, and deaths with confirmed Covid-19, in seven regions of England over March through August 2020. We compared differences in Rt with the demographic and social context of transmission, and found the differences between Rt may be linked to biased representations of sub-populations in each data source: from uneven testing rates, or increasing severity of disease with age, seen via outbreaks in care home populations and changing age distributions of cases. We compared the divergence between Rt estimates with spatio-temporal variation in case detection, and the proportion at risk of severe disease, represented by the age distribution of test positive cases and hospital admissions and the proportion of deaths in care homes. We estimated the time-varying reproduction number for Covid-19 over March through August across England and English NHS regions, using test-positive cases, hospital admissions, and deaths with confirmed Covid-19.	./cache/cord-256696-leqakx22.txt	./txt/cord-256696-leqakx22.txt