id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-256891-as6tbfrh	Rubin, Samuel J. S.	Clinical characteristics associated with COVID-19 severity in California	2020-03-30		.txt	text/plain	1139	62	42	Given the rapidly progressing COVID-19 pandemic, this report on a US cohort of 54 COVID-19 patients from Stanford Hospital and data regarding risk factors for severe disease obtained at initial clinical presentation is of high importance and is immediately clinically relevant. We identified low presenting oxygen saturation as predictive of severe disease outcomes, such as diagnosis of pneumonia, acute respiratory distress syndrome (ARDS), and admission to the ICU, and also replicated data from China suggesting a link between hypertension and disease severity. Use of ACE-I or ARB was not significantly associated with recommendation for further hospital care, admission to ICU, diagnosis of pneumonia, or progression to ARDS. When analyzed by logistic regression to control for age, the only factor independently significantly associated with recommendation for further in-hosptial care, diagnosis of pneumonia, and progression to ARDS was initial oxygen saturation measurement as a continuous variable. Clinical characteristics of US COVID-19 patients and factors from initial presentation that associate with disease severity were identified.	./cache/cord-256891-as6tbfrh.txt	./txt/cord-256891-as6tbfrh.txt