id author title date pages extension mime words sentences flesch summary cache txt cord-257144-3q0un5rl Giri, Allan Mutagenic, Genotoxic and Immunomodulatory effects of Hydroxychloroquine and Chloroquine: a review to evaluate its potential to use as a prophylactic drug against COVID-19 2020-09-02 .txt text/plain 5580 285 45 title: Mutagenic, Genotoxic and Immunomodulatory effects of Hydroxychloroquine and Chloroquine: a review to evaluate its potential to use as a prophylactic drug against COVID-19 Hydroxychloroquine (HCQ) and Chloroquine (CQ) are two anti-malarial drugs that are now being extensively used by front-line healthcare workers and other common people as a prophylactic drug against the Corona Virus Disease − 19 (COVID-19) in India and as well as in many parts of the world. Thus, we recognize the need to critically review the mutagenic, genotoxic, and immunomodulatory effects of these drugs, to find out whether it is safe to use as a prophylactic drug against COVID-19. Moreover, the potentials of these drugs as Fig. 5 Endosomal TLR 7 and 9 inhibition by HCQ and CQ: Mammalian Toll-like receptors (TLR) 7 and 9 initiate immune response when it encounters microbial nucleic acids (only shown here is a viral particle). ./cache/cord-257144-3q0un5rl.txt ./txt/cord-257144-3q0un5rl.txt