id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-258019-njky7v5x	Kinaret, Pia A.S.	Covid-19 acute responses and possible long term consequences: What nanotoxicology can teach us	2020-08-10		.txt	text/plain	1359	79	40	However, similarities between the responses to SARS-CoV-2 and certain nanomaterials suggest fibrotic pulmonary disease as a concern for public health in the next future. Also rigid multi-walled carbon nanotubes (rMWCNT), among other nanomaterials, induce innate immune response by activation of NF-κB, STAT3 and HIF-1/2, and consequent cytokine cascade [15, 16] . As the Covid-19 disease progresses, massive damage of the pulmonary tissue occurs by induction of an uncontrolled innate immune response, mainly mediated by M1 pro-inflammatory macrophages and granulocytes. Moreover, up-regulation of antigen processing pathways, RIG-1 and several viral-induced human disease pathways have been reported consequently to carbon nanomaterial exposure, both in vitro [23] and in murine lung in vivo [19, 24] . On the other hand, certain nanoparticles might induce lung fibrosis by a combination of metabolic tissue damage and primary activation of the innate immune cells. Here we summarized noticeable cellular and molecular similarities between the acute responses to both SARS-CoV-2 infection and certain nanomaterials exposure.	./cache/cord-258019-njky7v5x.txt	./txt/cord-258019-njky7v5x.txt