id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-261670-rd9uq6tc	Stringer, Kathleen A.	COVID‐19: The Uninvited Guest in the Intensive Care Unit — Implications for Pharmacotherapy	2020-05-04		.txt	text/plain	2882	154	42	Fever, cough, and dyspnea are the most common signs of COVID-19 5 ; it is a respiratory tract infection with pneumonia being the hallmark of more severe illness and the acute respiratory distress syndrome (ARDS), a serious complication and manifestation of its most critical form (Table 1) . 13 Although these findings have not been replicated in human studies or in the setting of COVID-19, such potential upregulation of ACE2 by ACE inhibitors or ARBs has resulted in speculation that these medications might worsen infection or predispose patients to myocardial injury. In a preclinical model of severe acute respiratory syndrome (SARS Co-V), treatment with losartan improved angiotensin signaling, ARDS, and survival, 14 and severe COVID infections are associated with low (not high) expression of ACE2. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study	./cache/cord-261670-rd9uq6tc.txt	./txt/cord-261670-rd9uq6tc.txt