id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-262863-f07v5uk8	Bertocchi, Ilaria	The hidden role of NLRP3 inflammasome in obesity‐related COVID‐19 exacerbations: lessons for drug repurposing	2020-08-09		.txt	text/plain	5438	252	30	We and others have demonstrated that NLRP3 inflammasome over-activation is involved not only in the pathogenesis of diabesity, but also in the exacerbation of related cardiovascular injuries, including myocardial infarction, and this process is associated to an increase in the local inflammatory response. Similarly, the diabesityrelated basal activation of the NLRP3 inflammasome cascade, leading to increase in either gastrointestinal or vascular permeability, may contribute to exacerbate SARS-CoV-2 systemic diffusion and enhance the intricate mechanisms of intracellular cross talk operational in the pathogenesis of COVID-19. Up to nowadays six clinical trials (NCT04347980, NCT04325061, NCT04395105, NCT04344730, NCT04360876, NCT04327401), reported on clinicaltrials.gov are recruiting patients to test the efficacy of the corticosteroid dexamethasone, whose beneficial effects in airway inflammation has been recently demonstrated to involve lung inhibition of the activity of NLRP3 inflammasome and the release of IL-1β and IL-18 (Guan, Ma, Fan, Chen, Miao & Wu, 2020) .	./cache/cord-262863-f07v5uk8.txt	./txt/cord-262863-f07v5uk8.txt