id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-265022-p5cab562	Kotfis, Katarzyna	COVID-19: ICU delirium management during SARS-CoV-2 pandemic	2020-04-28		.txt	text/plain	5426	256	34	Indeed, patients with COVID-19 are at accelerated risk for delirium due to at least seven factors including (1) direct central nervous system (CNS) invasion, (2) induction of CNS inflammatory mediators, (3) secondary effect of other organ system failure, (4) effect of sedative strategies, (5) prolonged mechanical ventilation time, (6) immobilization, and (7) other needed but unfortunate environmental factors including social isolation and quarantine without family. Given early insights into the pathobiology of the virus, as well as the emerging interventions utilized to treat the critically ill patients, delirium prevention and management will prove exceedingly challenging, especially in the intensive care unit (ICU). Many hospitalized patients with COVID-19 will develop delirium, and given early insights into the pathobiology of this virus indicating invasion into the brain stem, as well as the emerging interventions utilized to treat these critically ill patients, delirium prevention and management may prove exceedingly challenging, especially in the intensive care unit (ICU).	./cache/cord-265022-p5cab562.txt	./txt/cord-265022-p5cab562.txt