id author title date pages extension mime words sentences flesch summary cache txt cord-265155-jbvrcjx8 Aroniadis, Olga C. Current Knowledge and Research Priorities in the Digestive Manifestations of COVID-19 2020-04-22 .txt text/plain 1606 85 39 Herein we discuss the known digestive manifestations of COVID-19 and their potential implications, important questions that remain unanswered, and what gastroenterologists should know to care for affected patients and contribute to extinguishing the pandemic. This is based on: 1) a high incidence (in some reports) of digestive symptoms among infected patients, 1-4 2) expression of Angiotensin Converting Enzyme 2 (ACE2) receptors -the viral target for cellular entry -throughout the digestive system, 1,2 3) presence of viral RNA in the stool of infected patients [1] [2] [3] 5 , and 4) prior experience with the 2003 SARS-coronavirus and the 2012 Middle Eastern Respiratory Syndrome (MERS)-coronavirus, both of which are known to infect and injure the GI tract. Multiple studies have confirmed the presence of SARS-nCoV-2 RNA in the stool of COVID-19 patients, including some who never tested positive in the upper respiratory tract. Digestive Symptoms in COVID-19 Patients with Mild Disease Severity: Clinical Presentation, Stool Viral RNA Testing, and Outcomes ./cache/cord-265155-jbvrcjx8.txt ./txt/cord-265155-jbvrcjx8.txt