id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-267612-1h7xpkbe	Lipsker, Dan	A chilblain epidemic during the COVID-19 pandemic. A sign of natural resistance to SARS-CoV-2?	2020-06-06		.txt	text/plain	516	36	50	Dan Lipsker 1,2 , MD, PhD Since the start of the COVID-19 pandemic, "epidemics" of chilblains or chilblain-like acral lesions have been reported in the social media, the general press and the medical literature in Italy, Spain, the UK and France (1) (2) (3) (4) (5) . The great majority of the cases we observed and those reported in the literature share the following common features: -lesions were of sudden onset in young patients without a previous history of chilblains in most of them and they were not necessarily triggered by exposure to cold; -those young patients were otherwise asymptomatic or pauci-symptomatic and only a few had mild clinical signs compatible with COVID-19; -none of them had pneumonia or severe manifestations of COVID-19; -clinical signs of COVID-19 or contact with infected persons occurred a few days to one month before chilblains; -SARS-CoV-2 infection could be demonstrated by nasopharyngeal swab or by serology only in very limited number of patients. I therefore hypothesize that in a few genetically predisposed individuals the contact with SARS-CoV-2 triggers a strong interferon response, of which chilblain are the cutaneous expression. Chilblain-like lesions: a case series of 41 patients during the COVID-19 pandemic	./cache/cord-267612-1h7xpkbe.txt	./txt/cord-267612-1h7xpkbe.txt