id author title date pages extension mime words sentences flesch summary cache txt cord-268145-0sv6fdtj Long, Brit Just the Facts: What are the roles of oxygen escalation and noninvasive ventilation in COVID-19? 2020-05-13 .txt text/plain 1555 104 53 Patients with increased work of breathing and hypoxemia due to COVID-19 who fail escalation of oxygen therapy and demonstrate clinical distress should undergo endotracheal intubation. 2 Wherever possible, patients with respiratory distress or hypoxemia and suspected or confirmed COVID-19 should first be placed in a negative pressure room or private room with the door closed given the potential need for aerosol-generating procedures. 2, 3 Flow rate and the fraction of inspired oxygen (FiO2) can be titrated based on patient requirements, reducing anatomical dead space, providing positive pressure, reducing inspiratory effort, and improving dynamic compliance. 1,2 High-flow nasal cannula is also more comfortable than other noninvasive positive pressure ventilation (NIPPV) devices. NIPPV other than high-flow nasal cannula may have a role in the management of hypoxemic COVID-19 patients. You escalate oxygen therapy while using awake repositioning, and, finally with high-flow nasal cannula, the patient's work of breathing improves and oxygen saturation reaches 90%. ./cache/cord-268145-0sv6fdtj.txt ./txt/cord-268145-0sv6fdtj.txt