id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-268662-mw8ec7u2	Salton, Francesco	Prolonged low-dose methylprednisolone in patients with severe COVID-19 pneumonia	2020-09-12		.txt	text/plain	4402	275	50	METHODS: We conducted a multicenter, observational study to explore the association between exposure to prolonged, low-dose, MP treatment and need for ICU referral, intubation or death within 28 days (composite primary endpoint) in patients with severe COVID-19 pneumonia admitted to Italian respiratory high-dependency units. [6] We hypothesized that early MP treatment in hypoxemic patients with severe SARS-CoV-2 pneumonia at higher risk for ARF progression requiring invasive MV, may quicken disease resolution, reducing the need for ICU support and mortality. Multivariable Cox proportional-hazard models estimated the hazard ratio (HR) of both the primary composite endpoint and all-cause death, with the corresponding 95% confidence intervals (95% CI), taking into account the confounding factors (i.e., sex, age, and baseline values of SOFA score, PaO 2 :FiO 2 , CRP levels) potentially associated with the outcome. In our multicenter study, patients exposed to MP encountered the primary composite endpoint of ICU referral, need for invasive MV or in-hospital all-cause death significantly less compared to the control group (adjusted HR 0.41).	./cache/cord-268662-mw8ec7u2.txt	./txt/cord-268662-mw8ec7u2.txt