id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-268948-1ns6zi27	Shi, Yaling	Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China	2020-03-16		.txt	text/plain	3162	206	58	In the current study, we analyzed multiple cytokines and immune cell populations in the blood of Chinese COVID-19 patients. Total T cell number was significantly decreased in COVID-19 patients, but no significant difference was observed between mild and severe patients ( Figure 1G ). Similarly, CD4+ T helper cells and CD8+ cytotoxic T cells were diminished in COVID-19 patients as compared with the control group, but no significant difference was found between mild and severe patients ( Figure 1H & 1I) . We found that Tregs were increased in mild COVID-19 patients as compared with controls ( Figure 3B ). In the present clinical study, we analyzed almost all immune cell types in both mild and severe COVID-19 patients. IL-10 acts as an anti-inflammatory cytokine deriving from alternatively activated macrophages, Th2 cells, Tregs, etc 16 In conclusion, our study shows that the comprehensive decrease of lymphocytes, and the elevation of IL-2 and IL-6 are reliable indicators of severe COVID-19.	./cache/cord-268948-1ns6zi27.txt	./txt/cord-268948-1ns6zi27.txt