id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-269130-zsem29ss	Lingappan, K.	Understanding the age divide in COVID-19: why are children overwhelmingly spared?	2020-07-01		.txt	text/plain	3121	163	45	The differences in the clinical course are highlighted by the lack of progression of the SARS-CoV-2 infection beyond mild symptoms in a majority of children, whereas in adults the disease progresses to acute lung injury and an acute respiratory distress syndrome (ARDS)-like phenotype with high mortality. The pathophysiological mechanisms leading to decreased lung injury in children may involve the decreased expression of the mediators necessary for viral entry into the respiratory epithelium and differences in the immune system responses in children. On the other hand, the heightened immune response to the virus in many adult patients can lead to the worsening of lung disease with SARS-CoV-2 infection (37) . Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice	./cache/cord-269130-zsem29ss.txt	./txt/cord-269130-zsem29ss.txt