id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-270591-0szbkhiz	Shi, Chen	Comprehensive Landscape of Heparin Therapy for COVID-19	2020-10-22		.txt	text/plain	6198	354	41	Clinical observations found that systemic symptoms caused by SARS-CoV-2 infection are attenuated when using the anticoagulant agent heparin, indicating that heparin may play other roles in managing COVID-19, in addition to prevention of pulmonary thrombosis. This review discusses the pharmacological mechanisms of heparin regarding its anticoagulant, anti-inflammatory and direct antiviral activities, providing current evidence concerning the effectiveness and safety of heparin therapy for this major public health emergency. In addition to its anticoagulant and anti-inflammatory activity, heparin may possess a direct antiviral effect to SARS-CoV-2, based on the preclinical studies for other viral infections. There are both preclinical evidence and clinical data to demonstrate the benefits of heparin therapy for SARS-CoV-2 infection.With anticoagulant and anti-inflammatory effects, heparin can offer supportive treatment and alleviate the systematic symptoms of COVID-19.	./cache/cord-270591-0szbkhiz.txt	./txt/cord-270591-0szbkhiz.txt