id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-270654-cz2y6ta9	Deftereos, Spyridon G.	The Greek study in the effects of colchicine in COvid-19 complications prevention (GRECCO-19 study): Rationale and study design	2020-04-03		.txt	text/plain	2114	136	43	Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. Based on the aforementioned data, the question which arises is whether colchicine, administered in a relatively low dose, could potentially have an effect the patients' clinical course by limiting the myocardial necrosis and pneumonia development in the context of COVID-19. Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC Severe Acute Respiratory Syndrome Coronavirus Viroporin 3a Activates the NLRP3 Inflammasome Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation	./cache/cord-270654-cz2y6ta9.txt	./txt/cord-270654-cz2y6ta9.txt