id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-271416-53qxs7ge	Zhou, Kehua	Towards precision management of cardiovascular patients with COVID-19 to reduce mortality	2020-04-28		.txt	text/plain	1098	61	46	1 Suppression of the classical angiotensin converting enzyme (ACE)-angiotensin II (angII)-angiotensin receptor (AT) 1 axis may be part of the treatment of COVID-19 while decreasing CVD complications and mortalities. Lower levels of ACE2 mediates the occurrence of cytokine production that can cause or is the result of the imbalance between oxygen supply and demand, 2,5 similar to the pathophysiology of type 2 myocardial infarction in COVID-19, especially in those with underlying CVDs. Going one step further, we postulate that CVD patients with a poorer tolerance to hypoxia may have higher morality risks of COVID-19, which may also apply to healthy people. In conclusion, the alignment between our postulated clinical mechanisms and epidemiological estimates, despite some confounding factors, enables us to propose a novel hypothesis between patients of high-altitude origin and their lower mortality risk of COVID-19. The association of angiotensin-converting enzyme gene insertion/deletion polymorphisms with adaptation to high altitude: A meta-analysis	./cache/cord-271416-53qxs7ge.txt	./txt/cord-271416-53qxs7ge.txt