id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-273050-reez33md	Wang, Zhenling	Type I IFN deficiency: an immunological characteristic of severe COVID-19 patients	2020-09-14		.txt	text/plain	1337	85	46	reported that type I interferon (IFN) deficiency, could be a hallmark of severe coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Compared with patients that had mild-to-moderate infection, the ISG score (based on the mean expression value of six ISGs defining a type I IFN signature) was significantly reduced in critical patients. By correlated analysis of viral loading with IFN-α production either on protein or on gene level, the authors suggest that the most severe cases of COVID-19 are featured by impaired IFN-α production. To further explore the transcription factors that may cause the excessive inflammatory response of COVID-19, the authors observed that upregulated genes in severe or critical patients mainly belonged to the NF-κB pathway by a kinetic analysis. Impaired type I IFN response featured immunological characteristics of severe COVID-19 patients, accompanied by lymphocytopenia, hypercytokinaemia, and high blood viral load. Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients	./cache/cord-273050-reez33md.txt	./txt/cord-273050-reez33md.txt