id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-273318-82ptu8fi	Prats-Uribe, A.	Heterogeneity and temporal variation in the management of COVID-19: a multinational drug utilization study including 71,921 hospitalized patients from China, South Korea, Spain, and the United States of America	2020-09-18		.txt	text/plain	4712	260	49	Design: International network cohort Setting: Hospital electronic health records from Columbia University Irving Medical Centre (NYC, USA), Stanford (CA, USA), Tufts (MA, USA), Premier (USA), Optum EHR (USA), department of veterans affairs (USA), NFHCRD (Honghu, China) and HM Hospitals (Spain); and nationwide claims from HIRA (South Korea) Participants: patients hospitalized for COVID-19 from January to June 2020 Main outcome measures: Prescription/dispensation of any medicine on or 30 days after hospital admission date Analyses: Number and percentage of users overall and over time Results: 71,921 people were included: 304 from China, 2,089 from Spain, 7,599 from South Korea, and 61,929 from the USA. • Drug repurposing is a common approach in the clinical management of novel diseases and conditions for which there are no available pharmacotherapies • Hydroxychloroquine was widely used in the management of COVID-19 patients during the early phases of the pandemic • Recent NIH (and other) guidelines recommend the use of concomitant therapies including immune-based, antithrombotic, antibiotic and other treatments What this study adds • This study demonstrates great variability and extensive drug repurposing and utilization in the management of COVID-19 patients.	./cache/cord-273318-82ptu8fi.txt	./txt/cord-273318-82ptu8fi.txt