id author title date pages extension mime words sentences flesch summary cache txt cord-273811-ymnvwwjw Rubio-Rivas, M. Beneficial and Harmful Outcomes of Tocilizumab in Severe COVID-19: A Systematic Review and Meta-Analysis 2020-09-08 .txt text/plain 4828 341 55 Two investigators (M.R-R., J.M.M-L.) independently abstracted the following details: study characteristics, including setting; intervention or exposure characteristics, including medication dose and duration; patient characteristics, including severity of disease; and outcomes, including mortality, admission to ICU, adverse events such as secondary infections, and length of hospital stay. More restrictive analysis excluding studies with <20 included patients, NOS <7 and studies with important risk of bias, showed pooled mortality in the TCZ-group to be 18.9% ( is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint Pending published evidence from RCTs, this systematic review and meta-analysis focused on available real-world observational studies, revealing a beneficial effect of TCZ use in preventing mortality in hospitalized adults with COVID-19. ./cache/cord-273811-ymnvwwjw.txt ./txt/cord-273811-ymnvwwjw.txt