id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-274824-kaefedl1	Turski, Waldemar A.	AhR and IDO1 in pathogenesis of Covid-19 and the “Systemic AhR Activation Syndrome:” a translational review and therapeutic perspectives	2020-09-24		.txt	text/plain	5928	284	36	as pro viral factor TiPARP, and to the modulation of cytokine gene expression, specifically, interleukin 1␤ (IL-1␤), IL-10, and TNF-␣ ( Fig. 1) , which is consistent with the role for AhR activation in the host response to CoV infection Grunewald, Shaban, Mackin, Fehr, & Perlman, 2020; Neavin, Liu, Ray, & Weinshilboum, 2018) . Since CoV persistently activate AhRs, this may lead to up-regulation of multiple sets of downstream effectors resulting in different pathologies (Fig. 2) depending on time after infection, individuals overall state of health, comorbidities, and environmental factors affecting AhRs. We believe it is therefore appropriate to describe this disease as a systemic AhR activation syndrome (SAAS), which can manifest in an acute (current pandemic), and perhaps later, in a chronic form, in survivors.	./cache/cord-274824-kaefedl1.txt	./txt/cord-274824-kaefedl1.txt