id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-275004-qzg03dvg	Veras, Flavio Protasio	SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology	2020-09-14		.txt	text/plain	6380	383	51	The concentration of NETs was augmented in plasma, tracheal aspirate, and lung autopsies tissues from COVID-19 patients, and their neutrophils released higher levels of NETs. Notably, we found that viable SARS-CoV-2 can directly induce the release of NETs by healthy neutrophils. The well-known similarities between sepsis and key events involved in the COVID-19 pathophysiology, such as cytokine overproduction (Mehta et al., 2020) , microthrombosis (Magro et al., 2020; Dolhnikoff et al., 2020) , and acute respiratory distress syndrome (Lai et al., 2020) , led us to hypothesize that NETs are triggered during SARS-CoV-2 infection and might contribute to tissue injury in COVID-19 patients. In summary, in the present study, we demonstrated that in COVID-19 patients, circulating and lung-infiltrating neutrophils are releasing higher levels of NETs. We also showed that SARS-CoV-2 directly stimulates neutrophils to release NETs in mechanisms dependent on ACE2 and serine protease activity axis and effective viral replication.	./cache/cord-275004-qzg03dvg.txt	./txt/cord-275004-qzg03dvg.txt