id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-276493-hoaxv5e0	Jeong, Gi Uk	Therapeutic Strategies Against COVID-19 and Structural Characterization of SARS-CoV-2: A Review	2020-07-14		.txt	text/plain	5687	363	56	With increasing structural data of key proteins in both SARS-CoV-2 and the host, such as the spike glycoprotein (S), the main protease (M pro ), RNA-dependent RNA polymerase (RdRp), and human angiotensin-converting enzyme 2 (hACE2), the structure-based design of new drugs has emerged as the most promising antiviral strategy. Several structure-based drug discovery studies have investigated the interaction of inhibitors in the substrate-binding pockets of SARS-CoV-2 M pro ( Figure 3C ) (Dai et al., 2020; Jin et al., 2020; Zhang et al., 2020b) . Because most inhibitors occupy the substrate binding pocket of SARS-CoV-2 FIGURE 4 | CryoEM structure of RdRp in complex with cofactors (nsp7 and nsp8), RNA template, and remdesivir. In addition, we provided structural insights into the mechanism of action of well-characterized drugs targeting the interaction between hACE2 and the spike protein of SARS-CoV-2 for viral entry, as well as M pro and RdRp for viral replication.	./cache/cord-276493-hoaxv5e0.txt	./txt/cord-276493-hoaxv5e0.txt