id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-277879-7ftu9b9q	Martinez-Sanz, J.	Effects of Tocilizumab on Mortality in Hospitalized Patients with COVID-19: A Multicenter Cohort Study	2020-06-09		.txt	text/plain	4019	228	47	Propensity score logistic models predicted exposure at baseline and censoring over time as a result of recognized confounders of severe COVID-19 17, 18 including age, gender, comorbidities (hypertension, diabetes, ischemic heart disease, kidney disease, congestive heart failure, lung disease), oxygen blood saturation and need for oxygen therapy at baseline, and time-varying parameters of clinical severity (blood pressure, heart rate, total lymphocyte and neutrophil count, lactate dehydrogenase, alanine aminotransferase, urea, D-dimers, and CRP). . https://doi.org/10.1101/2020.06.08.20125245 doi: medRxiv preprint Figure 3 and Table S2 show the adjusted hazard ratios for exploratory sensitivity analyses restricted to patients with baseline lymphocyte count <1000 cell/µl and baseline D-dimer >1000 ng/mL segregated by CRP levels. 14 However, there are key analytical issues in this setting, including the risk of immortal time bias (i.e., the requirement for patients to survive long enough to receive the intervention of interest, which can lead to a potentially incorrect estimation of a positive treatment effect), and indication bias from time-varying confounding (e.g., the use of tocilizumab following elevations of CRP).	./cache/cord-277879-7ftu9b9q.txt	./txt/cord-277879-7ftu9b9q.txt