id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-279131-1unb0z79	Buijsers, Baranca	Beneficial non-anticoagulant mechanisms underlying heparin treatment of COVID-19 patients	2020-08-25		.txt	text/plain	3989	219	30	Here, we summarise potential beneficial, non-anticoagulant mechanisms underlying treatment of COVID-19 patients with heparin/LMWH, which include: (i) Inhibition of heparanase activity, responsible for endothelial leakage; (ii) Neutralisation of chemokines, and cytokines; (iii) Interference with leukocyte trafficking; (iv) Reducing viral cellular entry, and (v) Neutralisation of extracellular cytotoxic histones. In addition to functioning as anticoagulants, heparins have other therapeutic functions that are relevant for the treatment of COVID-19-associated clinical manifestations, i.e. neutralisation of inflammatory chemokines, and cytokines, such as CXCL-1, IL-6, and IL-8 that play a key role in ARDS; neutralisation of extracellular cytotoxic histones and by interfering with leukocyte trafficking [20] . Data for this review were identified by searches of PubMed, and preprint servers, and references from relevant articles using the search terms "COVID-19", "Heparin", "Non-anticoagulant functions of heparin", "Low molecular weight heparin", "ARDS", "Kidney dysfunction", "Endothelial barrier dysfunction", "Heparanase", "Heparan sulphate", "Viral entry", "Heparanase inhibition", "Inflammation", "Complement system", and "Neutrophil extracellular traps".	./cache/cord-279131-1unb0z79.txt	./txt/cord-279131-1unb0z79.txt