id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280416-wd6jm2ms	Mukhopadhyay, S.	Dynamic dysregulation of IL-6 and genes functional in NETosis, complement and coagulation in severe COVID-19 illness	2020-10-14		.txt	text/plain	4105	248	48	Comprehensive and unbiased re-analysis of published blood transcriptome data from patients of COVID-19 reveals significant up-regulation of the gene set functional in NETosis, but no evidence of general cytokine storm. In severe COVID-19 illness, there is significant up-regulation of complement and coagulation pathway, and negative correlation between NETosis and respiratory function (oxygen saturation). However, at present, it is difficult to predict with certainty the patients at high-risk for clinical severity and poor outcome, although multiple pathophysiological processes have been proposed, such as, cytokine storm [2, 3] , coagulation and complement activation [4] , neutrophil extracellular trap -NETosis [5] . Gene set enrichment analysis (permutation testing) revealed that the genes functional in NETosis were strongly up-regulated in the blood of COVID-19 patients compared to healthy subjects ( Figure 1A ). Our analysis (of data from [13]) also revealed significant up-regulation of the complement pathway genes in severe COVID-19 illness.	./cache/cord-280416-wd6jm2ms.txt	./txt/cord-280416-wd6jm2ms.txt