id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280528-7ivw72l0	TUFAN, Abdurrahman	COVID-19, immune system response, hyperinflammation and repurposing antirheumatic drugs	2020-04-21		.txt	text/plain	7053	364	42	In this review, to gain better information about appropriate anti-inflammatory treatments, mostly used in rheumatology for COVID-19, we have focused the attention on the structural features of SARS-CoV-2, the host immune response against SARS-CoV-2 and its association with the cytokine storm. The effective antiviral responses of the host innate and adaptive immunity, including the production of various proinflammatory cytokines, the activation of T cells, CD4 and CD8+ T cells, are essential for controlling the viral replication, limiting the spread of virus, inflammation and cleaning the infected cells [31, 32] . Few retrospective studies have revealed that the lung injury reported with Murray score is strongly associated with the level of IL-1α, IL-1ra, IL-2, IL-7, IL-10, IL-17, IFN-ɣ, inducible interferon protein (IP)-10, G-CSF, and MCP-3 and these cytokines and chemokines excluding MCP-3 are positively related to SARS-CoV-2 viral load 2 [7] .	./cache/cord-280528-7ivw72l0.txt	./txt/cord-280528-7ivw72l0.txt