id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-280960-88hzovg2	Galani, I. E.	Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison	2020-08-24		.txt	text/plain	4630	284	55	By investigating temporal IFN and inflammatory cytokine patterns in 32 COVID-19 patients hospitalized for pneumonia and longitudinally followed for the development of respiratory failure and death, we reveal that IFN-{lambda} and type I IFN production is both diminished and delayed, induced only in a fraction of patients as they become critically ill. By comparison, in 16 flu patients hospitalized for pneumonia with similar clinicopathological characteristics to COVID-19 and 24 milder non-hospitalized flu patients IFN-{lambda} and type I IFN are robustly induced, earlier, at higher levels and independently of disease severity, while pro-inflammatory cytokines are only acutely and transiently produced. 81 Here, we have performed a comprehensive temporal analysis of type I and type III IFN, and major 82 inflammatory cytokine patterns in 32 COVID-19 and 16 influenza A virus infected (flu) patients 83 hospitalized for community acquired pneumonia and longitudinally followed up according to current 84 WHO guidelines 18 .	./cache/cord-280960-88hzovg2.txt	./txt/cord-280960-88hzovg2.txt