id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-282458-5v9k4yyj	Balakrishnan, Vijayakumar	Screening of FDA Approved Drugs Against SARS-CoV-2 Main Protease: Coronavirus Disease	2020-09-28		.txt	text/plain	2360	137	56	Finally, all the chosen drugs used in the IFD studies were analyzed for the favorable docking score, glide energy, glide emodel and interaction studies (hydrogen bond and hydrophobic) with COVID-19 Mpro. This IFD complex has possessed docking score − 14.183, glide energy − 114.183, Table 2 ) and has very good non-bonded interactions with the active site residues. In this study, the FDA-approved (~ 1500 compounds) drugs were screened using HTVs. Based on the results, four drugs were compared with the N3 inhibitor which was previously redocked at the active site of COVID-19 Mpro. The four drugs Sincalide, Pentagastrin, Ritonavir and Phytonadione have been found to possess better results with COVID-19 Mpro (Coronavirus disease). In particular, the potent inhibition exhibited by the FDA approved Sincalide and Pentagastrin drugs were found to be more efficient in terms of docking score, energy and capability of forming hydrogen bond interactions with the active site residues.	./cache/cord-282458-5v9k4yyj.txt	./txt/cord-282458-5v9k4yyj.txt