id author title date pages extension mime words sentences flesch summary cache txt cord-285327-m0yaa1oa Vuitton, Dominique A. A plea for the pathogenic role of immune complexes in severe Covid-19 2020-06-08 .txt text/plain 675 37 41 This hypothesis is justified by the delayed occurrence of the cytokine storm and patient's aggravation, pathological observations of endothelitis, association with disseminated microvascular thrombosis in the most severe cases, and location of the lesions to specific organs, including heart, brain, kidney and skin [1, 4] ; similar observations are common in experimental and clinical models of pathogenic ICs, such as serum sickness, or viral diseases with IC deposition and massive inflammatory reactions [5] . In the recent weeks, observations of intravenous immunoglobulins-(Igs-) responsive Kawasaki-like disease in children with SARS-CoV2 infection [6] and the efficacy of IL-1 receptor antagonist (anakinra) in a severely ill COVID-19 teenage patient [7] were published. The specific humoral and cellular immune response towards SARS-CoV2 was comprehensively analyzed in a non-severe case of the disease [11] . Breadth of J o u r n a l P r e -p r o o f Journal Pre-proof concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19 ./cache/cord-285327-m0yaa1oa.txt ./txt/cord-285327-m0yaa1oa.txt