id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-286084-2275xvxb	Dixit, Alok	Ivermectin: Potential Role as Repurposed Drug for COVID-19	2020-08-19		.txt	text/plain	2238	113	45	Currently there is no effective treatment for coronavirus infection; major effort is to develop vaccine against the virus and development of therapeutic drugs for the disease. IVM is shown to be effective in vitro against RNA and deoxyribonucleic acid (DNA) viruses, including human immunodeficiency virus-1 (HIV-1), dengue virus (DENV), influenza, Venezuelan equine encephalitis virus (VEEV) and Zika virus (14) . Currently, remdesivir is a promising potential therapy for COVID-19 due to its broad-spectrum and potent in vitro activity against several novel coronavirus (nCoVs), including SARS-CoV-2 with EC 50 (half maximal effective concentration) and EC 90 (concentration to induce 90% maximal response) values of 0.77 μM and 1.76 μM, respectively (8). IVM which is a widely used as antiparasitic drug has shown to have antiviral activity in in vitro studies against HIV, dengue, influenza, VEEV and Zika virus. Studies are available for its use against RNA virus and have also been tested for its effectiveness against SARS-CoV-2 in vitro.	./cache/cord-286084-2275xvxb.txt	./txt/cord-286084-2275xvxb.txt