id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-286520-oh95lnf9	Levi, Marcel	Coronavirus Disease 2019 Coagulopathy: Disseminated Intravascular Coagulation and Thrombotic Microangiopathy—Either, Neither, or Both	2020-06-08		.txt	text/plain	1676	108	38	22 Overt intravascular hemolysis and severe thrombocytopenia, as seen in typical cases of thrombocytopenic thrombotic purpura (TTP), is not a clinical feature of COVID-19 infection. However, COVID-19 infection with associated endothelial cell perturbation may lead to decreased ADAMTS-13 levels due to consumption or proteolytic degradation, resulting in high levels of uncleaved von Willebrand factor multimers and ensuing deposit of microvascular platelet thrombi. The resulting plasmin generation may be an important factor explaining the high levels of D-dimer seen in patients with severe COVID-19 infection. Severe COVID-19 infection is associated with coagulation abnormalities that encompass elements reminiscent of both DIC and TMA (►Fig. 1). Endothelial cell perturbation in coronavirus infection also leads to release of plasminogen activators that in combination with the procoagulant response may be responsible for the (very) high D-dimer levels. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis	./cache/cord-286520-oh95lnf9.txt	./txt/cord-286520-oh95lnf9.txt