id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-287459-k9x3z2h1	Abu-Farha, Mohamed	The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target	2020-05-17		.txt	text/plain	4822	253	41	Since lipids play a crucial function in the viral life cycle, we asked whether drugs targeting lipid metabolism, such as statins, can be utilized against SARS-CoV-2 and other viruses. Similarly, increased expression of age-dependent phospholipase A2 group IID (PLA2G2D), an enzyme that usually contributes to anti-inflammatory/pro-resolving lipid mediator expression, resulted in worsened outcomes in aged mice infected with SARS-CoV, suggesting that inhibition of such factor could represent a potential therapeutic option [36] . Of high relevance to this review and the ongoing COVID-19 pandemic is the role of lipid rafts in viral entry into the host cells. Taken together, these studies suggest a beneficial impact for statins and potentially other lipid-lowering drugs such as PCSK9 inhibitors for treatment of COVID-19, especially that of the most severely infected people which are suffering from cardiovascular disease and diabetes [55] .	./cache/cord-287459-k9x3z2h1.txt	./txt/cord-287459-k9x3z2h1.txt