id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288931-d4fyitnk	Parisi, Valentina	Precision medicine in COVID-19: IL-1β a potential target	2020-04-18		.txt	text/plain	320	29	43	A wide spectrum of disease severity has been described, ranging from asymptomatic, mildly symptomatic, severe symptomatic requiring hospitalization, to respiratory failure from acute respiratory distress syndrome (ARDS). Overall, these evidences suggest that the prognosis appears to be more conditioned by the host's response than by the infection itself, thus a precision medicine approach is highly desirable. In cardiovascular diseases, an important source of inflammatory mediators, including IL-1β, is the visceral adipose tissue (4) . In conclusion, there are many open questions that merit to be explored: i) to verify the role of NLRP3 in the clinical variability of COVID-19; ii) to test the potential therapeutic effect in COVID-19 of IL-1β inhibition (canakinumab, anakinra); iii) to explore the role of visceral adipose tissue in the inflammatory response to SARS-CoV-2 infection. Inhibitory Effects of Toll-Like Receptor 4, NLRP3 Inflammasome, and Interleukin-1β on White Adipocyte Browning	./cache/cord-288931-d4fyitnk.txt	./txt/cord-288931-d4fyitnk.txt