id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-289064-435bp4rt	Muniangi-Muhitu, Hermine	Covid-19 and Diabetes: A Complex Bidirectional Relationship	2020-10-08		.txt	text/plain	5744	290	43	Identified risk factors for disease severity and death from SARS-Cov2 infection include older age, male sex, diabetes, obesity and hypertension. We consider roles for the immune system, the observed phenomenon of microangiopathy in severe Covid-19 infection and the potential for direct viral toxicity on metabolically-relevant tissues including pancreatic beta cells and targets of insulin action. (18) , patients with diabetes and hypertension who had been treated with ACE inhibitors or angiotensin receptor blockers (ARB) had a high number of ACE2 receptors in the lung, and could therefore be at higher risk of developing severe symptoms, if infected with Covid-19. With respect to the glycemic deterioration seen in patients with preexisting T2D during Covid-19, a very recent report (63) provides the intriguing observation that ACE2 expression at both the mRNA and protein is increased substantially in human beta cells in response to response to inflammatory cytokines, presumably rendering these cells more susceptible to infection.	./cache/cord-289064-435bp4rt.txt	./txt/cord-289064-435bp4rt.txt