id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-289574-engwi8h3	An, Peng-jiao	Biochemical indicators of coronavirus disease 2019 exacerbation and the clinical implications	2020-05-23		.txt	text/plain	3188	220	39	Accumulating evidence suggested that the progression of COVID-19 is associated with lymphopenia and excessive inflammation, and a subset of severe cases might exhibit cytokine storm triggered by secondary hemophagocytic lymphohistiocytosis (sHLH). Previously, it has been found that the serum levels of pro-inflammatory cytokines [IFN-γ, IL-1, IL-6, IL-12, and transforming growth factor-β (TGF-β)], and chemokines (CCL2, CXCL9, CXCL10, and IL-8) in SARS-CoV infected patients were higher than those in healthy individuals. Procalcitonin (PCT), released by bacterial infectious tissues under the irritation of pro-inflammatory cytokines, is a more specific marker of serious bacterial infection compared to C-reactive protein (CRP) and IL-6 [111] PCT-based strategy has been applied to guide antibiotic use in ICU or emergency wards, since the serum PCT levels in patients with severe bacterial infections are much higher than those with simple viral infections or non-specific inflammatory diseases [111] [112] [113] . The definition and risks of Cytokine Release Syndrome-Like in 11 COVID-19-Infected Pneumonia critically ill patients: Disease Characteristics and Retrospective Analysis	./cache/cord-289574-engwi8h3.txt	./txt/cord-289574-engwi8h3.txt