id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-290677-3gdcyrrz	De Virgiliis, Francesco	Lung innervation in the eye of a cytokine storm: neuroimmune interactions and COVID-19	2020-08-25		.txt	text/plain	6108	278	34	In line with these findings, virus-induced airway hyperresponsiveness in humans seems to be mediated by the vagus nerve 53 , raising the possibility that the dyspnoea and respiratory failure observed in patients with severe COVID-19 is exacerbated by neuroimmune crosstalk in the lungs. A plausible hypothesis is that these NAMs act in concert with neuronal cells to control inflammation, and that malfunctioning of this system in older or immunocompromised people could contribute to the cytokine storm and ARDS in patients with severe COVID-19 or other respiratory virus infections. In the context of SARS-CoV-2 infection, specific tissueresident macrophages that are involved in modulating inflammation following viral infection are in close contact with vagal fibres innervating the lungs, and this 'neuroimmune synapse' could be one of the keys to controlling aberrant inflammation in patients with severe COVID-19.	./cache/cord-290677-3gdcyrrz.txt	./txt/cord-290677-3gdcyrrz.txt