id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291144-6p40cqvk	Strom, Mark A.	Reticular skin eruption as the initial sign of coronavirus disease 2019 infection	2020-06-24		.txt	text/plain	1076	63	37	INTRODUCTION Several recent reports have described clinically significant coagulopathy associated with a spectrum of severity of coronavirus disease 2019 (COVID-19) infection. Here we describe a patient whose initial sign of COVID-19 infection was a reticular skin eruption, portending the discovery of hypercoagulability and development of severe disease. In fact, one pathologic study of 5 COVID-19 patients, 3 of whom had cutaneous signs of systemic hypercoagulability including retiform purpura and livedo racemosa, found a potential role for complement-associated microvascular injury. 7 It is notable that our patient's skin findings preceded other symptoms of COVID-19 and may have heralded the development of coagulopathy. Reticular skin findings are increasingly described in patients with COVID-19, although they appear less frequently than other cutaneous manifestations. A recent report from the United States found transient livedo reticularis pattern in 2 patients recovering from COVID-19 who were asymptomatic at the time. Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases	./cache/cord-291144-6p40cqvk.txt	./txt/cord-291144-6p40cqvk.txt