id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-291226-xdq2edy0	Stefely, Jonathan A.	Marked factor V activity elevation in severe COVID‐19 is associated with venous thromboembolism	2020-08-24		.txt	text/plain	5592	287	50	To begin testing the hypothesis that factor V activity elevation is associated with COVID-19, we measured a panel of coagulation parameters in the earliest available specimen from the first 102 SARS-CoV-2 positive patient specimens submitted to our coagulation laboratory without any exclusion criteria, 17 contemporaneous controls, and 260 to 478 historical controls per test prior to the COVID-19 pandemic. Using a validated clinical laboratory assay, we found factor V activity to be markedly elevated in many patients in this severe COVID-19 cohort (median 150 IU/dL, n = 102) compared to the expected reference median value of 100 IU/dL activity (Figures 1A and 1B) . Compared to all patient specimens tested in our laboratory during the four years prior to the COVID-19 pandemic (April 2016 -February 2020) (n = 446), factor V activity was significantly higher in our cohort of patients with severe COVID-19 (COVID-19 median 150 IU/dL, historical control median 81 IU/dL, P < 1x10 -32 ) ( Figure 1A ).	./cache/cord-291226-xdq2edy0.txt	./txt/cord-291226-xdq2edy0.txt