id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-292030-cjz4nuag	Qiu, Guangyu	Dual-Functional Plasmonic Photothermal Biosensors for Highly Accurate Severe Acute Respiratory Syndrome Coronavirus 2 Detection	2020-04-13		.txt	text/plain	5689	305	48	In this work, a dual-functional plasmonic biosensor combining the plasmonic photothermal (PPT) effect and localized surface plasmon resonance (LSPR) sensing transduction provides an alternative and promising solution for the clinical COVID-19 diagnosis. The two-dimensional gold nanoislands (AuNIs) functionalized with complementary DNA receptors can perform a sensitive detection of the selected sequences from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through nucleic acid hybridization. 26−29 In this work, we developed a dual-functional LSPR biosensor through combining the photothermal effect and plasmonic sensing transduction for SARS-CoV-2 viral nucleic acid detection. The plasmonic chip with the twodimensional distribution of nanoabsorbers (AuNIs) is capable to generate the local PPT heat and transduce the in situ hybridization for highly sensitive and accurate SARS-CoV-2 detection. According to the phase-sensing diagram in Figure 4b and S6a, the LSPR response of the dual-functional AuNI biosensor started to increase when the RdRp-COVID genes were injected into the microfluidic chamber at about 200 s and attained the maximum phase value after about 800 s hybridization.	./cache/cord-292030-cjz4nuag.txt	./txt/cord-292030-cjz4nuag.txt